Adgrl1 (adhesion G protein-coupled receptor L1) - Rat Genome Database

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Gene: Adgrl1 (adhesion G protein-coupled receptor L1) Rattus norvegicus
Analyze
Symbol: Adgrl1
Name: adhesion G protein-coupled receptor L1
RGD ID: 620768
Description: Enables cell adhesion molecule binding activity; toxic substance binding activity; and transmembrane signaling receptor activity. Involved in calcium-mediated signaling using intracellular calcium source; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and positive regulation of synapse maturation. Located in growth cone; plasma membrane; and synapse. Is active in glutamatergic synapse and presynaptic membrane. Orthologous to human ADGRL1 (adhesion G protein-coupled receptor L1); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcium-independent alpha-latrotoxin receptor 1; CIRL-1; CL1BA; latrophilin 1; latrophilin-1; Lphn1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81941,107,162 - 41,148,752 (-)NCBIGRCr8
mRatBN7.21924,202,405 - 24,244,137 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,204,360 - 24,244,139 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1931,025,506 - 31,065,123 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01931,679,912 - 31,719,528 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01933,902,636 - 33,942,265 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01925,029,037 - 25,069,146 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,029,037 - 25,069,142 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,021,693 - 36,047,251 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41925,891,157 - 25,931,128 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11925,895,986 - 25,935,954 (-)NCBI
Celera1923,752,024 - 23,791,544 (-)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IBA,IDA,IEA)
glutamatergic synapse  (IDA,IEP,IMP)
growth cone  (IDA,IEA)
membrane  (IEA)
neuron projection  (IDA)
plasma membrane  (IBA,IDA)
presynaptic membrane  (IBA,IDA,IEA,IEP,IMP)
synapse  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Involvement of the calcium-independent receptor for alpha-latrotoxin in brain ischemia. Bin Sun H, etal., Brain Res Mol Brain Res. 2002 Aug 15;104(2):246-9.
2. Isolation and biochemical characterization of a Ca2+-independent alpha-latrotoxin-binding protein. Davletov BA, etal., J Biol Chem 1996 Sep 20;271(38):23239-45.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. alpha-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor. Krasnoperov VG, etal., Neuron 1997 Jun;18(6):925-37.
6. The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins. Kreienkamp HJ, etal., J Biol Chem. 2000 Oct 20;275(42):32387-90.
7. Alpha-latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors. Lelianova VG, etal., J Biol Chem 1997 Aug 22;272(34):21504-8.
8. The latrophilin family: multiply spliced G protein-coupled receptors with differential tissue distribution. Matsushita H, etal., FEBS Lett 1999 Jan 29;443(3):348-52.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Norepinephrine exocytosis stimulated by alpha-latrotoxin requires both external and stored Ca2+ and is mediated by latrophilin, G proteins and phospholipase C. Rahman MA, etal., Philos Trans R Soc Lond B Biol Sci. 1999 Feb 28;354(1381):379-86.
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities. Silva JP, etal., Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12113-8. doi: 10.1073/pnas.1019434108. Epub 2011 Jul 1.
14. The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family. Tobaben S, etal., J Biol Chem 2000 Nov 17;275(46):36204-10.
Additional References at PubMed
PMID:9830014   PMID:9920906   PMID:12270923   PMID:19161337   PMID:22262843   PMID:22871113   PMID:24613359   PMID:32996461  


Genomics

Comparative Map Data
Adgrl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81941,107,162 - 41,148,752 (-)NCBIGRCr8
mRatBN7.21924,202,405 - 24,244,137 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,204,360 - 24,244,139 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1931,025,506 - 31,065,123 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01931,679,912 - 31,719,528 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01933,902,636 - 33,942,265 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01925,029,037 - 25,069,146 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,029,037 - 25,069,142 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,021,693 - 36,047,251 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41925,891,157 - 25,931,128 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11925,895,986 - 25,935,954 (-)NCBI
Celera1923,752,024 - 23,791,544 (-)NCBICelera
Cytogenetic Map19q11NCBI
ADGRL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381914,147,743 - 14,206,169 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1914,147,743 - 14,206,187 (-)EnsemblGRCh38hg38GRCh38
GRCh371914,258,555 - 14,316,981 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,119,549 - 14,177,997 (-)NCBINCBI36Build 36hg18NCBI36
Build 341914,119,549 - 14,177,997NCBI
Celera1914,152,822 - 14,211,284 (-)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1913,829,970 - 13,888,419 (-)NCBIHuRef
CHM1_11914,258,980 - 14,317,433 (-)NCBICHM1_1
T2T-CHM13v2.01914,274,383 - 14,332,836 (-)NCBIT2T-CHM13v2.0
Adgrl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,626,598 - 84,668,583 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl884,626,734 - 84,668,583 (+)EnsemblGRCm39 Ensembl
GRCm38883,900,098 - 83,941,954 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl883,900,105 - 83,941,954 (+)EnsemblGRCm38mm10GRCm38
MGSCv37886,423,997 - 86,465,853 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36886,790,818 - 86,830,082 (+)NCBIMGSCv36mm8
Celera888,192,529 - 88,234,715 (+)NCBICelera
Cytogenetic Map8C2NCBI
cM Map840.22NCBI
Adgrl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541532,846,161 - 32,883,617 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541532,849,066 - 32,883,628 (-)NCBIChiLan1.0ChiLan1.0
ADGRL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22019,079,713 - 19,138,721 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11918,081,534 - 18,140,492 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01913,713,395 - 13,772,360 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11914,439,730 - 14,475,877 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1914,439,730 - 14,475,877 (-)Ensemblpanpan1.1panPan2
ADGRL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12048,316,909 - 48,383,783 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2048,339,945 - 48,381,667 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2048,192,793 - 48,258,299 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02048,836,078 - 48,901,545 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2048,858,591 - 48,899,602 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12048,047,337 - 48,112,760 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,473,880 - 48,537,373 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02048,716,611 - 48,782,111 (+)NCBIUU_Cfam_GSD_1.0
Adgrl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118207,531,905 - 207,560,180 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366592,794,520 - 2,822,848 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366592,794,520 - 2,822,795 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADGRL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl264,997,159 - 65,044,298 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1264,997,159 - 65,046,509 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,300,262 - 65,321,420 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADGRL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1612,782,202 - 12,795,742 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660746,800,557 - 6,863,556 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adgrl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249011,374,300 - 1,418,068 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249011,376,295 - 1,418,126 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adgrl1
109 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:915
Count of miRNA genes:190
Interacting mature miRNAs:230
Transcripts:ENSRNOT00000041025, ENSRNOT00000043971, ENSRNOT00000045699
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat

Markers in Region
D19Got21  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,233,287 - 24,233,495 (-)MAPPERmRatBN7.2
Rnor_6.01925,039,533 - 25,039,740NCBIRnor6.0
Rnor_5.01936,017,638 - 36,017,845UniSTSRnor5.0
RGSC_v3.41925,920,562 - 25,920,769RGDRGSC3.4
RGSC_v3.41925,920,562 - 25,920,769UniSTSRGSC3.4
RGSC_v3.11925,925,388 - 25,925,595RGD
Celera1923,780,835 - 23,781,042UniSTS
Cytogenetic Map19q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 28 36 21 15 21 74 35 36 11
Low 3 15 21 20 4 20 8 11 5 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF081144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF081145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF081146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF081147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF111099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U72487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U78105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000043971   ⟹   ENSRNOP00000045873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1924,204,360 - 24,226,458 (-)Ensembl
Rnor_6.0 Ensembl1925,043,680 - 25,068,275 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000045699   ⟹   ENSRNOP00000043269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1924,204,366 - 24,243,995 (-)Ensembl
Rnor_6.0 Ensembl1925,029,037 - 25,069,142 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098082   ⟹   ENSRNOP00000091684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1924,204,363 - 24,229,278 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101340   ⟹   ENSRNOP00000085538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1924,204,363 - 24,244,139 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101400   ⟹   ENSRNOP00000089805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1924,204,360 - 24,233,906 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103294   ⟹   ENSRNOP00000086387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1924,204,363 - 24,233,906 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113469   ⟹   ENSRNOP00000090901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1924,204,363 - 24,244,139 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115789   ⟹   ENSRNOP00000079689
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1924,204,360 - 24,217,452 (-)Ensembl
RefSeq Acc Id: NM_022962   ⟹   NP_075251
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,109,119 - 41,148,752 (-)NCBI
mRatBN7.21924,204,362 - 24,243,995 (-)NCBI
Rnor_6.01925,029,037 - 25,069,146 (+)NCBI
Rnor_5.01936,021,693 - 36,047,251 (+)NCBI
RGSC_v3.41925,891,157 - 25,931,128 (-)RGD
Celera1923,752,024 - 23,791,544 (-)RGD
Sequence:
RefSeq Acc Id: XM_039097964   ⟹   XP_038953892
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,107,162 - 41,148,697 (-)NCBI
mRatBN7.21924,202,405 - 24,243,989 (-)NCBI
RefSeq Acc Id: XM_039097965   ⟹   XP_038953893
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,107,162 - 41,148,697 (-)NCBI
mRatBN7.21924,202,405 - 24,243,989 (-)NCBI
RefSeq Acc Id: XM_039097966   ⟹   XP_038953894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,107,162 - 41,148,697 (-)NCBI
mRatBN7.21924,202,405 - 24,243,941 (-)NCBI
RefSeq Acc Id: XM_039097967   ⟹   XP_038953895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,107,162 - 41,148,697 (-)NCBI
mRatBN7.21924,202,405 - 24,244,137 (-)NCBI
RefSeq Acc Id: XM_039097968   ⟹   XP_038953896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,107,162 - 41,125,103 (-)NCBI
mRatBN7.21924,202,405 - 24,220,344 (-)NCBI
RefSeq Acc Id: XM_039097969   ⟹   XP_038953897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,107,162 - 41,125,103 (-)NCBI
mRatBN7.21924,202,405 - 24,220,344 (-)NCBI
RefSeq Acc Id: XM_039097971   ⟹   XP_038953899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,107,162 - 41,125,080 (-)NCBI
mRatBN7.21924,202,405 - 24,220,335 (-)NCBI
RefSeq Acc Id: XM_063278273   ⟹   XP_063134343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,107,162 - 41,120,970 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_075251   ⟸   NM_022962
- Peptide Label: precursor
- UniProtKB: A0A8I6AG63 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000043269   ⟸   ENSRNOT00000045699
RefSeq Acc Id: ENSRNOP00000045873   ⟸   ENSRNOT00000043971
RefSeq Acc Id: XP_038953895   ⟸   XM_039097967
- Peptide Label: isoform X4
- UniProtKB: A6IYC5 (UniProtKB/TrEMBL),   A0A8I6AG63 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953893   ⟸   XM_039097965
- Peptide Label: isoform X2
- UniProtKB: O88917 (UniProtKB/Swiss-Prot),   O88916 (UniProtKB/Swiss-Prot),   O35818 (UniProtKB/Swiss-Prot),   O09026 (UniProtKB/Swiss-Prot),   A6IYC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953892   ⟸   XM_039097964
- Peptide Label: isoform X1
- UniProtKB: O88917 (UniProtKB/Swiss-Prot),   O88916 (UniProtKB/Swiss-Prot),   O35818 (UniProtKB/Swiss-Prot),   O09026 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038953894   ⟸   XM_039097966
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AG63 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953897   ⟸   XM_039097969
- Peptide Label: isoform X6
- UniProtKB: A0A8I6G3M0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953896   ⟸   XM_039097968
- Peptide Label: isoform X5
- UniProtKB: A0A8I6G3M0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953899   ⟸   XM_039097971
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AB35 (UniProtKB/TrEMBL),   A6IYC7 (UniProtKB/TrEMBL),   A0A8I6G3M0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000079689   ⟸   ENSRNOT00000115789
RefSeq Acc Id: ENSRNOP00000086387   ⟸   ENSRNOT00000103294
RefSeq Acc Id: ENSRNOP00000089805   ⟸   ENSRNOT00000101400
RefSeq Acc Id: ENSRNOP00000091684   ⟸   ENSRNOT00000098082
RefSeq Acc Id: ENSRNOP00000085538   ⟸   ENSRNOT00000101340
RefSeq Acc Id: ENSRNOP00000090901   ⟸   ENSRNOT00000113469
RefSeq Acc Id: XP_063134343   ⟸   XM_063278273
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AB35 (UniProtKB/TrEMBL),   A6IYC7 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 2 profile   GPS   Olfactomedin-like   SUEL-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88917-F1-model_v2 AlphaFold O88917 1-1515 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620768 AgrOrtholog
BioCyc Gene G2FUF-6034 BioCyc
Ensembl Genes ENSRNOG00000029134 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043971.7 UniProtKB/TrEMBL
  ENSRNOT00000045699.5 UniProtKB/TrEMBL
  ENSRNOT00000098082.1 UniProtKB/TrEMBL
  ENSRNOT00000101340.1 UniProtKB/TrEMBL
  ENSRNOT00000101400 ENTREZGENE
  ENSRNOT00000101400.1 UniProtKB/TrEMBL
  ENSRNOT00000103294.1 UniProtKB/TrEMBL
  ENSRNOT00000113469.1 UniProtKB/TrEMBL
  ENSRNOT00000115789.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.610 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.740 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.220.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.1240.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GAIN_dom_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GAIN_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracell_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracellular_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_latrophilin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_latrophilin_rcpt_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Latrophilin-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lectin_gal-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lectin_gal-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Olfac-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65096 UniProtKB/Swiss-Prot
NCBI Gene 65096 ENTREZGENE
PANTHER ADHESION G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12011:SF62 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gal_Lectin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Latrophilin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OLF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adgrl1 PhenoGen
PRINTS GPCRSECRETIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LATROPHILIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OLF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUEL_LECTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029134 RatGTEx
SMART GPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HormR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OLF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A141_RAT UniProtKB/TrEMBL
  A0A8I6A3I4_RAT UniProtKB/TrEMBL
  A0A8I6AB35 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ACM1_RAT UniProtKB/TrEMBL
  A0A8I6AG63 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G3M0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QLY5_RAT UniProtKB/TrEMBL
  A6IYC5 ENTREZGENE, UniProtKB/TrEMBL
  A6IYC6 ENTREZGENE, UniProtKB/TrEMBL
  A6IYC7 ENTREZGENE, UniProtKB/TrEMBL
  AGRL1_RAT UniProtKB/Swiss-Prot
  D4A144_RAT UniProtKB/TrEMBL
  O09026 ENTREZGENE
  O35818 ENTREZGENE
  O88916 ENTREZGENE
  O88917 ENTREZGENE
UniProt Secondary O09026 UniProtKB/Swiss-Prot
  O35818 UniProtKB/Swiss-Prot
  O88916 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-16 Adgrl1  adhesion G protein-coupled receptor L1  Lphn1  latrophilin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Lphn1  latrophilin 1  CL1BA  CL1BA protein  Symbol and Name updated 1299863 APPROVED
2002-08-07 CL1BA  CL1BA protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product a member of the secretin receptor family 632419