Serpini1 (serpin family I member 1)

Gene: Serpini1 (serpin family I member 1) Rattus norvegicus

Analyze

Symbol:

Serpini1

Name:

serpin family I member 1

RGD ID:

619896

Description:

Enables serine-type endopeptidase inhibitor activity. Involved in positive regulation of neuron projection development. Predicted to be located in neuronal cell body and secretory granule lumen. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in familial encephalopathy with neuroserpin inclusion bodies. Orthologous to human SERPINI1 (serpin family I member 1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

neuroserpin; peptidase inhibitor 12; PI-12; protease inhibitor 17; raPIT5a; serine (or cysteine) peptidase inhibitor, clade I, member 1; serine (or cysteine) proteinase inhibitor clade member 1; serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1; serine protease inhibitor 17; serpin I1; serpin peptidase inhibitor, clade I (neuroserpin), member 1; serpin peptidase inhibitor, clade I, member 1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SERPINI1 (serpin family I member 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Serpini1 (serine (or cysteine) peptidase inhibitor, clade I, member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Serpini1 (serpin family I member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SERPINI1 (serpin family I member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SERPINI1 (serpin family I member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Serpini1 (serpin family I member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SERPINI1 (serpin family I member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SERPINI1 (serpin family I member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Serpini1 (serpin family I member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SERPINI1 (serpin family I member 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Serpini1 (serine (or cysteine) peptidase inhibitor, clade I, member 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	serpini1 (serpin peptidase inhibitor, clade I (neuroserpin), member 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn27A	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	srp-1	Alliance	DIOPT (OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	srp-3	Alliance	DIOPT (InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	srp-6	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn28B	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	srp-2	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	srp-7	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn28Da	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	srp-8	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn28Db	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Spn42Da	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn42Db	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn42Dc	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Spn42De	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn43Aa	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Spn88Ea	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	Spn88Eb	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	serpini1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	162,645,209 - 162,731,737 (+)	NCBI		GRCr8
mRatBN7.2	2	160,346,403 - 160,433,135 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	160,346,758 - 160,433,135 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	167,519,261 - 167,605,550 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	165,523,542 - 165,609,838 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	160,156,334 - 160,242,616 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	174,013,058 - 174,111,693 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	174,013,288 - 174,111,752 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	193,348,764 - 193,446,692 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	166,445,765 - 166,555,032 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	166,395,870 - 166,505,138 (+)	NCBI
Celera	2	154,541,696 - 154,627,933 (+)	NCBI		Celera
Cytogenetic Map	2	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cerebral cavernous malformation (ISO)

cerebral cavernous malformation 3 (ISO)

familial encephalopathy with neuroserpin inclusion bodies (ISO,ISS)

genetic disease (ISO)

Nervous System Malformations (ISO)

progressive myoclonus epilepsy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,2-dichloroethane (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

4-hydroxynon-2-enal (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

8-Br-cAMP (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

antirheumatic drug (ISO)

atrazine (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

calcitriol (ISO)

chlordecone (ISO)

choline (ISO)

cocaine (EXP)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dicrotophos (ISO)

dioxygen (EXP)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

fenamidone (ISO)

fluoxetine (EXP)

folic acid (ISO)

furan (EXP)

gentamycin (EXP)

haloperidol (ISO)

imipramine (EXP)

L-methionine (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

manganese(II) chloride (EXP)

mercury dibromide (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

nickel atom (ISO)

olanzapine (ISO)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

phenethyl isothiocyanate (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

rotenone (ISO)

sarin (ISO)

SB 431542 (ISO)

sertraline (EXP)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sotorasib (ISO)

succimer (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trametinib (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

triptonide (ISO)

tungsten (ISO)

undecane (EXP)

urethane (ISO)

valproic acid (ISO)

venlafaxine hydrochloride (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of neuron projection development (IDA)

Cellular Component

cytoplasmic vesicle lumen (ISO,ISS)

extracellular space (IBA,ISO,ISS)

neuronal cell body (ISO,ISS)

perikaryon (IEA)

secretory granule lumen (ISO)

Molecular Function

serine-type endopeptidase inhibitor activity (IBA,IDA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Expression and functional characterization of the serine protease inhibitor neuroserpin in endocrine cells.	Hill RM, etal., Ann N Y Acad Sci 2002 Oct;971:406-15.
4.	Neuroserpin is expressed in the pituitary and adrenal glands and induces the extension of neurite-like processes in AtT-20 cells.	Hill RM, etal., Biochem J 2000 Feb 1;345 Pt 3:595-601.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	A multilevel screening strategy defines a molecular fingerprint of proregenerative olfactory ensheathing cells and identifies SCARB2, a protein that improves regenerative sprouting of injured sensory spinal axons.	Roet KC, etal., J Neurosci. 2013 Jul 3;33(27):11116-35. doi: 10.1523/JNEUROSCI.1002-13.2013.
12.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:9442076	PMID:11935397	PMID:15489334	PMID:16849336	PMID:17040209	PMID:18092357	PMID:19285087	PMID:20010310	PMID:20648651	PMID:23163103	PMID:23376485	PMID:23533145
PMID:24006456	PMID:24608243	PMID:25363759	PMID:25874935

Genomics

Comparative Map Data

Serpini1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	162,645,209 - 162,731,737 (+)	NCBI		GRCr8
mRatBN7.2	2	160,346,403 - 160,433,135 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	160,346,758 - 160,433,135 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	167,519,261 - 167,605,550 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	165,523,542 - 165,609,838 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	160,156,334 - 160,242,616 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	174,013,058 - 174,111,693 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	174,013,288 - 174,111,752 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	193,348,764 - 193,446,692 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	166,445,765 - 166,555,032 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	166,395,870 - 166,505,138 (+)	NCBI
Celera	2	154,541,696 - 154,627,933 (+)	NCBI		Celera
Cytogenetic Map	2	q32	NCBI

SERPINI1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	167,735,721 - 167,825,569 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	167,735,243 - 167,825,569 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	167,453,509 - 167,543,357 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	168,936,217 - 169,026,048 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	168,936,224 - 169,026,056	NCBI
Celera	3	165,851,868 - 165,941,800 (+)	NCBI		Celera
Cytogenetic Map	3	q26.1	NCBI
HuRef	3	164,823,494 - 164,913,496 (+)	NCBI		HuRef
CHM1_1	3	167,416,304 - 167,506,237 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	170,519,576 - 170,609,466 (+)	NCBI		T2T-CHM13v2.0

Serpini1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	75,464,800 - 75,549,830 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	75,464,854 - 75,550,802 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	75,557,493 - 75,642,523 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	75,557,547 - 75,643,495 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	75,361,455 - 75,446,445 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	75,643,500 - 75,728,281 (+)	NCBI		MGSCv36	mm8
Celera	3	75,622,674 - 75,707,678 (+)	NCBI		Celera
Cytogenetic Map	3	E3	NCBI
cM Map	3	33.76	NCBI

Serpini1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955448	16,947,403 - 16,984,130 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955448	16,947,375 - 16,982,114 (+)	NCBI	ChiLan1.0	ChiLan1.0

SERPINI1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	165,635,710 - 165,725,485 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	165,640,437 - 165,730,210 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	164,755,803 - 164,845,572 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	172,812,348 - 172,902,372 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	172,865,891 - 172,902,372 (+)	Ensembl	panpan1.1		panPan2

SERPINI1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	34	32,553,876 - 32,624,708 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	34	32,553,902 - 32,624,526 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	34	41,634,867 - 41,710,496 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	34	32,632,851 - 32,708,874 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	34	32,633,267 - 32,708,863 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	34	32,577,993 - 32,648,768 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	34	32,538,519 - 32,614,495 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	34	32,810,135 - 32,886,159 (+)	NCBI		UU_Cfam_GSD_1.0

Serpini1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	98,971,772 - 99,053,590 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936593	4,570,987 - 4,603,130 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936593	4,569,183 - 4,649,901 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SERPINI1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	106,559,736 - 106,658,110 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	106,559,326 - 106,636,930 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	115,121,198 - 115,199,343 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SERPINI1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	21,610,545 - 21,696,611 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	21,610,791 - 21,645,701 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666063	30,454,469 - 30,541,000 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Serpini1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	45,739,911 - 45,795,570 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	45,698,714 - 45,791,744 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Serpini1
445 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	295
Count of miRNA genes:	193
Interacting mature miRNAs:	231
Transcripts:	ENSRNOT00000013904
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	136445150	202447032	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118275	202447032	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
738007	Anxrr7	Anxiety related response QTL 7	4.4		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	118189491	163189491	Rat
6903312	Bw112	Body weight QTL 112	3.2	0.0013	body mass (VT:0001259)	body weight (CMO:0000012)	2	143657569	184114274	Rat
631501	Bp101	Blood pressure QTL 101	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150341684	202446871	Rat
631520	Bp73	Blood pressure QTL 73		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	147686913	168355276	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	112456140	212696837	Rat
6907363	Bp357	Blood pressure QTL 357	4.1	0.002	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	129540907	174540907	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	157142078	226277316	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	81689826	221035911	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	133914684	202447032	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56043031	202447032	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	143657411	190602963	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	143657411	190602963	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	141194931	223265385	Rat
1302793	Bw16	Body weight QTL 16	5	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	2	157142209	202446871	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43171017	184114403	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	74786664	206665859	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	150540301	202447032	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	114837675	212549332	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	114837527	185876470	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	114837527	185876470	Rat
1359032	Hrtrt18	Heart rate QTL 18			heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	157142078	192625452	Rat
1581502	Esta3	Estrogen-induced thymic atrophy QTL 3			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	136916935	189599348	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	221167075	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	78665619	219826953	Rat
1598833	Bp295	Blood pressure QTL 295	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	147798556	192798556	Rat
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	114837527	211674221	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	76539322	202447032	Rat
61401	Niddm2	Non-insulin dependent diabetes mellitus QTL 2	4.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	144599348	189599348	Rat
1598805	Memor8	Memory QTL 8	3		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	150341585	189039377	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46123260	202447032	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	43154682	202446871	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43154682	202446871	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
724568	Uae13	Urinary albumin excretion QTL 13	4.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	2	143157029	210020885	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	182042367	Rat
2301415	Cm67	Cardiac mass QTL 67		0.003	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	152413072	175950118	Rat
2301966	Bp322	Blood pressure QTL 322	3.58		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150540301	202447032	Rat
1358900	Bw48	Body weight QTL 48	4.88		body mass (VT:0001259)	body weight (CMO:0000012)	2	157142078	211086598	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	112456140	212696837	Rat
12879836	Kidm61	Kidney mass QTL 61		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	152413072	185122374	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	141194931	223265385	Rat
12879837	Am2	Aortic mass QTL 2		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	152413072	185122374	Rat
12879840	Bw179	Body weight QTL 179		0.005	body mass (VT:0001259)	body weight (CMO:0000012)	2	152413072	185122374	Rat
71113	Cari2	Carrageenan-induced inflammation QTL 2	2.7	0.009	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	2	141596551	202447032	Rat
12879847	Am4	Aortic mass QTL 4		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	152413072	175950118	Rat
11565180	Kidm56	Kidney mass QTL 56		0.003	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	152413072	175950118	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	2	135552573	202446871	Rat
12879846	Cm90	Cardiac mass QTL 90		0.011	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	2	152413072	175950118	Rat
11565181	Bw176	Body weight QTL 176		0.002	body mass (VT:0001259)	body weight (CMO:0000012)	2	152413072	175950118	Rat
12879845	Cm89	Cardiac mass QTL 89		0.008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	152413072	175950118	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
12879838	Cm86	Cardiac mass QTL 86		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	152413072	185122374	Rat
12879839	Cm85	Cardiac mass QTL 85		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	152413072	185122374	Rat
1359022	Ppulsi1	Prepulse inhibition QTL 1	3.63		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	2	136916935	213594495	Rat

Markers in Region

RH139560

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	160,432,695 - 160,432,876 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	174,111,254 - 174,111,434	NCBI	Rnor6.0
Rnor_5.0	2	193,446,191 - 193,446,371	UniSTS	Rnor5.0
RGSC_v3.4	2	166,554,593 - 166,554,773	UniSTS	RGSC3.4
Celera	2	154,627,494 - 154,627,674	UniSTS
RH 3.4 Map	2	1044.6	UniSTS
Cytogenetic Map	2	q32	UniSTS

RH140400

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	160,432,705 - 160,432,876 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	174,111,264 - 174,111,434	NCBI	Rnor6.0
Rnor_5.0	2	193,446,201 - 193,446,371	UniSTS	Rnor5.0
RGSC_v3.4	2	166,554,603 - 166,554,773	UniSTS	RGSC3.4
Celera	2	154,627,504 - 154,627,674	UniSTS
Cytogenetic Map	2	q32	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			1						70		10
Low	3	16	26	11	19	11	1	1	4	35	29	11	1
Below cutoff		27	27	27		27	7	8			2		7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053779	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761076	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281153	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF193014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF193015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC061536	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213873	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ234773	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000013904 ⟹ ENSRNOP00000013905

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	160,346,758 - 160,433,135 (+)	Ensembl
Rnor_6.0 Ensembl	2	174,013,288 - 174,111,752 (+)	Ensembl

RefSeq Acc Id:

NM_053779 ⟹ NP_446231

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	162,645,362 - 162,731,732 (+)	NCBI
mRatBN7.2	2	160,346,758 - 160,433,135 (+)	NCBI
Rnor_6.0	2	174,013,426 - 174,111,693 (+)	NCBI
Rnor_5.0	2	193,348,764 - 193,446,692 (+)	NCBI
RGSC_v3.4	2	166,445,765 - 166,555,032 (+)	RGD
Celera	2	154,541,696 - 154,627,933 (+)	RGD

Sequence:

show sequence

GAGAGAGGCAAGAGCAGGATCCCGAGCGAACACATCCTGCCCAGCATCCTCTCCAGCATCCCAA
GCCAAGCCGAGGTTGCAGGTGTGAGGGAGACTTGAAACCATTCCATCATGGCTTACCTTGGACT
GCTCTCTTTAGTGGCCTTGCAAAGTTTGGTGACAGGGGCAGCTTTCCCAGATGAAACCATAGCC
GAGTGGTCAGTGAATGTGTATAACCATCTTCGAGCCACTGGGGAAGATGAAAACATCCTCTTCT
CTCCACTAAGCATTGCCCTTGCTATGGGGGTGATGGAGCTCGGGGCTCAAGGATCTACTCTGAA
AGAAATCCGCCATTCAATGGGATACGAGAGCCTGAAAAGTGGTGAAGAATTTTCTTTCCTGAGG
GATTTTTCTAGCATGGTCTCTGCTGAAGAAGGCCAATATGTGATGAAAATTGCCAATTCACTCT
TTGTGCAAAACGGATTTCATATCAATGAGGAATTCTTGCAAATGATGAAAATGTACTTTAATGC
AGAAGTCAATCATGTGGACTTCAGTGAAAATGTGGCGGTGGCCAACTACATCAATAAGTGGGTG
GAGAATTATACAAACAGTCTATTGAAAGATCTGGTGTCCCCGGGGGATTTTGACGCTGTCACCC
ATCTGGCCCTTATCAATGCTGTATATTTCAAAGGGAACTGGAAGTCTCAGTTTAGACCTGAAAA
TACCAGAACTTTCTCCTTCACAAAAGATGATGAAAGTGAAGTACAGATTCCAATGATGTATCAA
CAAGGAGAATTTTATTACGGGGAATTTAGTGATGGATCCAATGAGGCTGGTGGCATCTACCAAG
TCCTTGAGATACCTTATGAGGGAGACGAGATCAGCATGATGCTGGTACTGTCCAGACAGGAAGT
CCCACTGGCCACACTGGAGCCTCTGCTCAAACCACAGCTGATCGAAGAATGGGCAAACTCCGTG
AAGAAACAAAAGGTGGAAGTCTACTTGCCCAGGTTCACCGTGGAACAGGAAATTGATTTAAAAG
ACATCTTGAAAGCCCTTGGGGTCACTGAAATTTTCATCAAAGATGCAAATTTGACTGCCATGTC
AGATAAGAAAGAACTGTTCCTCTCCAAAGCTGTTCACAAGTCCTTCATTGAGGTTAATGAAGAA
GGGTCAGAAGCAGCTGTGGCCTCAGGAATGATTGCAATTAGCAGGATGGCTGTGCTGTTCCCCC
AGGTTATTGTCGACCATCCATTTTTATTTCTCATCAAGAACAGGAAAACTGGTACAATCTTATT
CATGGGACGAGTCATGCACCCTGAAACAATGAACACAAGTGGCCATGACTTTGAGGAACTTTAA
ATGATGACGTTTGAGTACAAAGGCAGCAGTAGCAAAGCACATTATGTCTTCAAGTGGTATATAT
TTAGGATTTTTGTTTTAAAGTATTACTTAAGGAAATATTTAAAATAGTTCTGGATAGTAGTAAA
TCCACGTGACCTATAAGTTAGCCTGTCCAAAAAAAAAATGTTATCAGTGTAATGACTATGGTCC
CATTGTTGCATTGTGTCTGGTGTGCTGTTGTTTAAAATAAAAGTACATATTGAAAATGTGAACA
ACTTTTTTCATTTTAGAGCTAGTTGTAGTCTATACAACACTGTATCTGAGATTTGAAAACTATG
CCATTTCTTTAGGAATTATAATAAAGTAATCCTACAAGGCAAAAATGTAGAAACCATTGTTTCT
GAGTTTTCTCATCATCTTGCAGAATCAACACCAAAGTGAGCGACATACATGTATATAATAAGCA
ATACTGTGAAGGGAAGGCAAACAGGCCACAGAAATTGAGATTGTCATTTACTGTAGGGCTCCAT
GACAAAGATTTATGAAAAAAAAGTGGGATACGTAAGGCCCACAGACTTTACTGACTTTGTGTAT
ACTGTAGTATTATACTTTTAAATTATTAAAGTATACATCTTTTATTTATTTTAAAAGTTTACTG
TGACTCAGAATTAATAACAAGCTCAGATATCTCATTAGCTATGCTAGATGGCATCAAGAGCCCC
CATAGAGGAATTTGCCTTGTACCATTGAAGTTTCAGTGAAGTTTTTGATGTTCGCACAAAGACG
AAATCACACAGTGGCACATTCTCTAGACTATACCCAAGAAAGTCACCAAGTGGGACAGTCATGA
ACCAGCAAAATAGATGTGATTACTTTATAAAAAAGAATCACTGGTAAGTGCATCATATGGAGTC
AATGCTTCTTAAACTCACACCTCGTCACCTACTACAAATTAGGTTCTTACCCAAGATATCTAAA
GCATAGTAGGGACTACATTTCAGACATCAGAATGATGCCACAGGGATTTGGCCATGAGCTTTGG
TGTTTGTCACTTGGGTTGTAAAATTTTACTTGAAGTCAGCAGCACATTTTCACAGACAGAGATT
AGAGAGAATCAGGGCGAAGGCAGGAGGTAATTAATCTGCACTAATAATACAATGCCCTTGTCAA
GCATTGGTGTGATTCCAAAGTATTTCTAGTACATACTATAGATATGTAAGATTCTTCTGTATAT
TACAACACTTGAAATATAGCTGTTAAAACATGGAGACATTTATATAGGTAATACCCATGAAAGG
ATTTATGAATATCCCAGGACACGGTACTTAATGCTGAAATCTTTTACAGCTTATATTTTCAGAG
GACTCGTAGTTTATTCATAAATCTTCACATTATTATAGAATAGTGCTCTTGTTTTCATTTATAA
TTTATGGAGCTGGGATGCCTGATGTTAATTCAGAGTTTACATTCTGTGCTAAGACCAGTCTTTA
TCTCTGTATCCTTCTTGTTAATATGACATATATGGCTATACCTATGTGTTCAATAGTTAGATAA
ATGTATTGCCTGTAAGGAAAAATAAACATCATTATGC

hide sequence

RefSeq Acc Id:

XM_008761076 ⟹ XP_008759298

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	162,645,209 - 162,731,737 (+)	NCBI
mRatBN7.2	2	160,346,403 - 160,431,818 (+)	NCBI
Rnor_6.0	2	174,013,058 - 174,110,376 (+)	NCBI

Sequence:

show sequence

CTGGGTCCAAGGATAGGCGGGGAAGAAGCCTCTGGGGACTAGATGGGTGGGTGGGCTCCACCTA
GTCCGAAGCAACAGTACGCCGCCCCCAGGACAACTCACTCCAGTGTTCACCGAGCCAGCCCGCT
GAGAAAACTAAGTCGGACCTGAGGAAGGGCCAGGTGCGATGCCAGAGGGGAGAATGTTGGAGGT
GGAGCGGCCGGAGAACCAGGAGCTAAGAGACTCAAAACCCTGTACCGCTCTGCGCCTAGGATGC
GCAGACAGCAGAGGGAGGAGCCGCGGTCGGAGCCTCGGCCAATTAGAGGCGGGGAAGGCGGAGC
TTGAATCTCAGAAGAAGCCTGGGCTCAGCCTGGTCTATAGTTTCCCTGGAGAGAGGCAAGAGCA
GGATCCCGAGCGAACACATCCTGCCCAGCATCCTCTCCAGCATCCCAAGCCAAGCCGAGGTTGC
AGGTGTGAGGGAGGGTGTTATGTAGCCCCGGAGTAGTCTCAAACTACCATTATAACTGACGATT
ACCTTGAGCACTTGATCTTCTGTCATCTACTTCACAACTTTTGGGACTATAGACACATGCAACC
GTGCCAAGTCTTATGTGGTATGGTGGCCACAAAATTAGGACATCTTTTGTCCTAAGCAAACACT
CTGCCAATTTAACCACACCCCAGCCAGAGAACCTGTTATCTAAATATCAATTAGCACTAGACTT
GAAACCATTCCATCATGGCTTACCTTGGACTGCTCTCTTTAGTGGCCTTGCAAAGTTTGGTGAC
AGGGGCAGCTTTCCCAGATGAAACCATAGCCGAGTGGTCAGTGAATGTGTATAACCATCTTCGA
GCCACTGGGGAAGATGAAAACATCCTCTTCTCTCCACTAAGCATTGCCCTTGCTATGGGGGTGA
TGGAGCTCGGGGCTCAAGGATCTACTCTGAAAGAAATCCGCCATTCAATGGGATACGAGAGCCT
GAAAAGTGGTGAAGAATTTTCTTTCCTGAGGGATTTTTCTAGCATGGTCTCTGCTGAAGAAGGC
CAATATGTGATGAAAATTGCCAATTCACTCTTTGTGCAAAACGGATTTCATATCAATGAGGAAT
TCTTGCAAATGATGAAAATGTACTTTAATGCAGAAGTCAATCATGTGGACTTCAGTGAAAATGT
GGCGGTGGCCAACTACATCAATAAGTGGGTGGAGAATTATACAAACAGTCTATTGAAAGATCTG
GTGTCCCCGGGGGATTTTGACGCTGTCACCCATCTGGCCCTTATCAATGCTGTATATTTCAAAG
GGAACTGGAAGTCTCAGTTTAGACCTGAAAATACCAGAACTTTCTCCTTCACAAAAGATGATGA
AAGTGAAGTACAGATTCCAATGATGTATCAACAAGGAGAATTTTATTACGGGGAATTTAGTGAT
GGATCCAATGAGGCTGGTGGCATCTACCAAGTCCTTGAGATACCTTATGAGGGAGACGAGATCA
GCATGATGCTGGTACTGTCCAGACAGGAAGTCCCACTGGCCACACTGGAGCCTCTGCTCAAACC
ACAGCTGATCGAAGAATGGGCAAACTCCGTGAAGAAACAAAAGGTGGAAGTCTACTTGCCCAGG
TTCACCGTGGAACAGGAAATTGATTTAAAAGACATCTTGAAAGCCCTTGGGGTCACTGAAATTT
TCATCAAAGATGCAAATTTGACTGCCATGTCAGATAAGAAAGAACTGTTCCTCTCCAAAGCTGT
TCACAAGTCCTTCATTGAGGTTAATGAAGAAGGGTCAGAAGCAGCTGTGGCCTCAGGAATGATT
GCAATTAGCAGGATGGCTGTGCTGTTCCCTCAGGTTATTGTCGACCATCCATTTTTATTTCTCA
TCAAGAACAGGAAAACTGGTACAATCTTATTCATGGGACGAGTCATGCACCCTGAAACAATGAA
CACAAGTGGCCATGACTTTGAGGAACTTTAAATGATGACGTTTGAGTACAAAGGCAGCAGTAGC
AAAGCACATTATGTCTTCAAGTGGTATATATTTAGGATTTTTGTTTTAAAGTATTACTTAAGGA
AATATTTAAAATAGTTCTGGATAGTAGTAAATCCACGTGACCTATAAGTTAGCCTGTCCAAAAA
AAAAAATGTTATCAGTGTAATGACTGTGGTCCCATTGTTGCATTGTGTCTGGTGTGCTGTTGTT
TAAAATAAAAGTACATATTGAAAATGTGAA

hide sequence

RefSeq Acc Id:

XM_063281153 ⟹ XP_063137223

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	162,645,209 - 162,731,737 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_446231	(Get FASTA)	NCBI Sequence Viewer
	XP_008759298	(Get FASTA)	NCBI Sequence Viewer
	XP_063137223	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF70386	(Get FASTA)	NCBI Sequence Viewer
	AAF70387	(Get FASTA)	NCBI Sequence Viewer
	AAH61536	(Get FASTA)	NCBI Sequence Viewer
	EDM00882	(Get FASTA)	NCBI Sequence Viewer
	EDM00883	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000013905
	ENSRNOP00000013905.4
	ENSRNOP00055001854
	ENSRNOP00060008825
	ENSRNOP00065017405
GenBank Protein	Q9JLD2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_446231 ⟸ NM_053779
- Peptide Label:	precursor
- UniProtKB:	Q9JLD1 (UniProtKB/Swiss-Prot), Q9JLD2 (UniProtKB/Swiss-Prot), A6J5Q7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAYLGLLSLVALQSLVTGAAFPDETIAEWSVNVYNHLRATGEDENILFSPLSIALAMGVMELGA QGSTLKEIRHSMGYESLKSGEEFSFLRDFSSMVSAEEGQYVMKIANSLFVQNGFHINEEFLQMM KMYFNAEVNHVDFSENVAVANYINKWVENYTNSLLKDLVSPGDFDAVTHLALINAVYFKGNWKS QFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLV LSRQEVPLATLEPLLKPQLIEEWANSVKKQKVEVYLPRFTVEQEIDLKDILKALGVTEIFIKDA NLTAMSDKKELFLSKAVHKSFIEVNEEGSEAAVASGMIAISRMAVLFPQVIVDHPFLFLIKNRK TGTILFMGRVMHPETMNTSGHDFEEL hide sequence

RefSeq Acc Id:	XP_008759298 ⟸ XM_008761076
- Peptide Label:	isoform X1
- UniProtKB:	Q9JLD1 (UniProtKB/Swiss-Prot), Q9JLD2 (UniProtKB/Swiss-Prot), A6J5Q7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAYLGLLSLVALQSLVTGAAFPDETIAEWSVNVYNHLRATGEDENILFSPLSIALAMGVMELGA QGSTLKEIRHSMGYESLKSGEEFSFLRDFSSMVSAEEGQYVMKIANSLFVQNGFHINEEFLQMM KMYFNAEVNHVDFSENVAVANYINKWVENYTNSLLKDLVSPGDFDAVTHLALINAVYFKGNWKS QFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLV LSRQEVPLATLEPLLKPQLIEEWANSVKKQKVEVYLPRFTVEQEIDLKDILKALGVTEIFIKDA NLTAMSDKKELFLSKAVHKSFIEVNEEGSEAAVASGMIAISRMAVLFPQVIVDHPFLFLIKNRK TGTILFMGRVMHPETMNTSGHDFEEL hide sequence

RefSeq Acc Id:

ENSRNOP00000013905 ⟸ ENSRNOT00000013904

RefSeq Acc Id:	XP_063137223 ⟸ XM_063281153
- Peptide Label:	isoform X1

Protein Domains

SERPIN

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9JLD2-F1-model_v2	AlphaFold	Q9JLD2	1-410	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:619896	AgrOrtholog
BioCyc Gene	G2FUF-52770	BioCyc
Ensembl Genes	ENSRNOG00000010248	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOG00055001513	UniProtKB/Swiss-Prot
	ENSRNOG00060007133	UniProtKB/Swiss-Prot
	ENSRNOG00065013647	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000013904	ENTREZGENE
	ENSRNOT00000013904.7	UniProtKB/Swiss-Prot
	ENSRNOT00055002446	UniProtKB/Swiss-Prot
	ENSRNOT00060011722	UniProtKB/Swiss-Prot
	ENSRNOT00065022448	UniProtKB/Swiss-Prot
Gene3D-CATH	2.30.39.10	UniProtKB/Swiss-Prot
	3.30.497.10	UniProtKB/Swiss-Prot
	Alpha-1-antitrypsin, domain 1	UniProtKB/TrEMBL
	Antithrombin, subunit I, domain 2	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:6920827	IMAGE-MGC_LOAD
InterPro	Serpin_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Serpin_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Serpin_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Serpin_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Serpin_sf_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Serpin_sf_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:116459	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:72736	IMAGE-MGC_LOAD
NCBI Gene	116459	ENTREZGENE
PANTHER	NEUROSERPIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11461	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Serpin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Serpini1	PhenoGen
PROSITE	SERPIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000010248	RatGTEx
	ENSRNOG00055001513	RatGTEx
	ENSRNOG00060007133	RatGTEx
	ENSRNOG00065013647	RatGTEx
SMART	SERPIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Serpins	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt	A6J5Q6_RAT	UniProtKB/TrEMBL
	A6J5Q7	ENTREZGENE, UniProtKB/TrEMBL
	NEUS_RAT	UniProtKB/Swiss-Prot
	Q9JLD1	ENTREZGENE
	Q9JLD2	ENTREZGENE
UniProt Secondary	Q9JLD1	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-04-13	Serpini1	serpin family I member 1	Serpini1	serpin peptidase inhibitor, clade I (neuroserpin), member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-10-16	Serpini1	serpin peptidase inhibitor, clade I (neuroserpin), member 1	Serpini1	serpin peptidase inhibitor, clade I, member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-03-05	Serpini1	serpin peptidase inhibitor, clade I, member 1	Serpini1	serine (or cysteine) peptidase inhibitor, clade I, member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Serpini1	serine (or cysteine) peptidase inhibitor, clade I, member 1		serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1	Name updated	1299863	APPROVED
2002-08-07	Serpini1	serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to dense-core secretory granules	633913
gene_expression	expressed by endocrine cells in the adrenal and pituitary glands	633912

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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