Cspg4 (chondroitin sulfate proteoglycan 4) - Rat Genome Database

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Gene: Cspg4 (chondroitin sulfate proteoglycan 4) Rattus norvegicus
Analyze
Symbol: Cspg4
Name: chondroitin sulfate proteoglycan 4
RGD ID: 619942
Description: Enables collagen binding activity. Involved in negative regulation of neuron projection development and neuron remodeling. Predicted to be located in nucleoplasm; plasma membrane; and ruffle. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in relapsing-remitting multiple sclerosis. Orthologous to human CSPG4 (chondroitin sulfate proteoglycan 4); INTERACTS WITH 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: chondroitin sulfate proteoglycan NG2; HSN tumor-specific antigen; membrane-spanning proteoglycan NG2; Ng2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8866,160,942 - 66,195,987 (+)NCBIGRCr8
mRatBN7.2857,264,962 - 57,300,010 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl857,264,962 - 57,300,010 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx862,788,359 - 62,823,425 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0861,067,205 - 61,102,268 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0858,931,641 - 58,966,706 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0861,532,465 - 61,567,510 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl861,532,465 - 61,567,510 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0860,101,160 - 60,136,205 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4860,610,835 - 60,645,877 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1860,629,888 - 60,664,931 (+)NCBI
Celera856,733,067 - 56,768,114 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
cisplatin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
flavonoids  (EXP)
FR900359  (ISO)
furan  (EXP)
genistein  (ISO)
hexane  (EXP)
linuron  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methimazole  (EXP)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
naphthalenes  (EXP)
nickel sulfate  (ISO)
nitrofen  (EXP)
ochratoxin A  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
permethrin  (EXP)
phenethyl caffeate  (EXP)
phenylephrine  (EXP)
potassium chromate  (ISO)
propiconazole  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
sevoflurane  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
titanium dioxide  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Human homologue of the rat chondroitin sulfate proteoglycan, NG2, detected by monoclonal antibody 7.1, identifies childhood acute lymphoblastic leukemias with t(4;11)(q21;q23) or t(11;19)(q23;p13) and MLL gene rearrangements. Behm FG, etal., Blood 1996 Feb 1;87(3):1134-9.
2. NG2 and phosphacan are present in the astroglial scar after human traumatic spinal cord injury. Buss A, etal., BMC Neurol. 2009 Jul 15;9:32.
3. The alterations of oligodendrocyte, myelin in corpus callosum, and cognitive dysfunction following chronic cerebral ischemia in rats. Chida Y, etal., Brain Res. 2011 Sep 26;1414:22-31. Epub 2011 Jul 20.
4. Spinal cathepsin S and fractalkine contribute to chronic pain in collagen induced arthritis. Clark AK, etal., Arthritis Rheum. 2011 Dec 27. doi: 10.1002/art.34351.
5. Lentiviral vector-mediated knockdown of the neuroglycan 2 proteoglycan or expression of neurotrophin-3 promotes neurite outgrowth in a cell culture model of the glial scar. Donnelly EM, etal., J Gene Med. 2010 Nov;12(11):863-72. doi: 10.1002/jgm.1509. Epub 2010 Oct 26.
6. NG2, a member of chondroitin sulfate proteoglycans family mediates the inflammatory response of activated microglia. Gao Q, etal., Neuroscience. 2010 Jan 20;165(2):386-94. Epub .
7. Cerebral cortex demyelination and oligodendrocyte precursor response to experimental autoimmune encephalomyelitis. Girolamo F, etal., Neurobiol Dis. 2011 Sep;43(3):678-89. Epub 2011 Jun 6.
8. Reduced inflammation accompanies diminished myelin damage and repair in the NG2 null mouse spinal cord. Kucharova K, etal., J Neuroinflammation. 2011 Nov 13;8:158.
9. Lack of aspartoacylase activity disrupts survival and differentiation of neural progenitors and oligodendrocytes in a mouse model of Canavan disease. Kumar S, etal., J Neurosci Res. 2009 Nov 15;87(15):3415-27.
10. The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eye. Liu W, etal., Cell. 2011 Jun 24;145(7):1088-101. doi: 10.1016/j.cell.2011.05.015.
11. The effect of long-term release of Shh from implanted biodegradable microspheres on recovery from spinal cord injury in mice. Lowry N, etal., Biomaterials. 2012 Jan 11.
12. Accumulation of macrophage-like cells expressing NG2 proteoglycan and Iba1 in ischemic core of rat brain after transient middle cerebral artery occlusion. Matsumoto H, etal., J Cereb Blood Flow Metab. 2008 Jan;28(1):149-63. Epub 2007 Jun 13.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Expression of NG2-positive cells during optic neuritis. Nakamura K, etal., Jpn J Ophthalmol. 2010 Jan;54(1):100-2. Epub 2010 Feb 12.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Patients with active relapsing-remitting multiple sclerosis synthesize antibodies recognizing oligodendrocyte progenitor cell surface protein: implications for remyelination. Niehaus A, etal., Ann Neurol. 2000 Sep;48(3):362-71.
17. The primary structure of NG2, a novel membrane-spanning proteoglycan. Nishiyama A, etal., J Cell Biol 1991 Jul;114(2):359-71.
18. NG2 positive cells of rat spinal cord activated during experimental autoimmune encephalomyelitis are spatially associated with radially oriented astroglia and express p75 receptor: a role for nerve growth factor in oligodendrocyte progenitor migration? Oderfeld-Nowak B, etal., Arch Ital Biol. 2009 Dec;147(4):105-15.
19. Chronic lithium treatment decreases NG2 cell proliferation in rat dentate hilus, amygdala and corpus callosum. Orre K, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2009 Apr 30;33(3):503-10. Epub 2009 Feb 6.
20. Downstream of kinase, p62(dok), is a mediator of Fc gamma IIB inhibition of Fc epsilon RI signaling. Ott VL, etal., J Immunol 2002 May 1;168(9):4430-9.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family. Staub E, etal., FEBS Lett 2002 Sep 11;527(1-3):114-8.
25. Histopathologic characterization of the BTBR mouse model of autistic-like behavior reveals selective changes in neurodevelopmental proteins and adult hippocampal neurogenesis. Stephenson DT, etal., Mol Autism. 2011 May 16;2(1):7.
26. Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissue. Tang X, etal., J Neurosci Res 2003 Feb 1;71(3):427-44.
27. The membrane-spanning proteoglycan NG2 binds to collagens V and VI through the central nonglobular domain of its core protein. Tillet E, etal., J Biol Chem. 1997 Apr 18;272(16):10769-76.
28. Multiple regions of the NG2 proteoglycan inhibit neurite growth and induce growth cone collapse. Ughrin YM, etal., J Neurosci 2003 Jan 1;23(1):175-86.
29. Deficiency of NG2+ cells contributes to the susceptibility of stroke-prone spontaneously hypertensive rats. Wang P, etal., CNS Neurosci Ther. 2011 Oct;17(5):327-32. doi: 10.1111/j.1755-5949.2011.00265.x.
30. GGF2 (Nrg1-beta3) treatment enhances NG2(+) cell response and improves functional recovery after spinal cord injury. Whittaker MT, etal., Glia. 2012 Feb;60(2):281-94. doi: 10.1002/glia.21262. Epub 2011 Oct 31.
31. Astrocytes and oligodendrocytes can be generated from NG2+ progenitors after acute brain injury: intracellular localization of oligodendrocyte transcription factor 2 is associated with their fate choice. Zhao JW, etal., Eur J Neurosci. 2009 May;29(9):1853-69. Epub 2009 Apr 28.
Additional References at PubMed
PMID:2269670   PMID:8077056   PMID:8305732   PMID:8590808   PMID:8824254   PMID:9281375   PMID:10036240   PMID:10358027   PMID:10366628   PMID:10587647   PMID:10889192   PMID:10967549  
PMID:11493670   PMID:11668599   PMID:14572468   PMID:14664826   PMID:15023573   PMID:15181153   PMID:15504744   PMID:15817274   PMID:15824037   PMID:15866049   PMID:16093329   PMID:16534776  
PMID:16627368   PMID:16902766   PMID:17503442   PMID:17591920   PMID:17686464   PMID:19581412   PMID:19861972   PMID:20053907   PMID:21423176   PMID:22640018   PMID:23376485   PMID:23447615  
PMID:23533145   PMID:25471575   PMID:26437238   PMID:27068509   PMID:27498042   PMID:27582000   PMID:32967214   PMID:33822814   PMID:34102261  


Genomics

Comparative Map Data
Cspg4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8866,160,942 - 66,195,987 (+)NCBIGRCr8
mRatBN7.2857,264,962 - 57,300,010 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl857,264,962 - 57,300,010 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx862,788,359 - 62,823,425 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0861,067,205 - 61,102,268 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0858,931,641 - 58,966,706 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0861,532,465 - 61,567,510 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl861,532,465 - 61,567,510 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0860,101,160 - 60,136,205 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4860,610,835 - 60,645,877 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1860,629,888 - 60,664,931 (+)NCBI
Celera856,733,067 - 56,768,114 (+)NCBICelera
Cytogenetic Map8q24NCBI
CSPG4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381575,674,322 - 75,713,466 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1575,674,322 - 75,712,848 (-)EnsemblGRCh38hg38GRCh38
GRCh371575,966,663 - 76,005,189 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361573,753,718 - 73,792,244 (-)NCBINCBI36Build 36hg18NCBI36
Build 341573,754,018 - 73,792,151NCBI
Celera1552,892,353 - 52,930,874 (-)NCBICelera
Cytogenetic Map15q24.2NCBI
HuRef1552,722,948 - 52,761,468 (-)NCBIHuRef
CHM1_11576,086,119 - 76,124,652 (-)NCBICHM1_1
T2T-CHM13v2.01573,545,032 - 73,584,178 (-)NCBIT2T-CHM13v2.0
Cspg4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39956,772,388 - 56,807,154 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl956,772,317 - 56,807,154 (+)EnsemblGRCm39 Ensembl
GRCm38956,865,104 - 56,899,870 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl956,865,033 - 56,899,870 (+)EnsemblGRCm38mm10GRCm38
MGSCv37956,712,911 - 56,747,677 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36956,663,297 - 56,697,272 (+)NCBIMGSCv36mm8
Celera954,090,244 - 54,125,014 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map930.32NCBI
Cspg4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554502,631,327 - 2,662,269 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554502,631,310 - 2,663,118 (+)NCBIChiLan1.0ChiLan1.0
CSPG4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21664,867,979 - 64,906,630 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11569,030,759 - 69,070,439 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01554,583,010 - 54,621,240 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11574,176,684 - 74,214,717 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1574,177,909 - 74,200,498 (-)Ensemblpanpan1.1panPan2
CSPG4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13038,465,486 - 38,498,365 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3038,465,241 - 38,497,971 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3038,394,709 - 38,427,802 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03038,670,891 - 38,703,644 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3038,670,951 - 38,703,634 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13038,620,966 - 38,654,238 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03038,663,208 - 38,700,081 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03038,897,574 - 38,936,898 (-)NCBIUU_Cfam_GSD_1.0
Cspg4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640116,590,615 - 116,627,014 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647134,438,676 - 34,475,052 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647134,438,676 - 34,475,005 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSPG4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl757,949,455 - 57,988,335 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1757,949,182 - 57,988,602 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2762,640,958 - 62,678,668 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CSPG4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1267,735,972 - 7,761,355 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl267,694,014 - 7,761,342 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048133,933,356 - 133,972,969 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cspg4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624894561,683 - 594,878 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624894564,252 - 595,048 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cspg4
156 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:163
Count of miRNA genes:114
Interacting mature miRNAs:142
Transcripts:ENSRNOT00000023326
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat

Markers in Region
D8Rat151  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2857,278,597 - 57,278,740 (+)MAPPERmRatBN7.2
Rnor_6.0861,546,100 - 61,546,242NCBIRnor6.0
Rnor_5.0860,114,795 - 60,114,937UniSTSRnor5.0
RGSC_v3.4860,624,410 - 60,624,716RGDRGSC3.4
RGSC_v3.4860,624,467 - 60,624,609UniSTSRGSC3.4
RGSC_v3.1860,643,521 - 60,643,663RGD
Celera856,746,703 - 56,746,845UniSTS
RH 3.4 Map8650.5RGD
RH 3.4 Map8650.5UniSTS
RH 2.0 Map8500.7RGD
SHRSP x BN Map841.41RGD
Cytogenetic Map8q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 27 2 1 1 1 15 14 25 10 1
Low 3 16 23 9 18 9 7 10 57 21 14 1 7
Below cutoff 28 28 28 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023326   ⟹   ENSRNOP00000023326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl857,264,962 - 57,300,010 (+)Ensembl
Rnor_6.0 Ensembl861,532,465 - 61,567,510 (+)Ensembl
RefSeq Acc Id: NM_031022   ⟹   NP_112284
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,160,942 - 66,195,987 (+)NCBI
mRatBN7.2857,264,962 - 57,300,010 (+)NCBI
Rnor_6.0861,532,465 - 61,567,510 (+)NCBI
Rnor_5.0860,101,160 - 60,136,205 (+)NCBI
RGSC_v3.4860,610,835 - 60,645,877 (+)RGD
Celera856,733,067 - 56,768,114 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_112284 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA39884 (Get FASTA)   NCBI Sequence Viewer  
  EDL95589 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023326
  ENSRNOP00000023326.3
GenBank Protein Q00657 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_112284   ⟸   NM_031022
- Peptide Label: precursor
- UniProtKB: Q00657 (UniProtKB/Swiss-Prot),   F1LS79 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023326   ⟸   ENSRNOT00000023326
Protein Domains
Laminin G   Laminin G-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q00657-F1-model_v2 AlphaFold Q00657 1-2326 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696001
Promoter ID:EPDNEW_R6526
Type:initiation region
Name:Cspg4_1
Description:chondroitin sulfate proteoglycan 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0861,532,413 - 61,532,473EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619942 AgrOrtholog
BioCyc Gene G2FUF-30344 BioCyc
Ensembl Genes ENSRNOG00000017208 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023326 ENTREZGENE
  ENSRNOT00000023326.4 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CSPG_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81651 UniProtKB/Swiss-Prot
NCBI Gene 81651 ENTREZGENE
PANTHER CHONDROITIN SULFATE PROTEOGLYCAN 4-LIKE ISOFORM X2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EXTRACELLULAR MATRIX ORGANIZING PROTEIN FRAS1 UniProtKB/TrEMBL
  MATRIX PROTEIN, PUTATIVE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cadherin_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cspg4 PhenoGen
PROSITE CSPG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017208 RatGTEx
SMART LamG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6J4R6_RAT UniProtKB/TrEMBL
  CSPG4_RAT UniProtKB/Swiss-Prot
  F1LS79 ENTREZGENE, UniProtKB/TrEMBL
  Q00657 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Cspg4  chondroitin sulfate proteoglycan 4    membrane-spanning proteoglycan NG2  Name updated 1299863 APPROVED
2002-08-07 Cspg4  membrane-spanning proteoglycan NG2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains extracellular domain contains three subdomains: an N-terminal globular domain (domain 1), a central extended domain that has the sites for glycosaminoglycan (GAG) attachment (domain 2), and a juxtamembrane domain (domain 3) 632592
gene_expression expressed in neurons and macrophages 625651
gene_process domains 1 and 3 of NG2 can inhibit neurite growth independently 632592
gene_process may prohibit axonal regeneration after injury 625651
gene_regulation protein expression increases after 24 hr of injury, peaks at 1 week, and remains elevated for at least an additional 7 weeks after spinal cord injury (SCI) 625651