Prmt1 (protein arginine methyltransferase 1) - Rat Genome Database

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Gene: Prmt1 (protein arginine methyltransferase 1) Rattus norvegicus
Analyze
Symbol: Prmt1
Name: protein arginine methyltransferase 1
RGD ID: 62020
Description: Enables identical protein binding activity; protein methyltransferase activity; and snoRNP binding activity. Involved in several processes, including liver regeneration; positive regulation of erythrocyte differentiation; and positive regulation of hemoglobin biosynthetic process. Located in cytosol. Part of protein-containing complex. Biomarker of asthma. Orthologous to human PRMT1 (protein arginine methyltransferase 1); PARTICIPATES IN androgen signaling pathway; estrogen signaling pathway; histone modification pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: heterogeneous nuclear ribonucleoproteins methyltransferase-like 2; heterogeneous nuclear ribonucleoproteins methyltransferase-like 2 (S. cerevisiae); histone-arginine N-methyltransferase PRMT1; Hrmt1l2; protein arginine N-methyltransferase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,595,339 - 104,605,552 (-)NCBIGRCr8
mRatBN7.2195,458,853 - 95,468,176 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,458,850 - 95,468,345 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1100,844,258 - 100,853,464 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,316,924 - 109,326,130 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,607,317 - 102,616,523 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,971,132 - 100,980,411 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,971,273 - 100,980,340 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,035,572 - 102,044,849 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,449,061 - 95,458,267 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,527,171 - 95,536,378 (-)NCBI
Celera189,720,386 - 89,729,592 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
arsenous acid  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
berberine  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
cyclosporin A  (ISO)
dapsone  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
gallic acid  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glafenine  (EXP)
indometacin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
melatonin  (EXP)
methimazole  (EXP)
methotrexate  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
obeticholic acid  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
ribavirin  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
S-adenosyl-L-homocysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sulfadimethoxine  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiophenes  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
cytosol  (IDA,IEA)
lysosomal membrane  (IEA)
methylosome  (ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,ISO)
protein-containing complex  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Arginine methylation an emerging regulator of protein function. Bedford MT and Richard S, Mol Cell 2005 Apr 29;18(3):263-72.
2. Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production. Bonham K, etal., FEBS J. 2010 May;277(9):2096-108. doi: 10.1111/j.1742-4658.2010.07623.x. Epub 2010 Mar 22.
3. Androgen receptor coregulators and their involvement in the development and progression of prostate cancer. Chmelar R, etal., Int J Cancer. 2007 Feb 15;120(4):719-33.
4. Histone arginine methylation. Di Lorenzo A and Bedford MT, FEBS Lett. 2011 Jul 7;585(13):2024-31. doi: 10.1016/j.febslet.2010.11.010. Epub 2010 Nov 11.
5. The predominant protein-arginine methyltransferase from Saccharomyces cerevisiae. Gary JD, etal., J Biol Chem 1996 May 24;271(21):12585-94.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Readers of histone methylarginine marks. Gayatri S and Bedford MT, Biochim Biophys Acta. 2014 Aug;1839(8):702-710. doi: 10.1016/j.bbagrm.2014.02.015. Epub 2014 Feb 28.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Hall JM and McDonnell DP, Mol Interv. 2005 Dec;5(6):343-57.
10. Protein arginine methyltransferase 1 interacts with and activates p38alpha to facilitate erythroid differentiation. Hua WK, etal., PLoS One. 2013;8(3):e56715. doi: 10.1371/journal.pone.0056715. Epub 2013 Mar 6.
11. Involvement of PRMT1 in hnRNPQ activation and internalization of insulin receptor. Iwasaki H Biochem Biophys Res Commun. 2008 Jul 25;372(2):314-9. doi: 10.1016/j.bbrc.2008.05.051. Epub 2008 May 19.
12. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
13. Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4. Lakowski TM and Frankel A, Biochem J. 2009 Jun 26;421(2):253-61. doi: 10.1042/BJ20090268.
14. Multimerization of expressed protein-arginine methyltransferases during the growth and differentiation of rat liver. Lim Y, etal., Biochim Biophys Acta. 2005 May 25;1723(1-3):240-7. Epub 2005 Mar 17.
15. Arginine methylation of recombinant murine fibrillarin by protein arginine methyltransferase. Lin CH, etal., J Protein Chem 2002 Oct;21(7):447-53.
16. Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1. Lin WJ, etal., Biochem J 2001 Mar 15;354(Pt 3):635-43.
17. The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase. Lin WJ, etal., J Biol Chem 1996 Jun 21;271(25):15034-44.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Glucagon-like peptide-1 receptor agonist inhibits asymmetric dimethylarginine generation in the kidney of streptozotocin-induced diabetic rats by blocking advanced glycation end product-induced protein arginine methyltranferase-1 expression. Ojima A, etal., Am J Pathol. 2013 Jan;182(1):132-41. doi: 10.1016/j.ajpath.2012.09.016. Epub 2012 Nov 14.
21. Arginine N-methyltransferase 1 is required for early postimplantation mouse development, but cells deficient in the enzyme are viable. Pawlak MR, etal., Mol Cell Biol 2000 Jul;20(13):4859-69.
22. GOA pipeline RGD automated data pipeline
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
25. [Expression of protein arginine N-methyltransferases in E3 rat models of acute asthma]. Sun QZ, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2010 Apr;30(4):716-9.
26. PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation. Tang J, etal., J Biol Chem 1998 Jul 3;273(27):16935-45.
27. Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3. Tang J, etal., J Biol Chem 2000 Jun 30;275(26):19866-76.
28. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
29. Arginine methylation of the cellular nucleic acid binding protein does not affect its subcellular localization but impedes RNA binding. Wei HM, etal., FEBS Lett. 2014 May 2;588(9):1542-8. doi: 10.1016/j.febslet.2014.03.052. Epub 2014 Apr 12.
30. Structure of the predominant protein arginine methyltransferase PRMT1 and analysis of its binding to substrate peptides. Zhang X and Cheng X, Structure. 2003 May;11(5):509-20. doi: 10.1016/s0969-2126(03)00071-6.
31. Crystal structure of the conserved core of protein arginine methyltransferase PRMT3. Zhang X, etal., EMBO J. 2000 Jul 17;19(14):3509-19.
Additional References at PubMed
PMID:10772824   PMID:11448779   PMID:12397599   PMID:15489334   PMID:16169070   PMID:16682010   PMID:18316480   PMID:18495660   PMID:18657504   PMID:18773938   PMID:19124016   PMID:19460357  
PMID:19467247   PMID:20442406   PMID:21080372   PMID:21652632   PMID:21736313   PMID:22082260   PMID:22387551   PMID:22681889   PMID:22697391   PMID:22785485   PMID:23214442   PMID:23455924  
PMID:23977297   PMID:24478314   PMID:25284789   PMID:25416956   PMID:25865156   PMID:26026059   PMID:26575292   PMID:26876602   PMID:28040436   PMID:29119338   PMID:29128891   PMID:31160378  
PMID:31787756   PMID:31813251   PMID:33826088   PMID:34688662  


Genomics

Comparative Map Data
Prmt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,595,339 - 104,605,552 (-)NCBIGRCr8
mRatBN7.2195,458,853 - 95,468,176 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,458,850 - 95,468,345 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1100,844,258 - 100,853,464 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,316,924 - 109,326,130 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,607,317 - 102,616,523 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,971,132 - 100,980,411 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,971,273 - 100,980,340 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,035,572 - 102,044,849 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,449,061 - 95,458,267 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,527,171 - 95,536,378 (-)NCBI
Celera189,720,386 - 89,729,592 (-)NCBICelera
Cytogenetic Map1q22NCBI
PRMT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,676,153 - 49,688,447 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1949,675,786 - 49,689,029 (+)EnsemblGRCh38hg38GRCh38
GRCh371950,180,528 - 50,191,704 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,872,308 - 54,883,516 (+)NCBINCBI36Build 36hg18NCBI36
Build 341954,872,354 - 54,883,516NCBI
Celera1947,049,830 - 47,061,036 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1946,557,181 - 46,568,351 (+)NCBIHuRef
CHM1_11950,182,198 - 50,193,506 (+)NCBICHM1_1
T2T-CHM13v2.01952,677,341 - 52,688,515 (+)NCBIT2T-CHM13v2.0
Prmt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,626,179 - 44,635,844 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl744,625,413 - 44,635,992 (-)EnsemblGRCm39 Ensembl
GRCm38744,976,755 - 44,986,420 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,975,989 - 44,986,568 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,232,128 - 52,241,702 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36744,844,800 - 44,854,374 (-)NCBIMGSCv36mm8
Celera740,428,328 - 40,437,891 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.07NCBI
Prmt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,203,283 - 1,215,021 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,205,340 - 1,215,672 (-)NCBIChiLan1.0ChiLan1.0
PRMT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,794,221 - 55,805,705 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,714,976 - 57,726,452 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01946,691,795 - 46,705,179 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11955,610,938 - 55,623,135 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1955,610,938 - 55,623,135 (+)Ensemblpanpan1.1panPan2
PRMT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11106,849,864 - 106,859,896 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1106,849,864 - 106,874,075 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1106,433,570 - 106,443,601 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01107,371,449 - 107,381,481 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,371,449 - 107,381,410 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,043,700 - 107,053,728 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01106,685,774 - 106,695,794 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01107,526,251 - 107,536,278 (-)NCBIUU_Cfam_GSD_1.0
Prmt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,873,842 - 21,884,543 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366643,491,920 - 3,504,667 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366643,492,032 - 3,502,738 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRMT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,714,157 - 54,732,574 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,718,845 - 54,730,411 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,447,908 - 50,459,466 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRMT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,854,873 - 42,863,113 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,854,918 - 42,863,014 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607322,796,021 - 22,808,631 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prmt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248324,589,743 - 4,602,402 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248324,593,594 - 4,602,514 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prmt1
23 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:117
Count of miRNA genes:94
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000064272
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat

Markers in Region
BI285876  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,458,857 - 95,459,077 (+)MAPPERmRatBN7.2
mRatBN7.21487,551,063 - 87,551,283 (+)MAPPERmRatBN7.2
Rnor_6.01100,971,137 - 100,971,356NCBIRnor6.0
Rnor_6.01493,040,983 - 93,041,202NCBIRnor6.0
Rnor_5.01492,831,791 - 92,832,010UniSTSRnor5.0
Rnor_5.01102,035,577 - 102,035,796UniSTSRnor5.0
RGSC_v3.4195,449,062 - 95,449,281UniSTSRGSC3.4
RGSC_v3.41493,881,141 - 93,881,360UniSTSRGSC3.4
Celera1486,680,959 - 86,681,178UniSTS
Celera189,720,387 - 89,720,606UniSTS
RH 3.4 Map14654.09UniSTS
Cytogenetic Map1q22UniSTS
Hrmt1l2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21767,626,147 - 67,626,358 (+)MAPPERmRatBN7.2
mRatBN7.21487,552,031 - 87,552,243 (+)MAPPERmRatBN7.2
Rnor_6.01493,041,951 - 93,042,162NCBIRnor6.0
Rnor_6.01771,397,715 - 71,397,925NCBIRnor6.0
Rnor_5.01773,092,124 - 73,092,334UniSTSRnor5.0
Rnor_5.01492,832,759 - 92,832,970UniSTSRnor5.0
RGSC_v3.41493,882,109 - 93,882,320UniSTSRGSC3.4
RGSC_v3.41778,879,926 - 78,880,136UniSTSRGSC3.4
Celera1767,123,381 - 67,123,591UniSTS
Celera1486,681,927 - 86,682,138UniSTS
Cytogenetic Map1q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 47 31 19 31 8 11 74 35 41 11 8
Low 1 10 10 10
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_024363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC127719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U60882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000064272   ⟹   ENSRNOP00000063624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,458,850 - 95,466,093 (-)Ensembl
Rnor_6.0 Ensembl1100,971,273 - 100,980,340 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098850   ⟹   ENSRNOP00000084758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,458,857 - 95,468,078 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100032   ⟹   ENSRNOP00000087098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,458,850 - 95,468,061 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103705   ⟹   ENSRNOP00000096484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,458,850 - 95,468,061 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113175   ⟹   ENSRNOP00000078126
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,458,850 - 95,468,224 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115255   ⟹   ENSRNOP00000087248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,458,853 - 95,468,345 (-)Ensembl
RefSeq Acc Id: NM_024363   ⟹   NP_077339
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,595,339 - 104,604,545 (-)NCBI
mRatBN7.2195,458,857 - 95,468,063 (-)NCBI
Rnor_6.01100,971,136 - 100,980,342 (-)NCBI
Rnor_5.01102,035,572 - 102,044,849 (-)NCBI
RGSC_v3.4195,449,061 - 95,458,267 (-)RGD
Celera189,720,386 - 89,729,592 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229144   ⟹   XP_006229206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,595,339 - 104,605,552 (-)NCBI
mRatBN7.2195,458,853 - 95,468,176 (-)NCBI
Rnor_6.01100,971,132 - 100,980,411 (-)NCBI
Rnor_5.01102,035,572 - 102,044,849 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063272501   ⟹   XP_063128571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,595,339 - 104,602,243 (-)NCBI
RefSeq Acc Id: XM_063272507   ⟹   XP_063128577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,595,339 - 104,602,249 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_077339   ⟸   NM_024363
- UniProtKB: Q63009 (UniProtKB/Swiss-Prot),   A6JAU8 (UniProtKB/TrEMBL),   A0A8L2QUM0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229206   ⟸   XM_006229144
- Peptide Label: isoform X1
- UniProtKB: A6JAU9 (UniProtKB/TrEMBL),   A0A8L2QUM0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000063624   ⟸   ENSRNOT00000064272
RefSeq Acc Id: ENSRNOP00000084758   ⟸   ENSRNOT00000098850
RefSeq Acc Id: ENSRNOP00000087248   ⟸   ENSRNOT00000115255
RefSeq Acc Id: ENSRNOP00000096484   ⟸   ENSRNOT00000103705
RefSeq Acc Id: ENSRNOP00000078126   ⟸   ENSRNOT00000113175
RefSeq Acc Id: ENSRNOP00000087098   ⟸   ENSRNOT00000100032
RefSeq Acc Id: XP_063128577   ⟸   XM_063272507
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063128571   ⟸   XM_063272501
- Peptide Label: isoform X2
Protein Domains
Methyltransferase   SAM-dependent MTase PRMT-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63009-F1-model_v2 AlphaFold Q63009 1-353 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690016
Promoter ID:EPDNEW_R541
Type:multiple initiation site
Name:Prmt1_1
Description:protein arginine methyltransferase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01100,980,357 - 100,980,417EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62020 AgrOrtholog
BIND 130433
  130434
BioCyc Gene G2FUF-59737 BioCyc
Ensembl Genes ENSRNOG00000026109 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055005632 UniProtKB/Swiss-Prot
  ENSRNOG00060007875 UniProtKB/Swiss-Prot
  ENSRNOG00065028078 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000064272 ENTREZGENE
  ENSRNOT00000064272.4 UniProtKB/TrEMBL
  ENSRNOT00000098850.1 UniProtKB/TrEMBL
  ENSRNOT00000100032.1 UniProtKB/TrEMBL
  ENSRNOT00000103705.1 UniProtKB/TrEMBL
  ENSRNOT00000113175.1 UniProtKB/TrEMBL
  ENSRNOT00000115255.1 UniProtKB/TrEMBL
  ENSRNOT00055009066 UniProtKB/Swiss-Prot
  ENSRNOT00060013117 UniProtKB/Swiss-Prot
  ENSRNOT00065048584 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hnrnp arginine n-methyltransferase1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7106257 IMAGE-MGC_LOAD
InterPro Arg_MeTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Methyltransf_25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60421 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93411 IMAGE-MGC_LOAD
NCBI Gene 60421 ENTREZGENE
PANTHER PROTEIN ARGININE N-METHYLTRANSFERASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11006 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Methyltransf_25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prmt1 PhenoGen
PROSITE SAM_MT_PRMT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026109 RatGTEx
  ENSRNOG00055005632 RatGTEx
  ENSRNOG00060007875 RatGTEx
  ENSRNOG00065028078 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228983
UniProt A0A8I5Y864_RAT UniProtKB/TrEMBL
  A0A8I5ZYM2_RAT UniProtKB/TrEMBL
  A0A8I6A3L2_RAT UniProtKB/TrEMBL
  A0A8I6A3V3_RAT UniProtKB/TrEMBL
  A0A8I6GM37_RAT UniProtKB/TrEMBL
  A0A8L2QUM0 ENTREZGENE, UniProtKB/TrEMBL
  A6JAU8 ENTREZGENE, UniProtKB/TrEMBL
  A6JAU9 ENTREZGENE, UniProtKB/TrEMBL
  A6JAV0_RAT UniProtKB/TrEMBL
  ANM1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-24 Prmt1  protein arginine methyltransferase 1  Prmt1  protein arginine N-methyltransferase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Prmt1  protein arginine N-methyltransferase 1  Hrmt1l2  heterogeneous nuclear ribonucleoproteins methyltransferase-like 2 (S. cerevisiae)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Hrmt1l2  heterogeneous nuclear ribonucleoproteins methyltransferase-like 2 (S. cerevisiae)       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds immediate early protein TIS21 and the leukemia-associated protein BTG1 in vitro 61630