Fgl2 (fibrinogen-like 2) - Rat Genome Database

Name: Fgl2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Fgl2 (fibrinogen-like 2) Rattus norvegicus

Analyze

Symbol:

Fgl2

Name:

fibrinogen-like 2

RGD ID:

620170

Description:

Predicted to enable peptidase activator activity. Predicted to be involved in parturition. Predicted to act upstream of or within several processes, including T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; negative regulation of antigen processing and presentation; and negative regulation of memory T cell differentiation. Predicted to be located in cell surface. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to human FGL2 (fibrinogen like 2); INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

fibroleukin

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FGL2 (fibrinogen like 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Fgl2 (fibrinogen-like protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Fgl2 (fibrinogen like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FGL2 (fibrinogen like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FGL2 (fibrinogen like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fgl2 (fibrinogen like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FGL2 (fibrinogen like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FGL2 (fibrinogen like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fgl2 (fibrinogen like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Fgl2 (fibrinogen-like protein 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	FGL2 (fibrinogen like 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fgl2a (fibrinogen-like 2a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6788	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Xenopus tropicalis (tropical clawed frog):	fgl2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Allele / Splice:

Fgl2^m1Mcwi Fgl2^m2Mcwi Fgl2^m4Mcwi Fgl2^m3Mcwi

Genetic Models:

FHH-Fgl2^m1Mcwi SS-Fgl2^m4Mcwi SS-Fgl2^m2Mcwi BN-Fgl2^m3Mcwi

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	14,602,762 - 14,608,405 (-)	NCBI		GRCr8
mRatBN7.2	4	13,710,566 - 13,716,207 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	13,710,575 - 13,716,207 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	18,837,881 - 18,843,545 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	14,647,254 - 14,652,909 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	13,023,530 - 13,029,194 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	10,323,598 - 10,329,241 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	10,323,607 - 10,329,241 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	10,315,666 - 10,321,309 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	9,176,333 - 9,181,976 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	9,178,562 - 9,181,975 (-)	NCBI
Celera	4	9,274,110 - 9,279,753 (-)	NCBI		Celera
Cytogenetic Map	4	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

allergic contact dermatitis (ISO)

autoimmune glomerulonephritis (ISS)

Chromosome 7q11.23 Deletion Syndrome, Distal, 1.2-MB (ISO)

COVID-19 (ISO)

Experimental Autoimmune Myocarditis (IEP)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

pleomorphic xanthoastrocytoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2,4-trimethylbenzene (EXP)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

2-palmitoylglycerol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acetohydrazide (ISO)

acrolein (ISO)

acrylamide (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

asbestos (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzoates (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

C60 fullerene (EXP)

cadmium dichloride (EXP)

cadmium sulfate (ISO)

cantharidin (ISO)

carbon nanotube (ISO)

cefaloridine (EXP)

CGP 52608 (ISO)

chromium(6+) (ISO)

Cuprizon (EXP)

cycloheximide (ISO)

cyclosporin A (EXP)

D-glucose (ISO)

DDT (EXP)

diarsenic trioxide (ISO)

dibenz[a,h]anthracene (ISO)

dibutyl phthalate (EXP)

dimethylarsinic acid (EXP)

dioxygen (EXP,ISO)

diquat (ISO)

diuron (EXP)

doxorubicin (ISO)

fenvalerate (EXP)

flavonoids (EXP)

folic acid (ISO)

fucoxanthin (ISO)

glucose (ISO)

irinotecan (EXP)

lipopolysaccharide (ISO)

N-nitrosodiethylamine (ISO)

N-nitrosodimethylamine (EXP)

N-Nitrosopyrrolidine (ISO)

naphthalenes (EXP)

nickel atom (ISO)

nickel sulfate (ISO)

O-methyleugenol (ISO)

oxaliplatin (EXP)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium bromate (ISO)

progesterone (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

S-adenosyl-L-methioninate (ISO)

S-adenosyl-L-methionine (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

Soman (EXP)

sulforaphane (ISO)

tacrolimus hydrate (EXP,ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

tributylstannane (EXP)

trichloroethene (EXP)

triphenyl phosphate (EXP)

triptonide (ISO)

undecane (EXP)

valproic acid (EXP)

vinclozolin (EXP)

zidovudine (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of defense response to virus (ISO)

negative regulation of dendritic cell antigen processing and presentation (ISO)

negative regulation of macrophage antigen processing and presentation (ISO)

negative regulation of memory T cell differentiation (ISO)

parturition (TAS)

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell (ISO)

Cellular Component

cell surface (ISO)

collagen-containing extracellular matrix (IBA)

extracellular space (IBA)

Molecular Function

peptidase activator activity (ISO)

peptidase activity (TAS)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Cloning and tissue expression of the tissue prothrombinase Fgl-2 in the Sprague-Dawley rat.	Rychlik DF, etal., J Soc Gynecol Investig 2003 Feb;10(2):67-73.
8.	Fibrinogen-like protein-2 causes deterioration in cardiac function in experimental autoimmune myocarditis rats through regulation of programmed death-1 and inflammatory cytokines.	Zheng Z, etal., Immunology. 2018 Feb;153(2):246-252. doi: 10.1111/imm.12837. Epub 2017 Oct 16.

Additional References at PubMed

PMID:12477932	PMID:19056867	PMID:21063837	PMID:22387586	PMID:22456282	PMID:23376485	PMID:23432784	PMID:23533145	PMID:23674850	PMID:26182381	PMID:26482204	PMID:29128901
PMID:29341118	PMID:36508913

Genomics

Comparative Map Data

Fgl2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	14,602,762 - 14,608,405 (-)	NCBI		GRCr8
mRatBN7.2	4	13,710,566 - 13,716,207 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	13,710,575 - 13,716,207 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	18,837,881 - 18,843,545 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	14,647,254 - 14,652,909 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	13,023,530 - 13,029,194 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	10,323,598 - 10,329,241 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	10,323,607 - 10,329,241 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	10,315,666 - 10,321,309 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	9,176,333 - 9,181,976 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	9,178,562 - 9,181,975 (-)	NCBI
Celera	4	9,274,110 - 9,279,753 (-)	NCBI		Celera
Cytogenetic Map	4	q11	NCBI

FGL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	77,193,369 - 77,199,819 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	77,193,369 - 77,199,848 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	76,822,686 - 76,829,136 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	76,660,624 - 76,667,086 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	76,470,142 - 76,473,795	NCBI
Celera	7	71,523,351 - 71,529,814 (-)	NCBI		Celera
Cytogenetic Map	7	q11.23	NCBI
HuRef	7	71,425,321 - 71,431,783 (-)	NCBI		HuRef
CHM1_1	7	76,752,975 - 76,759,437 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	78,444,483 - 78,450,933 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	76,155,751 - 76,162,213 (-)	NCBI

Fgl2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	21,577,671 - 21,583,384 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	21,577,640 - 21,583,372 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	21,372,673 - 21,378,386 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	21,372,642 - 21,378,374 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	20,878,491 - 20,884,204 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	20,884,527 - 20,890,197 (+)	NCBI		MGSCv36	mm8
Celera	5	18,336,281 - 18,342,004 (+)	NCBI		Celera
Cytogenetic Map	5	A3	NCBI
cM Map	5	9.83	NCBI

Fgl2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955410	7,899,309 - 7,902,722 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955410	7,899,263 - 7,903,499 (+)	NCBI	ChiLan1.0	ChiLan1.0

FGL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	95,044,215 - 95,109,732 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	143,308,854 - 143,374,372 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	69,114,082 - 69,120,575 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	82,926,035 - 82,932,550 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	82,926,266 - 82,932,550 (-)	Ensembl	panpan1.1		panPan2

FGL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	17,328,794 - 17,335,429 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	17,331,780 - 17,335,401 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	16,987,483 - 16,994,083 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	17,648,480 - 17,655,066 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	18	17,399,538 - 17,406,132 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	17,338,550 - 17,345,153 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	17,607,841 - 17,614,446 (-)	NCBI		UU_Cfam_GSD_1.0

Fgl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	59,496,212 - 59,501,673 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936479	20,619,931 - 20,652,981 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936479	20,619,955 - 20,625,416 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FGL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	102,868,802 - 102,875,576 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	102,869,044 - 102,875,564 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	113,105,965 - 113,115,736 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	9	q16-q17	NCBI

FGL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	71,735,486 - 71,741,951 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	71,735,253 - 71,742,954 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	32,255,115 - 32,263,210 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fgl2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624739	26,503,965 - 26,507,305 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624739	26,501,149 - 26,507,305 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Fgl2
12 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	211
Count of miRNA genes:	156
Interacting mature miRNAs:	166
Transcripts:	ENSRNOT00000017232
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61351	Bp33	Blood pressure QTL 33		0.0018	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	1	27716890	Rat
61408	Scl23	Serum cholesterol level QTL 23		0.0005	blood HDL phospholipid amount (VT:0010504)	serum high density lipoprotein phospholipid level (CMO:0001567)	4	1	27716890	Rat
724557	Plsm1	Polydactyly-luxate syndrome (PLS) morphotypes QTL 1		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	4	1	27716890	Rat
1641905	Colcr1	Colorectal carcinoma resistance QTL 1	4.3	0.0003	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	4	1	29494328	Rat
61333	Gluco16	Glucose level QTL 16	4.3	0.00001	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	1	30372989	Rat
9589097	Slep11	Serum leptin concentration QTL 11	5.09	0.001	blood leptin amount (VT:0005667)	plasma leptin level (CMO:0000781)	4	1	31934116	Rat
8552903	Pigfal2	Plasma insulin-like growth factor 1 level QTL 2	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	1	31934116	Rat
9589046	Scfw2	Subcutaneous fat weight QTL 2	5.54	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	4	1	31934116	Rat
9590100	Sffal4	Serum free fatty acids level QTL 4	7.36	0.05	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	4	1	31934116	Rat
738021	Hcar13	Hepatocarcinoma resistance QTL 13	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	4	1	32584199	Rat
1357341	Gluco5	Glucose level QTL 5	6.4		adipocyte free fatty acid secretion trait (VT:0010465)	absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)	4	1	33250345	Rat
1357343	Gluco4	Glucose level QTL 4		0.00002	adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)	4	1	33250345	Rat
61415	Eae11	Experimental allergic encephalomyelitis QTL 11	2.9		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	4	1	39505420	Rat
634323	Hc2	Hypercalciuria QTL 2	2.15		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	4	210796	45210796	Rat
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	5214602	78882945	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5214602	146446691	Rat
2302371	Stl22	Serum triglyceride level QTL 22	5.15		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5218294	57114705	Rat
1358203	Stl19	Serum triglyceride level QTL 19	2.8	0.002	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5218294	65958103	Rat
1358201	Gluco12	Glucose level QTL12	1.6		adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake (CMO:0000870)	4	5218392	29593287	Rat
631642	Stl2	Serum triglyceride level QTL 2	3.3		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5219178	56647776	Rat
631209	Bw2	Body weight QTL2	4.2		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	9940885	44463908	Rat
1300141	Bp178	Blood pressure QTL 178			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	10024901	39524530	Rat
6478724	Anxrr35	Anxiety related response QTL 35		0.00449	defecation behavior trait (VT:0010462)	defecation measurement (CMO:0000997)	4	10084089	55084089	Rat
6478766	Anxrr47	Anxiety related response QTL 47		0.09637	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	10084089	55084089	Rat
6478769	Anxrr48	Anxiety related response QTL 48		0.02514	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	10084089	55084089	Rat
8694374	Bw155	Body weight QTL 155	3.39	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	4	10084089	55084089	Rat
9590304	Scort17	Serum corticosterone level QTL 17	4.96	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	10084089	55084089	Rat
8552906	Pigfal3	Plasma insulin-like growth factor 1 level QTL 3			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	10084089	55084089	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	10814170	91360527	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	11320076	180699135	Rat

Markers in Region

AA955206

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	13,710,820 - 13,710,962 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	10,323,853 - 10,323,994	NCBI	Rnor6.0
Rnor_5.0	4	10,315,921 - 10,316,062	UniSTS	Rnor5.0
RGSC_v3.4	4	9,176,588 - 9,176,729	UniSTS	RGSC3.4
Celera	4	9,274,365 - 9,274,506	UniSTS
RH 3.4 Map	4	46.2	UniSTS
Cytogenetic Map	4	q11	UniSTS

RH141508

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	13,711,428 - 13,711,639 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	10,324,461 - 10,324,671	NCBI	Rnor6.0
Rnor_5.0	4	10,316,529 - 10,316,739	UniSTS	Rnor5.0
RGSC_v3.4	4	9,177,196 - 9,177,406	UniSTS	RGSC3.4
Celera	4	9,274,973 - 9,275,183	UniSTS
RH 3.4 Map	4	45.6	UniSTS
Cytogenetic Map	4	q11	UniSTS

Genetic Models

This gene Fgl2 is modified in the following models/strains:

FHH-Fgl2^m1Mcwi SS-Fgl2^m4Mcwi SS-Fgl2^m2Mcwi BN-Fgl2^m3Mcwi

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	12	42	26	19	26	4	4		8	17	11	4
Low		31	15	15		15	4	7	72	27	24		4
Below cutoff									2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053455	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF323608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC072502	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC085357	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC107665	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB582252	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000017232 ⟹ ENSRNOP00000017232

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	13,710,575 - 13,716,207 (-)	Ensembl
Rnor_6.0 Ensembl	4	10,323,607 - 10,329,241 (-)	Ensembl

RefSeq Acc Id:

NM_053455 ⟹ NP_445907

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	14,602,762 - 14,608,405 (-)	NCBI
mRatBN7.2	4	13,710,566 - 13,716,207 (-)	NCBI
Rnor_6.0	4	10,323,598 - 10,329,241 (-)	NCBI
Rnor_5.0	4	10,315,666 - 10,321,309 (-)	NCBI
RGSC_v3.4	4	9,176,333 - 9,181,976 (-)	RGD
Celera	4	9,274,110 - 9,279,753 (-)	RGD

Sequence:

show sequence

GGCTGGGCTGCTGCACTGCAAGGATGAGGCTTCCTGGCTGGTTGTGGCTGAGCTCCGCGGTCCT
CGCTGCCTGCCGAGCGGCGGAGAAGCACAACCTGACTGAAGGGCTGGAGGATGCGAGCGCCCAG
GCTGCCTGCCCCGCGAGGCTGGAGGGCAGCGGGAGGTGCGAGGGCAGCCAGTGCCCCTTCCAGC
TCACCCTGCCCACGCTGACCCTCCAGCTCCCGCAGCAGTTCGGCAGCATGGAGGAGGTGCTCAA
AGAAGTGCGGACCCTCCAGGAAGCTGTGGACAGTCTGAAGAAATCCTGCCAGGACTGCAAGTTG
CAGGCTGATGAACATCCAGACCCTGGCGGGAATGGAGCAGAGACGGCCGAGGACAATCGAGTCC
AGGAACTGGAGAGTCAGGTGAACAAGCTGTCCTCAGAGCTGAAGAATGCAAAGGAGGAGATCCA
GGGGCTGCAGGGGCGCCTGGAGTCGCTCCAACTGGTAAATATGAACAACATCGAGAACTACGTG
GACAACAAAGTGGCAAATCTAACCTCTGTGGTCAACAGTTTGGATAGCAAGTGTTTCAAGTGCC
CCAGCCAAGAACACAACCAGCCAAATCCAGTTCAACATCTAATATACAAAGATTGCTCTGACTA
CTACGTGTTAGGGAAGAGAAGCAGTGGGACCTACAGAGTTACGCCTGATCACAGGAACAGCAGC
TTTGAGGTCTACTGCGACATGGAGACCACGGGTGGAGGCTGGACAGTGCTGCAGGCTCGCCTTG
ATGGGAGCACCAACTTCACCAGAGGGTGGAAGGACTACAAAGCCGGCTTCGGGAACCTTGAACG
AGAATTTTGGCTGGGCAACGATAAAATTCATCTTCTGACCAAGAGTAAGGAAATGATTTTGAGA
ATAGATCTCGAAGACTTTAATGGTCTCACACTTTACGCCGTGTACGATCAGTTTTATGTGGCTA
ACGAGTTTCTCAAATACCGGTTACACCTCGGTAACTATAATGGCACGGCAGGGGATGCCTTGCG
TTTTAGCCGACATTACAACCACGACCTGAGGTTTTTCACCACCCCAGACAGAGACAATGATCGG
TACCCCTCTGGGAACTGTGGGCTCTATTACAGCTCAGGCTGGTGGTTTGATGCATGTCTCTCTG
CCAACTTAAATGGCAAATATTATCACCAGAGATACAAAGGGGTCCGTAATGGGATTTTCTGGGG
CACCTGGCCTGGTGTAAGTCAGGCACACCCAGGGGGCTACAAGTTCTCCTTCAAGAAGGCCAAG
ATGATGATAAGACCCAAGAGTTTTAAGCCATAAATTCATGCTCGTTTCTCTGGGCACTCACTAT
CTAAGAGGACAGTGCATTCCTCCAGCCTTGACTGTATGCCTCAGTTTATATCCCCTTCCTGTGG
CTAAACACTCCCTTTTAAGCTTTACAGCTTTAAAATAAAGCTGGAAATGTCTAAAACAGACTCT
TTGGTGGCTGTTATATGAGGAATGCTCGAAAGCACTGGAAATAGTGACGATTATACATTATAAT
TGCAAGACTTTTCATTTTTATTAGTTGAAAAGTTTCCTACTATTTTTATTATTTTTTATAATAA
AAAACTAAATTATTCAGCAAGCTAAATTCTGTATACTCAAGTTTTATTTTCACTAGGGCTAAAC
GCACACATTTGAAAATACACCAGTCTTTTTCAGGGTACAGACGCTCGTGTATCTGGAGCTAAGA
ACTATAGTATTTTCTTTGGTCCAAGAAATAGTTTAGTTCTCAAAAAGAAAGTCAGGGATGGGGT
TTTGGTGGGCAGGGATTAAATAGCTAAATTTATTTATCTAATGCAAAATATGGCATTAAAATGC
CTTAAAATACAGTAGCATAATATATGTCTTTTTCCTCTCCAAAATTGGAAAATACTGCTACCCT
GGAGATTGTGGTTTCGTGGTGACCCACGTACTGTTTATAGCCTGTTAGACCCTGATACAGAAGC
TGCTTTGTCATCTCCTCTCTGTGCACGATAGTGTTTAGTGTAAGGTGCGAGACTACTGTAAGGC
TTCCTTGGAGAAAGGCATGGTAAGGGAAAACAGCGTTTAATTATACTTTGAAGGCCAATGCTAG
ACCCAAAGCAAGACTTGAGTTGTTGAGGAATCAACTTCCTAGGAAGCAGACTTTTCTAGAACAA
ATATATTTATTGTGATACATTTTGATAGAGTAGTTCAAATATTATTCATTTTAATCCTAAGTCG
TCAACTGCTTATTTCATTCTCAGAAATTCACAGAAAAACTATATATAATTTTAGTCCAGTGTAA
GTGCCTGGAGTTCCTTGATTGTGGAATGCTGAGGGCCATGTTAAAAGGCTTGGGAGGAAGTTTC
ATTTATCACTGTAGAAAAGGATCACTTCAGAGAGGAAAGATGCTCTTCAGTGGAATCTGAGGAA
CTGTACGCGGTCAGTCATAGGAGGAGGTGATCAGACAGGGCGCAGTGTTTAAGCAAAAACTTTG
ATCTTTAAGTTTTGGTAGATTTCTAATATACTAACCAAGCCTTTGAAATATAAGCACAAAGATT
CTATTTTAGTTAGTCTTTAAATATAACTAGGAAGGACAGTTATTGACTTGACTACTTAAATTTT
CAAATACGTAGCCGCTGTAAAAAAAAAAAACTTTAAAAAGAGCAAGATATTATTTTAAAAATAT
GCAACATGAAGTTTTCAGCTGAATACAATGACAATTAAAGTATTAATAACATAATTAAATTACC
AGAGTAAGGTGAATGCACGCTGAATTAAATGACCAAAATATAAAATATAGATTTCCAAGACTGT
TTACCTGCTTGGCAAAATATTGAATGTAAGTAGCAATAATTAGTTTTATTTCTCCTTTGCTTTT
TAAAAAAGAAAAAGAAGATTTTGATATTATACAATTGATGTGTTTCAAATTCTGTTTGTTATAT
GTAACCATAGAAGTGTAATGACATTTCCGTCATGAAAATGGATTTATTATAGCAAAACCCCTAT
GCATTCCTCTTTAGTGTGTCTTTTTCAGTGTAACAATGAAGCCATGTGAATGCTCTATCTTTGC
ACGTCCAATGGATTCAAATGATGTTTTCTATTATACTCTAGAGATTTTTCTAATGAACTCTTTA
ACACAGAAATTTATTTTTGGAATCCCTTTCTGTCACTTATTTAAGAATATATTGTAGGCTTTGA
TAACCTTTAACCTGTTTGTTGGAATAGTCCTTGGCCTTAACTATTCACTAATGTATGCCAGTCC
TCATAGGTGGACACTATTGGCAAGTCTGTGTTTTAGAGTCTTGGCTTCATCTCGGTGGCTAACG
CTGGTCTTAACTATCGCTTTTTGGCTGAACATTCTTATCCTTTAAAATGCTGAGTGGAACTAAT
TTCTTAGGAATCTGGTTGAGTCACCCATCACCGAATGAGAAAGCCATTTTTCTGAAAAGTAATA
ATGCAGCAAATGTCTTCAGCCTCTGATGGACAGAACTTGTGTACAAAGCACAGGATGCATGGGA
GTCACACACAGTGCTGGCTGGTCCGGGGCTCTTAATAGCTGCCCCTCGCCCCTCAGAAAGTTTT
CAAGCTGGAATGGATATGTGTGATTACAATAAACTCTCGTTTAGGATTTCTTTTCATTGATGTA
TAATTAATGTTACATTTCATGTCTCATTAAAGCCTTGTAAAATAAAAAAAAAAAAAAAAAAAAA
AAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_445907	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG42269	(Get FASTA)	NCBI Sequence Viewer
	AAH72502	(Get FASTA)	NCBI Sequence Viewer
	AAH85357	(Get FASTA)	NCBI Sequence Viewer
	AAI07666	(Get FASTA)	NCBI Sequence Viewer
	EDL99430	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000017232
	ENSRNOP00000017232.4

RefSeq Acc Id:	NP_445907 ⟸ NM_053455
- Peptide Label:	precursor
- UniProtKB:	G3V7P2 (UniProtKB/TrEMBL), A6K5C1 (UniProtKB/TrEMBL), Q32Q89 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRLPGWLWLSSAVLAACRAAEKHNLTEGLEDASAQAACPARLEGSGRCEGSQCPFQLTLPTLTL QLPQQFGSMEEVLKEVRTLQEAVDSLKKSCQDCKLQADEHPDPGGNGAETAEDNRVQELESQVN KLSSELKNAKEEIQGLQGRLESLQLVNMNNIENYVDNKVANLTSVVNSLDSKCFKCPSQEHNQP NPVQHLIYKDCSDYYVLGKRSSGTYRVTPDHRNSSFEVYCDMETTGGGWTVLQARLDGSTNFTR GWKDYKAGFGNLEREFWLGNDKIHLLTKSKEMILRIDLEDFNGLTLYAVYDQFYVANEFLKYRL HLGNYNGTAGDALRFSRHYNHDLRFFTTPDRDNDRYPSGNCGLYYSSGWWFDACLSANLNGKYY HQRYKGVRNGIFWGTWPGVSQAHPGGYKFSFKKAKMMIRPKSFKP hide sequence

RefSeq Acc Id:

ENSRNOP00000017232 ⟸ ENSRNOT00000017232

Protein Domains

Fibrinogen C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V7P2-F1-model_v2	AlphaFold	G3V7P2	1-429	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692811

Promoter ID:

EPDNEW_R3335

Type:

single initiation site

Name:

Fgl2_1

Description:

fibrinogen-like 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	10,329,229 - 10,329,289	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620170	AgrOrtholog
BioCyc Gene	G2FUF-45972	BioCyc
Ensembl Genes	ENSRNOG00000012881	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000017232	ENTREZGENE
	ENSRNOT00000017232.6	UniProtKB/TrEMBL
Gene3D-CATH	3.90.215.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7098857	IMAGE-MGC_LOAD
	IMAGE:7134872	IMAGE-MGC_LOAD
	IMAGE:7936431	IMAGE-MGC_LOAD
InterPro	Fibrinogen-like_C	UniProtKB/TrEMBL
	Fibrinogen_a/b/g_C	UniProtKB/TrEMBL
	Fibrinogen_a/b/g_C_1	UniProtKB/TrEMBL
	Fibrinogen_CS	UniProtKB/TrEMBL
KEGG Report	rno:84586	UniProtKB/TrEMBL
MGC_CLONE	MGC:105299	IMAGE-MGC_LOAD
	MGC:124553	IMAGE-MGC_LOAD
	MGC:91435	IMAGE-MGC_LOAD
NCBI Gene	84586	ENTREZGENE
PANTHER	FIBRINOGEN/TENASCIN/ANGIOPOEITIN	UniProtKB/TrEMBL
	PTHR19143:SF189	UniProtKB/TrEMBL
Pfam	Fibrinogen_C	UniProtKB/TrEMBL
PhenoGen	Fgl2	PhenoGen
PROSITE	FIBRINOGEN_C_1	UniProtKB/TrEMBL
	FIBRINOGEN_C_2	UniProtKB/TrEMBL
	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000012881	RatGTEx
SMART	FBG	UniProtKB/TrEMBL
Superfamily-SCOP	Fibrinogen_a/b/g_C	UniProtKB/TrEMBL
UniProt	A6K5C1	ENTREZGENE, UniProtKB/TrEMBL
	G3V7P2	ENTREZGENE, UniProtKB/TrEMBL
	Q32Q89	ENTREZGENE, UniProtKB/TrEMBL
	Q5U3X5_RAT	UniProtKB/TrEMBL
	Q6IN12_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-01-20	Fgl2	fibrinogen-like 2			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Fgl2	fibrinogen-like 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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