Ncoa2 (nuclear receptor coactivator 2) - Rat Genome Database

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Gene: Ncoa2 (nuclear receptor coactivator 2) Rattus norvegicus
Analyze
Symbol: Ncoa2
Name: nuclear receptor coactivator 2
RGD ID: 620108
Description: Enables DNA polymerase binding activity and nuclear receptor binding activity. Involved in several processes, including positive regulation of female receptivity; positive regulation of glucocorticoid receptor signaling pathway; and response to estradiol. Located in dendritic spine. Used to study polycystic ovary syndrome. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; lung non-small cell carcinoma; and prostate adenocarcinoma. Orthologous to human NCOA2 (nuclear receptor coactivator 2); PARTICIPATES IN aldosterone signaling pathway; altered androgen signaling pathway; androgen signaling pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glucocorticoid receptor interacting protein 1; glucocorticoid receptor-interacting protein 1; GRIP-1; Grip1; LOC102549300; NCoA-2; Tif2; transcriptional intermediary factor 2; uncharacterized LOC102549300
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8510,618,712 - 10,852,776 (+)NCBIGRCr8
mRatBN7.255,835,642 - 6,069,693 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl55,835,706 - 6,067,451 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx58,132,076 - 8,209,657 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.059,770,968 - 9,848,544 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.059,460,403 - 9,538,097 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.055,466,544 - 5,696,540 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl55,616,483 - 5,694,598 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0510,306,581 - 10,538,264 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.455,197,891 - 5,275,776 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.155,197,890 - 5,273,000 (+)NCBI
Celera55,570,901 - 5,648,759 (+)NCBICelera
Cytogenetic Map5q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-linalyl acetate  (ISO)
(S)-colchicine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,3,4,5-Tetrachloro-4'-biphenylol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-[(2,4-dichlorophenyl)methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol  (EXP)
2-hydroxypropanoic acid  (ISO)
22,23-dihydroavermectin B1a  (ISO)
3,3',5'-triiodo-L-thyronine  (ISO)
3,3',5'-triiodothyronine  (ISO)
3,3',5,5'-tetraiodothyroacetic acid  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3'-diindolylmethane  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3beta-hydroxycholest-5-en-26-oic acid  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-terpineol  (ISO)
4-tert-Octylphenol  (ISO)
acetamide  (EXP)
Acetyl tributyl citrate  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-terpineol  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
androst-4-ene-3,17-dione  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benidipine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
Benzyl parahydroxybenzoate  (ISO)
bezafibrate  (ISO)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butamben  (ISO)
butanal  (ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
chenodeoxycholic acid  (ISO)
cholesterol  (ISO)
cilnidipine  (ISO)
clevidipine  (ISO)
cobalt dichloride  (ISO)
coenzyme Q10  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyproterone acetate  (ISO)
daidzein  (ISO)
daunorubicin  (ISO)
DDT  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
Doramectin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
emamectin  (ISO)
emodin  (ISO)
entinostat  (ISO)
eprinomectin  (ISO)
ethanol  (ISO)
Ethyl salicylate  (ISO)
ethylparaben  (ISO)
Falecalcitriol  (ISO)
felodipine  (ISO)
flavonol  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
galangin  (ISO)
geldanamycin  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
guggulsterone  (ISO)
GW 1929  (ISO)
hexadecanoic acid  (ISO)
Isradipine  (ISO)
ivermectin  (ISO)
lacidipine  (ISO)
lead diacetate  (EXP,ISO)
linalyl acetate  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl salicylate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
milbemycin  (ISO)
N-benzoyl-L-alanine  (ISO)
nicardipine  (ISO)
nimodipine  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propylparaben  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
Selamectin  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
thyroxine  (ISO)
tiratricol  (ISO)
titanium dioxide  (ISO)
toxaphene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (ISO)
vorinostat  (ISO)
wogonin  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Acute disruption of select steroid receptor coactivators prevents reproductive behavior in rats and unmasks genetic adaptation in knockout mice. Apostolakis EM, etal., Mol Endocrinol. 2002 Jul;16(7):1511-23.
2. The mutational landscape of prostate cancer. Barbieri CE, etal., Eur Urol. 2013 Oct;64(4):567-76. doi: 10.1016/j.eururo.2013.05.029. Epub 2013 May 18.
3. Androgen receptor coregulators and their involvement in the development and progression of prostate cancer. Chmelar R, etal., Int J Cancer. 2007 Feb 15;120(4):719-33.
4. Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins. Chung HJ, etal., J Neurosci. 2000 Oct 1;20(19):7258-67.
5. Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis. Dasgupta S, etal., J Clin Invest. 2015 Mar 2;125(3):1174-88. doi: 10.1172/JCI76029. Epub 2015 Feb 9.
6. MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP. Deguchi K, etal., Cancer Cell. 2003 Mar;3(3):259-71.
7. Genetic and Environmental Models of Circadian Disruption Link SRC-2 Function to Hepatic Pathology. Fleet T, etal., J Biol Rhythms. 2016 Oct;31(5):443-60. doi: 10.1177/0748730416657921. Epub 2016 Jul 17.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Estrogen receptor alpha/beta, AIB1, and TIF2 in colorectal carcinogenesis: do coregulators have prognostic significance? Grivas PD, etal., Int J Colorectal Dis. 2009 Jun;24(6):613-22. doi: 10.1007/s00384-009-0647-9. Epub 2009 Feb 6.
11. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Hall JM and McDonnell DP, Mol Interv. 2005 Dec;5(6):343-57.
12. Differential regulation of steroid nuclear receptor coregulator expression between normal and neoplastic prostate epithelial cells. Heemers HV, etal., Prostate. 2010 Jun 15;70(9):959-70.
13. CASK associates with glutamate receptor interacting protein and signaling molecules. Hong CJ and Hsueh YP, Biochem Biophys Res Commun. 2006 Dec 22;351(3):771-6. Epub 2006 Oct 30.
14. Uterine progesterone signaling is a target for metformin therapy in PCOS-like rats. Hu M, etal., J Endocrinol. 2018 May;237(2):123-137. doi: 10.1530/JOE-18-0086. Epub 2018 Mar 13.
15. Differential expression of p160 steroid receptor coactivators in the rat testis and epididymis. Igarashi-Migitaka J, etal., Eur J Endocrinol. 2005 Oct;153(4):595-604.
16. Novel glucocorticoid receptor coactivator effector mechanisms. Jenkins BD, etal., Trends Endocrinol Metab. 2001 Apr;12(3):122-6.
17. Sustained expression of steroid receptor coactivator SRC-2/TIF-2 is associated with better prognosis in malignant pleural mesothelioma. Jennings CJ, etal., J Thorac Oncol. 2012 Jan;7(1):243-8. doi: 10.1097/JTO.0b013e31822f6544.
18. Interaction of DNA polymerase beta with GRIP1 during meiosis. Jonason AS, etal., Chromosoma. 2001 Nov;110(6):402-10. Epub 2001 Sep 12.
19. Subfertility linked to combined luteal insufficiency and uterine progesterone resistance. Konno T, etal., Endocrinology. 2010 Sep;151(9):4537-50. Epub 2010 Jul 21.
20. Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. Lee Y, etal., Carcinogenesis. 2013 Feb;34(2):307-13. doi: 10.1093/carcin/bgs356. Epub 2012 Nov 8.
21. Mechanistic principles in NR box-dependent interaction between nuclear hormone receptors and the coactivator TIF2. Leers J, etal., Mol Cell Biol 1998 Oct;18(10):6001-13.
22. GRIP1 in GABAergic synapses. Li RW, etal., J Comp Neurol. 2005 Jul 18;488(1):11-27.
23. Knockdown of NCOA2 Inhibits the Growth and Progression of Gastric Cancer by Affecting the Wnt Signaling Pathway-Related Protein Expression. Lin Z, etal., Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820928072. doi: 10.1177/1533033820928072.
24. Coactivator and corepressor gene expression in rat cerebellum during postnatal development and the effect of altered thyroid status. Martinez de Arrieta C, etal., Endocrinology. 2000 May;141(5):1693-8.
25. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. The human glucocorticoid receptor: molecular basis of biologic function. Nicolaides NC, etal., Steroids. 2010 Jan;75(1):1-12. Epub 2009 Oct 7.
28. A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer. O'Donnell KA, etal., Proc Natl Acad Sci U S A. 2012 May 22;109(21):E1377-86. doi: 10.1073/pnas.1115433109. Epub 2012 May 3.
29. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
30. GOA pipeline RGD automated data pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs). Rochette-Egly C and Germain P, Nucl Recept Signal. 2009 May 8;7:e005.
34. SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer. Suresh S, etal., PLoS Genet. 2017 Mar 8;13(3):e1006650. doi: 10.1371/journal.pgen.1006650. eCollection 2017 Mar.
35. Recruitment of the p160 coactivators by the glucocorticoid receptor: dependence on the promoter context and cell type but not hypoxic conditions. Trousson A, etal., J Steroid Biochem Mol Biol. 2007 May;104(3-5):305-11. Epub 2007 Mar 23.
36. Estrogen signaling in colorectal carcinoma microenvironment: expression of ERbeta1, AIB-1, and TIF-2 is upregulated in cancer-associated myofibroblasts and correlates with disease progression. Tzelepi V, etal., Virchows Arch. 2009 Apr;454(4):389-99. doi: 10.1007/s00428-009-0740-z. Epub 2009 Mar 7.
37. Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors. Wang L, etal., Arch Biochem Biophys. 2004 Aug 1;428(1):92-8.
38. Alterations of estradiol-induced histone H3 acetylation in the preoptic area and anteroventral periventricular nucleus of middle-aged female rats. Xu W, etal., Biochem Biophys Res Commun. 2019 Aug 27;516(3):894-899. doi: 10.1016/j.bbrc.2019.06.145. Epub 2019 Jul 1.
39. Interactions of the mineralocorticoid receptor--within and without. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
40. Steroid receptor coactivator-2 expression in brain and physical associations with steroid receptors. Yore MA, etal., Neuroscience. 2010 Sep 1;169(3):1017-28. Epub 2010 Jun 2.
41. Disruption of NCOA2 by recurrent fusion with LACTB2 in colorectal cancer. Yu J, etal., Oncogene. 2016 Jan 14;35(2):187-95. doi: 10.1038/onc.2015.72. Epub 2015 Mar 30.
Additional References at PubMed
PMID:8643509   PMID:10478845   PMID:11583620   PMID:11675124   PMID:12130539   PMID:12709428   PMID:15001550   PMID:15072553   PMID:15383530   PMID:15539428   PMID:15641800   PMID:16109736  
PMID:16148126   PMID:17363140   PMID:18798693   PMID:19039140   PMID:23132854   PMID:24529706   PMID:24550004   PMID:24571987  


Genomics

Comparative Map Data
Ncoa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8510,618,712 - 10,852,776 (+)NCBIGRCr8
mRatBN7.255,835,642 - 6,069,693 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl55,835,706 - 6,067,451 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx58,132,076 - 8,209,657 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.059,770,968 - 9,848,544 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.059,460,403 - 9,538,097 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.055,466,544 - 5,696,540 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl55,616,483 - 5,694,598 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0510,306,581 - 10,538,264 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.455,197,891 - 5,275,776 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.155,197,890 - 5,273,000 (+)NCBI
Celera55,570,901 - 5,648,759 (+)NCBICelera
Cytogenetic Map5q11NCBI
NCOA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38870,109,782 - 70,456,446 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl870,109,782 - 70,403,808 (-)EnsemblGRCh38hg38GRCh38
GRCh37871,022,017 - 71,316,452 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36871,186,821 - 71,478,574 (-)NCBINCBI36Build 36hg18NCBI36
Build 34871,186,820 - 71,478,574NCBI
Celera867,021,935 - 67,313,703 (-)NCBICelera
Cytogenetic Map8q13.3NCBI
HuRef866,517,566 - 66,809,329 (-)NCBIHuRef
CHM1_1871,079,808 - 71,371,655 (-)NCBICHM1_1
T2T-CHM13v2.0870,539,621 - 70,834,144 (-)NCBIT2T-CHM13v2.0
Ncoa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,209,329 - 13,444,451 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl113,209,329 - 13,444,307 (-)EnsemblGRCm39 Ensembl
GRCm38113,139,105 - 13,374,227 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,139,105 - 13,374,083 (-)EnsemblGRCm38mm10GRCm38
MGSCv37113,129,240 - 13,364,164 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36113,127,689 - 13,359,278 (-)NCBIMGSCv36mm8
Celera113,103,226 - 13,334,430 (-)NCBICelera
Cytogenetic Map1A3NCBI
cM Map14.12NCBI
Ncoa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554449,313,447 - 9,584,913 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554449,313,748 - 9,587,109 (+)NCBIChiLan1.0ChiLan1.0
NCOA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2785,839,497 - 86,141,138 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1861,469,337 - 61,770,965 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0866,632,139 - 66,929,526 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1868,293,012 - 68,480,104 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl868,293,018 - 68,400,479 (-)Ensemblpanpan1.1panPan2
NCOA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12919,253,849 - 19,471,640 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2919,222,842 - 19,545,371 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2919,511,986 - 19,805,562 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02919,347,144 - 19,643,120 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2919,347,185 - 19,642,297 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12919,386,646 - 19,682,493 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02919,452,837 - 19,748,399 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02919,733,575 - 20,029,399 (-)NCBIUU_Cfam_GSD_1.0
Ncoa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530359,680,707 - 59,940,562 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649614,844,855 - 15,016,454 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649614,844,923 - 15,102,922 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCOA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl464,954,238 - 65,246,572 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1464,888,029 - 65,245,757 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2470,584,741 - 70,791,313 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NCOA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1865,855,232 - 66,151,733 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl865,855,235 - 66,040,947 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603975,279,759 - 75,586,607 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ncoa2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474420,938,555 - 21,078,690 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474420,795,385 - 21,078,706 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ncoa2
1153 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:94
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000011026
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
631551Vetf1Vascular elastic tissue fragility QTL 150.0001aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)522822265904428Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 36 43 27 18 27 1 1 74 35 40 11 1
Low 2 7 14 14 1 14 7 10 1 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000011026   ⟹   ENSRNOP00000011026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl55,847,334 - 6,067,451 (+)Ensembl
Rnor_6.0 Ensembl55,616,483 - 5,694,598 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095919   ⟹   ENSRNOP00000092311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl55,835,706 - 6,029,139 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119206   ⟹   ENSRNOP00000093156
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl55,847,334 - 6,067,451 (+)Ensembl
RefSeq Acc Id: NM_031822   ⟹   NP_114010
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8510,618,722 - 10,852,776 (+)NCBI
mRatBN7.255,835,642 - 6,069,693 (+)NCBI
Rnor_6.055,616,483 - 5,694,598 (+)NCBI
Rnor_5.0510,306,581 - 10,538,264 (+)NCBI
RGSC_v3.455,197,891 - 5,275,776 (+)RGD
Celera55,570,901 - 5,648,759 (+)RGD
Sequence:
RefSeq Acc Id: XM_006237744   ⟹   XP_006237806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8510,618,712 - 10,852,776 (+)NCBI
mRatBN7.255,835,642 - 6,069,693 (+)NCBI
Rnor_6.055,466,544 - 5,696,540 (+)NCBI
Rnor_5.0510,306,581 - 10,538,264 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237747   ⟹   XP_006237809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8510,768,214 - 10,852,776 (+)NCBI
mRatBN7.255,985,136 - 6,069,693 (+)NCBI
Rnor_6.055,613,995 - 5,696,540 (+)NCBI
Rnor_5.0510,306,581 - 10,538,264 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593660   ⟹   XP_017449149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8510,619,081 - 10,852,776 (+)NCBI
mRatBN7.255,836,034 - 6,069,693 (+)NCBI
Rnor_6.055,466,892 - 5,696,540 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039110852   ⟹   XP_038966780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8510,618,730 - 10,852,776 (+)NCBI
mRatBN7.255,835,654 - 6,069,693 (+)NCBI
RefSeq Acc Id: XM_039110853   ⟹   XP_038966781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8510,618,712 - 10,852,776 (+)NCBI
mRatBN7.255,835,642 - 6,069,693 (+)NCBI
RefSeq Acc Id: XM_063288483   ⟹   XP_063144553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8510,620,293 - 10,852,776 (+)NCBI
RefSeq Acc Id: XM_063288484   ⟹   XP_063144554
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8510,746,663 - 10,852,776 (+)NCBI
RefSeq Acc Id: XM_063288485   ⟹   XP_063144555
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8510,620,269 - 10,852,776 (+)NCBI
RefSeq Acc Id: XM_063288486   ⟹   XP_063144556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8510,620,087 - 10,852,776 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_114010   ⟸   NM_031822
- UniProtKB: F1MA61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237806   ⟸   XM_006237744
- Peptide Label: isoform X1
- UniProtKB: Q9WUI9 (UniProtKB/Swiss-Prot),   F1MA61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237809   ⟸   XM_006237747
- Peptide Label: isoform X1
- UniProtKB: Q9WUI9 (UniProtKB/Swiss-Prot),   F1MA61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449149   ⟸   XM_017593660
- Peptide Label: isoform X1
- UniProtKB: Q9WUI9 (UniProtKB/Swiss-Prot),   F1MA61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011026   ⟸   ENSRNOT00000011026
RefSeq Acc Id: XP_038966781   ⟸   XM_039110853
- Peptide Label: isoform X2
- UniProtKB: Q9WUI9 (UniProtKB/Swiss-Prot),   A0A8I6AJ68 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966780   ⟸   XM_039110852
- Peptide Label: isoform X1
- UniProtKB: Q9WUI9 (UniProtKB/Swiss-Prot),   F1MA61 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000093156   ⟸   ENSRNOT00000119206
RefSeq Acc Id: ENSRNOP00000092311   ⟸   ENSRNOT00000095919
RefSeq Acc Id: XP_063144556   ⟸   XM_063288486
- Peptide Label: isoform X1
- UniProtKB: F1MA61 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144555   ⟸   XM_063288485
- Peptide Label: isoform X1
- UniProtKB: F1MA61 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144553   ⟸   XM_063288483
- Peptide Label: isoform X1
- UniProtKB: F1MA61 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144554   ⟸   XM_063288484
- Peptide Label: isoform X1
- UniProtKB: F1MA61 (UniProtKB/TrEMBL)
Protein Domains
bHLH   PAS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WUI9-F1-model_v2 AlphaFold Q9WUI9 1-1465 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620108 AgrOrtholog
BioCyc Gene G2FUF-42249 BioCyc
Ensembl Genes ENSRNOG00000007975 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011026.6 UniProtKB/TrEMBL
  ENSRNOT00000095919.1 UniProtKB/TrEMBL
  ENSRNOT00000119206.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.140.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF4927 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NCOA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_rcpt_coact UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_rcpt_coact_Ncoa-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_rcpt_coact_Ncoa_int_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_rcpt_coactivator UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRC/p160_LXXLL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83724 UniProtKB/Swiss-Prot
NCBI Gene 83724 ENTREZGENE
PANTHER PTHR10684 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10684:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF1518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF4927 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NCOA_u2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_rec_co-act UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS_11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRC-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ncoa2 PhenoGen
PIRSF Nuclear_receptor_coactivator UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007975 RatGTEx
SMART DUF1518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69125 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AJ68 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AVI1_RAT UniProtKB/TrEMBL
  A6JFD5_RAT UniProtKB/TrEMBL
  F1MA61 ENTREZGENE, UniProtKB/TrEMBL
  NCOA2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ncoa2  nuclear receptor coactivator 2  LOC102549300  uncharacterized LOC102549300  Data merged from RGD:7582276 737654 PROVISIONAL
2013-12-18 LOC102549300  uncharacterized LOC102549300      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-02-26 Ncoa2  nuclear receptor coactivator 2      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Ncoa2  nuclear receptor coactivator 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains three short conserved NR box motifs 633360