Enables gamma-aminobutyric acid:sodium:chloride symporter activity and identical protein binding activity. Involved in several processes, including gamma-aminobutyric acid import; negative regulation of GABAergic synaptic transmission; and positive regulation of gamma-aminobutyric acid secretion. Located in cell surface. Is active in GABA-ergic synapse; postsynaptic membrane; and presynaptic membrane. Used to study brain ischemia. Biomarker of cerebral infarction; epilepsy; temporal lobe epilepsy; and withdrawal disorder. Human ortholog(s) of this gene implicated in alcohol dependence and myoclonic-atonic epilepsy. Orthologous to human SLC6A1 (solute carrier family 6 member 1); INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate.
[enilconazole co-treated with clothianidin] results in decreased expression of SLC6A1 mRNA and [thiacloprid co-treated with clothianidin] results in decreased expression of SLC6A1 mRNA
[enilconazole co-treated with clothianidin] results in decreased expression of SLC6A1 mRNA and [thiacloprid co-treated with enilconazole] results in decreased expression of SLC6A1 mRNA
[lead acetate results in increased abundance of Lead] which results in decreased expression of SLC6A1 protein and Ascorbic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SLC6A1 protein]
[lead acetate results in increased abundance of Lead] which results in decreased expression of SLC6A1 protein and Ascorbic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SLC6A1 protein]
[thiacloprid co-treated with clothianidin] results in decreased expression of SLC6A1 mRNA and [thiacloprid co-treated with enilconazole] results in decreased expression of SLC6A1 mRNA
GABBR1 and SLC6A1, Two Genes Involved in Modulation of GABA Synaptic Transmission, Influence Risk for Alcoholism: Results from Three Ethnically Diverse Populations.
Electrophysiology and immunohistochemistry in the hippocampal ca1 and the dentate gyrus of rats chronically exposed to 1-bromopropane, a substitute for specific chlorofluorocarbons.
Oligomerization of the human serotonin transporter and of the rat GABA transporter 1 visualized by fluorescence resonance energy transfer microscopy in living cells.
Down-regulation of GAT-1 mRNA expression in the microdissected hypothalamic medial preoptic area of rat offspring exposed maternally to ethinylestradiol.
Effect of levetiracetam on molecular regulation of hippocampal glutamate and GABA transporters in rats with chronic seizures induced by amygdalar FeCl3 injection.
Changes in GABA transporters in the rat hippocampus after kainate-induced neuronal injury: decrease in GAT-1 and GAT-3 but upregulation of betaine/GABA transporter BGT-1.