Gnai2 (G protein subunit alpha i2) - Rat Genome Database

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Gene: Gnai2 (G protein subunit alpha i2) Rattus norvegicus
Analyze
Symbol: Gnai2
Name: G protein subunit alpha i2
RGD ID: 620243
Description: Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of cell population proliferation; and regulation of signal transduction. Located in plasma membrane. Used to study hypertension. Biomarker of hypertension. Orthologous to human GNAI2 (G protein subunit alpha i2); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family; angiotensin II signaling pathway via AT2 receptor; dopamine signaling pathway via D2 family of receptors; INTERACTS WITH (R,R,R)-alpha-tocopherol; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adenylate cyclase-inhibiting G alpha protein; G alpha inhibitory type 2 (a); G alpha inhibitory type 2 (b); Galphai2; GTP-binding protein (G-alpha-i2); guanine nucleotide binding protein (G protein), alpha inhibiting 2; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; guanine nucleotide binding protein, alpha inhibiting 2; guanine nucleotide-binding protein G(i) subunit alpha-2; guanine nucleotide-binding protein G(i), alpha-2 subunit; heterotrimeric guanine nucleotide-binding protein 1c; Hg1c
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,167,045 - 117,187,652 (-)NCBIGRCr8
mRatBN7.28108,288,401 - 108,309,009 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,288,401 - 108,308,979 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8113,915,238 - 113,935,641 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,114,396 - 112,134,799 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,957,178 - 109,977,581 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,370,730 - 116,391,337 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,370,744 - 116,391,307 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08115,726,562 - 115,746,754 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,861,952 - 112,882,647 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18112,881,416 - 112,902,054 (-)NCBI
Celera8107,594,933 - 107,615,332 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
8-Br-cAMP  (EXP)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
aluminium atom  (EXP)
aluminium(0)  (EXP)
amino acid  (ISO)
amitrole  (EXP)
antimycin A  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
butan-1-ol  (ISO)
caffeine  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
cannabigerol  (ISO)
captan  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
diazinon  (EXP)
dibenziodolium  (EXP)
dichlorine  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
diphenhydramine  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
ethanol  (EXP,ISO)
fenpyroximate  (ISO)
fenthion  (ISO)
flavonoids  (EXP)
fluoxetine  (EXP,ISO)
folic acid  (ISO)
folpet  (ISO)
fumonisin B1  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
haloperidol  (EXP)
hydrogen cyanide  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
malathion  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
morphine  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nicotine  (ISO)
nitroprusside  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
peroxynitrous acid  (EXP)
phenobarbital  (ISO)
PhIP  (EXP)
picoxystrobin  (ISO)
picrotoxin  (EXP)
propiconazole  (EXP)
propofol  (ISO)
pyrimidifen  (ISO)
quercetin  (EXP)
reactive oxygen species  (ISO)
reserpine  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
streptozocin  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tebufenpyrad  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
theophylline  (EXP)
thifluzamide  (ISO)
thioacetamide  (EXP)
tipifarnib  (EXP)
toluene  (EXP)
topiramate  (EXP)
trichostatin A  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IMP)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IBA,IEA,ISO)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (IEA)
cell division  (ISO,ISS)
cell population proliferation  (ISO)
G protein-coupled acetylcholine receptor signaling pathway  (ISO)
G protein-coupled adenosine receptor signaling pathway  (IBA,IDA,IEA)
G protein-coupled glutamate receptor signaling pathway  (IDA)
G protein-coupled receptor signaling pathway  (IDA)
gamma-aminobutyric acid signaling pathway  (IBA,IDA,IEA)
modulation of chemical synaptic transmission  (ISO)
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway  (IDA)
negative regulation of apoptotic signaling pathway  (IMP)
negative regulation of calcium ion-dependent exocytosis  (IMP)
negative regulation of protein tyrosine phosphatase activity  (IMP)
negative regulation of synaptic transmission  (IDA)
positive regulation of cell migration  (IMP)
positive regulation of cell population proliferation  (IMP,ISO)
positive regulation of ERK1 and ERK2 cascade  (IMP)
positive regulation of insulin receptor signaling pathway  (IMP)
positive regulation of NAD(P)H oxidase activity  (IMP)
positive regulation of neural precursor cell proliferation  (IMP)
positive regulation of superoxide anion generation  (IMP)
positive regulation of urine volume  (IMP)
positive regulation of vascular associated smooth muscle cell proliferation  (IMP)
regulation of calcium ion transport  (IDA)
regulation of heart contraction  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Knockdown of Inhibitory Guanine Nucleotide Binding Protein Gia-2 by Antisense Oligodeoxynucleotides Attenuates the Development of Hypertension and Tachycardia in Spontaneously Hypertensive Rats. Ali El-Basyuni Y, etal., J Am Heart Assoc. 2016 Oct 26;5(11). pii: JAHA.116.004594. doi: 10.1161/JAHA.116.004594.
2. Integrins regulate opioid receptor signaling in trigeminal ganglion neurons. Berg KA, etal., Neuroscience. 2007 Feb 9;144(3):889-97. Epub 2006 Dec 8.
3. PGE2 amplifies the effects of IL-1beta on vascular smooth muscle cell de-differentiation: a consequence of the versatility of PGE2 receptors 3 due to the emerging expression of adenylyl cyclase 8. Clement N, etal., J Cell Physiol. 2006 Sep;208(3):495-505.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules. Gromada J, etal., J Physiol. 2001 Sep 1;535(Pt 2):519-32.
7. Molecular properties of muscarinic acetylcholine receptors. Haga T Proc Jpn Acad Ser B Phys Biol Sci. 2013;89(6):226-56.
8. Losartan-induced attenuation of blood pressure in L-NAME hypertensive rats is associated with reversal of the enhanced expression of Gi alpha proteins. Hashim S and Anand-Srivastava MB, J Hypertens. 2004 Jan;22(1):181-90.
9. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. Head BP, etal., J Biol Chem. 2005 Sep 2;280(35):31036-44. Epub 2005 Jun 16.
10. Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain. Itoh H, etal., Proc Natl Acad Sci U S A 1986 Jun;83(11):3776-80.
11. Effect of G protein heterotrimer composition on coupling of neurotransmitter receptors to N-type Ca(2+) channel modulation in sympathetic neurons. Jeong SW and Ikeda SR, Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):907-12.
12. Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium. Jones DT and Reed RR, J Biol Chem 1987 Oct 15;262(29):14241-9.
13. Brain heterotrimeric Gai2-subunit protein-gated pathways mediate central sympathoinhibition to maintain fluid and electrolyte homeostasis during stress. Kapusta DR, etal., FASEB J. 2012 Jul;26(7):2776-87. doi: 10.1096/fj.11-196550. Epub 2012 Mar 29.
14. RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity. Kimple RJ, etal., J Biol Chem. 2001 Aug 3;276(31):29275-81. Epub 2001 May 31.
15. Right ventricular outflow tract tachycardia due to a somatic cell mutation in G protein subunitalphai2. Lerman BB, etal., J Clin Invest. 1998 Jun 15;101(12):2862-8.
16. Evidence for the involvement of Gi2 in activation of extracellular signal-regulated kinases in hepatocytes. Melien O, etal., BMC Cell Biol 2001;2(1):13.
17. Evidence for the involvement of Gi2 in activation of extracellular signal-regulated kinases in hepatocytes. Melien O, etal., BMC Cell Biol. 2001;2:13. Epub 2001 Jul 24.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Functionally selective dopamine D(2), D(3) receptor partial agonists. Moller D, etal., J Med Chem. 2014 Jun 12;57(11):4861-75. doi: 10.1021/jm5004039. Epub 2014 May 23.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
23. AT2 receptors: beneficial counter-regulatory role in cardiovascular and renal function. Padia SH and Carey RM, Pflugers Arch. 2013 Jan;465(1):99-110. doi: 10.1007/s00424-012-1146-3. Epub 2012 Sep 5.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. Overexpression of wild-type Galpha(i)-2 suppresses beta-adrenergic signaling in cardiac myocytes. Rau T, etal., FASEB J. 2003 Mar;17(3):523-5. doi: 10.1096/fj.02-0660fje. Epub 2003 Jan 21.
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Exogenous myristoylated-G(i2)alpha subunits of GTP-binding proteins are mitogens following their internalization by astrocytes in culture. Sanchez-Blazquez P, etal., Brain Res Mol Brain Res. 2003 Jan 31;110(1):15-26.
31. Gi2 signaling enhances proliferation of neural progenitor cells in the developing brain. Shinohara H, etal., J Biol Chem. 2004 Sep 24;279(39):41141-8. doi: 10.1074/jbc.M406721200. Epub 2004 Jul 22.
32. Selective interactions between Gi alpha1 and Gi alpha3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization. Shu FJ, etal., Cell Signal. 2007 Jan;19(1):163-76. Epub 2006 Jul 25.
33. G-protein alpha subunit isoforms couple differentially to receptors that mediate presynaptic inhibition at rat hippocampal synapses. Straiker AJ, etal., J Neurosci 2002 Apr 1;22(7):2460-8.
34. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
35. Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor. Tall GG, etal., J Biol Chem 2003 Mar 7;278(10):8356-62.
36. Galpha(i2) enhances insulin signaling via suppression of protein-tyrosine phosphatase 1B. Tao J, etal., J Biol Chem. 2001 Oct 26;276(43):39705-12. doi: 10.1074/jbc.M105216200. Epub 2001 Aug 10.
37. [Alteration of the expression of rat cardiac Galphaq/11 and Gialpha2 proteins during endothelin-1 pre-treatment]. Wang XT, etal., Sheng Li Xue Bao. 2000 Dec;52(6):459-62.
38. Lysophosphatidic acid rescues bone mesenchymal stem cells from hydrogen peroxide-induced apoptosis. Wang XY, etal., Apoptosis. 2015 Mar;20(3):273-84. doi: 10.1007/s10495-014-1074-0.
39. [Alterations of cardiac Gi protein alpha subunits during ischemia-reperfusion in rats]. Wang Y, etal., Sheng Li Xue Bao. 1998 Oct;50(5):514-8.
40. The essential role of Gia2 in prostate cancer cell migration. Zhong M, etal., Mol Cancer Res. 2012 Oct;10(10):1380-8. doi: 10.1158/1541-7786.MCR-12-0219. Epub 2012 Aug 30.
Additional References at PubMed
PMID:2159473   PMID:8622915   PMID:11121039   PMID:11158953   PMID:11299198   PMID:11685543   PMID:12519789   PMID:14712229   PMID:15312896   PMID:15376236   PMID:15489334   PMID:15950765  
PMID:17430589   PMID:17575083   PMID:17635935   PMID:18316484   PMID:18441196   PMID:18472243   PMID:18504258   PMID:18665079   PMID:18981538   PMID:19003918   PMID:19056867   PMID:19199708  
PMID:19946888   PMID:20458337   PMID:21079996   PMID:21480366   PMID:22082260   PMID:23106098   PMID:23376485   PMID:24155894   PMID:24769233   PMID:28692698   PMID:29476059   PMID:35352799  


Genomics

Comparative Map Data
Gnai2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,167,045 - 117,187,652 (-)NCBIGRCr8
mRatBN7.28108,288,401 - 108,309,009 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,288,401 - 108,308,979 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8113,915,238 - 113,935,641 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,114,396 - 112,134,799 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,957,178 - 109,977,581 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,370,730 - 116,391,337 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,370,744 - 116,391,307 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08115,726,562 - 115,746,754 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,861,952 - 112,882,647 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18112,881,416 - 112,902,054 (-)NCBI
Celera8107,594,933 - 107,615,332 (-)NCBICelera
Cytogenetic Map8q32NCBI
GNAI2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38350,227,068 - 50,263,358 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl350,226,292 - 50,259,362 (+)EnsemblGRCh38hg38GRCh38
GRCh37350,264,500 - 50,296,794 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,248,651 - 50,271,790 (+)NCBINCBI36Build 36hg18NCBI36
Build 34350,248,650 - 50,271,790NCBI
Celera350,246,476 - 50,269,614 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef350,329,335 - 50,352,473 (+)NCBIHuRef
CHM1_1350,225,922 - 50,249,058 (+)NCBICHM1_1
T2T-CHM13v2.0350,256,406 - 50,288,697 (+)NCBIT2T-CHM13v2.0
Gnai2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,491,324 - 107,512,542 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9107,491,324 - 107,512,566 (-)EnsemblGRCm39 Ensembl
GRCm389107,614,125 - 107,635,391 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,614,125 - 107,635,367 (-)EnsemblGRCm38mm10GRCm38
MGSCv379107,516,469 - 107,537,673 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369107,472,714 - 107,493,430 (-)NCBIMGSCv36mm8
Celera9107,222,922 - 107,240,939 (-)NCBICelera
Cytogenetic Map9F1NCBI
cM Map958.43NCBI
Gnai2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,059,038 - 2,079,957 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555322,059,038 - 2,079,120 (+)NCBIChiLan1.0ChiLan1.0
GNAI2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2250,209,618 - 50,242,401 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1350,224,024 - 50,247,178 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0350,154,731 - 50,187,948 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1351,398,981 - 51,422,000 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,398,981 - 51,421,988 (+)Ensemblpanpan1.1panPan2
GNAI2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,075,085 - 39,094,697 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,075,085 - 39,094,697 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2038,996,147 - 39,015,757 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02039,431,154 - 39,450,979 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2039,430,574 - 39,451,075 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12038,798,956 - 38,818,559 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02039,202,455 - 39,222,063 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,482,556 - 39,502,160 (-)NCBIUU_Cfam_GSD_1.0
Gnai2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560265,019,103 - 65,040,746 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365291,779,571 - 1,801,255 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365291,779,582 - 1,801,251 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNAI2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,705,321 - 32,733,794 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11332,705,326 - 32,733,804 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,891,199 - 35,912,182 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GNAI2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,623,394 - 11,646,464 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2211,623,408 - 11,647,191 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041155,339,947 - 155,363,875 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gnai2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247304,103,905 - 4,126,737 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247304,096,061 - 4,126,538 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gnai2
99 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:535
Count of miRNA genes:241
Interacting mature miRNAs:290
Transcripts:ENSRNOT00000022550
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8102370617108923645Rat

Markers in Region
RH125971  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21162,754,211 - 162,754,428 (+)MAPPERmRatBN7.2
mRatBN7.28108,288,987 - 108,289,202 (+)MAPPERmRatBN7.2
Rnor_6.08116,371,317 - 116,371,531NCBIRnor6.0
Rnor_6.01173,076,047 - 173,076,263NCBIRnor6.0
Rnor_5.01180,073,344 - 180,073,560UniSTSRnor5.0
Rnor_5.08115,727,149 - 115,727,363UniSTSRnor5.0
RGSC_v3.48112,862,539 - 112,862,753UniSTSRGSC3.4
Celera8107,595,520 - 107,595,734UniSTS
Celera1160,661,514 - 160,661,730UniSTS
Cytogenetic Map8q32UniSTS
RH140777  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,288,979 - 108,289,160 (+)MAPPERmRatBN7.2
Rnor_6.08116,371,309 - 116,371,489NCBIRnor6.0
Rnor_5.08115,727,141 - 115,727,321UniSTSRnor5.0
RGSC_v3.48112,862,531 - 112,862,711UniSTSRGSC3.4
Celera8107,595,512 - 107,595,692UniSTS
RH 3.4 Map81116.4UniSTS
Cytogenetic Map8q32UniSTS
BI273769  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21162,754,530 - 162,754,724 (+)MAPPERmRatBN7.2
mRatBN7.28108,288,701 - 108,288,891 (+)MAPPERmRatBN7.2
Rnor_6.08116,371,031 - 116,371,220NCBIRnor6.0
Rnor_6.01173,076,366 - 173,076,559NCBIRnor6.0
Rnor_5.08115,726,863 - 115,727,052UniSTSRnor5.0
Rnor_5.01180,073,663 - 180,073,856UniSTSRnor5.0
RGSC_v3.48112,862,253 - 112,862,442UniSTSRGSC3.4
Celera8107,595,234 - 107,595,423UniSTS
Celera1160,661,833 - 160,662,026UniSTS
RH 3.4 Map11361.4UniSTS
Cytogenetic Map8q32UniSTS
Gnai2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21162,753,060 - 162,753,533 (+)MAPPERmRatBN7.2
Rnor_6.01173,074,896 - 173,075,368NCBIRnor6.0
Rnor_5.01180,072,193 - 180,072,665UniSTSRnor5.0
Celera1160,660,363 - 160,660,835UniSTS
Cytogenetic Map8q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC106346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY899210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY899211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO394955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR465951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ120471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ120472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M12672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M17528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OU667092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000022550   ⟹   ENSRNOP00000022550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8108,288,401 - 108,308,979 (-)Ensembl
Rnor_6.0 Ensembl8116,370,744 - 116,391,307 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078720   ⟹   ENSRNOP00000073025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8116,370,767 - 116,391,158 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111582   ⟹   ENSRNOP00000094425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8108,288,401 - 108,295,796 (-)Ensembl
RefSeq Acc Id: NM_031035   ⟹   NP_112297
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,167,045 - 117,187,622 (-)NCBI
mRatBN7.28108,288,401 - 108,308,979 (-)NCBI
Rnor_6.08116,370,730 - 116,391,307 (-)NCBI
Rnor_5.08115,726,562 - 115,746,754 (-)NCBI
RGSC_v3.48112,861,952 - 112,882,647 (-)RGD
Celera8107,594,933 - 107,615,332 (-)RGD
Sequence:
RefSeq Acc Id: XM_006243858   ⟹   XP_006243920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,167,051 - 117,187,652 (-)NCBI
mRatBN7.28108,288,401 - 108,309,009 (-)NCBI
Rnor_6.08116,370,730 - 116,391,337 (-)NCBI
Rnor_5.08115,726,562 - 115,746,754 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063266205   ⟹   XP_063122275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,167,051 - 117,187,652 (-)NCBI
RefSeq Acc Id: XM_063266206   ⟹   XP_063122276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,167,051 - 117,183,441 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_112297   ⟸   NM_031035
- UniProtKB: P04897 (UniProtKB/Swiss-Prot),   Q45QN0 (UniProtKB/TrEMBL),   A6I2Z9 (UniProtKB/TrEMBL),   Q5EEY4 (UniProtKB/TrEMBL),   Q45QN1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243920   ⟸   XM_006243858
- Peptide Label: isoform X1
- UniProtKB: P04897 (UniProtKB/Swiss-Prot),   Q45QN0 (UniProtKB/TrEMBL),   A6I2Z9 (UniProtKB/TrEMBL),   Q5EEY4 (UniProtKB/TrEMBL),   Q45QN1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022550   ⟸   ENSRNOT00000022550
RefSeq Acc Id: ENSRNOP00000073025   ⟸   ENSRNOT00000078720
RefSeq Acc Id: ENSRNOP00000094425   ⟸   ENSRNOT00000111582
RefSeq Acc Id: XP_063122275   ⟸   XM_063266205
- Peptide Label: isoform X1
- UniProtKB: P04897 (UniProtKB/Swiss-Prot),   A6I2Z9 (UniProtKB/TrEMBL),   Q45QN0 (UniProtKB/TrEMBL),   Q45QN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122276   ⟸   XM_063266206
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AKS3 (UniProtKB/TrEMBL)
Protein Domains
G-alpha

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04897-F1-model_v2 AlphaFold P04897 1-355 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696280
Promoter ID:EPDNEW_R6803
Type:initiation region
Name:Gnai2_1
Description:G protein subunit alpha i2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08116,391,281 - 116,391,341EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620243 AgrOrtholog
BioCyc Gene G2FUF-29182 BioCyc
Ensembl Genes ENSRNOG00000016592 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055013363 UniProtKB/Swiss-Prot
  ENSRNOG00060029241 UniProtKB/Swiss-Prot
  ENSRNOG00065008318 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022550 ENTREZGENE
  ENSRNOT00000022550.7 UniProtKB/Swiss-Prot
  ENSRNOT00000111582.1 UniProtKB/TrEMBL
  ENSRNOT00055022918 UniProtKB/Swiss-Prot
  ENSRNOT00060050877 UniProtKB/Swiss-Prot
  ENSRNOT00065013208 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7121183 IMAGE-MGC_LOAD
InterPro Gprotein_alpha_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gprotein_alpha_su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GproteinA_insert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81664 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93387 IMAGE-MGC_LOAD
NCBI Gene 81664 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10218 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam G-alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gnai2 PhenoGen
PRINTS GPROTEINA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPROTEINAI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016592 RatGTEx
  ENSRNOG00055013363 RatGTEx
  ENSRNOG00060029241 RatGTEx
  ENSRNOG00065008318 RatGTEx
SMART G_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AKS3 ENTREZGENE, UniProtKB/TrEMBL
  A6I2Z9 ENTREZGENE, UniProtKB/TrEMBL
  GNAI2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q45QN0 ENTREZGENE
  Q45QN1 ENTREZGENE, UniProtKB/TrEMBL
  Q5EEY3_RAT UniProtKB/TrEMBL
  Q5EEY4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q45QN0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Gnai2  G protein subunit alpha i2  Gnai2  guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-05-03 Gnai2  guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2  Gnai2  guanine nucleotide binding protein (G protein), alpha inhibiting 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-25 Gnai2  guanine nucleotide binding protein (G protein), alpha inhibiting 2  Gnai2  guanine nucleotide binding protein, alpha inhibiting 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Gnai2  guanine nucleotide binding protein, alpha inhibiting 2    GTP-binding protein (G-alpha-i2)  Name updated 1299863 APPROVED
2002-08-07 Gnai2  GTP-binding protein (G-alpha-i2)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA-abundant in hippocampus 625670
gene_function selectively interacts with different G-protein coupled receptors 625670
gene_physical_interaction interacts with cannabinoid CB1 and somatostatin (SSTR) receptors 625670
gene_process involved in presynaptic inhibition 625670