Ccr3 (C-C motif chemokine receptor 3) - Rat Genome Database

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Gene: Ccr3 (C-C motif chemokine receptor 3) Rattus norvegicus
Analyze
Symbol: Ccr3
Name: C-C motif chemokine receptor 3
RGD ID: 620593
Description: Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Involved in ERK1 and ERK2 cascade; angioblast cell migration; and leukocyte chemotaxis. Located in endosome and extracellular space. Used to study asthma and myocardial infarction. Biomarker of rhinitis. Human ortholog(s) of this gene implicated in asthma; ovary epithelial cancer; and rhinitis. Orthologous to human CCR3 (C-C motif chemokine receptor 3); PARTICIPATES IN chemokine mediated signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-C chemokine receptor type 3; C-C CKR-3; CC-CKR-3; CCR-3; chemokine (C-C motif) receptor 3; chemokine (C-C) receptor 3; CKR3; Cmkbr3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88132,463,533 - 132,511,601 (+)NCBIGRCr8
mRatBN7.28123,586,100 - 123,634,178 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,616,236 - 123,634,990 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8129,226,802 - 129,236,184 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08127,425,930 - 127,435,312 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08125,243,844 - 125,253,226 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08133,026,539 - 133,040,999 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8133,029,625 - 133,040,997 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08132,180,887 - 132,190,686 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48128,759,943 - 128,769,341 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18128,779,679 - 128,789,067 (+)NCBI
Celera8122,724,521 - 122,733,919 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Linkage and haplotype analysis for chemokine receptors clustered on chromosome 3p21.3 and transmitted in family pedigrees with asthma and atopy. Al-Abdulhadi SA and Al-Rabia MW, Ann Saudi Med. 2010 Mar-Apr;30(2):115-22.
2. Multitargeted approach using antisense oligonucleotides for the treatment of asthma. Allakhverdi Z, etal., Ann N Y Acad Sci. 2006 Oct;1082:62-73.
3. Expression of chemokine receptors on Th1/Th2 CD4+ lymphocytes in patients with multiple sclerosis. Andalib A, etal., Iran J Immunol. 2011 Mar;8(1):1-10.
4. The two-view radionuclide ventriculogram. Advantages of the LPO view. Arrington ER, etal., Clin Nucl Med. 1992 May;17(5):371-4.
5. Th2 dominance in nasal mucosa in patients with Wegener's granulomatosis. Balding CE, etal., Clin Exp Immunol. 2001 Aug;125(2):332-9.
6. Treatment with anti-CC chemokine receptor 3 monoclonal antibody or dexamethasone inhibits the migration and differentiation of bone marrow CD34 progenitor cells in an allergic mouse model. Ben S, etal., Allergy. 2008 Sep;63(9):1164-76.
7. CCR3- and CXCR4-mediated interactions regulate migration of CD34+ human bone marrow progenitors to ischemic myocardium and subsequent tissue repair. Bonaros N, etal., J Thorac Cardiovasc Surg. 2008 Oct;136(4):1044-53. Epub 2008 Jul 7.
8. Chronic idiopathic urticaria: infiltrating cells and related cytokines in autologous serum-induced wheals. Caproni M, etal., Clin Immunol. 2005 Mar;114(3):284-92.
9. Anti-CCR3 monoclonal antibody inhibits eosinophil infiltration in Angiostrongylus cantonensis-infected ICR mice. Chuang CC, etal., Acta Trop. 2010 Mar;113(3):209-13. Epub 2009 Nov 1.
10. Toll-like receptor-2-mediated C-C chemokine receptor 3 and eotaxin-driven eosinophil influx induced by Mycobacterium bovis BCG pleurisy. D'Avila H, etal., Infect Immun. 2007 Mar;75(3):1507-11. Epub 2006 Dec 11.
11. Eosinophils are Dispensable for Allergic Remodeling and Immunity in a Model of House Dust Mite-Induced Airway Disease. Fattouh R, etal., Am J Respir Crit Care Med. 2010 Aug 23.
12. Spatial and temporal expression of CCR3 and the common beta chain of the IL-3, IL-5 and GM-CSF receptor in the nasal epithelium and lymphoid tissues in a rat model of allergic rhinitis. Fortin M, etal., Cytokine. 2010 Aug 7.
13. Effects of antisense oligodeoxynucleotides targeting CCR3 on the airway response to antigen in rats. Fortin M, etal., Oligonucleotides. 2006 Fall;16(3):203-12.
14. T lymphocytes expressing CCR3 are increased in allergic rhinitis compared with non-allergic controls and following allergen immunotherapy. Francis JN, etal., Allergy. 2007 Jan;62(1):59-65.
15. Enhanced CCR5+/CCR3+ T helper cell ratio in patients with active cutaneous lupus erythematosus. Freutel S, etal., Lupus. 2011 Oct;20(12):1300-4. Epub 2011 Aug 15.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice. Glass WG, etal., J Immunol. 2004 Sep 15;173(6):4030-9. doi: 10.4049/jimmunol.173.6.4030.
18. Inherited determinants of ovarian cancer survival. Goode EL, etal., Clin Cancer Res. 2010 Feb 1;16(3):995-1007. Epub 2010 Jan 26.
19. Study of the HIV-1 receptors CD4, CXCR4, CCR5 and CCR3 in the human and rat testis. Habasque C, etal., Mol Hum Reprod 2002 May;8(5):419-25.
20. Effect of Pyeongwee-San (KMP6) on 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice. Han NR, etal., Life Sci. 2012 Jan 16;90(3-4):147-53. Epub 2011 Oct 29.
21. Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. Hartl D, etal., J Immunol. 2008 Dec 1;181(11):8053-67.
22. Monomeric recombinant TCR ligand reduces relapse rate and severity of experimental autoimmune encephalomyelitis in SJL/J mice through cytokine switch. Huan J, etal., J Immunol. 2004 Apr 1;172(7):4556-66.
23. Role of Eotaxin-1 (CCL11) and CC chemokine receptor 3 (CCR3) in bleomycin-induced lung injury and fibrosis. Huaux F, etal., Am J Pathol. 2005 Dec;167(6):1485-96.
24. CC chemokine and CC chemokine receptor profiles in visceral and subcutaneous adipose tissue are altered in human obesity. Huber J, etal., J Clin Endocrinol Metab. 2008 Aug;93(8):3215-21. Epub 2008 May 20.
25. Analysis of the expression profiles of cytokines and cytokine-related genes during the progression of breast cancer growth in mice. Jung MY, etal., Oncol Rep. 2009 Nov;22(5):1141-7.
26. The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP1, MIP-1alpha, MIP-1beta, IP-10)-positive cells in human periapical granulomas. Kabashima H, etal., Cytokine. 2001 Oct 21;16(2):62-6.
27. Increased expression of RANTES, CCR3 and CCR5 in the lesional skin of patients with atopic eczema. Kato Y, etal., Int Arch Allergy Immunol. 2006;139(3):245-57. Epub 2006 Jan 30.
28. Association of the CCR3 gene polymorphism with aspirin exacerbated respiratory disease. Kim SH, etal., Respir Med. 2010 May;104(5):626-32. Epub 2009 Dec 21.
29. A novel CC-chemokine receptor 3 antagonist, Ki19003, inhibits airway eosinophilia and subepithelial/peribronchial fibrosis induced by repeated antigen challenge in mice. Komai M, etal., J Pharmacol Sci. 2010 Feb;112(2):203-13. Epub 2010 Feb 4.
30. Transcriptional analyses before and after suppression of immediate hypersensitivity reactions by CCR3 blockade in eyes with experimental allergic conjunctivitis. Komatsu N, etal., Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5307-13. Epub 2008 Jul 24.
31. Heterogeneity of CD4 and CD8+ memory T cells in localized and generalized Wegener's granulomatosis. Lamprecht P, etal., Arthritis Res Ther. 2003;5(1):R25-31. Epub 2002 Oct 24.
32. Genetic effect of CCR3 and IL5RA gene polymorphisms on eosinophilia in asthmatic patients. Lee JH, etal., J Allergy Clin Immunol. 2007 Nov;120(5):1110-7.
33. mRNA expression of chemokine receptors on peripheral blood mononuclear cells and correlation with clinical features in systemic lupus erythematosus patients. Li YM, etal., Chin Med Sci J. 2010 Sep;25(3):162-8.
34. Selective activation of the prostaglandin E2 circuit in chronic injury-induced pathologic angiogenesis. Liclican EL, etal., Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6311-20. Epub 2010 Jul 7.
35. Increased expression of chemokine receptor CCR3 and its ligands in ulcerative colitis: the role of colonic epithelial cells in in vitro studies. Manousou P, etal., Clin Exp Immunol. 2010 Nov;162(2):337-47.
36. CCR3 Blockade Attenuates Eosinophilic Ileitis and Associated Remodeling. Masterson JC, etal., Am J Pathol. 2011 Nov;179(5):2302-14. Epub 2011 Sep 23.
37. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
38. Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis. Nakamura H, etal., Int Arch Allergy Immunol. 2007;142(4):329-34. Epub 2006 Nov 28.
39. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
40. Didecyldimethylammonium chloride induces pulmonary inflammation and fibrosis in mice. Ohnuma A, etal., Exp Toxicol Pathol. 2009 Sep 15.
41. Pinellia ternata, Citrus reticulata, and their combinational prescription inhibit eosinophil infiltration and airway hyperresponsiveness by suppressing CCR3+ and Th2 cytokines production in the ovalbumin-induced asthma model. Ok IS, etal., Mediators Inflamm. 2009;2009:413270. Epub 2009 Aug 2.
42. Expression of the inflammatory chemokines CCL2, CCL5 and CXCL2 and the receptors CCR1-3 and CXCR2 in T lymphocytes from mammary tumor-bearing mice. Owen JL, etal., Cell Immunol. 2011;270(2):172-82. Epub 2011 May 10.
43. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
44. CD4+ CCR5+ and CD4+ CCR3+ lymphocyte subset and monocyte apoptosis in patients with acute visceral leishmaniasis. Potestio M, etal., Immunology. 2004 Oct;113(2):260-8.
45. GOA pipeline RGD automated data pipeline
46. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
47. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
48. Chemokine receptors in a regulation of interstitial lung fibrosis and inflammation. Sterclova M, etal., Exp Lung Res. 2009 Aug;35(6):514-23.
49. CCR3 is a target for age-related macular degeneration diagnosis and therapy. Takeda A, etal., Nature. 2009 Jul 9;460(7252):225-30. Epub 2009 Jun 14.
50. Gene expression signatures of peripheral CD4+ T cells clearly discriminate between patients with acute and chronic hepatitis B infection. TrehanPati N, etal., Hepatology. 2009 Mar;49(3):781-90.
51. Localization and expression of CCR3 and CCR5 by interleukin-1 beta in the RIN-5AH insulin-producing model system: a protective mechanism involving down-regulation of chemokine receptors. Vassiliadis S, etal., JOP 2002 May;3(3):66-75.
52. Exacerbation of facial motoneuron loss after facial nerve axotomy in CCR3-deficient mice. Wainwright DA, etal., ASN Neuro. 2009 Dec 11;1(5):e00024.
53. Eotaxin induces migration of RBL-2H3 mast cells via a Rac-ERK-dependent pathway. Woo CH, etal., Biochem Biophys Res Commun. 2002 Nov 1;298(3):392-7.
Additional References at PubMed
PMID:7594543   PMID:9655467   PMID:11425309   PMID:12538707   PMID:16722399   PMID:22183343   PMID:28279120   PMID:31151084   PMID:34795678  


Genomics

Comparative Map Data
Ccr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88132,463,533 - 132,511,601 (+)NCBIGRCr8
mRatBN7.28123,586,100 - 123,634,178 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,616,236 - 123,634,990 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8129,226,802 - 129,236,184 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08127,425,930 - 127,435,312 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08125,243,844 - 125,253,226 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08133,026,539 - 133,040,999 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8133,029,625 - 133,040,997 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08132,180,887 - 132,190,686 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48128,759,943 - 128,769,341 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18128,779,679 - 128,789,067 (+)NCBI
Celera8122,724,521 - 122,733,919 (+)NCBICelera
Cytogenetic Map8q32NCBI
CCR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,210,696 - 46,266,706 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,130,890 - 46,266,706 (+)EnsemblGRCh38hg38GRCh38
GRCh37346,283,872 - 46,308,197 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,258,692 - 46,283,166 (+)NCBINCBI36Build 36hg18NCBI36
Build 34346,258,691 - 46,283,166NCBI
Celera346,221,217 - 46,245,543 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,327,575 - 46,351,905 (+)NCBIHuRef
CHM1_1346,233,878 - 46,258,185 (+)NCBICHM1_1
T2T-CHM13v2.0346,226,558 - 46,282,568 (+)NCBIT2T-CHM13v2.0
Ccr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,817,799 - 123,831,729 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9123,822,009 - 123,831,726 (+)EnsemblGRCm39 Ensembl
GRCm389124,017,825 - 124,031,692 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9124,021,972 - 124,031,689 (+)EnsemblGRCm38mm10GRCm38
MGSCv379123,936,703 - 123,946,421 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369123,870,898 - 123,879,738 (+)NCBIMGSCv36mm8
Celera9124,968,286 - 124,978,018 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map975.05NCBI
Ccr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542025,701,407 - 25,723,353 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542025,702,917 - 25,723,269 (-)NCBIChiLan1.0ChiLan1.0
CCR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2246,204,630 - 46,230,081 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1346,209,398 - 46,234,849 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0346,147,928 - 46,172,947 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1347,253,878 - 47,278,630 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,253,878 - 47,278,630 (+)Ensemblpanpan1.1panPan2
CCR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,382,380 - 42,398,449 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,383,135 - 42,384,217 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2042,299,062 - 42,300,141 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02042,864,741 - 42,903,643 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,865,496 - 42,866,578 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12042,106,665 - 42,107,744 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,508,009 - 42,509,088 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,789,121 - 42,790,200 (-)NCBIUU_Cfam_GSD_1.0
Ccr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118200,674,516 - 200,675,950 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936596223,660 - 224,739 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936596223,660 - 224,739 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,285,012 - 29,376,343 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,251,950 - 29,286,470 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,348,402 - 32,450,254 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,648,410 - 7,698,523 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl227,697,068 - 7,698,135 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041159,459,370 - 159,477,790 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473074,768,668 - 74,769,798 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473074,768,668 - 74,769,749 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ccr3
251 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:24
Interacting mature miRNAs:24
Transcripts:ENSRNOT00000008809
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat

Markers in Region
PMC112554P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28123,631,159 - 123,632,084 (+)MAPPERmRatBN7.2
Rnor_6.08133,037,941 - 133,038,905NCBIRnor6.0
Rnor_5.08132,189,221 - 132,190,185UniSTSRnor5.0
RGSC_v3.48128,768,277 - 128,769,201UniSTSRGSC3.4
Celera8122,732,855 - 122,733,779UniSTS
Cytogenetic Map8q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 11 2
Low 2 1 10 2 7 2 2 1 3 10
Below cutoff 1 10 27 19 1 19 8 8 21 10 14 1 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008809   ⟹   ENSRNOP00000008809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8123,616,309 - 123,634,990 (+)Ensembl
Rnor_6.0 Ensembl8133,029,625 - 133,040,997 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104574   ⟹   ENSRNOP00000090310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8123,623,788 - 123,634,990 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119301   ⟹   ENSRNOP00000093164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8123,616,236 - 123,634,990 (+)Ensembl
RefSeq Acc Id: NM_053958   ⟹   NP_446410
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,500,249 - 132,509,647 (+)NCBI
mRatBN7.28123,622,826 - 123,632,224 (+)NCBI
Rnor_6.08133,029,607 - 133,039,045 (+)NCBI
Rnor_5.08132,180,887 - 132,190,686 (+)NCBI
RGSC_v3.48128,759,943 - 128,769,341 (+)RGD
Celera8122,724,521 - 122,733,919 (+)RGD
Sequence:
RefSeq Acc Id: XM_039080707   ⟹   XP_038936635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,463,533 - 132,511,601 (+)NCBI
mRatBN7.28123,586,101 - 123,634,178 (+)NCBI
RefSeq Acc Id: XM_039080708   ⟹   XP_038936636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,463,533 - 132,511,601 (+)NCBI
mRatBN7.28123,586,100 - 123,634,178 (+)NCBI
RefSeq Acc Id: XM_063264781   ⟹   XP_063120851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,478,769 - 132,511,601 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_446410   ⟸   NM_053958
- UniProtKB: O55169 (UniProtKB/Swiss-Prot),   O54814 (UniProtKB/Swiss-Prot),   A0A0A0MXU9 (UniProtKB/TrEMBL),   A6I4D1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008809   ⟸   ENSRNOT00000008809
RefSeq Acc Id: XP_038936636   ⟸   XM_039080708
- Peptide Label: isoform X1
- UniProtKB: O55169 (UniProtKB/Swiss-Prot),   O54814 (UniProtKB/Swiss-Prot),   A0A0A0MXU9 (UniProtKB/TrEMBL),   A6I4D1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936635   ⟸   XM_039080707
- Peptide Label: isoform X1
- UniProtKB: O55169 (UniProtKB/Swiss-Prot),   O54814 (UniProtKB/Swiss-Prot),   A0A0A0MXU9 (UniProtKB/TrEMBL),   A6I4D1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000093164   ⟸   ENSRNOT00000119301
RefSeq Acc Id: ENSRNOP00000090310   ⟸   ENSRNOT00000104574
RefSeq Acc Id: XP_063120851   ⟸   XM_063264781
- Peptide Label: isoform X1
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54814-F1-model_v2 AlphaFold O54814 1-359 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620593 AgrOrtholog
BioCyc Gene G2FUF-28599 BioCyc
Ensembl Genes ENSRNOG00000006736 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008809.5 UniProtKB/TrEMBL
  ENSRNOT00000104574.1 UniProtKB/TrEMBL
  ENSRNOT00000119301.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Chemokine_CCR3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117027 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 117027 ENTREZGENE
PANTHER C-C CHEMOKINE RECEPTOR TYPE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CELL ADHESION MOLECULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ccr3 PhenoGen
PRINTS CCCHEMOKINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CHEMOKINER3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006736 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MXU9 ENTREZGENE, UniProtKB/TrEMBL
  A6I4D1 ENTREZGENE, UniProtKB/TrEMBL
  CCR3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  O55169 ENTREZGENE
UniProt Secondary O55169 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Ccr3  C-C motif chemokine receptor 3  Ccr3  chemokine (C-C motif) receptor 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Ccr3  chemokine (C-C motif) receptor 3  Cmkbr3  chemokine (C-C) receptor 3  Symbol and Name updated 1299863 APPROVED
2002-08-07 Cmkbr3  chemokine (C-C) receptor 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression is absent from the testes 634762
gene_function a coreceptor for HIV virus 632390