Tesk1 (testis associated actin remodelling kinase 1)

Gene: Tesk1 (testis associated actin remodelling kinase 1) Rattus norvegicus

Analyze

Symbol:

Tesk1

Name:

testis associated actin remodelling kinase 1

RGD ID:

62059

Description:

Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of protein autophosphorylation; positive regulation of stress fiber assembly; and spermatogenesis. Located in perinuclear region of cytoplasm. Colocalizes with cytoplasmic vesicle. Orthologous to human TESK1 (testis associated actin remodelling kinase 1); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

dual specificity testis-specific protein kinase 1; testicular protein kinase 1; testis specific protein kinase 1; testis-specific kinase 1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	62,487,763 - 62,493,492 (+)	NCBI		GRCr8
mRatBN7.2	5	57,691,922 - 57,697,698 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	57,691,969 - 57,697,698 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	59,671,582 - 59,677,308 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	61,490,395 - 61,496,121 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	61,467,194 - 61,472,918 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	58,937,615 - 58,943,358 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	58,937,615 - 58,943,358 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	63,463,575 - 63,469,304 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	59,913,793 - 59,918,422 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	59,913,971 - 59,918,601 (+)	NCBI
Celera	5	56,273,675 - 56,279,404 (+)	NCBI		Celera
Cytogenetic Map	5	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acromesomelic dysplasia, Maroteaux type (ISO)

anauxetic dysplasia (ISO)

autosomal recessive distal hereditary motor neuronopathy 2 (ISO)

distal arthrogryposis type 1A (ISO)

frontotemporal dementia and/or amyotrophic lateral sclerosis 6 (ISO)

galactosemia (ISO)

genetic disease (ISO)

hyperphosphatasia with impaired intellectual development syndrome 2 (ISO)

primary ciliary dyskinesia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

2-methylcholine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

8-Br-cAMP (ISO)

acrylamide (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

chlorpyrifos (ISO)

cobalt dichloride (ISO)

cocaine (EXP)

cyclosporin A (ISO)

dexamethasone (ISO)

diazinon (ISO)

doxorubicin (ISO)

fenthion (ISO)

folic acid (ISO)

folpet (ISO)

FR900359 (ISO)

indometacin (ISO)

menadione (ISO)

methidathion (ISO)

methotrexate (ISO)

methoxyacetic acid (EXP)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (EXP)

phenobarbital (ISO)

plumbagin (EXP)

rac-lactic acid (ISO)

sunitinib (ISO)

Tanshinone I (ISO)

testosterone (ISO)

theophylline (ISO)

Trapidil (EXP)

urethane (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (IBA)

establishment of vesicle localization (ISO,ISS)

negative regulation of cilium assembly (ISO,ISS)

negative regulation of phosphorylation (ISS)

negative regulation of protein autophosphorylation (IDA)

podocyte cell migration (ISO,ISS)

positive regulation of protein localization to nucleus (ISO,ISS)

positive regulation of protein phosphorylation (ISO,ISS)

positive regulation of stress fiber assembly (IBA,IDA)

positive regulation of substrate adhesion-dependent cell spreading (ISO,ISS)

regulation of actin cytoskeleton organization (ISO)

regulation of protein localization (IDA)

spermatogenesis (IEP)

Cellular Component

centrosome (ISO,ISS)

cytoplasm (IBA,IDA,ISO)

cytoplasmic vesicle (IDA)

lamellipodium (IEA)

nucleus (IBA)

perinuclear region of cytoplasm (IDA)

Molecular Function

ATP binding (IEA)

metal ion binding (IEA)

protein binding (IPI,ISO)

protein kinase activity (IDA,ISO,ISS)

protein kinase binding (IPI)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IBA,IMP)

protein serine/threonine/tyrosine kinase activity (IEA)

protein tyrosine kinase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.	Chandramouli S, etal., J Biol Chem. 2008 Jan 18;283(3):1679-91. doi: 10.1074/jbc.M705457200. Epub 2007 Nov 1.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton.	Johne C, etal., Mol Biol Cell. 2008 Apr;19(4):1391-403. doi: 10.1091/mbc.E07-07-0730. Epub 2008 Jan 23.
5.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
6.	Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin.	LaLonde DP, etal., J Biol Chem. 2005 Jun 3;280(22):21680-8. doi: 10.1074/jbc.M500752200. Epub 2005 Apr 6.
7.	Spatiotemporal expression of testicular protein kinase 1 after rat sciatic nerve injury.	Lou D, etal., J Mol Neurosci. 2012 May;47(1):180-91. doi: 10.1007/s12031-012-9712-x.
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	GOA pipeline	RGD automated data pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
14.	Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells.	Toshima J, etal., J Biol Chem 1995 Dec 29;270(52):31331-7.
15.	Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1.	Toshima JY, etal., J Biol Chem 2001 Nov 16;276(46):43471-81.

Additional References at PubMed

PMID:10207045	PMID:15489334	PMID:31484832

Genomics

Comparative Map Data

Tesk1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	62,487,763 - 62,493,492 (+)	NCBI		GRCr8
mRatBN7.2	5	57,691,922 - 57,697,698 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	57,691,969 - 57,697,698 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	59,671,582 - 59,677,308 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	61,490,395 - 61,496,121 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	61,467,194 - 61,472,918 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	58,937,615 - 58,943,358 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	58,937,615 - 58,943,358 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	63,463,575 - 63,469,304 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	59,913,793 - 59,918,422 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	59,913,971 - 59,918,601 (+)	NCBI
Celera	5	56,273,675 - 56,279,404 (+)	NCBI		Celera
Cytogenetic Map	5	q22	NCBI

TESK1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	35,605,262 - 35,610,033 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	35,605,262 - 35,610,041 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	35,605,259 - 35,610,030 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	35,595,281 - 35,600,038 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	35,595,366 - 35,600,029	NCBI
Celera	9	35,538,842 - 35,543,599 (+)	NCBI		Celera
Cytogenetic Map	9	p13.3	NCBI
HuRef	9	35,561,511 - 35,565,732 (+)	NCBI		HuRef
CHM1_1	9	35,605,086 - 35,609,864 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	35,625,926 - 35,630,697 (+)	NCBI		T2T-CHM13v2.0

Tesk1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	43,442,277 - 43,448,075 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	43,441,939 - 43,448,064 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	43,442,277 - 43,448,075 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	43,441,939 - 43,448,064 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	43,455,149 - 43,460,947 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	43,463,039 - 43,469,161 (+)	NCBI		MGSCv36	mm8
Celera	4	43,475,911 - 43,481,710 (+)	NCBI		Celera
Cytogenetic Map	4	A5	NCBI
cM Map	4	23.04	NCBI

Tesk1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955472	668,352 - 699,620 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955472	670,847 - 676,060 (-)	NCBI	ChiLan1.0	ChiLan1.0

TESK1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	88,977,614 - 88,982,391 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	88,983,553 - 88,988,330 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	35,456,965 - 35,461,736 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	36,260,165 - 36,264,545 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	36,258,902 - 36,264,545 (+)	Ensembl	panpan1.1		panPan2

TESK1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	52,166,049 - 52,170,611 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	52,166,276 - 52,170,309 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	50,734,356 - 50,738,706 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	53,231,692 - 53,236,046 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	53,231,707 - 53,235,744 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	51,776,354 - 51,780,701 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	51,759,750 - 51,764,109 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	52,461,910 - 52,466,261 (+)	NCBI		UU_Cfam_GSD_1.0

Tesk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	167,068,349 - 167,072,817 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936524	3,615,927 - 3,621,474 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936524	3,615,933 - 3,620,384 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TESK1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	236,341,261 - 236,345,962 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	236,341,160 - 236,345,964 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	264,064,388 - 264,070,983 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TESK1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	44,985,770 - 44,990,520 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	44,984,687 - 44,990,183 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	42,094,178 - 42,100,748 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tesk1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624868	5,198,984 - 5,204,019 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624868	5,198,276 - 5,203,376 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tesk1
51 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	195
Count of miRNA genes:	136
Interacting mature miRNAs:	150
Transcripts:	ENSRNOT00000023695
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	1	90450412	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	1	131345958	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	729470	86724018	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
8662454	Vetf3	Vascular elastic tissue fragility QTL 3	27.4		artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	5	2282226	69540447	Rat
7394712	Emca13	Estrogen-induced mammary cancer QTL 13			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	9823266	99753708	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	12789751	113558310	Rat
1600358	Mamtr5	Mammary tumor resistance QTL 5			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	18873947	63873947	Rat
1358353	Srcrtb2	Stress Responsive Cort Basal QTL 2	3.48	0.003	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	18873947	74251464	Rat
8552954	Pigfal14	Plasma insulin-like growth factor 1 level QTL 14	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	21226744	66226744	Rat
1578767	Stresp17	Stress response QTL 17	4.3	0.01	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	5	27955440	72955440	Rat
1578776	Stresp18	Stress response QTL 18	2.9		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	5	27955440	72955440	Rat
6903292	Stl28	Serum triglyceride level QTL 28	2.6	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	5	28515489	73515489	Rat
6903306	Scl35	Serum cholesterol QTL 35	2.6	0.0073	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	28515489	73515489	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	31663789	131345958	Rat
1598807	Glom12	Glomerulus QTL 12	2.7		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	33215665	78215665	Rat
1298067	Scl15	Serum cholesterol level QTL 15	4.8	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	33215665	78215665	Rat
1302786	Kidm8	Kidney mass QTL 8	28.15		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	33215665	78215665	Rat
1576317	Eutr2	Estrogen induced uterine response QTL 2		0.01	uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	34730116	104251008	Rat
2316959	Gluco59	Glucose level QTL 59	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	34944474	113558310	Rat
1641922	Alcrsp8	Alcohol response QTL 8			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	5	35189153	68564008	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	35189153	141643988	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	40128307	148607290	Rat
1331773	Scl26	Serum cholesterol level QTL 26	3.065		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	43726656	86724018	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	43726656	129132602	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
1300115	Hrtrt7	Heart rate QTL 7	2.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	47869062	90099692	Rat
9589025	Epfw7	Epididymal fat weight QTL 7	20.66	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	5	49463600	94463600	Rat
7411561	Bw134	Body weight QTL 134	24	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	49463600	94463600	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	50328551	141643988	Rat
2303615	Vencon7	Ventilatory control QTL 7		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	5	50983895	95983895	Rat
2303574	Gluco42	Glucose level QTL 42	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	53496719	98496719	Rat
61359	Eaex	Experimental allergic encephalomyelitis QTL x	3		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	5	55715622	100715622	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55805606	132207589	Rat

Markers in Region

RH134422

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	57,697,175 - 57,697,569 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	58,942,836 - 58,943,229	NCBI	Rnor6.0
Rnor_5.0	5	63,468,782 - 63,469,175	UniSTS	Rnor5.0
RGSC_v3.4	5	59,917,900 - 59,918,293	UniSTS	RGSC3.4
Celera	5	56,278,882 - 56,279,275	UniSTS
RH 3.4 Map	5	396.21	UniSTS
Cytogenetic Map	5	q22	UniSTS

RH140696

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	57,697,590 - 57,697,977 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	58,943,251 - 58,943,637	NCBI	Rnor6.0
Rnor_5.0	5	63,469,197 - 63,469,583	UniSTS	Rnor5.0
RGSC_v3.4	5	59,918,315 - 59,918,701	UniSTS	RGSC3.4
Celera	5	56,279,297 - 56,279,683	UniSTS
Cytogenetic Map	5	q22	UniSTS

RH141088

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	57,697,435 - 57,697,616 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	58,943,096 - 58,943,276	NCBI	Rnor6.0
Rnor_5.0	5	63,469,042 - 63,469,222	UniSTS	Rnor5.0
RGSC_v3.4	5	59,918,160 - 59,918,340	UniSTS	RGSC3.4
Celera	5	56,279,142 - 56,279,322	UniSTS
Cytogenetic Map	5	q22	UniSTS

TESK1-1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	57,695,416 - 57,696,422 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	58,941,077 - 58,942,082	NCBI	Rnor6.0
Rnor_5.0	5	63,467,023 - 63,468,028	UniSTS	Rnor5.0
RGSC_v3.4	5	59,916,141 - 59,917,146	UniSTS	RGSC3.4
Celera	5	56,277,123 - 56,278,128	UniSTS
Cytogenetic Map	5	q22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	28	2	2	3	2		3	66	27	36	3
Low		15	55	39	16	39	8	8	8	8	5	8	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031578	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC121204	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC081773	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473962	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D50864	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000080909 ⟹ ENSRNOP00000071965

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	57,691,969 - 57,697,698 (+)	Ensembl
Rnor_6.0 Ensembl	5	58,937,615 - 58,943,358 (+)	Ensembl

RefSeq Acc Id:

NM_031578 ⟹ NP_113766

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	62,487,763 - 62,493,492 (+)	NCBI
mRatBN7.2	5	57,691,969 - 57,697,698 (+)	NCBI
Rnor_6.0	5	58,937,615 - 58,943,358 (+)	NCBI
Rnor_5.0	5	63,463,575 - 63,469,304 (+)	NCBI
RGSC_v3.4	5	59,913,793 - 59,918,422 (+)	RGD
Celera	5	56,273,675 - 56,279,404 (+)	RGD

Sequence:

show sequence

GGGCTGTAGAGGCCTCTGCACCTCCTCCTCTGGCCTGAGGGGGGCATACCCGCGTCTACAGACG
CGGGGCGCAACCTGCCGAAAGGGGTCACACCGCTGGGCGAGAGCTAGGGGAGGAGTCACCTTGA
GAGGAGGGGTCACAATGATTAGCCGAGTCACTCTGAAAGGTCTCTTTTAGTGAAAGGAACACAA
AGAGGAGGGGGTGCAGCACTAAGGGGCTCTGGATACACACTGATGTGCCAGTGTCATCCCAAGG
AAAGGTCCCCCTGAAGGAGAGCGGGCTCCGAGGGGCAGCGGCCTTTGAGGGGGCGGGATCCTGT
CGAGGGGTGGGCTGTGACGGAGGGCGGGGCTTTCTTGCAGGTGCAGGCTTCCCCTAAGAGGGTT
ATTAGGACAAAGAAGTAGGAGGGTGGTCACCGGGCGGAGCGCAGGAATCTCAACTTTACTCAGG
GGAATGGAGATGGAGTGAGGAGGGGTCGGGCCAGGTCAGGGATGCGGAGGCCAGAGGCTCCCTA
CAGCCCTGGGTACCACGACCGGAGAAAACAGGTGTTAGCGAGCCCCGAGATTTAGGGTGTCGGG
GTCAGAAGCCCCTTGAAATGGGCAGTCGGAGTGGGGCGCAGACTGGGCAGGCAGCGGGCTTGAT
CCGTGGAGCCCAGGGCGCAGGAGAATTCGCGCCTGCAGTCAACCCTTAAGTCGTCCTGTTATTC
ACGCCCCGGCCTACGCGCCGGGACGCACCTGAGGGGGCGTGGCCGGGCCACAGCTCGGGCTCCA
AGGAGTTAACCGCAGACCCGGCCGGCCACGCCCCGGGCAGGCCGCGCAGCCTGAGCCCGGCGGC
GAAGCGGAGCAGCAGCCGCCCGCGGGGAGCCCGCCGCCGGCGCCCGGGAGCGCCGCCGCCGCCC
GGCCCAGGCCCAGGCCCAGGCCCCGCGCAGAGCGGAGAGCCGCGGCGTTCCACCAGGCCCAACT
CGCCGGCGCGGCGGGGGCGGGCCCAGGACCTTCGGCAGGTCCTCCCGGAGTCCGCCGGGCGGGA
GTCCCGGCACCCGGGATCAGGTTGGGCCGGCGCCCATGGCGAGCGCGGCCTGCCCGGGTCCCGG
GGATCCGGCCATGTGAAGCAGGCCGGGGCTGGGGGCCCGGCCATGGCCGGGGAACGGCCACCGC
TGCGGGGCCCCGGGCCCGGAGAGACTCCGGTGGAGGGGCCGGGGGGCGCAGGCGGAGGCCCGGG
CCGGGGCCGGCCCTCCTCCTACCGGGCCCTCCGCAGCGCCGTGTCCAGCCTGGCGCGCGTGGAC
GATTTCGACTGCGCAGAGAAGATCGGGGCTGGTTTCTTCTCTGAGGTCTATAAGGTTCGGCACC
GACAGTCGGGACAAGTCATGGTGCTGAAGATGAACAAGCTCCCCAGTAACCGGAGCAACACTCT
AAGGGAGGTGCAGCTGATGAACCGGCTCCGGCATCCTAACATCCTCAGGTTCATGGGGGTCTGT
GTGCACCAAGGGCAGCTGCACGCGCTTACAGAGTATATGAATGGGGGTACCCTGGAACAGCTGC
TGAGCTCCCCAGAACCCCTCTCCTGGCCAGTCAGGCTCCACCTAGCACTGGACATTGCACAAGG
CCTACGGTACCTACACGCCAAAGGTGTGTTTCACCGAGACCTCACATCCAAGAACTGTCTGGTC
CGACGGGAAGACGGAGGCTTCACAGCTGTTGTGGGTGACTTCGGACTGGCTGAAAAGATCCCTG
TGTATAGGGAAGGGGCAAGGAAGGAGCCATTGGCTGTGGTGGGCTCCCCATACTGGATGGCCCC
AGAGGTGTTGCGGGGAGAGCTGTATGATGAGAAGGCCGACGTCTTCGCCTTTGGGATTGTCCTC
TGTGAGCTCATCGCCCGAGTACCTGCAGACCCTGACTACCTACCCCGTACTGAGGACTTTGGTC
TGGATGTGCCTGCTTTTCGAACTCTGGTGGGAAATGACTGTCCGCTACCTTTCCTGCTTCTGGC
CATCCACTGCTGCAGCATGGAACCCAGCGCCCGTGCCCCTTTTACTGAAATTACCCAGCACCTG
GAACAAATCCTGGAGCAGCTGCCTGAGCCCACGCCCCTCGCCAAGATGCCCCTTGCCAAGGCTC
CCTTGACATACAATCAGGGGTCTGTTCCAAGAGGAGGTCCCTCTGCCACGCTTCCCAGGTCAGA
CCCCCGGCTCTCCCGAAGCCGGTCAGACCTCTTCCTGCCACCTTCACCAGAATCACCCCCCAGT
TGGGGGGACAATCTAACACGAGTCAACCCCTTCTCACTGCGGGAAGACCTCAGGGGTGGCAAGA
TCAAACTTCTGGACACACCCTGCAAGCCGGCCACTCCACTGCCCCTGGTGCCACCATCACCACT
GACCTCTACCCAGCTGCCCTTGGTGGCCTCTCCAGAGTCCCTGGTCCAGCCTGAGACTCCCGTC
CGCCGCTGTCGTTCACTCCCTTCATCCCCTGAGCTCCCCCGACGGATGGAAACTGCACTGCCAG
GTCCTGGCCCGTCCCCCGTGGGCCCCTCGACTGAGGAAAGGATGGACTGTGAGGGCAGCAGCCC
TGAGCCAGAGCCCCCAGGGCCGGCTCCCCAGCTGCCTCTGGCTGTGGCCACTGACAACTTCATC
AGTACGTGTTCCTCAGCCTCTCAGCCCTGGTCTGCTAGACCAGGACCTTCCCTCAATAATAACC
CCCCTGCTGTGGTGGTGAATTCCCCACAAGGATGGGCGAGGGAGCCCTGGAACCGGGCACAGCA
TAGCCTTCCCCGGGCAGCAGCCCTGGAGCGGACAGAACCCTCACCACCCCCATCAGCTCCCCGG
GAGCAGGAGGAGGGGCTGCCCTGCCCTGGCTGCTGCCTCAGCCCCTTCAGCTTTGGCTTCCTAT
CCATGTGCCCCCGCCCTACCCCAGCTGTTGCCCGCTACCGCAACTTGAACTGTGAGGCGGGCAG
TCTTCTCTGCCACCGAGGGCATCATGCCAAGCCACCCACACCCAGCCTGCAGCTGCCTGGGGCA
CGCTCTTAGCACTGAGGCCTGTGATCTCAGGCTTCCAACCTTGGCCTTCGGGATACCCTGTAAG
GACAGAGTGCACTTGCTGGACAATGCCAGCCCCAGATGGGCTGACTGGCTCTTCTCCCCGTATA
GGGGAGCCTCAGCATGGTCTCAATGGACAGAGCACTTCCTGTCCAACCCCTGGGATCACTGGAC
TAGACACAGCATTGCTGACACACAAGACTAACACGTGCAAAATATTTAAAAATATTTCAATAAA
ACTGCCTGGCTGGCTCCGGGCCATCCATCCACTCAGCGGAGCGCCCTCCCCTGACCCATCTCTA
GTTCGGGAAGTTCTTAAGGAAGGTCAAAGTCTTTTCTGGAGGCTTCTTTACTCTTCCCAAGAAT
AGTTTCTGGAGCAGCTTTCAAGCAAGCAGCAGGTCGCCAGACCAGAATCAGCCCTTAGCTGGGC
GTGCCCAAGAGTGAGGGAGTGCTGGAGGAATAGCAGTCTTGAGAATTGGCAGGCCATAGGTTAA
GGATGTAGGTCACAAGGTCTTGTTCAAGTGTCTGGAAAAATAAAGCACCAGTGAGCTCCCC

hide sequence

Protein Sequences


Protein RefSeqs	NP_113766	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH81773	(Get FASTA)	NCBI Sequence Viewer
	BAA09460	(Get FASTA)	NCBI Sequence Viewer
	EDL98735	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000071965
	ENSRNOP00000071965.1
	ENSRNOP00055023093
	ENSRNOP00060005982
	ENSRNOP00065011864
GenBank Protein	Q63572	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_113766 ⟸ NM_031578

- UniProtKB:

Q63572 (UniProtKB/Swiss-Prot), A6IJ14 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAGERPPLRGPGPGETPVEGPGGAGGGPGRGRPSSYRALRSAVSSLARVDDFDCAEKIGAGFFS
EVYKVRHRQSGQVMVLKMNKLPSNRSNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMN
GGTLEQLLSSPEPLSWPVRLHLALDIAQGLRYLHAKGVFHRDLTSKNCLVRREDGGFTAVVGDF
GLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYL
PRTEDFGLDVPAFRTLVGNDCPLPFLLLAIHCCSMEPSARAPFTEITQHLEQILEQLPEPTPLA
KMPLAKAPLTYNQGSVPRGGPSATLPRSDPRLSRSRSDLFLPPSPESPPSWGDNLTRVNPFSLR
EDLRGGKIKLLDTPCKPATPLPLVPPSPLTSTQLPLVASPESLVQPETPVRRCRSLPSSPELPR
RMETALPGPGPSPVGPSTEERMDCEGSSPEPEPPGPAPQLPLAVATDNFISTCSSASQPWSARP
GPSLNNNPPAVVVNSPQGWAREPWNRAQHSLPRAAALERTEPSPPPSAPREQEEGLPCPGCCLS
PFSFGFLSMCPRPTPAVARYRNLNCEAGSLLCHRGHHAKPPTPSLQLPGARS

hide sequence

RefSeq Acc Id:

ENSRNOP00000071965 ⟸ ENSRNOT00000080909

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q63572-F1-model_v2	AlphaFold	Q63572	1-628	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693672

Promoter ID:

EPDNEW_R4197

Type:

initiation region

Name:

Tesk1_2

Description:

testis-specific kinase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R4198

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	58,937,595 - 58,937,655	EPDNEW

RGD ID:

13693673

Promoter ID:

EPDNEW_R4198

Type:

single initiation site

Name:

Tesk1_1

Description:

testis-specific kinase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R4197

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	58,938,445 - 58,938,505	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:62059	AgrOrtholog
BioCyc Gene	G2FUF-41512	BioCyc
Ensembl Genes	ENSRNOG00000053729	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOG00055016877	UniProtKB/Swiss-Prot
	ENSRNOG00060004800	UniProtKB/Swiss-Prot
	ENSRNOG00065009759	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000080909	ENTREZGENE
	ENSRNOT00000080909.2	UniProtKB/Swiss-Prot
	ENSRNOT00055028670	UniProtKB/Swiss-Prot
	ENSRNOT00060007993	UniProtKB/Swiss-Prot
	ENSRNOT00065015695	UniProtKB/Swiss-Prot
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7131899	IMAGE-MGC_LOAD
InterPro	Kinase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_kinase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:29460	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:93358	IMAGE-MGC_LOAD
NCBI Gene	29460	ENTREZGENE
PANTHER	DUAL SPECIFICITY TESTIS-SPECIFIC PROTEIN KINASE 1	UniProtKB/TrEMBL
	LIM DOMAIN KINASE 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR46485:SF3	UniProtKB/Swiss-Prot
Pfam	PK_Tyr_Ser-Thr	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
PharmGKB	TESK1	RGD
PhenoGen	Tesk1	PhenoGen
PRINTS	TYRKINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000053729	RatGTEx
	ENSRNOG00055016877	RatGTEx
	ENSRNOG00060004800	RatGTEx
	ENSRNOG00065009759	RatGTEx
Superfamily-SCOP	Protein kinase-like (PK-like)	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR	TC218388
UniProt	A6IJ14	ENTREZGENE, UniProtKB/TrEMBL
	Q63572	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-03-16	Tesk1	testis associated actin remodelling kinase 1	Tesk1	testis-specific kinase 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-24	Tesk1	testis-specific kinase 1	Tesk1	testis specific protein kinase 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Tesk1	testis specific protein kinase 1			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	mRNA expressed specifically in testicular germ cells	61764
gene_homology	aa sequence shares 92% identity with human TESK1	61764
gene_process	may play a central role in spermatogenesis	61764
gene_protein	predicted protein contains 628 aa residues	61764

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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