Atp12a (ATPase H+/K+ transporting non-gastric alpha2 subunit) - Rat Genome Database

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Gene: Atp12a (ATPase H+/K+ transporting non-gastric alpha2 subunit) Rattus norvegicus
Analyze
Symbol: Atp12a
Name: ATPase H+/K+ transporting non-gastric alpha2 subunit
RGD ID: 620569
Description: Contributes to P-type potassium:proton transporter activity. Involved in response to metal ion and response to organic cyclic compound. Located in apical plasma membrane. Biomarker of hypokalemia. Orthologous to human ATP12A (ATPase H+/K+ transporting non-gastric alpha2 subunit); PARTICIPATES IN oxidative phosphorylation pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATPase, H+/K+ transporting, nongastric, alpha polypeptide; H-K-ATPase alpha 2; HK alpha 2; hydrogen/potassium-exchanging ATPase 12A; non-gastric H(+)/K(+) ATPase subunit alpha; non-gastric Na(+)/K(+) ATPase subunit alpha; potassium-transporting ATPase alpha chain 2; proton pump; sodium pump
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81534,559,209 - 34,583,866 (+)NCBIGRCr8
mRatBN7.21530,443,571 - 30,468,229 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1530,443,571 - 30,468,229 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1532,434,949 - 32,459,608 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01533,585,588 - 33,610,251 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01531,843,686 - 31,868,345 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01536,561,306 - 36,590,171 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1536,565,495 - 36,590,171 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01540,419,506 - 40,444,086 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41535,295,274 - 35,321,453 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11535,310,973 - 35,337,153 (+)NCBI
Celera1530,164,486 - 30,189,115 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification of thyroid regulatory elements in the Na-K-ATPase alpha3 gene promoter. Bajpai M, etal., Mol Biol Rep 2001 Mar;28(1):1-7.
2. Expression of HKalpha2 protein is increased selectively in renal medulla by chronic hypokalemia. Codina J, etal., Am J Physiol. 1998 Sep;275(3 Pt 2):F433-40.
3. Isolation and characterization of a cDNA encoding the putative distal colon H+,K(+)-ATPase. Similarity of deduced amino acid sequence to gastric H+,K(+)-ATPase and Na+,K(+)-ATPase and mRNA expression in distal colon, kidney, and uterus. Crowson MS and Shull GE, J Biol Chem 1992 Jul 5;267(19):13740-8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. A novel N-terminal splice variant of the rat H+-K+-ATPase alpha2 subunit. Cloning, functional expression, and renal adaptive response to chronic hypokalemia. Kone BC and Higham SC, J Biol Chem 1998 Jan 30;273(5):2543-52.
8. The effect of beta-subunit assembly on function and localization of the colonic H+,K+-ATPase alpha-subunit. Li J, etal., Kidney Int. 2004 Sep;66(3):1068-75.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Mouse Genome Database (MGD) Mouse Genome Database (MGD)
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Nongastric H-K-ATPase in rodent prostate: lobe-specific expression and apical localization. Pestov NB, etal., Am J Physiol Cell Physiol. 2002 Apr;282(4):C907-16.
13. Identification of the beta-subunit for nongastric H-K-ATPase in rat anterior prostate. Pestov NB, etal., Am J Physiol Cell Physiol. 2004 Jun;286(6):C1229-37. doi: 10.1152/ajpcell.00393.2003. Epub 2004 Jan 28.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. RefSeq and LocusLink: NCBI gene-centered resources Pruitt KD and Maglott DR, Nucleic Acids Res. 2001 Jan 1;29(1):137-40.
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Colonic H-K-ATPase beta-subunit: identification in apical membranes and regulation by dietary K depletion. Sangan P, etal., Am J Physiol. 1999 Feb;276(2):C350-60. doi: 10.1152/ajpcell.1999.276.2.C350.
19. The non-gastric H,K-ATPase is oligomycin-sensitive and can function as an H+,NH4(+)-ATPase. Swarts HG, etal., J Biol Chem. 2005 Sep 30;280(39):33115-22. Epub 2005 Jul 26.
20. Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats. Sárközy M, etal., Cardiovasc Diabetol. 2013 Jan 15;12:16. doi: 10.1186/1475-2840-12-16.
Additional References at PubMed
PMID:9449685   PMID:9872395   PMID:16525125   PMID:16531406  


Genomics

Comparative Map Data
Atp12a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81534,559,209 - 34,583,866 (+)NCBIGRCr8
mRatBN7.21530,443,571 - 30,468,229 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1530,443,571 - 30,468,229 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1532,434,949 - 32,459,608 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01533,585,588 - 33,610,251 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01531,843,686 - 31,868,345 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01536,561,306 - 36,590,171 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1536,565,495 - 36,590,171 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01540,419,506 - 40,444,086 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41535,295,274 - 35,321,453 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11535,310,973 - 35,337,153 (+)NCBI
Celera1530,164,486 - 30,189,115 (+)NCBICelera
Cytogenetic Map15p12NCBI
ATP12A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381324,680,408 - 24,712,472 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1324,680,408 - 24,712,472 (+)EnsemblGRCh38hg38GRCh38
GRCh371325,254,546 - 25,286,610 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361324,152,695 - 24,183,918 (+)NCBINCBI36Build 36hg18NCBI36
Build 341324,152,694 - 24,183,909NCBI
Celera136,318,100 - 6,349,140 (+)NCBICelera
Cytogenetic Map13q12.12NCBI
HuRef136,067,884 - 6,098,930 (+)NCBIHuRef
CHM1_11325,223,064 - 25,254,444 (+)NCBICHM1_1
T2T-CHM13v2.01323,888,443 - 23,920,536 (+)NCBIT2T-CHM13v2.0
Atp12a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391456,602,525 - 56,626,008 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1456,602,525 - 56,626,007 (+)EnsemblGRCm39 Ensembl
GRCm381456,364,669 - 56,388,551 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1456,365,068 - 56,388,550 (+)EnsemblGRCm38mm10GRCm38
MGSCv371456,983,905 - 57,007,388 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361455,319,139 - 55,342,661 (+)NCBIMGSCv36mm8
Celera1454,162,904 - 54,186,387 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Atp12a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955497225,158 - 252,789 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955497225,401 - 251,024 (+)NCBIChiLan1.0ChiLan1.0
ATP12A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21424,276,840 - 24,308,884 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11315,385,828 - 15,417,870 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0135,972,372 - 6,004,411 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11324,263,240 - 24,294,136 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1324,268,003 - 24,294,136 (+)Ensemblpanpan1.1panPan2
ATP12A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12518,753,192 - 18,779,781 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2518,753,872 - 18,779,831 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2518,779,443 - 18,805,985 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02518,891,731 - 18,918,495 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2518,892,411 - 18,918,565 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12518,753,678 - 18,780,440 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02518,765,635 - 18,792,406 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02518,822,596 - 18,849,151 (-)NCBIUU_Cfam_GSD_1.0
Atp12a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945120,815,441 - 120,830,841 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367202,363,933 - 2,378,426 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367202,363,933 - 2,378,426 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP12A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl11114,325 - 144,092 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.111113,901 - 144,765 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21187,521,754 - 87,551,316 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATP12A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.134,146,462 - 4,178,880 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl34,147,308 - 4,177,888 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605740,312,486 - 40,336,633 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp12a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477618,467,967 - 18,495,651 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477618,466,952 - 18,495,693 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atp12a
52 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:218
Count of miRNA genes:151
Interacting mature miRNAs:176
Transcripts:ENSRNOT00000028093
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8
Low 4 2 18 12
Below cutoff 2 31 14 6 8 6 2 2 33 9 24 8 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028093   ⟹   ENSRNOP00000028093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1530,443,571 - 30,468,229 (+)Ensembl
Rnor_6.0 Ensembl1536,565,495 - 36,590,171 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091753   ⟹   ENSRNOP00000070001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1536,566,031 - 36,590,171 (+)Ensembl
RefSeq Acc Id: NM_001301664   ⟹   NP_001288593
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81534,559,745 - 34,583,866 (+)NCBI
mRatBN7.21530,444,107 - 30,468,229 (+)NCBI
Rnor_6.01536,566,031 - 36,590,171 (+)NCBI
Celera1530,165,022 - 30,189,115 (+)NCBI
Sequence:
RefSeq Acc Id: NM_133517   ⟹   NP_598201
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81534,559,209 - 34,583,866 (+)NCBI
mRatBN7.21530,443,571 - 30,468,229 (+)NCBI
Rnor_6.01536,565,495 - 36,590,171 (+)NCBI
Rnor_5.01540,419,506 - 40,444,086 (+)NCBI
RGSC_v3.41535,295,274 - 35,321,453 (+)RGD
Celera1530,164,486 - 30,189,115 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_598201   ⟸   NM_133517
- Peptide Label: isoform a
- UniProtKB: P54708 (UniProtKB/Swiss-Prot),   G3V8S4 (UniProtKB/TrEMBL),   A6KH95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001288593   ⟸   NM_001301664
- Peptide Label: isoform b
- UniProtKB: P54708 (UniProtKB/Swiss-Prot),   A6KH96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028093   ⟸   ENSRNOT00000028093
RefSeq Acc Id: ENSRNOP00000070001   ⟸   ENSRNOT00000091753
Protein Domains
Cation-transporting P-type ATPase C-terminal   Cation-transporting P-type ATPase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54708-F1-model_v2 AlphaFold P54708 1-1036 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699711
Promoter ID:EPDNEW_R10235
Type:single initiation site
Name:Atp12a_1
Description:ATPase H+/K+ transporting non-gastric alpha2 subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01536,565,497 - 36,565,557EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620569 AgrOrtholog
BioCyc Gene G2FUF-13634 BioCyc
Ensembl Genes ENSRNOG00000020685 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028093 ENTREZGENE
  ENSRNOT00000028093.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.1000 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calcium-transporting ATPase, cytoplasmic transduction domain A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calcium-transporting ATPase, transmembrane domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATPase_P-typ_cation-transptr_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_cation-transptr_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_cyto_dom_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_P_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_TM_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-type_ATPase_IIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_typ_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_typ_ATPase_HD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171028 UniProtKB/TrEMBL
NCBI Gene 171028 ENTREZGENE
PANTHER PTHR43294:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cation_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cation_ATPase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cation_ATPase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E1-E2_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atp12a PhenoGen
PRINTS CATATPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAKATPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ATPASE_E1_E2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020685 RatGTEx
SMART Cation_ATPase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56784 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81653 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81660 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81665 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KH95 ENTREZGENE, UniProtKB/TrEMBL
  A6KH96 ENTREZGENE, UniProtKB/TrEMBL
  AT12A_RAT UniProtKB/Swiss-Prot
  G3V8S4 ENTREZGENE, UniProtKB/TrEMBL
  P54708 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Atp12a  ATPase H+/K+ transporting non-gastric alpha2 subunit  Atp12a  ATPase, H+/K+ transporting, nongastric, alpha polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Atp12a  ATPase, H+/K+ transporting, nongastric, alpha polypeptide      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Atp12a  ATPase, H+/K+ transporting, nongastric, alpha polypeptide      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed at high levels in distal colon 727259
gene_expression expressed in colon, kidney, and uterus with trace mRNA levels in heart and forestomach 727259