Crx (cone-rod homeobox) - Rat Genome Database

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Gene: Crx (cone-rod homeobox) Rattus norvegicus
Analyze
Symbol: Crx
Name: cone-rod homeobox
RGD ID: 620511
Description: Enables DNA binding activity. Involved in circadian rhythm and positive regulation of photoreceptor cell differentiation. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 7 and cone-rod dystrophy 2. Orthologous to human CRX (cone-rod homeobox); PARTICIPATES IN retinitis pigmentosa pathway; INTERACTS WITH ammonium chloride; copper atom; copper(0).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cone-rod homeobox containing; cone-rod homeobox containing gene; cone-rod homeobox protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8185,667,971 - 85,681,852 (-)NCBIGRCr8
mRatBN7.2176,539,812 - 76,553,694 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl176,540,141 - 76,545,818 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx181,908,471 - 81,914,093 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013,654,790 - 3,660,412 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0183,663,620 - 83,669,242 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0177,744,593 - 77,758,913 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl177,745,288 - 77,750,960 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0179,009,202 - 79,023,481 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4176,190,656 - 76,196,333 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1176,268,766 - 76,274,444 (-)NCBI
Celera171,030,638 - 71,036,315 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Genes and mutations causing retinitis pigmentosa. Daiger SP, etal., Clin Genet. 2013 Aug;84(2):132-41. doi: 10.1111/cge.12203. Epub 2013 Jun 19.
2. De novo mutations in the CRX homeobox gene associated with Leber congenital amaurosis. Freund CL, etal., Nat Genet 1998 Apr;18(4):311-2.
3. Docosahexaenoic acid promotes photoreceptor differentiation without altering Crx expression. Garelli A, etal., Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3017-27.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. A pineal regulatory element (PIRE) mediates transactivation by the pineal/retina-specific transcription factor CRX. Li X, etal., Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1876-81.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Molecular cloning of the cone-rod homeobox gene (Crx) from the rat and its temporal expression pattern in the retina under a daily light-dark cycle. Sakamoto K, etal., Neurosci Lett 1999 Feb 12;261(1-2):101-4.
Additional References at PubMed
PMID:10625658   PMID:10887186   PMID:12407160   PMID:14613968   PMID:15689355   PMID:16539743   PMID:16574740   PMID:20026326   PMID:21052544   PMID:24877634   PMID:30803008  


Genomics

Comparative Map Data
Crx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8185,667,971 - 85,681,852 (-)NCBIGRCr8
mRatBN7.2176,539,812 - 76,553,694 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl176,540,141 - 76,545,818 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx181,908,471 - 81,914,093 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013,654,790 - 3,660,412 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0183,663,620 - 83,669,242 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0177,744,593 - 77,758,913 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl177,745,288 - 77,750,960 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0179,009,202 - 79,023,481 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4176,190,656 - 76,196,333 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1176,268,766 - 76,274,444 (-)NCBI
Celera171,030,638 - 71,036,315 (-)NCBICelera
Cytogenetic Map1q21NCBI
CRX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381947,821,937 - 47,843,324 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1947,819,779 - 47,843,330 (+)EnsemblGRCh38hg38GRCh38
GRCh371948,325,194 - 48,346,581 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,016,911 - 53,038,393 (+)NCBINCBI36Build 36hg18NCBI36
Build 341953,016,975 - 53,038,392NCBI
Celera1945,130,795 - 45,152,290 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1944,751,798 - 44,773,295 (+)NCBIHuRef
CHM1_11948,327,266 - 48,348,759 (+)NCBICHM1_1
T2T-CHM13v2.01950,652,778 - 50,674,184 (+)NCBIT2T-CHM13v2.0
Crx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39715,599,872 - 15,613,880 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl715,599,872 - 15,613,893 (-)EnsemblGRCm39 Ensembl
GRCm38715,865,947 - 15,879,955 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl715,865,947 - 15,879,968 (-)EnsemblGRCm38mm10GRCm38
MGSCv37716,451,296 - 16,465,304 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36715,024,471 - 15,038,416 (-)NCBIMGSCv36mm8
Celera713,064,380 - 13,078,683 (-)NCBICelera
Cytogenetic Map7A2NCBI
cM Map78.6NCBI
Crx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555741,544,917 - 1,548,912 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555741,544,917 - 1,548,912 (+)NCBIChiLan1.0ChiLan1.0
CRX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22053,983,564 - 53,999,402 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11955,853,180 - 55,869,032 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01944,828,119 - 44,856,284 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11953,451,064 - 53,485,267 (+)NCBIpanpan1.1PanPan1.1panPan2
CRX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11108,249,911 - 108,261,015 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1108,249,911 - 108,261,010 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1107,732,789 - 107,743,823 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01108,775,575 - 108,786,695 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1108,775,575 - 108,786,690 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11108,443,942 - 108,454,986 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01108,088,397 - 108,099,501 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,956,307 - 108,967,430 (+)NCBIUU_Cfam_GSD_1.0
LOC101960714
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934919,791,903 - 19,800,967 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366641,409,229 - 1,419,234 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366641,408,618 - 1,419,096 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl653,506,410 - 53,512,190 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1653,506,410 - 53,509,858 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,089,411 - 49,092,899 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CRX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1641,125,912 - 41,133,478 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl641,126,125 - 41,132,951 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607320,889,919 - 20,895,927 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crx
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248326,104,229 - 6,108,146 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248326,103,530 - 6,108,129 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Crx
83 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:64
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000018858
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hepatobiliary system nervous system reproductive system
High
Medium
Low 3 2
Below cutoff 1 1 1 6 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018858   ⟹   ENSRNOP00000018858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl176,540,141 - 76,545,818 (-)Ensembl
Rnor_6.0 Ensembl177,745,288 - 77,750,960 (-)Ensembl
RefSeq Acc Id: NM_021855   ⟹   NP_068627
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8185,667,971 - 85,681,852 (-)NCBI
mRatBN7.2176,539,812 - 76,553,694 (-)NCBI
Rnor_6.0177,745,288 - 77,750,960 (-)NCBI
Rnor_5.0179,009,202 - 79,023,481 (-)NCBI
RGSC_v3.4176,190,656 - 76,196,333 (-)RGD
Celera171,030,638 - 71,036,315 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_068627 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF61630 (Get FASTA)   NCBI Sequence Viewer  
  BAA76666 (Get FASTA)   NCBI Sequence Viewer  
  EDM08352 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018858
  ENSRNOP00000018858.3
Reference Protein Sequences
RefSeq Acc Id: NP_068627   ⟸   NM_021855
- UniProtKB: F1LPR9 (UniProtKB/TrEMBL),   Q9WTQ9 (UniProtKB/TrEMBL),   A0A9K3Y7X4 (UniProtKB/TrEMBL),   Q9JLT8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018858   ⟸   ENSRNOT00000018858
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WTQ9-F1-model_v2 AlphaFold Q9WTQ9 1-299 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620511 AgrOrtholog
BioCyc Gene G2FUF-60640 BioCyc
Ensembl Genes ENSRNOG00000013890 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018858 ENTREZGENE
  ENSRNOT00000018858.5 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
  Otx_TF_C UniProtKB/TrEMBL
KEGG Report rno:60446 UniProtKB/TrEMBL
NCBI Gene 60446 ENTREZGENE
PANTHER CONE-ROD HOMEOBOX PROTEIN UniProtKB/TrEMBL
  HOMEOBOX PROTEIN UniProtKB/TrEMBL
Pfam Homeobox UniProtKB/TrEMBL
  TF_Otx UniProtKB/TrEMBL
PhenoGen Crx PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013890 RatGTEx
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A0A9K3Y7X4 ENTREZGENE, UniProtKB/TrEMBL
  F1LPR9 ENTREZGENE
  Q9JLT8 ENTREZGENE, UniProtKB/TrEMBL
  Q9WTQ9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LPR9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-15 Crx  cone-rod homeobox  Crx  cone-rod homeobox containing gene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Crx  cone-rod homeobox containing gene  Crx  cone-rod homeobox protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Crx  cone-rod homeobox protein      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Crx  cone-rod homeobox protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA levels in the rat retina were constant under a daily light-dark cycle 632541