Slc8a3 (solute carrier family 8 member A3) - Rat Genome Database

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Gene: Slc8a3 (solute carrier family 8 member A3) Rattus norvegicus
Analyze
Symbol: Slc8a3
Name: solute carrier family 8 member A3
RGD ID: 620197
Description: Enables calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration and calcium:sodium antiporter activity. Involved in cellular response to cAMP; metal ion transport; and telencephalon development. Acts upstream of or within intracellular calcium ion homeostasis. Located in several cellular components, including dendritic spine; neuronal cell body; and sarcolemma. Is active in postsynaptic membrane. Biomarker of brain ischemia and status epilepticus. Orthologous to human SLC8A3 (solute carrier family 8 member A3); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: na(+)/Ca(2+)-exchange protein 3; Ncx3; sodium/calcium exchanger 3; solute carrier family 8 (sodium/calcium exchanger), member 3; solute carrier family 8 member 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86106,605,611 - 106,739,208 (-)NCBIGRCr8
mRatBN7.26100,874,359 - 101,007,989 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6100,874,369 - 101,007,508 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6101,035,603 - 101,168,663 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06101,334,786 - 101,467,840 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06100,714,051 - 100,846,713 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06104,889,500 - 105,099,408 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6104,891,376 - 105,097,054 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06113,212,215 - 113,244,454 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.06113,051,977 - 113,067,568 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46105,012,888 - 105,159,942 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16105,016,343 - 105,163,398 (-)NCBI
Celera698,727,252 - 98,860,656 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Na+/Ca2+ exchanger subtype (NCX1, NCX2, NCX3) protein expression in the rat hippocampus following 3 min and 8 min durations of global cerebral ischemia. Bojarski C, etal., Brain Res. 2008 Jan 16;1189:198-202. Epub 2007 Nov 1.
2. Permanent focal brain ischemia induces isoform-dependent changes in the pattern of Na+/Ca2+ exchanger gene expression in the ischemic core, periinfarct area, and intact brain regions. Boscia F, etal., J Cereb Blood Flow Metab. 2006 Apr;26(4):502-17.
3. High level over-expression of different NCX isoforms in HEK293 cell lines and primary neuronal cultures is protective following oxygen glucose deprivation. Cross JL, etal., Neurosci Res. 2012 Jul;73(3):191-8. doi: 10.1016/j.neures.2012.04.007. Epub 2012 Apr 27.
4. Expression of the Na(+)/Ca(2+) exchanger in skeletal muscle. Fraysse B, etal., Am J Physiol Cell Physiol. 2001 Jan;280(1):C146-54.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Calcium extrusion protein expression in the hippocampal formation of chronic epileptic rats after kainate-induced status epilepticus. Ketelaars SO, etal., Epilepsia. 2004 Oct;45(10):1189-201.
7. Sodium-calcium exchangers in rat trigeminal ganglion neurons. Kuroda H, etal., Mol Pain. 2013 Apr 29;9:22. doi: 10.1186/1744-8069-9-22.
8. Functional comparison of the three isoforms of the Na+/Ca2+ exchanger (NCX1, NCX2, NCX3). Linck B, etal., Am J Physiol. 1998 Feb;274(2 Pt 1):C415-23.
9. Altered gene expression of Na+/Ca2+ exchanger isoforms NCX1, NCX2 and NCX3 in chronic ischemic rat brain. Lu J, etal., Neurosci Lett 2002 Oct 25;332(1):21-4.
10. Na+/Ca2+ exchangers: three mammalian gene families control Ca2+ transport. Lytton J Biochem J. 2007 Sep 15;406(3):365-82.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Cellular and subcellular localization of Na+-Ca2+ exchanger protein isoforms, NCX1, NCX2, and NCX3 in cerebral cortex and hippocampus of adult rat. Minelli A, etal., Cell Calcium. 2007 Mar;41(3):221-34. Epub 2006 Aug 17.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3. Nicoll DA, etal., J Biol Chem 1996 Oct 4;271(40):24914-21.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Na(+)-Ca(2+) exchanger isoforms in rat neuronal preparations: different changes in their expression during postnatal development. Sakaue M, etal., Brain Res. 2000 Oct 27;881(2):212-6.
20. NCX3 regulates mitochondrial Ca(2+) handling through the AKAP121-anchored signaling complex and prevents hypoxia-induced neuronal death. Scorziello A, etal., J Cell Sci. 2013 Dec 15;126(Pt 24):5566-77. doi: 10.1242/jcs.129668. Epub 2013 Oct 7.
21. BHK cells transfected with NCX3 are more resistant to hypoxia followed by reoxygenation than those transfected with NCX1 and NCX2: Possible relationship with mitochondrial membrane potential. Secondo A, etal., Cell Calcium. 2007 Dec;42(6):521-35. Epub 2007 Mar 6.
22. High levels of synaptosomal Na(+)-Ca(2+) exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer's disease. Sokolow S, etal., Cell Calcium. 2011 Apr;49(4):208-16. doi: 10.1016/j.ceca.2010.12.008. Epub 2011 Mar 5.
23. Immunohistochemical detection of the sodium-calcium exchanger in rat hippocampus cultures using subtype-specific antibodies. Thurneysen T, etal., Ann N Y Acad Sci 2002 Nov;976:367-75.
Additional References at PubMed
PMID:12502534   PMID:12722103   PMID:14722618   PMID:15472108   PMID:15680332   PMID:15681692   PMID:16679322   PMID:18079274   PMID:18234895   PMID:20628398   PMID:20928830   PMID:21593315  
PMID:21959935   PMID:23403180   PMID:23688374   PMID:23919677   PMID:24029230   PMID:24632945   PMID:26041911   PMID:26608990   PMID:26924806   PMID:28428550   PMID:29274751   PMID:29763795  


Genomics

Comparative Map Data
Slc8a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86106,605,611 - 106,739,208 (-)NCBIGRCr8
mRatBN7.26100,874,359 - 101,007,989 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6100,874,369 - 101,007,508 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6101,035,603 - 101,168,663 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06101,334,786 - 101,467,840 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06100,714,051 - 100,846,713 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06104,889,500 - 105,099,408 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6104,891,376 - 105,097,054 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06113,212,215 - 113,244,454 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.06113,051,977 - 113,067,568 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46105,012,888 - 105,159,942 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16105,016,343 - 105,163,398 (-)NCBI
Celera698,727,252 - 98,860,656 (-)NCBICelera
Cytogenetic Map6q24NCBI
SLC8A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381470,044,215 - 70,189,405 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1470,044,215 - 70,189,480 (-)EnsemblGRCh38hg38GRCh38
GRCh371470,510,932 - 70,655,668 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361469,580,687 - 69,725,540 (-)NCBINCBI36Build 36hg18NCBI36
Build 341469,580,686 - 69,725,540NCBI
Celera1450,575,050 - 50,719,920 (-)NCBICelera
Cytogenetic Map14q24.2NCBI
HuRef1450,679,036 - 50,824,067 (-)NCBIHuRef
CHM1_11470,448,984 - 70,593,925 (-)NCBICHM1_1
T2T-CHM13v2.01464,251,720 - 64,396,975 (-)NCBIT2T-CHM13v2.0
Slc8a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391281,244,686 - 81,380,506 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1281,244,689 - 81,379,954 (-)EnsemblGRCm39 Ensembl
GRCm381281,197,915 - 81,333,732 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1281,197,915 - 81,333,180 (-)EnsemblGRCm38mm10GRCm38
MGSCv371282,298,902 - 82,434,167 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361282,118,294 - 82,252,028 (-)NCBIMGSCv36mm8
Celera1282,663,653 - 82,799,351 (-)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1237.44NCBI
Slc8a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955466220,099 - 360,851 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955466220,346 - 359,627 (+)NCBIChiLan1.0ChiLan1.0
SLC8A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21571,164,475 - 71,309,970 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11470,380,988 - 70,526,483 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01450,634,091 - 50,779,712 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11469,505,703 - 69,650,382 (-)NCBIpanpan1.1PanPan1.1panPan2
SLC8A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1843,780,363 - 43,926,142 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl843,781,120 - 43,926,343 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha843,468,296 - 43,609,170 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0844,007,522 - 44,148,880 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl844,007,523 - 44,133,356 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1843,621,943 - 43,763,260 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0843,695,111 - 43,836,566 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0844,055,432 - 44,196,751 (-)NCBIUU_Cfam_GSD_1.0
Slc8a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864060,820,218 - 60,955,215 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649513,236,470 - 13,371,011 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649513,236,480 - 13,370,973 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC8A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl793,643,618 - 93,796,917 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1793,643,609 - 93,797,483 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2799,955,640 - 100,109,379 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC8A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12447,287,487 - 47,428,608 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2447,288,256 - 47,427,776 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605335,512,872 - 35,653,693 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc8a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473430,888,952 - 31,031,975 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473430,889,302 - 31,033,098 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc8a3
635 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:582
Count of miRNA genes:251
Interacting mature miRNAs:303
Transcripts:ENSRNOT00000048606
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat

Markers in Region
AU046738  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26100,874,568 - 100,874,723 (+)MAPPERmRatBN7.2
Rnor_6.06104,891,225 - 104,891,379NCBIRnor6.0
Rnor_5.06113,051,824 - 113,051,978UniSTSRnor5.0
RGSC_v3.46105,012,735 - 105,012,889UniSTSRGSC3.4
Celera698,727,452 - 98,727,606UniSTS
Cytogenetic Map6q24UniSTS
AW742262  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26100,875,098 - 100,875,342 (+)MAPPERmRatBN7.2
Rnor_6.06104,891,755 - 104,891,998NCBIRnor6.0
Rnor_5.06113,052,354 - 113,052,597UniSTSRnor5.0
RGSC_v3.46105,013,265 - 105,013,508UniSTSRGSC3.4
Celera698,727,982 - 98,728,225UniSTS
Cytogenetic Map6q24UniSTS
BE110255  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26100,949,606 - 100,949,807 (+)MAPPERmRatBN7.2
Rnor_6.06104,966,732 - 104,966,932NCBIRnor6.0
Rnor_5.06113,127,651 - 113,127,851UniSTSRnor5.0
RGSC_v3.46105,090,055 - 105,090,255UniSTSRGSC3.4
Celera698,802,336 - 98,802,536UniSTS
RH 3.4 Map6704.6UniSTS
Cytogenetic Map6q24UniSTS
BF413600  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26100,882,609 - 100,882,742 (+)MAPPERmRatBN7.2
Rnor_6.06104,899,265 - 104,899,397NCBIRnor6.0
Rnor_5.06113,059,865 - 113,059,997UniSTSRnor5.0
RGSC_v3.46105,020,776 - 105,020,908UniSTSRGSC3.4
Celera698,735,493 - 98,735,625UniSTS
RH 3.4 Map6716.4UniSTS
Cytogenetic Map6q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 5 52 3
Low 2 2 10 2 2 5 6 22 22 33 11 5
Below cutoff 1 40 42 34 16 34 13 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_078620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC122625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000048606   ⟹   ENSRNOP00000041987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6100,874,369 - 101,007,272 (-)Ensembl
Rnor_6.0 Ensembl6104,891,376 - 105,097,054 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099130   ⟹   ENSRNOP00000088179
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6100,874,369 - 101,007,508 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102013   ⟹   ENSRNOP00000093954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6100,874,369 - 101,007,272 (-)Ensembl
RefSeq Acc Id: NM_078620   ⟹   NP_511175
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,605,621 - 106,738,505 (-)NCBI
mRatBN7.26100,874,369 - 101,007,272 (-)NCBI
Rnor_6.06104,891,025 - 105,097,054 (-)NCBI
Rnor_5.06113,051,977 - 113,067,568 (-)NCBI
Rnor_5.06113,212,215 - 113,244,454 (-)NCBI
RGSC_v3.46105,012,888 - 105,159,942 (-)RGD
Celera698,727,252 - 98,860,656 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593987   ⟹   XP_017449476
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,605,611 - 106,738,378 (-)NCBI
mRatBN7.26100,874,359 - 101,007,453 (-)NCBI
Rnor_6.06104,889,500 - 105,097,254 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593993   ⟹   XP_017449482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,605,611 - 106,738,378 (-)NCBI
mRatBN7.26100,874,359 - 101,007,452 (-)NCBI
Rnor_6.06104,889,500 - 105,097,254 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593995   ⟹   XP_017449484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,605,611 - 106,738,378 (-)NCBI
mRatBN7.26100,874,359 - 101,007,453 (-)NCBI
Rnor_6.06104,889,500 - 104,912,806 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039111700   ⟹   XP_038967628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,605,611 - 106,738,378 (-)NCBI
mRatBN7.26100,874,359 - 101,007,453 (-)NCBI
RefSeq Acc Id: XM_039111701   ⟹   XP_038967629
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,605,611 - 106,739,208 (-)NCBI
mRatBN7.26100,874,359 - 101,007,989 (-)NCBI
RefSeq Acc Id: XM_039111702   ⟹   XP_038967630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,605,611 - 106,738,378 (-)NCBI
mRatBN7.26100,874,359 - 101,007,454 (-)NCBI
RefSeq Acc Id: XM_039111703   ⟹   XP_038967631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,605,611 - 106,738,378 (-)NCBI
mRatBN7.26100,874,359 - 101,007,454 (-)NCBI
RefSeq Acc Id: XM_063261489   ⟹   XP_063117559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,605,611 - 106,739,207 (-)NCBI
RefSeq Acc Id: XM_063261490   ⟹   XP_063117560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,605,611 - 106,738,378 (-)NCBI
RefSeq Acc Id: XM_063261491   ⟹   XP_063117561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,605,611 - 106,739,206 (-)NCBI
RefSeq Acc Id: XM_063261492   ⟹   XP_063117562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,605,611 - 106,738,378 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_511175   ⟸   NM_078620
- Peptide Label: precursor
- UniProtKB: P70549 (UniProtKB/Swiss-Prot),   A6JDL8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449482   ⟸   XM_017593993
- Peptide Label: isoform X5
- UniProtKB: A0A8L2QN54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449476   ⟸   XM_017593987
- Peptide Label: isoform X2
- UniProtKB: P70549 (UniProtKB/Swiss-Prot),   A6JDL8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449484   ⟸   XM_017593995
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A8U6 (UniProtKB/TrEMBL),   A6JDL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000041987   ⟸   ENSRNOT00000048606
RefSeq Acc Id: XP_038967629   ⟸   XM_039111701
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A8U6 (UniProtKB/TrEMBL),   A6JDL9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967631   ⟸   XM_039111703
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038967630   ⟸   XM_039111702
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038967628   ⟸   XM_039111700
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A8U6 (UniProtKB/TrEMBL),   A6JDL9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000093954   ⟸   ENSRNOT00000102013
RefSeq Acc Id: ENSRNOP00000088179   ⟸   ENSRNOT00000099130
RefSeq Acc Id: XP_063117559   ⟸   XM_063261489
- Peptide Label: isoform X2
- UniProtKB: P70549 (UniProtKB/Swiss-Prot),   A6JDL8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117561   ⟸   XM_063261491
- Peptide Label: isoform X5
- UniProtKB: A0A8L2QN54 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117562   ⟸   XM_063261492
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063117560   ⟸   XM_063261490
- Peptide Label: isoform X5
- UniProtKB: A0A8L2QN54 (UniProtKB/TrEMBL)
Protein Domains
Calx-beta

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70549-F1-model_v2 AlphaFold P70549 1-927 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620197 AgrOrtholog
BioCyc Gene G2FUF-36897 BioCyc
Ensembl Genes ENSRNOG00000029871 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055019116 UniProtKB/Swiss-Prot
  ENSRNOG00060029848 UniProtKB/Swiss-Prot
  ENSRNOG00065017674 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000048606.4 UniProtKB/TrEMBL
  ENSRNOT00000099130.1 UniProtKB/TrEMBL
  ENSRNOT00000102013 ENTREZGENE
  ENSRNOT00000102013.1 UniProtKB/Swiss-Prot
  ENSRNOT00055032610 UniProtKB/Swiss-Prot
  ENSRNOT00060051854 UniProtKB/Swiss-Prot
  ENSRNOT00065029579 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1420.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.2030 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CalX-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calx_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na_Ca_Ex UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na_Ca_Ex_C-exten UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NaCa_Exmemb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NCX_ion-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:140448 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 140448 ENTREZGENE
PANTHER SODIUM/CALCIUM EXCHANGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SODIUM/CALCIUM EXCHANGER 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Calx-beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na_Ca_ex UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na_Ca_ex_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc8a3 PhenoGen
PRINTS NACAEXCHNGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029871 RatGTEx
  ENSRNOG00055019116 RatGTEx
  ENSRNOG00060029848 RatGTEx
  ENSRNOG00065017674 RatGTEx
SMART Calx_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF141072 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A8U6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QN54 ENTREZGENE, UniProtKB/TrEMBL
  A6JDL8 ENTREZGENE, UniProtKB/TrEMBL
  A6JDL9 ENTREZGENE, UniProtKB/TrEMBL
  NAC3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Slc8a3  solute carrier family 8 member A3  Slc8a3  solute carrier family 8 member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-24 Slc8a3  solute carrier family 8 member 3  Slc8a3  solute carrier family 8 (sodium/calcium exchanger), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Slc8a3  solute carrier family 8 (sodium/calcium exchanger), member 3      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Slc8a3  solute carrier family 8 (sodium/calcium exchanger), member 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expression restricted to brain and skeletal muscle 730187
gene_protein open reading frame of 2.8 kb encodes protein of 927 aa residues 730187