Upb1 (beta-ureidopropionase 1) - Rat Genome Database

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Gene: Upb1 (beta-ureidopropionase 1) Rattus norvegicus
Analyze
Symbol: Upb1
Name: beta-ureidopropionase 1
RGD ID: 620091
Description: Enables beta-ureidopropionase activity and zinc ion binding activity. Involved in beta-alanine metabolic process; in utero embryonic development; and liver development. Predicted to be active in cytosol. Orthologous to human UPB1 (beta-ureidopropionase 1); PARTICIPATES IN pyrimidine metabolic pathway; beta-alanine metabolic pathway; beta-ureidopropionase deficiency pathway; INTERACTS WITH 17beta-estradiol; 2,4,6-trinitrotoluene; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: beta-alanine synthase; beta-ureidopropionase; Bup1; N-carbamoyl-beta-alanine amidohydrolase; ureidopropionase, beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82013,216,693 - 13,243,016 (-)NCBIGRCr8
mRatBN7.22013,217,252 - 13,243,590 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2013,217,258 - 13,243,590 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,923,828 - 13,950,151 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02013,284,776 - 13,311,090 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,757,287 - 13,783,611 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02014,167,383 - 14,193,724 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2014,167,586 - 14,193,690 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02016,352,599 - 16,378,743 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,715,995 - 13,743,261 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12013,716,221 - 13,743,488 (-)NCBI
Celera2014,703,097 - 14,729,538 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
C60 fullerene  (EXP)
carbon nanotube  (ISO)
chlordecone  (ISO)
chromium(6+)  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
dioxygen  (ISO)
fentin chloride  (EXP)
flavonoids  (EXP)
furan  (EXP)
gentamycin  (EXP)
gliotoxin  (EXP)
glycidol  (EXP)
isotretinoin  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
Propiverine  (EXP)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (EXP)
tauroursodeoxycholic acid  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
toxaphene  (ISO)
triclosan  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Capacity of rat liver for pyrimidine synthesis and catabolism during fetal and neonatal development. Hardiman MK, etal., Arch Biochem Biophys. 1983 Jul 1;224(1):326-31.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Cloning, sequencing, and expression of a cDNA encoding beta-alanine synthase from rat liver. Kvalnes-Krick KL and Traut TW, J Biol Chem 1993 Mar 15;268(8):5686-93.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. Analysis of cyclic feed intake in rats fed on a zinc-deficient diet and the level of dihydropyrimidinase (EC 3.5.2.2). Tamaki N, etal., Br J Nutr. 1995 May;73(5):711-22.
Additional References at PubMed
PMID:15385443   PMID:15489334   PMID:19056867   PMID:22525402   PMID:23376485   PMID:29976570   PMID:30361391  


Genomics

Comparative Map Data
Upb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82013,216,693 - 13,243,016 (-)NCBIGRCr8
mRatBN7.22013,217,252 - 13,243,590 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2013,217,258 - 13,243,590 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,923,828 - 13,950,151 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02013,284,776 - 13,311,090 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,757,287 - 13,783,611 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02014,167,383 - 14,193,724 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2014,167,586 - 14,193,690 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02016,352,599 - 16,378,743 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,715,995 - 13,743,261 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12013,716,221 - 13,743,488 (-)NCBI
Celera2014,703,097 - 14,729,538 (-)NCBICelera
Cytogenetic Map20p12NCBI
UPB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382224,495,332 - 24,528,390 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2224,494,107 - 24,528,390 (+)EnsemblGRCh38hg38GRCh38
GRCh372224,891,300 - 24,924,358 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362223,221,251 - 23,252,553 (+)NCBINCBI36Build 36hg18NCBI36
Build 342223,215,804 - 23,247,106NCBI
Celera228,690,987 - 8,722,274 (+)NCBICelera
Cytogenetic Map22q11.23NCBI
HuRef227,840,918 - 7,872,203 (+)NCBIHuRef
CHM1_12224,849,971 - 24,881,302 (+)NCBICHM1_1
T2T-CHM13v2.02224,956,949 - 24,989,995 (+)NCBIT2T-CHM13v2.0
Upb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,242,745 - 75,277,513 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,236,949 - 75,277,513 (+)EnsemblGRCm39 Ensembl
GRCm381075,406,911 - 75,441,679 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,401,115 - 75,441,679 (+)EnsemblGRCm38mm10GRCm38
MGSCv371074,869,779 - 74,902,942 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361074,846,181 - 74,883,913 (+)NCBIMGSCv36mm8
Celera1076,453,987 - 76,488,021 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.53NCBI
Upb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554557,961,264 - 7,995,946 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554557,961,296 - 7,992,235 (+)NCBIChiLan1.0ChiLan1.0
UPB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22334,283,288 - 34,320,118 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12237,013,937 - 37,053,257 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0225,300,686 - 5,332,735 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12222,138,989 - 22,197,360 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2222,166,370 - 22,197,360 (+)Ensemblpanpan1.1panPan2
UPB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12628,194,968 - 28,225,977 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2628,195,081 - 28,225,567 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2627,269,282 - 27,301,115 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02629,598,247 - 29,630,273 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2629,599,300 - 29,630,269 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12627,681,607 - 27,713,443 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02627,298,626 - 27,330,446 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02628,288,066 - 28,320,106 (+)NCBIUU_Cfam_GSD_1.0
Upb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118142,039,199 - 142,085,682 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936619668,351 - 696,306 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936619668,380 - 713,720 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UPB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,533,231 - 49,565,075 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,533,208 - 49,561,518 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21452,975,014 - 53,003,329 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UPB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1197,605,999 - 7,639,339 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl197,605,537 - 7,639,017 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660854,807,773 - 4,841,973 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Upb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247479,911,448 - 9,940,537 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247479,911,323 - 9,940,770 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Upb1
200 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:42
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000058237
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20903971913461775Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat

Markers in Region
AI195023  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22013,217,317 - 13,217,407 (+)MAPPERmRatBN7.2
Rnor_6.02014,167,441 - 14,167,530NCBIRnor6.0
Rnor_5.02016,352,657 - 16,352,746UniSTSRnor5.0
RGSC_v3.42013,716,053 - 13,716,142UniSTSRGSC3.4
Celera2014,703,155 - 14,703,244UniSTS
Cytogenetic Map20p12UniSTS
RH131237  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22013,217,281 - 13,217,498 (+)MAPPERmRatBN7.2
Rnor_6.02014,167,405 - 14,167,621NCBIRnor6.0
Rnor_5.02016,352,621 - 16,352,837UniSTSRnor5.0
RGSC_v3.42013,716,017 - 13,716,233UniSTSRGSC3.4
Celera2014,703,119 - 14,703,335UniSTS
Cytogenetic Map20p12UniSTS
RH141685  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22013,230,474 - 13,230,691 (+)MAPPERmRatBN7.2
Rnor_6.02014,180,333 - 14,180,549NCBIRnor6.0
Rnor_5.02016,365,352 - 16,365,568UniSTSRnor5.0
RGSC_v3.42013,730,152 - 13,730,368UniSTSRGSC3.4
Celera2014,716,376 - 14,716,592UniSTS
RH 3.4 Map20154.86UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 35 35 35 25 7
Low 2 20 17 6 15 6 3 3 19 8 18 10 3
Below cutoff 1 22 5 4 5 6 45 2 14 1 5

Sequence


RefSeq Acc Id: ENSRNOT00000058237   ⟹   ENSRNOP00000055035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2013,217,258 - 13,243,590 (-)Ensembl
Rnor_6.0 Ensembl2014,167,586 - 14,193,690 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106652   ⟹   ENSRNOP00000092253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2013,217,260 - 13,243,590 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115726   ⟹   ENSRNOP00000092718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2013,217,258 - 13,243,590 (-)Ensembl
RefSeq Acc Id: NM_053845   ⟹   NP_446297
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82013,216,693 - 13,243,016 (-)NCBI
mRatBN7.22013,217,260 - 13,243,590 (-)NCBI
Rnor_6.02014,167,383 - 14,193,724 (-)NCBI
Rnor_5.02016,352,599 - 16,378,743 (-)NCBI
RGSC_v3.42013,715,995 - 13,743,261 (-)RGD
Celera2014,703,097 - 14,729,538 (-)RGD
Sequence:
RefSeq Acc Id: XM_039098386   ⟹   XP_038954314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82013,216,693 - 13,230,138 (-)NCBI
mRatBN7.22013,217,252 - 13,230,678 (-)NCBI
RefSeq Acc Id: NP_446297   ⟸   NM_053845
- UniProtKB: Q03248 (UniProtKB/Swiss-Prot),   D3Z8J1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000055035   ⟸   ENSRNOT00000058237
RefSeq Acc Id: XP_038954314   ⟸   XM_039098386
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000092253   ⟸   ENSRNOT00000106652
RefSeq Acc Id: ENSRNOP00000092718   ⟸   ENSRNOT00000115726
Protein Domains
CN hydrolase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q03248-F1-model_v2 AlphaFold Q03248 1-393 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701550
Promoter ID:EPDNEW_R12067
Type:multiple initiation site
Name:Upb1_1
Description:ureidopropionase, beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02014,193,730 - 14,193,790EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620091 AgrOrtholog
BioCyc Gene G2FUF-4112 BioCyc
BioCyc Pathway PWY-3982 [uracil degradation I (reductive)] BioCyc
  PWY-6430 [thymine degradation] BioCyc
BioCyc Pathway Image PWY-3982 BioCyc
  PWY-6430 BioCyc
Ensembl Genes ENSRNOG00000038258 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055021850 UniProtKB/Swiss-Prot
  ENSRNOG00060026107 UniProtKB/Swiss-Prot
  ENSRNOG00065027229 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000058237.5 UniProtKB/TrEMBL
  ENSRNOT00000106652.1 UniProtKB/TrEMBL
  ENSRNOT00000115726 ENTREZGENE
  ENSRNOT00000115726.1 UniProtKB/Swiss-Prot
  ENSRNOT00055037482 UniProtKB/Swiss-Prot
  ENSRNOT00060045225 UniProtKB/Swiss-Prot
  ENSRNOT00065046992 UniProtKB/Swiss-Prot
Gene3D-CATH 3.60.110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7130296 IMAGE-MGC_LOAD
InterPro C-N_Hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-N_Hydrolase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116593 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93280 IMAGE-MGC_LOAD
NCBI Gene 116593 ENTREZGENE
PANTHER BETA-UREIDOPROPIONASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NITRILASE C965.09-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CN_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB UPB1 RGD
PhenoGen Upb1 PhenoGen
PROSITE CN_HYDROLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038258 RatGTEx
  ENSRNOG00055021850 RatGTEx
  ENSRNOG00060026107 RatGTEx
  ENSRNOG00065027229 RatGTEx
Superfamily-SCOP SSF56317 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AH71_RAT UniProtKB/TrEMBL
  A6JKL1_RAT UniProtKB/TrEMBL
  A6JKL2_RAT UniProtKB/TrEMBL
  BUP1_RAT UniProtKB/Swiss-Prot
  D3Z8J1 ENTREZGENE, UniProtKB/TrEMBL
  Q03248 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-23 Upb1  beta-ureidopropionase 1  Upb1  ureidopropionase, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Upb1  ureidopropionase, beta      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Upb1  ureidopropionase, beta      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 393 amino acids; 44 kDa 634224