(+)-catechin multiple interactions ISO GCLC (Homo sapiens) 6480464 [Oxygen deficiency co-treated with Catechin] results in increased expression of GCLC mRNA CTD PMID:35883890 (+)-schisandrin B increases activity EXP 6480464 schizandrin B analog results in increased activity of GCLC protein CTD PMID:21328628 (+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of GCLC mRNA] CTD PMID:31150632 (+/-)-Aegeline multiple interactions ISO Gclc (Mus musculus) 6480464 [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 (-)-epigallocatechin 3-gallate increases expression ISO Gclc (Mus musculus) 6480464 epigallocatechin gallate results in increased expression of GCLC mRNA CTD PMID:25585349 (-)-epigallocatechin 3-gallate multiple interactions ISO GCLC (Homo sapiens) 6480464 [arsenite co-treated with epigallocatechin gallate] results in increased expression of GCLC protein CTD PMID:29572906 (1->4)-beta-D-glucan multiple interactions ISO Gclc (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of GCLC mRNA CTD PMID:36331819 (2,4,5-trichlorophenoxy)acetic acid increases expression ISO GCLC (Homo sapiens) 6480464 2 more ... CTD PMID:16426233 (2,4,5-trichlorophenoxy)acetic acid increases expression ISO Gclc (Mus musculus) 6480464 2 more ... CTD PMID:10377250 and PMID:16426233 (E)-cinnamyl alcohol increases expression ISO GCLC (Homo sapiens) 6480464 cinnamyl alcohol results in increased expression of GCLC mRNA CTD PMID:20566472 (R)-lipoic acid increases expression ISO GCLC (Homo sapiens) 6480464 Thioctic Acid results in increased expression of GCLC mRNA CTD PMID:16249512 more ... (R)-lipoic acid multiple interactions ISO GCLC (Homo sapiens) 6480464 Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLC mRNA] and Thioctic Acid results in increased expression of and results in increased activity of GCLC protein CTD PMID:26365678 (R)-lipoic acid multiple interactions ISO Gclc (Mus musculus) 6480464 Thioctic Acid inhibits the reaction [Silicon results in decreased expression of GCLC protein] CTD PMID:34252510 (R)-lipoic acid multiple interactions EXP 6480464 Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GCLC protein] more ... CTD PMID:27298056 and PMID:32061141 (R,R,R)-alpha-tocopherol multiple interactions ISO GCLC (Homo sapiens) 6480464 [alpha-Tocopherol co-treated with Paraquat] results in increased expression of GCLC mRNA CTD PMID:24530478 (RS)-coclaurine multiple interactions ISO Gclc (Mus musculus) 6480464 [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 (RS)-norcoclaurine multiple interactions ISO Gclc (Mus musculus) 6480464 [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 (S)-coclaurine multiple interactions ISO Gclc (Mus musculus) 6480464 [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 (S)-colchicine multiple interactions ISO Gclc (Mus musculus) 6480464 Colchicine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA] CTD PMID:37573684 (S)-naringenin multiple interactions ISO GCLC (Homo sapiens) 6480464 NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLC protein] CTD PMID:31254498 (S)-naringenin increases expression ISO GCLC (Homo sapiens) 6480464 naringenin results in increased expression of GCLC protein CTD PMID:31254498 (S)-nicotine multiple interactions ISO Gclc (Mus musculus) 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 1,1'-azobis(N,N-dimethylformamide) increases activity EXP 6480464 Diamide results in increased activity of GCLC protein CTD PMID:15115889 1,1'-azobis(N,N-dimethylformamide) increases expression EXP 6480464 Diamide results in increased expression of GCLC mRNA and Diamide results in increased expression of GCLC protein CTD PMID:15115889 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expression EXP 6480464 o and p'-DDT affects the expression of GCLC mRNA CTD PMID:17984292 1,2-dichloroethane multiple interactions ISO Gclc (Mus musculus) 6480464 [ethylene dichloride co-treated with Ethanol] results in increased expression of GCLC mRNA more ... CTD PMID:30664321 and PMID:37150348 1,2-dichloroethane increases expression ISO Gclc (Mus musculus) 6480464 ethylene dichloride results in increased expression of GCLC protein CTD PMID:37150348 1,2-dimethylhydrazine decreases expression ISO Gclc (Mus musculus) 6480464 1 and 2-Dimethylhydrazine results in decreased expression of GCLC mRNA CTD PMID:22206623 1,2-dimethylhydrazine multiple interactions ISO Gclc (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of GCLC mRNA CTD PMID:22206623 1,3-benzothiazole-2-thiol increases expression ISO GCLC (Homo sapiens) 6480464 captax results in increased expression of GCLC mRNA CTD PMID:20491607 1,3-dichloropropan-2-ol increases expression EXP 6480464 1 and 3-dichloro-2-propanol results in increased expression of GCLC mRNA CTD PMID:26143167 1-bromopropane multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 promotes the reaction [1-bromopropane results in increased expression of GCLC mRNA] CTD PMID:20211940 1-bromopropane increases expression ISO Gclc (Mus musculus) 6480464 1-bromopropane results in increased expression of GCLC mRNA CTD PMID:20211940 1-chloro-2,4-dinitrobenzene increases expression ISO GCLC (Homo sapiens) 6480464 Dinitrochlorobenzene results in increased expression of GCLC mRNA CTD PMID:20146380 and PMID:20566472 1-fluoro-2,4-dinitrobenzene increases expression ISO GCLC (Homo sapiens) 6480464 Dinitrofluorobenzene results in increased expression of GCLC mRNA CTD PMID:23999411 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expression ISO Gclc (Mus musculus) 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO Gclc (Mus musculus) 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of GCLC mRNA CTD PMID:20551477 1-naphthyl isothiocyanate decreases expression ISO Gclc (Mus musculus) 6480464 1-Naphthylisothiocyanate results in decreased expression of GCLC mRNA CTD PMID:37348807 1-naphthyl isothiocyanate multiple interactions ISO Gclc (Mus musculus) 6480464 [tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased expression of GCLC protein and tectorigenin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of GCLC mRNA] CTD PMID:37348807 15-deoxy-Delta(12,14)-prostaglandin J2 multiple interactions ISO GCLC (Homo sapiens) 6480464 15-deoxy-delta(12 more ... CTD PMID:21728338 15-deoxy-Delta(12,14)-prostaglandin J2 increases expression ISO GCLC (Homo sapiens) 6480464 15-deoxy-delta(12 more ... CTD PMID:21728338 17alpha-ethynylestradiol affects expression ISO GCLC (Homo sapiens) 6480464 Ethinyl Estradiol affects the expression of GCLC mRNA CTD PMID:20170705 and PMID:26865667 17beta-estradiol multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of GCLC mRNA CTD PMID:26496021 17beta-estradiol multiple interactions ISO GCLC (Homo sapiens) 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of GCLC mRNA CTD PMID:30165855 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of GCLC mRNA and Estradiol results in increased expression of GCLC protein CTD PMID:31119341 and PMID:32145629 1H-pyrazole increases expression ISO Gclc (Mus musculus) 6480464 pyrazole results in increased expression of GCLC mRNA CTD PMID:17945193 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone increases expression ISO Gclc (Mus musculus) 6480464 2' more ... CTD PMID:31029725 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone multiple interactions ISO Gclc (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [2' more ... CTD PMID:31029725 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO GCLC (Homo sapiens) 6480464 2 more ... CTD PMID:25659769 2,2',4,4'-Tetrabromodiphenyl ether multiple interactions ISO GCLC (Homo sapiens) 6480464 [Eicosapentaenoic Acid analog co-treated with Docosahexaenoic Acids analog] promotes the reaction [2 more ... CTD PMID:25659769 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Gclc (Mus musculus) 6480464 [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of GCLC mRNA more ... CTD PMID:16054899 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO GCLC (Homo sapiens) 6480464 [Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in increased expression of GCLC mRNA CTD PMID:29704546 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Gclc (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of GCLC mRNA CTD PMID:20702594 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Gclc (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of GCLC mRNA CTD PMID:15328365 more ... 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of GCLC mRNA CTD PMID:21215274 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO GCLC (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased expression of GCLC mRNA CTD PMID:19542225 and PMID:21802500 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of GCLC mRNA CTD PMID:16960034 2,3,7,8-Tetrachlorodibenzofuran affects expression ISO Gclc (Mus musculus) 6480464 2 more ... CTD PMID:20702594 2,4,6-trinitrobenzenesulfonic acid multiple interactions EXP 6480464 [Trinitrobenzenesulfonic Acid co-treated with Ethanol] results in increased expression of GCLC mRNA CTD PMID:10830784 2,4-dinitrotoluene affects expression EXP 6480464 2 and 4-dinitrotoluene affects the expression of GCLC mRNA CTD PMID:21346803 2,6-di-tert-butyl-4-methylphenol increases expression ISO Gclc (Mus musculus) 6480464 Butylated Hydroxytoluene results in increased expression of GCLC protein CTD PMID:21536018 2,6-dinitrotoluene affects expression EXP 6480464 2 and 6-dinitrotoluene affects the expression of GCLC mRNA CTD PMID:21346803 2-(chloromethyl)pyridine increases expression ISO GCLC (Homo sapiens) 6480464 2-chloromethylpyridine results in increased expression of GCLC mRNA CTD PMID:26198647 2-acetamidofluorene increases expression ISO GCLC (Homo sapiens) 6480464 2-Acetylaminofluorene results in increased expression of GCLC mRNA CTD PMID:16426233 2-acetamidofluorene multiple interactions EXP 6480464 [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCLC mRNA and [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GCLC mRNA CTD PMID:14656948 and PMID:16158176 2-acetamidofluorene increases expression ISO Gclc (Mus musculus) 6480464 2-Acetylaminofluorene results in increased expression of GCLC mRNA CTD PMID:16426233 2-amino-2-deoxy-D-galactopyranose multiple interactions ISO Gclc (Mus musculus) 6480464 8-oxoberberine promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of GCLC mRNA] more ... CTD PMID:35691465 2-amino-2-deoxy-D-glucopyranose increases expression ISO Gclc (Mus musculus) 6480464 Glucosamine analog results in increased expression of GCLC mRNA CTD PMID:21825963 2-butoxyethanol increases expression ISO Gclc (Mus musculus) 6480464 n-butoxyethanol results in increased expression of GCLC mRNA CTD PMID:19812364 2-chloroethanol increases expression EXP 6480464 Ethylene Chlorohydrin results in increased expression of GCLC mRNA and Ethylene Chlorohydrin results in increased expression of GCLC protein CTD PMID:31585129 2-chloroethanol multiple interactions EXP 6480464 allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of GCLC mRNA] more ... CTD PMID:31585129 2-hydroxyethyl methacrylate increases expression ISO GCLC (Homo sapiens) 6480464 hydroxyethyl methacrylate results in increased expression of GCLC mRNA and hydroxyethyl methacrylate results in increased expression of GCLC protein CTD PMID:30497689 2-hydroxypropanoic acid increases expression ISO GCLC (Homo sapiens) 6480464 Lactic Acid results in increased expression of GCLC mRNA CTD PMID:20566472 2-nitrofluorene increases expression EXP 6480464 2-nitrofluorene results in increased expression of GCLC mRNA CTD PMID:14600272 and PMID:15890375 2-tert-butylhydroquinone multiple interactions ISO Gclc (Mus musculus) 6480464 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA] more ... CTD PMID:19328227 more ... 2-tert-butylhydroquinone decreases expression ISO GCLC (Homo sapiens) 6480464 2-tert-butylhydroquinone results in decreased expression of GCLC mRNA CTD PMID:35724838 2-tert-butylhydroquinone increases expression ISO GCLC (Homo sapiens) 6480464 2-tert-butylhydroquinone results in increased expression of GCLC mRNA CTD PMID:27178040 and PMID:30806763 2-tert-butylhydroquinone increases expression EXP 6480464 2-tert-butylhydroquinone results in increased expression of GCLC mRNA CTD PMID:10978506 2-tert-butylhydroquinone increases activity ISO Gclc (Mus musculus) 6480464 2-tert-butylhydroquinone results in increased activity of GCLC protein CTD PMID:7955076 2-tert-butylhydroquinone affects expression ISO GCLC (Homo sapiens) 6480464 2-tert-butylhydroquinone affects the expression of GCLC mRNA CTD PMID:15946948 2-tert-butylhydroquinone increases expression ISO Gclc (Mus musculus) 6480464 2-tert-butylhydroquinone results in increased expression of GCLC mRNA CTD PMID:12007577 more ... 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:23196670 3,3',4,4',5-pentachlorobiphenyl increases expression ISO Gclc (Mus musculus) 6480464 3 more ... CTD PMID:23994337 3,3',5,5'-tetrabromobisphenol A multiple interactions ISO GCLC (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in increased expression of GCLC mRNA] CTD PMID:30951941 3,3',5,5'-tetrabromobisphenol A increases expression ISO GCLC (Homo sapiens) 6480464 tetrabromobisphenol A results in increased expression of GCLC mRNA CTD PMID:30951941 3,4-methylenedioxymethamphetamine multiple interactions EXP 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine inhibits the reaction [sulforaphane results in increased expression of GCLC mRNA] CTD PMID:21871945 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin results in decreased expression of GCLC mRNA CTD PMID:28522335 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO Gclc (Mus musculus) 6480464 [Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GCLC mRNA more ... CTD PMID:16054899 and PMID:33412187 3-nitropropanoic acid multiple interactions EXP 6480464 [naringin co-treated with 3-nitropropionic acid] results in increased expression of GCLC mRNA CTD PMID:22871521 3-O-Caffeoyl-1-O-methylquinic acid multiple interactions ISO GCLC (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of GCLC mRNA] CTD PMID:16631525 3-O-Caffeoyl-1-O-methylquinic acid increases expression ISO GCLC (Homo sapiens) 6480464 3-O-caffeoyl-1-methylquinic acid results in increased expression of GCLC mRNA CTD PMID:16631525 3-phenylprop-2-enal multiple interactions ISO GCLC (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cinnamaldehyde results in increased expression of GCLC protein] more ... CTD PMID:20351055 and PMID:21469739 3-phenylprop-2-enal increases expression ISO GCLC (Homo sapiens) 6480464 cinnamaldehyde results in increased expression of GCLC mRNA and cinnamaldehyde results in increased expression of GCLC protein CTD PMID:17178418 more ... 3H-1,2-dithiole-3-thione multiple interactions EXP 6480464 [1 and 2-dithiol-3-thione results in increased activity of GCLC protein] which results in decreased susceptibility to Acrolein CTD PMID:12535742 3H-1,2-dithiole-3-thione increases expression ISO GCLC (Homo sapiens) 6480464 1 and 2-dithiol-3-thione results in increased expression of GCLC mRNA CTD PMID:19073213 and PMID:19408115 3H-1,2-dithiole-3-thione increases expression ISO Gclc (Mus musculus) 6480464 1 more ... CTD PMID:18367636 and PMID:22959925 3H-1,2-dithiole-3-thione multiple interactions ISO Gclc (Mus musculus) 6480464 [1 more ... CTD PMID:18367636 and PMID:22495766 3H-1,2-dithiole-3-thione increases expression EXP 6480464 1 and 2-dithiol-3-thione results in increased expression of GCLC mRNA CTD PMID:15946642 3H-1,2-dithiole-3-thione increases activity EXP 6480464 1 and 2-dithiol-3-thione results in increased activity of GCLC protein CTD PMID:12535742 4,4'-methylene-bis-(2-chloroaniline) increases expression ISO GCLC (Homo sapiens) 6480464 Methylenebis(chloroaniline) results in increased expression of GCLC mRNA CTD PMID:26198647 4,4'-sulfonyldiphenol multiple interactions ISO GCLC (Homo sapiens) 6480464 [bisphenol S co-treated with cylindrospermopsin] results in increased expression of GCLC mRNA CTD PMID:32244372 4,4'-sulfonyldiphenol increases expression ISO Gclc (Mus musculus) 6480464 bisphenol S results in increased expression of GCLC mRNA CTD PMID:33297965 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression EXP 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of GCLC mRNA CTD PMID:15890375 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2 and 6-dinitrotoluene affects the expression of GCLC mRNA CTD PMID:21346803 4-hydroxy-TEMPO multiple interactions EXP 6480464 tempol inhibits the reaction [Aldosterone results in increased expression of GCLC protein] CTD PMID:24512358 and PMID:25204689 4-hydroxynon-2-enal increases expression ISO Gclc (Mus musculus) 6480464 4-hydroxy-2-nonenal results in increased expression of GCLC mRNA CTD PMID:19191707 4-hydroxynon-2-enal increases expression EXP 6480464 4-hydroxy-2-nonenal results in increased expression of GCLC protein CTD PMID:24291486 4-hydroxynon-2-enal multiple interactions EXP 6480464 NFE2L2 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GCLC mRNA] CTD PMID:24291486 4-hydroxyphenyl retinamide increases expression ISO Gclc (Mus musculus) 6480464 Fenretinide results in increased expression of GCLC mRNA CTD PMID:28973697 4-hydroxyphenyl retinamide increases expression ISO GCLC (Homo sapiens) 6480464 Fenretinide results in increased expression of GCLC mRNA CTD PMID:21319187 4-hydroxyphenyl retinamide multiple interactions ISO GCLC (Homo sapiens) 6480464 [Fenretinide co-treated with scriptaid] results in increased expression of GCLC mRNA and [Fenretinide co-treated with trichostatin A] results in increased expression of GCLC mRNA CTD PMID:21319187 4-nitro-1,2-phenylenediamine increases expression ISO GCLC (Homo sapiens) 6480464 1 and 2-diamino-4-nitrobenzene results in increased expression of GCLC mRNA CTD PMID:26198647 4-phenyl-3-furoxancarbonitrile increases expression ISO GCLC (Homo sapiens) 6480464 4-phenyl-3-furoxancarbonitrile results in increased expression of GCLC mRNA CTD PMID:22851183 4-phenyl-3-furoxancarbonitrile increases expression ISO Gclc (Mus musculus) 6480464 4-phenyl-3-furoxancarbonitrile analog results in increased expression of GCLC mRNA CTD PMID:22851183 5-(hydroxymethyl)cytosine multiple interactions ISO GCLC (Homo sapiens) 6480464 [hydroquinone affects the methylation of GCLC promoter] which results in increased abundance of 5-hydroxymethylcytosine CTD PMID:23940045 5-bromo-2'-deoxyuridine multiple interactions ISO Gclc (Mus musculus) 6480464 [Bromodeoxyuridine co-treated with furan] results in increased expression of GCLC mRNA CTD PMID:24910943 5-methylcytosine multiple interactions ISO GCLC (Homo sapiens) 6480464 [hydroquinone affects the methylation of GCLC promoter] which results in decreased abundance of 5-Methylcytosine CTD PMID:23940045 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of GCLC mRNA CTD PMID:30047161 7,8-dihydroxycoumarin increases expression ISO GCLC (Homo sapiens) 6480464 daphnetin results in increased expression of GCLC protein CTD PMID:30738023 [6]-Shogaol increases expression ISO Gclc (Mus musculus) 6480464 shogaol results in increased expression of GCLC mRNA CTD PMID:25148906 [6]-Shogaol increases expression ISO GCLC (Homo sapiens) 6480464 shogaol metabolite results in increased expression of GCLC protein and shogaol results in increased expression of GCLC protein CTD PMID:25148906 [6]-Shogaol multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of GCLC mRNA] CTD PMID:25148906 acetaldehyde increases expression EXP 6480464 Acetaldehyde results in increased expression of GCLC mRNA CTD PMID:11439094 acetic acid increases expression ISO GCLC (Homo sapiens) 6480464 Acetic Acid results in increased expression of GCLC mRNA CTD PMID:35750087 acetylcholine decreases response to substance ISO GCLC (Homo sapiens) 6480464 GCLC promoter SNP results in decreased susceptibility to Acetylcholine CTD PMID:12598062 acrolein increases expression EXP 6480464 Acrolein results in increased expression of GCLC mRNA CTD PMID:25145656 acrolein multiple interactions EXP 6480464 [1 and 2-dithiol-3-thione results in increased activity of GCLC protein] which results in decreased susceptibility to Acrolein CTD PMID:12535742 acrolein increases expression ISO GCLC (Homo sapiens) 6480464 Acrolein results in increased expression of GCLC mRNA CTD PMID:12084617 and PMID:28109747 acrylamide increases expression ISO GCLC (Homo sapiens) 6480464 Acrylamide results in increased expression of GCLC mRNA CTD PMID:32763439 acrylamide multiple interactions ISO Gclc (Mus musculus) 6480464 IL1B gene mutant form inhibits the reaction [Acrylamide results in increased expression of GCLC mRNA] CTD PMID:37540211 acrylamide increases expression ISO Gclc (Mus musculus) 6480464 Acrylamide results in increased expression of GCLC mRNA CTD PMID:37540211 actinomycin D multiple interactions ISO GCLC (Homo sapiens) 6480464 Dactinomycin inhibits the reaction [Vitamin K 3 results in increased expression of GCLC mRNA] CTD PMID:11972604 actinomycin D multiple interactions EXP 6480464 Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein] CTD PMID:24437944 Aescin multiple interactions ISO GCLC (Homo sapiens) 6480464 Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of GCLC protein] CTD PMID:36905866 Aescin increases expression ISO Gclc (Mus musculus) 6480464 Escin results in increased expression of GCLC protein CTD PMID:36905866 Aescin multiple interactions ISO Gclc (Mus musculus) 6480464 Escin inhibits the reaction [Dietary Fats results in decreased expression of GCLC protein] more ... CTD PMID:36905866 Aescin increases expression ISO GCLC (Homo sapiens) 6480464 Escin results in increased expression of GCLC protein CTD PMID:36905866 aflatoxin B1 increases expression ISO Gclc (Mus musculus) 6480464 Aflatoxin B1 results in increased expression of GCLC mRNA CTD PMID:19770486 aflatoxin B1 multiple interactions ISO Gclc (Mus musculus) 6480464 Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of GCLC mRNA] CTD PMID:35063475 aflatoxin B1 decreases expression ISO Gclc (Mus musculus) 6480464 Aflatoxin B1 results in decreased expression of GCLC mRNA CTD PMID:35063475 aflatoxin B1 decreases methylation ISO GCLC (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of GCLC gene CTD PMID:27153756 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of GCLC mRNA CTD PMID:15890375 more ... alachlor increases expression EXP 6480464 alachlor results in increased expression of GCLC protein CTD PMID:14563481 alcohol decreases expression ISO Gclc (Mus musculus) 6480464 Alcohols results in decreased expression of GCLC mRNA CTD PMID:18814483 alcohol multiple interactions ISO Gclc (Mus musculus) 6480464 Vitamin E inhibits the reaction [Alcohols results in increased expression of GCLC mRNA] CTD PMID:18814483 aldehydo-D-glucosamine increases expression ISO Gclc (Mus musculus) 6480464 Glucosamine analog results in increased expression of GCLC mRNA CTD PMID:21825963 aldosterone increases expression EXP 6480464 Aldosterone results in increased expression of GCLC protein CTD PMID:24512358 and PMID:25204689 aldosterone multiple interactions EXP 6480464 Spironolactone inhibits the reaction [Aldosterone results in increased expression of GCLC protein] and tempol inhibits the reaction [Aldosterone results in increased expression of GCLC protein] CTD PMID:24512358 and PMID:25204689 all-trans-retinal increases expression ISO GCLC (Homo sapiens) 6480464 Retinaldehyde results in increased expression of GCLC mRNA CTD PMID:25331497 and PMID:27751755 all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of GCLC mRNA and Tretinoin results in decreased expression of GCLC protein CTD PMID:30267739 all-trans-retinoic acid decreases expression ISO GCLC (Homo sapiens) 6480464 Tretinoin results in decreased expression of GCLC mRNA CTD PMID:33167477 allethrin multiple interactions EXP 6480464 [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of GCLC protein CTD PMID:34896426 alloxan multiple interactions EXP 6480464 ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCLC mRNA] more ... CTD PMID:33359794 alloxan decreases expression EXP 6480464 Alloxan results in decreased expression of GCLC mRNA and Alloxan results in decreased expression of GCLC protein CTD PMID:33359794 allyl isothiocyanate multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 protein affects the reaction [allyl isothiocyanate results in increased expression of GCLC mRNA] CTD PMID:24036144 allyl isothiocyanate increases expression ISO Gclc (Mus musculus) 6480464 allyl isothiocyanate results in increased expression of GCLC mRNA CTD PMID:24036144 allyl isothiocyanate increases activity ISO Gclc (Mus musculus) 6480464 allyl isothiocyanate results in increased activity of GCLC protein CTD PMID:24036144 alpha,alpha-trehalose multiple interactions EXP 6480464 Trehalose inhibits the reaction [cadmium acetate results in increased expression of GCLC protein] CTD PMID:29140578 alpha-D-galactose multiple interactions EXP 6480464 Saponins inhibits the reaction [Galactose results in decreased expression of GCLC mRNA] CTD PMID:25892055 alpha-D-galactose decreases expression EXP 6480464 Galactose results in decreased expression of GCLC mRNA CTD PMID:25892055 alpha-hexylcinnamaldehyde increases expression ISO GCLC (Homo sapiens) 6480464 hexyl cinnamic aldehyde results in increased expression of GCLC mRNA CTD PMID:20566472 alpha-linolenic acid increases activity ISO GCLC (Homo sapiens) 6480464 alpha-Linolenic Acid results in increased activity of GCLC protein CTD PMID:17092368 alpha-linolenic acid increases expression ISO GCLC (Homo sapiens) 6480464 alpha-Linolenic Acid results in increased expression of GCLC mRNA CTD PMID:17092368 alpha-Solamarine multiple interactions ISO Gclc (Mus musculus) 6480464 alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of GCLC protein] CTD PMID:35350913 Altertoxin II affects expression ISO GCLC (Homo sapiens) 6480464 altertoxin II affects the expression of GCLC mRNA CTD PMID:27178040 amitrole increases expression EXP 6480464 Amitrole results in increased expression of GCLC mRNA CTD PMID:30047161 amlexanox increases expression ISO Gclc (Mus musculus) 6480464 amlexanox results in increased expression of GCLC mRNA CTD PMID:31697998 amlexanox multiple interactions ISO Gclc (Mus musculus) 6480464 [Acetaminophen co-treated with amlexanox co-treated with dorsomorphin] affects the expression of GCLC mRNA and [Acetaminophen co-treated with amlexanox] affects the expression of GCLC mRNA CTD PMID:31697998 ampicillin decreases expression ISO GCLC (Homo sapiens) 6480464 Ampicillin results in decreased expression of GCLC mRNA CTD PMID:21632981 and PMID:26198647 andrographolide increases expression EXP 6480464 andrographolide results in increased expression of GCLC mRNA and andrographolide results in increased expression of GCLC protein CTD PMID:25110055 and PMID:29355602 andrographolide multiple interactions ISO GCLC (Homo sapiens) 6480464 [andrographolide co-treated with TNF protein] results in increased expression of GCLC mRNA CTD PMID:35724838 andrographolide decreases expression ISO GCLC (Homo sapiens) 6480464 andrographolide results in decreased expression of GCLC mRNA CTD PMID:35724838 andrographolide multiple interactions ISO Gclc (Mus musculus) 6480464 andrographolide inhibits the reaction [Acetaminophen results in decreased expression of GCLC mRNA] CTD PMID:29355602 andrographolide increases expression ISO GCLC (Homo sapiens) 6480464 andrographolide results in increased expression of GCLC protein CTD PMID:29355602 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO GCLC (Homo sapiens) 6480464 pyrazolanthrone inhibits the reaction [[clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA] more ... CTD PMID:21469739 and PMID:25881548 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO Gclc (Mus musculus) 6480464 pyrazolanthrone inhibits the reaction [Ozone results in increased expression of GCLC mRNA] and pyrazolanthrone promotes the reaction [arsenite results in increased expression of GCLC mRNA] CTD PMID:17460151 and PMID:19328227 antimonite multiple interactions ISO GCLC (Homo sapiens) 6480464 [Antimony Potassium Tartrate results in increased abundance of antimonite] which results in increased expression of GCLC mRNA CTD PMID:32076005 antimony(0) multiple interactions ISO GCLC (Homo sapiens) 6480464 GCLC protein inhibits the reaction [ABCC1 protein results in decreased susceptibility to Antimony] CTD PMID:11560771 apigenin increases expression ISO GCLC (Homo sapiens) 6480464 Apigenin results in increased expression of GCLC mRNA CTD PMID:11864778 apigenin increases expression EXP 6480464 Apigenin results in increased expression of GCLC mRNA and Apigenin results in increased expression of GCLC protein CTD PMID:22864849 apigenin multiple interactions EXP 6480464 [Apigenin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide CTD PMID:22864849 arachidonic acid increases activity ISO GCLC (Homo sapiens) 6480464 Arachidonic Acid results in increased activity of GCLC protein CTD PMID:17092368 arachidonic acid increases expression ISO GCLC (Homo sapiens) 6480464 Arachidonic Acid results in increased expression of GCLC mRNA CTD PMID:16704987 and PMID:17092368 Aroclor 1254 decreases expression ISO Gclc (Mus musculus) 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of GCLC mRNA CTD PMID:23650126 arotinoid acid multiple interactions ISO GCLC (Homo sapiens) 6480464 [4-(2-(5 more ... CTD PMID:34480604 arsane increases expression ISO GCLC (Homo sapiens) 6480464 Arsenic results in increased expression of GCLC mRNA and Arsenic results in increased expression of GCLC protein CTD PMID:18487201 and PMID:19945496 arsane multiple interactions ISO GCLC (Homo sapiens) 6480464 [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GCLC mRNA more ... CTD PMID:29751399 more ... arsane affects response to substance ISO GCLC (Homo sapiens) 6480464 GCLC gene SNP affects the susceptibility to Arsenic CTD PMID:29751399 arsane increases expression ISO Gclc (Mus musculus) 6480464 Arsenic results in increased expression of GCLC mRNA and Arsenic results in increased expression of GCLC protein CTD PMID:23000044 and PMID:35523338 arsane multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 mRNA affects the reaction [Arsenic results in increased expression of GCLC mRNA] and NFE2L2 protein affects the reaction [Arsenic results in increased expression of GCLC protein] CTD PMID:23000044 and PMID:35523338 arsenic atom increases expression ISO GCLC (Homo sapiens) 6480464 Arsenic results in increased expression of GCLC mRNA and Arsenic results in increased expression of GCLC protein CTD PMID:18487201 and PMID:19945496 arsenic atom multiple interactions ISO GCLC (Homo sapiens) 6480464 [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GCLC mRNA more ... CTD PMID:29751399 more ... arsenic atom affects response to substance ISO GCLC (Homo sapiens) 6480464 GCLC gene SNP affects the susceptibility to Arsenic CTD PMID:29751399 arsenic atom multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 mRNA affects the reaction [Arsenic results in increased expression of GCLC mRNA] and NFE2L2 protein affects the reaction [Arsenic results in increased expression of GCLC protein] CTD PMID:23000044 and PMID:35523338 arsenic atom increases expression ISO Gclc (Mus musculus) 6480464 Arsenic results in increased expression of GCLC mRNA and Arsenic results in increased expression of GCLC protein CTD PMID:23000044 and PMID:35523338 arsenite(3-) multiple interactions ISO Gclc (Mus musculus) 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [arsenite results in increased expression of GCLC mRNA] more ... CTD PMID:15894712 more ... arsenite(3-) multiple interactions ISO GCLC (Homo sapiens) 6480464 [arsenite co-treated with epigallocatechin gallate] results in increased expression of GCLC protein more ... CTD PMID:22476201 more ... arsenite(3-) increases expression ISO GCLC (Homo sapiens) 6480464 arsenite results in increased expression of GCLC mRNA and arsenite results in increased expression of GCLC protein CTD PMID:22476201 arsenite(3-) increases expression ISO Gclc (Mus musculus) 6480464 arsenite results in increased expression of GCLC mRNA and arsenite results in increased expression of GCLC protein CTD PMID:15894712 more ... arsenous acid multiple interactions ISO GCLC (Homo sapiens) 6480464 [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GCLC mRNA and [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GCLC protein CTD PMID:33434570 arsenous acid multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 protein affects the reaction [Arsenic Trioxide results in increased expression of GCLC mRNA] CTD PMID:29049341 arsenous acid decreases response to substance ISO GCLC (Homo sapiens) 6480464 GCLC protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 and PMID:29549912 arsenous acid increases expression ISO Gclc (Mus musculus) 6480464 Arsenic Trioxide results in increased expression of GCLC mRNA CTD PMID:29049341 arsenous acid increases expression ISO GCLC (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of GCLC mRNA and Arsenic Trioxide results in increased expression of GCLC protein CTD PMID:19417148 more ... arsenous acid decreases expression ISO GCLC (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of GCLC protein CTD PMID:25341331 and PMID:25419056 artesunate affects response to substance ISO GCLC (Homo sapiens) 6480464 GCLC mRNA affects the susceptibility to artesunate CTD PMID:15796179 artesunate decreases response to substance ISO GCLC (Homo sapiens) 6480464 GCLC mRNA results in decreased susceptibility to artesunate CTD PMID:15796179 astilbin multiple interactions ISO GCLC (Homo sapiens) 6480464 astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA] CTD PMID:29471006 atrazine increases expression ISO Gclc (Mus musculus) 6480464 Atrazine results in increased expression of GCLC mRNA CTD PMID:36216167 atrazine multiple interactions ISO Gclc (Mus musculus) 6480464 Lycopene inhibits the reaction [Atrazine results in increased expression of GCLC mRNA] CTD PMID:36216167 Augmentin increases expression ISO GCLC (Homo sapiens) 6480464 Amoxicillin-Potassium Clavulanate Combination results in increased expression of GCLC mRNA CTD PMID:34767876 azathioprine increases expression ISO GCLC (Homo sapiens) 6480464 Azathioprine results in increased expression of GCLC mRNA CTD PMID:22623647 and PMID:26198647 Bandrowski's base increases expression ISO GCLC (Homo sapiens) 6480464 Bandrowski's base results in increased expression of GCLC mRNA CTD PMID:20566472 Bardoxolone methyl increases expression ISO GCLC (Homo sapiens) 6480464 bardoxolone methyl results in increased expression of GCLC mRNA and bardoxolone methyl results in increased expression of GCLC protein CTD PMID:27480280 and PMID:34480604 Bardoxolone methyl decreases expression ISO GCLC (Homo sapiens) 6480464 bardoxolone methyl results in decreased expression of GCLC mRNA CTD PMID:35724838 bellidifolin increases expression EXP 6480464 bellidifolin results in increased expression of GCLC mRNA and bellidifolin results in increased expression of GCLC protein CTD PMID:30800665 benzalkonium chloride increases expression ISO GCLC (Homo sapiens) 6480464 Benzalkonium Compounds results in increased expression of GCLC mRNA CTD PMID:30806763 benzene affects expression EXP 6480464 Benzene affects the expression of GCLC mRNA CTD PMID:15878777 benzene multiple interactions ISO Gclc (Mus musculus) 6480464 Deferoxamine inhibits the reaction [Benzene results in decreased expression of GCLC mRNA] and ferrostatin-1 inhibits the reaction [Benzene results in decreased expression of GCLC mRNA] CTD PMID:35661779 benzene decreases expression ISO Gclc (Mus musculus) 6480464 Benzene results in decreased expression of GCLC mRNA CTD PMID:35661779 benzidine increases expression ISO GCLC (Homo sapiens) 6480464 benzidine results in increased expression of GCLC mRNA CTD PMID:26198647 benzo[a]pyrene multiple interactions ISO GCLC (Homo sapiens) 6480464 [Cadmium Chloride co-treated with Benzo(a)pyrene] results in increased expression of GCLC mRNA CTD PMID:25170436 benzo[a]pyrene increases methylation ISO GCLC (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of GCLC promoter CTD PMID:27901495 benzo[a]pyrene decreases methylation ISO GCLC (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased methylation of GCLC 3' UTR CTD PMID:27901495 benzo[a]pyrene increases expression ISO GCLC (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of GCLC mRNA CTD PMID:20106945 more ... benzo[a]pyrene increases expression ISO Gclc (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of GCLC mRNA CTD PMID:14625279 more ... benzo[a]pyrene multiple interactions ISO Gclc (Mus musculus) 6480464 [arsenite co-treated with Benzo(a)pyrene] results in increased expression of GCLC mRNA more ... CTD PMID:14625279 more ... benzo[a]pyrene diol epoxide I decreases expression ISO GCLC (Homo sapiens) 6480464 7 more ... CTD PMID:19150397 benzoic acid increases expression ISO GCLC (Homo sapiens) 6480464 Benzoic Acid results in increased expression of GCLC mRNA CTD PMID:20566472 benzoquinones increases expression ISO Gclc (Mus musculus) 6480464 Benzoquinones analog results in increased expression of GCLC protein CTD PMID:21651925 berberine multiple interactions EXP 6480464 Berberine inhibits the reaction [Bortezomib results in increased expression of GCLC mRNA] CTD PMID:35121005 beta-D-glucosamine increases expression ISO Gclc (Mus musculus) 6480464 Glucosamine analog results in increased expression of GCLC mRNA CTD PMID:21825963 beta-naphthoflavone increases expression ISO GCLC (Homo sapiens) 6480464 beta-Naphthoflavone results in increased expression of GCLC mRNA CTD PMID:16426233 beta-naphthoflavone increases expression ISO Gclc (Mus musculus) 6480464 beta-Naphthoflavone results in increased expression of GCLC mRNA CTD PMID:16426233 and PMID:23994337 bis(2-ethylhexyl) phthalate increases expression ISO Gclc (Mus musculus) 6480464 Diethylhexyl Phthalate results in increased expression of GCLC mRNA CTD PMID:35917956 more ... bis(2-ethylhexyl) phthalate multiple interactions ISO Gclc (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in decreased expression of GCLC mRNA and Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of GCLC mRNA] CTD PMID:35917956 more ... bisphenol A affects expression ISO GCLC (Homo sapiens) 6480464 bisphenol A affects the expression of GCLC mRNA CTD PMID:20170705 and PMID:30903817 bisphenol A multiple interactions ISO Gclc (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in decreased expression of GCLC mRNA CTD PMID:37364641 bisphenol A multiple interactions ISO GCLC (Homo sapiens) 6480464 [bisphenol A co-treated with cylindrospermopsin] results in increased expression of GCLC mRNA CTD PMID:32244372 bisphenol A decreases expression ISO Gclc (Mus musculus) 6480464 bisphenol A results in decreased expression of GCLC mRNA CTD PMID:30547568 and PMID:32156529 bisphenol A increases expression ISO GCLC (Homo sapiens) 6480464 bisphenol A results in increased expression of GCLC and bisphenol A results in increased expression of GCLC protein CTD PMID:31207516 and PMID:34186270 bisphenol A increases expression ISO Gclc (Mus musculus) 6480464 bisphenol A results in increased expression of GCLC mRNA and bisphenol A results in increased expression of GCLC protein CTD PMID:28796629 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of GCLC mRNA CTD PMID:25181051 more ... bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of GCLC mRNA CTD PMID:26496021 Bisphenol B increases expression ISO GCLC (Homo sapiens) 6480464 bisphenol B results in increased expression of GCLC protein CTD PMID:34186270 bisphenol F multiple interactions ISO GCLC (Homo sapiens) 6480464 [bisphenol F co-treated with cylindrospermopsin] results in increased expression of GCLC mRNA CTD PMID:32244372 bisphenol F increases expression ISO GCLC (Homo sapiens) 6480464 bisphenol F results in increased expression of GCLC protein CTD PMID:34186270 bleomycin A2 multiple interactions ISO Gclc (Mus musculus) 6480464 caffeic acid phenethyl ester inhibits the reaction [Bleomycin results in decreased expression of GCLC protein] CTD PMID:23570914 bleomycin A2 decreases expression ISO Gclc (Mus musculus) 6480464 Bleomycin results in decreased expression of GCLC protein CTD PMID:23570914 bleomycin A5 increases expression ISO GCLC (Homo sapiens) 6480464 bleomycetin results in increased expression of GCLC mRNA CTD PMID:21040473 boric acid increases expression ISO Gclc (Mus musculus) 6480464 boric acid results in increased expression of GCLC mRNA CTD PMID:30196486 boric acid increases expression ISO GCLC (Homo sapiens) 6480464 boric acid results in increased expression of GCLC mRNA CTD PMID:30196486 boric acid multiple interactions ISO Gclc (Mus musculus) 6480464 EIF2AK3 protein affects the reaction [boric acid results in increased expression of GCLC mRNA] CTD PMID:30196486 bortezomib increases expression EXP 6480464 Bortezomib results in increased expression of GCLC mRNA CTD PMID:35121005 bortezomib multiple interactions EXP 6480464 Berberine inhibits the reaction [Bortezomib results in increased expression of GCLC mRNA] CTD PMID:35121005 bosentan increases expression ISO GCLC (Homo sapiens) 6480464 Bosentan results in increased expression of GCLC mRNA CTD PMID:29761207 Brodifacoum increases expression EXP 6480464 bromfenacoum results in increased expression of GCLC protein CTD PMID:28903499 bromobenzene increases expression ISO Gclc (Mus musculus) 6480464 bromobenzene results in increased expression of GCLC protein CTD PMID:18078705 Bromochloroacetonitrile increases expression ISO GCLC (Homo sapiens) 6480464 bromochloroacetonitrile results in increased expression of GCLC mRNA CTD PMID:35842135 Brusatol decreases expression ISO GCLC (Homo sapiens) 6480464 brusatol results in decreased expression of GCLC protein CTD PMID:27639429 buspirone decreases expression EXP 6480464 Buspirone results in decreased expression of GCLC mRNA CTD PMID:24136188 buta-1,3-diene affects expression ISO Gclc (Mus musculus) 6480464 1 and 3-butadiene affects the expression of GCLC mRNA CTD PMID:29038090 butanal decreases expression ISO GCLC (Homo sapiens) 6480464 butyraldehyde results in decreased expression of GCLC mRNA CTD PMID:26079696 butane-2,3-dione increases expression EXP 6480464 Diacetyl results in increased expression of GCLC mRNA CTD PMID:25145656 butylated hydroxyanisole increases expression ISO GCLC (Homo sapiens) 6480464 Butylated Hydroxyanisole results in increased expression of GCLC mRNA CTD PMID:16426233 butylated hydroxyanisole increases expression ISO Gclc (Mus musculus) 6480464 Butylated Hydroxyanisole results in increased expression of GCLC mRNA and Butylated Hydroxyanisole results in increased expression of GCLC protein CTD PMID:16426233 and PMID:25922074 Butylbenzyl phthalate multiple interactions ISO Gclc (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in decreased expression of GCLC mRNA CTD PMID:37364641 cadmium atom increases expression ISO GCLC (Homo sapiens) 6480464 Cadmium results in increased expression of GCLC mRNA CTD PMID:21120746 cadmium atom increases expression ISO Gclc (Mus musculus) 6480464 Cadmium results in increased expression of GCLC mRNA CTD PMID:26363317 cadmium atom decreases expression ISO Gclc (Mus musculus) 6480464 Cadmium results in decreased expression of GCLC mRNA CTD PMID:37270049 cadmium atom multiple interactions ISO Gclc (Mus musculus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GCLC mRNA more ... CTD PMID:33398418 cadmium atom multiple interactions ISO GCLC (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GCLC protein and [GCLC results in decreased uptake of Cadmium] which results in decreased expression of SLC39A8 CTD PMID:18556457 and PMID:30359721 cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of GCLC and Cadmium results in increased expression of GCLC mRNA CTD PMID:19879314 and PMID:25388156 cadmium dichloride multiple interactions ISO GCLC (Homo sapiens) 6480464 [Cadmium Chloride co-treated with Benzo(a)pyrene] results in increased expression of GCLC mRNA more ... CTD PMID:18556457 more ... cadmium dichloride multiple interactions ISO Gclc (Mus musculus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GCLC mRNA more ... CTD PMID:33398418 cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of GCLC mRNA CTD PMID:25993096 cadmium dichloride increases expression ISO GCLC (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of GCLC mRNA and Cadmium Chloride results in increased expression of GCLC protein CTD PMID:24291162 more ... cadmium dichloride increases expression ISO Gclc (Mus musculus) 6480464 Cadmium Chloride results in increased expression of GCLC mRNA and Cadmium Chloride results in increased expression of GCLC protein CTD PMID:22677785 and PMID:29486218 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of GCLC mRNA CTD PMID:11254161 cadmium dichloride multiple interactions EXP 6480464 Cadmium Chloride results in increased expression of and results in increased activity of GCLC protein and GCLC affects the reaction [NFE2L2 protein results in decreased susceptibility to Cadmium Chloride] CTD PMID:11254161 and PMID:19682480 cadmium dichloride decreases uptake ISO GCLC (Homo sapiens) 6480464 GCLC results in decreased uptake of Cadmium Chloride CTD PMID:18556457 cadmium dichloride decreases response to substance ISO GCLC (Homo sapiens) 6480464 GCLC results in decreased susceptibility to Cadmium Chloride CTD PMID:18556457 cadmium sulfate multiple interactions ISO GCLC (Homo sapiens) 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GCLC mRNA CTD PMID:18654764 cadmium sulfate increases expression ISO Gclc (Mus musculus) 6480464 cadmium sulfate results in increased expression of GCLC mRNA CTD PMID:16221973 cadmium sulfate increases expression ISO GCLC (Homo sapiens) 6480464 cadmium sulfate results in increased expression of GCLC mRNA CTD PMID:12064557 cadmium sulfide decreases expression ISO GCLC (Homo sapiens) 6480464 cadmium sulfide results in decreased expression of GCLC mRNA CTD PMID:27866839 cafestol multiple interactions EXP 6480464 [cafestol co-treated with kahweol] inhibits the reaction [ochratoxin A results in decreased expression of GCLC protein] CTD PMID:17110534 caffeine multiple interactions ISO Gclc (Mus musculus) 6480464 [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 caffeine decreases phosphorylation ISO GCLC (Homo sapiens) 6480464 Caffeine results in decreased phosphorylation of GCLC protein CTD PMID:35688186 calcitriol multiple interactions EXP 6480464 [Calcium co-treated with Calcitriol] affects the expression of GCLC mRNA CTD PMID:15913539 calcium atom multiple interactions EXP 6480464 [Calcium co-treated with Calcitriol] affects the expression of GCLC mRNA CTD PMID:15913539 calcium(0) multiple interactions EXP 6480464 [Calcium co-treated with Calcitriol] affects the expression of GCLC mRNA CTD PMID:15913539 cannabidiol increases expression ISO GCLC (Homo sapiens) 6480464 Cannabidiol results in increased expression of GCLC mRNA CTD PMID:31518892 captan increases expression ISO Gclc (Mus musculus) 6480464 Captan results in increased expression of GCLC mRNA CTD PMID:31558096 carbamazepine affects expression ISO GCLC (Homo sapiens) 6480464 Carbamazepine affects the expression of GCLC mRNA CTD PMID:24752500 carbon disulfide increases expression EXP 6480464 Carbon Disulfide results in increased expression of GCLC mRNA CTD PMID:27530093 carbon monoxide increases expression EXP 6480464 Carbon Monoxide results in increased expression of GCLC mRNA CTD PMID:34032369 carbon monoxide multiple interactions EXP 6480464 [NFE2L2 protein co-treated with Carbon Monoxide] results in increased expression of GCLC mRNA CTD PMID:34032369 carbon nanotube increases expression ISO Gclc (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25554681 carbon nanotube decreases expression ISO Gclc (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25620056 carmustine multiple interactions EXP 6480464 [Buthionine Sulfoximine co-treated with Carmustine] results in decreased activity of GCLC protein and [Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of GCLC protein CTD PMID:12967637 and PMID:16288907 carnosic acid multiple interactions ISO GCLC (Homo sapiens) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GCLC protein] more ... CTD PMID:25446857 more ... carnosic acid multiple interactions EXP 6480464 salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLC protein] CTD PMID:25446857 carnosic acid increases expression ISO Gclc (Mus musculus) 6480464 salvin results in increased expression of GCLC mRNA CTD PMID:18329808 carnosic acid increases expression ISO GCLC (Homo sapiens) 6480464 salvin results in increased expression of GCLC protein CTD PMID:26577515 and PMID:26686574 Carnosol increases expression ISO GCLC (Homo sapiens) 6480464 carnosol results in increased expression of GCLC mRNA CTD PMID:20116392 celastrol multiple interactions EXP 6480464 celastrol inhibits the reaction [Doxorubicin results in decreased expression of GCLC mRNA] and celastrol inhibits the reaction [Doxorubicin results in decreased expression of GCLC protein] CTD PMID:30588110 ceric oxide decreases expression EXP 6480464 ceric oxide results in decreased expression of GCLC mRNA CTD PMID:29463257 cerium trichloride increases expression ISO GCLC (Homo sapiens) 6480464 cerous chloride results in increased expression of GCLC mRNA CTD PMID:28954213 cerium trichloride multiple interactions ISO GCLC (Homo sapiens) 6480464 [cerous chloride co-treated with lanthanum chloride] results in increased expression of GCLC mRNA CTD PMID:28954213 chenodeoxycholic acid multiple interactions ISO GCLC (Homo sapiens) 6480464 [Chenodeoxycholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione CTD PMID:17724089 chenodeoxycholic acid increases expression ISO GCLC (Homo sapiens) 6480464 Chenodeoxycholic Acid results in increased expression of GCLC protein CTD PMID:17724089 CHIR 99021 multiple interactions ISO GCLC (Homo sapiens) 6480464 [4-(2-(5 more ... CTD PMID:34480604 chlorambucil multiple interactions ISO GCLC (Homo sapiens) 6480464 [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Chlorambucil CTD PMID:10900222 chloroacetaldehyde increases expression ISO GCLC (Homo sapiens) 6480464 chloroacetaldehyde results in increased expression of GCLC mRNA CTD PMID:25596134 Chloroacetonitrile increases expression ISO GCLC (Homo sapiens) 6480464 chloroacetonitrile results in increased expression of GCLC mRNA CTD PMID:35842135 chlorogenic acid increases expression ISO GCLC (Homo sapiens) 6480464 Chlorogenic Acid results in increased expression of GCLC mRNA CTD PMID:29136249 chlorogenic acid multiple interactions ISO GCLC (Homo sapiens) 6480464 Chlorogenic Acid promotes the reaction [Acetaminophen results in increased expression of GCLC mRNA] CTD PMID:29136249 chlorohydrocarbon decreases activity ISO GCLC (Homo sapiens) 6480464 Hydrocarbons and Chlorinated analog results in decreased activity of GCLC protein CTD PMID:24355586 chlorohydrocarbon multiple interactions ISO GCLC (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [Hydrocarbons and Chlorinated analog results in increased expression of GCLC protein] CTD PMID:24355586 chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of GCLC mRNA CTD PMID:23125180 chloroprene increases expression ISO Gclc (Mus musculus) 6480464 Chloroprene results in increased expression of GCLC mRNA CTD PMID:23125180 chlorpromazine decreases expression EXP 6480464 Chlorpromazine results in decreased expression of GCLC mRNA CTD PMID:25596134 chlorpyrifos multiple interactions ISO Gclc (Mus musculus) 6480464 Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GCLC mRNA] CTD PMID:32955216 chlorpyrifos decreases expression ISO Gclc (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of GCLC mRNA CTD PMID:32955216 and PMID:37019170 cholesterol increases expression ISO Gclc (Mus musculus) 6480464 Cholesterol results in increased expression of GCLC protein CTD PMID:29486218 choline multiple interactions ISO Gclc (Mus musculus) 6480464 [Choline deficiency co-treated with Methionine deficiency] results in increased expression of GCLC mRNA and NFE2L2 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of GCLC mRNA] CTD PMID:20350562 chromium atom multiple interactions ISO GCLC (Homo sapiens) 6480464 [chromous chloride results in increased abundance of Chromium] which results in decreased expression of GCLC protein CTD PMID:30359721 chromium trinitrate increases expression ISO GCLC (Homo sapiens) 6480464 chromium nitrate results in increased expression of GCLC mRNA CTD PMID:20491607 chromium(6+) multiple interactions ISO Gclc (Mus musculus) 6480464 [Arsenates co-treated with chromium hexavalent ion] results in increased expression of GCLC mRNA more ... CTD PMID:19895865 and PMID:25820237 chromium(6+) increases expression EXP 6480464 chromium hexavalent ion results in increased expression of GCLC protein CTD PMID:18306314 chrysin multiple interactions EXP 6480464 [Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]] more ... CTD PMID:22864849 and PMID:33121995 chrysin increases expression EXP 6480464 chrysin results in increased expression of GCLC mRNA and chrysin results in increased expression of GCLC protein CTD PMID:22864849 cidofovir anhydrous decreases expression ISO GCLC (Homo sapiens) 6480464 Cidofovir results in decreased expression of GCLC mRNA CTD PMID:25596134 cinnamyl alcohol increases expression ISO GCLC (Homo sapiens) 6480464 cinnamyl alcohol results in increased expression of GCLC mRNA CTD PMID:20566472 ciprofibrate decreases activity EXP 6480464 ciprofibrate results in decreased activity of GCLC protein CTD PMID:7676460 ciprofibrate decreases expression EXP 6480464 ciprofibrate results in decreased expression of GCLC mRNA CTD PMID:7676460 cisplatin multiple interactions ISO GCLC (Homo sapiens) 6480464 astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA] more ... CTD PMID:17628013 more ... cisplatin decreases response to substance ISO GCLC (Homo sapiens) 6480464 GCLC protein results in decreased susceptibility to Cisplatin CTD PMID:29549912 cisplatin decreases expression ISO Gclc (Mus musculus) 6480464 Cisplatin results in decreased expression of GCLC mRNA CTD PMID:32428544 cisplatin increases expression ISO GCLC (Homo sapiens) 6480464 Cisplatin results in increased expression of GCLC mRNA CTD PMID:27480280 and PMID:28959534 cisplatin decreases expression ISO GCLC (Homo sapiens) 6480464 Cisplatin results in decreased expression of GCLC mRNA CTD PMID:25596134 and PMID:29471006 cisplatin increases expression ISO Gclc (Mus musculus) 6480464 Cisplatin results in increased expression of GCLC mRNA and Cisplatin results in increased expression of GCLC protein CTD PMID:20605904 cisplatin multiple interactions ISO Gclc (Mus musculus) 6480464 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA] more ... CTD PMID:20605904 and PMID:32428544 cisplatin increases phosphorylation ISO Gclc (Mus musculus) 6480464 Cisplatin results in increased phosphorylation of GCLC protein CTD PMID:22006019 citraconic acid increases expression EXP 6480464 citraconic acid results in increased expression of GCLC protein CTD PMID:27277809 citraconic acid increases expression ISO Gclc (Mus musculus) 6480464 citraconic acid results in increased expression of GCLC mRNA CTD PMID:27277809 clavulanic acid increases expression ISO GCLC (Homo sapiens) 6480464 Clavulanic Acid results in increased expression of GCLC mRNA CTD PMID:34767876 Clivoline multiple interactions ISO GCLC (Homo sapiens) 6480464 [clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA and pyrazolanthrone inhibits the reaction [[clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA] CTD PMID:25881548 clobetasol decreases expression ISO GCLC (Homo sapiens) 6480464 Clobetasol results in decreased expression of GCLC mRNA CTD PMID:16882163 clodronic acid decreases expression ISO GCLC (Homo sapiens) 6480464 Clodronic Acid results in decreased expression of GCLC mRNA CTD PMID:25596134 cobalt dichloride multiple interactions ISO GCLC (Homo sapiens) 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GCLC mRNA more ... CTD PMID:18654764 and PMID:29966676 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of GCLC mRNA CTD PMID:24386269 cobalt dichloride increases expression ISO GCLC (Homo sapiens) 6480464 cobaltous chloride results in increased expression of GCLC mRNA CTD PMID:19320972 and PMID:29966676 cocaine multiple interactions ISO Gclc (Mus musculus) 6480464 PRKCD protein affects the reaction [Cocaine results in increased expression of GCLC mRNA] and rottlerin promotes the reaction [Cocaine results in increased expression of GCLC mRNA] CTD PMID:30393195 cocaine increases expression ISO Gclc (Mus musculus) 6480464 Cocaine results in increased expression of GCLC mRNA CTD PMID:30393195 coniferyl aldehyde increases expression ISO GCLC (Homo sapiens) 6480464 coniferaldehyde results in increased expression of GCLC mRNA CTD PMID:26275128 conjugated linoleic acid increases activity ISO GCLC (Homo sapiens) 6480464 Linoleic Acids and Conjugated results in increased activity of GCLC protein CTD PMID:17092368 conjugated linoleic acid multiple interactions ISO GCLC (Homo sapiens) 6480464 [Linoleic Acids and Conjugated results in increased activity of GCLC protein] which results in decreased susceptibility to tert-Butylhydroperoxide CTD PMID:17092368 conjugated linoleic acid increases expression ISO GCLC (Homo sapiens) 6480464 Linoleic Acids and Conjugated results in increased expression of GCLC mRNA CTD PMID:17092368 copper atom decreases expression EXP 6480464 Copper results in decreased expression of GCLC mRNA CTD PMID:22465980 copper atom multiple interactions ISO GCLC (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of GCLC mRNA more ... CTD PMID:19747488 more ... copper atom increases expression ISO GCLC (Homo sapiens) 6480464 Copper results in increased expression of GCLC mRNA CTD PMID:19747488 copper(0) decreases expression EXP 6480464 Copper results in decreased expression of GCLC mRNA CTD PMID:22465980 copper(0) multiple interactions ISO GCLC (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of GCLC mRNA more ... CTD PMID:19747488 more ... copper(0) increases expression ISO GCLC (Homo sapiens) 6480464 Copper results in increased expression of GCLC mRNA CTD PMID:19747488 copper(II) chloride increases expression ISO GCLC (Homo sapiens) 6480464 cupric chloride results in increased expression of GCLC mRNA CTD PMID:17211630 copper(II) sulfate increases expression ISO GCLC (Homo sapiens) 6480464 Copper Sulfate results in increased expression of GCLC mRNA CTD PMID:19549813 cortisol increases expression EXP 6480464 Hydrocortisone results in increased expression of GCLC mRNA CTD PMID:10978506 cortisol multiple interactions ISO GCLC (Homo sapiens) 6480464 [4-(2-(5 more ... CTD PMID:34480604 coumarin increases expression EXP 6480464 coumarin results in increased expression of GCLC mRNA CTD PMID:18480146 crocidolite asbestos increases expression ISO Gclc (Mus musculus) 6480464 Asbestos more ... CTD PMID:15520183 crocidolite asbestos multiple interactions ISO Gclc (Mus musculus) 6480464 [GCLC protein co-treated with GCLM protein] inhibits the reaction [Asbestos more ... CTD PMID:15520183 cumene hydroperoxide increases expression ISO Gclc (Mus musculus) 6480464 cumene hydroperoxide results in increased expression of GCLC mRNA CTD PMID:30547568 curcumin increases activity ISO GCLC (Homo sapiens) 6480464 Curcumin results in increased activity of GCLC protein CTD PMID:10514034 curcumin multiple interactions ISO Gclc (Mus musculus) 6480464 Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of GCLC mRNA] more ... CTD PMID:29571711 more ... curcumin increases expression ISO GCLC (Homo sapiens) 6480464 Curcumin analog results in increased expression of GCLC mRNA and Curcumin results in increased expression of GCLC mRNA CTD PMID:23710286 and PMID:23954767 curcumin multiple interactions ISO GCLC (Homo sapiens) 6480464 Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GCLC mRNA] more ... CTD PMID:23954767 and PMID:31521693 curcumin increases expression EXP 6480464 Curcumin results in increased expression of GCLC mRNA and Curcumin results in increased expression of GCLC protein CTD PMID:17602960 more ... curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [Ketamine results in decreased expression of GCLC mRNA] more ... CTD PMID:17602960 more ... curcumin increases expression ISO Gclc (Mus musculus) 6480464 Curcumin results in increased expression of GCLC mRNA and Curcumin results in increased expression of GCLC protein CTD PMID:19168576 more ... cycloheximide multiple interactions ISO Gclc (Mus musculus) 6480464 Cycloheximide inhibits the reaction [arsenite results in increased activity of [GCLC protein binds to GCLM protein]] more ... CTD PMID:17628625 and PMID:19328227 cycloheximide multiple interactions EXP 6480464 Cycloheximide inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein] CTD PMID:24437944 cyclophosphamide multiple interactions ISO Gclc (Mus musculus) 6480464 Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of GCLC protein] CTD PMID:27633142 cyclophosphamide decreases expression ISO Gclc (Mus musculus) 6480464 Cyclophosphamide results in decreased expression of GCLC mRNA and Cyclophosphamide results in decreased expression of GCLC protein CTD PMID:27633142 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of GCLC mRNA CTD PMID:11589784 and PMID:25596134 cyclosporin A increases expression ISO GCLC (Homo sapiens) 6480464 Cyclosporine results in increased expression of GCLC mRNA CTD PMID:20106945 more ... cyhalothrin multiple interactions EXP 6480464 [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of GCLC protein CTD PMID:34896426 cylindrospermopsin increases expression ISO GCLC (Homo sapiens) 6480464 cylindrospermopsin results in increased expression of GCLC mRNA CTD PMID:23726867 and PMID:32244372 cylindrospermopsin multiple interactions ISO GCLC (Homo sapiens) 6480464 [4 more ... CTD PMID:32244372 cylindrospermopsin increases expression ISO Gclc (Mus musculus) 6480464 cylindrospermopsin results in increased expression of GCLC mRNA CTD PMID:20936652 cypermethrin multiple interactions EXP 6480464 [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of GCLC protein CTD PMID:34896426 cysteamine decreases activity ISO Gclc (Mus musculus) 6480464 Cysteamine results in decreased activity of GCLC protein CTD PMID:15282320 cysteamine multiple interactions ISO Gclc (Mus musculus) 6480464 [Cysteamine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione CTD PMID:15282320 DDE multiple interactions ISO GCLC (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC mRNA] more ... CTD PMID:25263748 DDE decreases expression ISO GCLC (Homo sapiens) 6480464 Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC mRNA and Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC protein CTD PMID:25263748 DDT increases expression ISO GCLC (Homo sapiens) 6480464 DDT results in increased expression of GCLC mRNA CTD PMID:26198647 DDT increases expression EXP 6480464 DDT results in increased expression of GCLC mRNA CTD PMID:29477483 deguelin increases expression ISO GCLC (Homo sapiens) 6480464 deguelin results in increased expression of GCLC mRNA CTD PMID:33512557 deoxycholic acid multiple interactions ISO GCLC (Homo sapiens) 6480464 [Deoxycholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA CTD PMID:17724089 Deoxycorticosterone acetate multiple interactions EXP 6480464 [Desoxycorticosterone Acetate co-treated with Sodium Chloride and Dietary co-treated with Potassium Chloride] results in decreased expression of GCLC mRNA CTD PMID:22228705 deoxynivalenol decreases expression ISO Gclc (Mus musculus) 6480464 deoxynivalenol results in decreased expression of GCLC mRNA CTD PMID:35817260 deoxynivalenol multiple interactions ISO GCLC (Homo sapiens) 6480464 Resveratrol inhibits the reaction [deoxynivalenol results in decreased expression of GCLC protein] CTD PMID:37419272 deoxynivalenol decreases expression ISO GCLC (Homo sapiens) 6480464 deoxynivalenol results in decreased expression of GCLC mRNA CTD PMID:37419272 deoxynivalenol multiple interactions ISO Gclc (Mus musculus) 6480464 Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of GCLC mRNA] CTD PMID:35817260 desferrioxamine B multiple interactions ISO Gclc (Mus musculus) 6480464 Deferoxamine inhibits the reaction [Benzene results in decreased expression of GCLC mRNA] CTD PMID:35661779 dexamethasone multiple interactions ISO Gclc (Mus musculus) 6480464 [Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GCLC mRNA more ... CTD PMID:16054899 and PMID:33412187 dexamethasone multiple interactions EXP 6480464 [beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA more ... CTD PMID:27028516 dextran sulfate multiple interactions ISO Gclc (Mus musculus) 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of GCLC mRNA CTD PMID:29950665 dextromethorphan multiple interactions ISO Gclc (Mus musculus) 6480464 PRKCD protein affects the reaction [Dextromethorphan affects the expression of GCLC mRNA] more ... CTD PMID:34740715 dextromethorphan affects expression ISO Gclc (Mus musculus) 6480464 Dextromethorphan affects the expression of GCLC mRNA CTD PMID:34740715 Di-n-octyl phthalate multiple interactions ISO Gclc (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in decreased expression of GCLC mRNA CTD PMID:37364641 diallyl disulfide multiple interactions EXP 6480464 diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA] CTD PMID:24293383 diallyl disulfide increases expression ISO GCLC (Homo sapiens) 6480464 diallyl disulfide results in increased expression of GCLC mRNA CTD PMID:34887701 diallyl disulfide increases expression ISO Gclc (Mus musculus) 6480464 diallyl disulfide results in increased expression of GCLC mRNA and diallyl disulfide results in increased expression of GCLC protein CTD PMID:34896185 and PMID:35526736 diallyl disulfide multiple interactions ISO Gclc (Mus musculus) 6480464 [diallyl disulfide co-treated with lipopolysaccharide more ... CTD PMID:34896185 Diallyl sulfide multiple interactions EXP 6480464 allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of GCLC mRNA] and allyl sulfide inhibits the reaction [Ethylene Chlorohydrin results in increased expression of GCLC protein] CTD PMID:31585129 Diallyl sulfide multiple interactions ISO Gclc (Mus musculus) 6480464 allyl sulfide inhibits the reaction [[ethylene dichloride co-treated with Ethanol] results in increased expression of GCLC protein] CTD PMID:37150348 diallyl trisulfide increases expression ISO GCLC (Homo sapiens) 6480464 diallyl trisulfide results in increased expression of GCLC mRNA CTD PMID:34887701 Diallyltetrasulfane increases expression ISO GCLC (Homo sapiens) 6480464 diallyl tetrasulfide results in increased expression of GCLC mRNA CTD PMID:34887701 diarsenic trioxide multiple interactions ISO GCLC (Homo sapiens) 6480464 [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GCLC mRNA and [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GCLC protein CTD PMID:33434570 diarsenic trioxide increases expression ISO Gclc (Mus musculus) 6480464 Arsenic Trioxide results in increased expression of GCLC mRNA CTD PMID:29049341 diarsenic trioxide decreases expression ISO GCLC (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of GCLC protein CTD PMID:25341331 and PMID:25419056 diarsenic trioxide increases expression ISO GCLC (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of GCLC mRNA and Arsenic Trioxide results in increased expression of GCLC protein CTD PMID:19417148 more ... diarsenic trioxide decreases response to substance ISO GCLC (Homo sapiens) 6480464 GCLC protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 and PMID:29549912 diarsenic trioxide multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 protein affects the reaction [Arsenic Trioxide results in increased expression of GCLC mRNA] CTD PMID:29049341 diazinon increases expression ISO GCLC (Homo sapiens) 6480464 Diazinon results in increased expression of GCLC mRNA CTD PMID:26198647 dibenzoylmethane increases expression ISO Gclc (Mus musculus) 6480464 dibenzoylmethane results in increased expression of GCLC mRNA CTD PMID:17942926 dibenzoylmethane multiple interactions ISO Gclc (Mus musculus) 6480464 [sulforaphane co-treated with dibenzoylmethane] results in increased expression of GCLC mRNA CTD PMID:17942926 Dibromoacetonitrile increases expression ISO GCLC (Homo sapiens) 6480464 dibromoacetonitrile results in increased expression of GCLC mRNA CTD PMID:35842135 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of GCLC mRNA CTD PMID:21266533 dibutyl phthalate multiple interactions ISO Gclc (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in decreased expression of GCLC mRNA CTD PMID:37364641 Dichloroacetonitrile increases expression ISO GCLC (Homo sapiens) 6480464 dichloroacetonitrile results in increased expression of GCLC mRNA CTD PMID:35842135 dichloromethane multiple interactions ISO Gclc (Mus musculus) 6480464 [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in decreased expression of GCLC mRNA CTD PMID:29335169 diclofenac decreases expression EXP 6480464 Diclofenac results in decreased expression of GCLC mRNA CTD PMID:17202759 diclofenac affects expression ISO GCLC (Homo sapiens) 6480464 Diclofenac affects the expression of GCLC mRNA CTD PMID:24752500 diclofenac affects response to substance EXP 6480464 GCLC protein affects the susceptibility to Diclofenac CTD PMID:19481141 diethyl malate affects expression ISO Gclc (Mus musculus) 6480464 diethyl malate affects the expression of GCLC mRNA CTD PMID:24814887 diethyl maleate increases expression EXP 6480464 diethyl maleate results in increased expression of GCLC mRNA and diethyl maleate results in increased expression of GCLC protein CTD PMID:10978506 more ... diethyl maleate increases expression ISO GCLC (Homo sapiens) 6480464 diethyl maleate results in increased expression of GCLC mRNA and diethyl maleate results in increased expression of GCLC protein CTD PMID:33545341 more ... diethyl maleate increases expression ISO Gclc (Mus musculus) 6480464 diethyl maleate results in increased expression of GCLC mRNA and diethyl maleate results in increased expression of GCLC protein CTD PMID:10915739 and PMID:25270620 diethyl maleate increases activity EXP 6480464 diethyl maleate results in increased activity of GCLC protein CTD PMID:15115889 diethyl maleate increases activity ISO Gclc (Mus musculus) 6480464 diethyl maleate results in increased activity of GCLC protein CTD PMID:10915739 diethyl phthalate multiple interactions ISO Gclc (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in decreased expression of GCLC mRNA CTD PMID:37364641 diethyl sulfate increases expression ISO GCLC (Homo sapiens) 6480464 diethyl sulfate results in increased expression of GCLC mRNA CTD PMID:20491607 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of GCLC mRNA CTD PMID:15890375 diethylstilbestrol increases expression ISO GCLC (Homo sapiens) 6480464 Diethylstilbestrol results in increased expression of GCLC mRNA CTD PMID:26198647 dihydrogen multiple interactions ISO Gclc (Mus musculus) 6480464 Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GCLC mRNA] CTD PMID:32955216 Diisodecyl phthalate multiple interactions ISO Gclc (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in decreased expression of GCLC mRNA CTD PMID:37364641 diisononyl phthalate multiple interactions ISO Gclc (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in decreased expression of GCLC mRNA CTD PMID:37364641 Dimerumic acid increases expression ISO Gclc (Mus musculus) 6480464 dimerumic acid results in increased expression of GCLC mRNA CTD PMID:24036144 Dimerumic acid increases activity ISO Gclc (Mus musculus) 6480464 dimerumic acid results in increased activity of GCLC protein CTD PMID:24036144 Dimerumic acid multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 protein affects the reaction [dimerumic acid results in increased expression of GCLC mRNA] CTD PMID:24036144 dimethyl fumarate multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLC mRNA] CTD PMID:27277809 dimethyl fumarate increases expression ISO Gclc (Mus musculus) 6480464 Dimethyl Fumarate results in increased expression of GCLC mRNA CTD PMID:27277809 and PMID:30248482 dimethyl fumarate increases expression EXP 6480464 Dimethyl Fumarate results in increased expression of GCLC protein CTD PMID:27277809 dimethylarsinic acid multiple interactions ISO GCLC (Homo sapiens) 6480464 [Cacodylic Acid results in increased abundance of Arsenic] which results in increased expression of GCLC protein CTD PMID:33434570 dinoseb increases expression ISO Gclc (Mus musculus) 6480464 dinoseb results in increased expression of GCLC mRNA CTD PMID:30547568 dioxygen multiple interactions EXP 6480464 [Oxygen deficiency co-treated with Oxygen] results in increased expression of GCLC protein more ... CTD PMID:25773745 dioxygen multiple interactions ISO GCLC (Homo sapiens) 6480464 [Oxygen deficiency co-treated with Catechin] results in increased expression of GCLC mRNA CTD PMID:35883890 dioxygen decreases expression ISO GCLC (Homo sapiens) 6480464 Oxygen deficiency results in decreased expression of GCLC mRNA CTD PMID:35883890 dioxygen increases expression ISO GCLC (Homo sapiens) 6480464 Oxygen deficiency results in increased expression of GCLC mRNA CTD PMID:25596134 and PMID:29966676 dioxygen multiple interactions ISO Gclc (Mus musculus) 6480464 [Oxygen deficiency co-treated with Oxygen] results in increased expression of GCLC mRNA CTD PMID:25922074 dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate increases expression ISO GCLC (Homo sapiens) 6480464 Antimony Potassium Tartrate results in increased expression of GCLC mRNA and Antimony Potassium Tartrate results in increased expression of GCLC protein CTD PMID:28713220 dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate multiple interactions ISO GCLC (Homo sapiens) 6480464 [Antimony Potassium Tartrate results in increased abundance of antimonite] which results in increased expression of GCLC mRNA CTD PMID:32076005 diprotium multiple interactions ISO Gclc (Mus musculus) 6480464 Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GCLC mRNA] CTD PMID:32955216 diprotium oxide multiple interactions ISO Gclc (Mus musculus) 6480464 [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of GCLC mRNA CTD PMID:29335169 diquat increases expression ISO Gclc (Mus musculus) 6480464 Diquat results in increased expression of GCLC mRNA CTD PMID:16962985 diquat multiple interactions ISO Gclc (Mus musculus) 6480464 [KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA CTD PMID:22762311 diquat decreases activity EXP 6480464 Diquat results in decreased activity of GCLC protein CTD PMID:7676460 diquat decreases expression EXP 6480464 Diquat results in decreased expression of GCLC mRNA CTD PMID:7676460 disodium selenite increases expression ISO Gclc (Mus musculus) 6480464 Sodium Selenite results in increased expression of GCLC mRNA CTD PMID:18449455 disodium selenite increases expression ISO GCLC (Homo sapiens) 6480464 Sodium Selenite results in increased expression of GCLC mRNA CTD PMID:24383545 disulfiram increases expression ISO GCLC (Homo sapiens) 6480464 Disulfiram results in increased expression of GCLC mRNA CTD PMID:20566472 diuron increases expression EXP 6480464 Diuron results in increased expression of GCLC mRNA CTD PMID:21551480 domoic acid increases expression ISO Gclc (Mus musculus) 6480464 domoic acid results in increased expression of GCLC mRNA and domoic acid results in increased expression of GCLC protein CTD PMID:23315585 dopamine multiple interactions ISO GCLC (Homo sapiens) 6480464 Dopamine promotes the reaction [Zinc deficiency results in increased cleavage of GCLC protein] CTD PMID:23377617 doramapimod increases expression ISO Gclc (Mus musculus) 6480464 doramapimod results in increased expression of GCLC mRNA CTD PMID:21328587 dorsomorphin multiple interactions ISO GCLC (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:24211276 and PMID:27188386 dorsomorphin multiple interactions ISO Gclc (Mus musculus) 6480464 [Acetaminophen co-treated with amlexanox co-treated with dorsomorphin] affects the expression of GCLC mRNA CTD PMID:31697998 doxorubicin multiple interactions EXP 6480464 celastrol inhibits the reaction [Doxorubicin results in decreased expression of GCLC mRNA] more ... CTD PMID:18371937 more ... doxorubicin decreases expression ISO Gclc (Mus musculus) 6480464 Doxorubicin results in decreased expression of GCLC mRNA CTD PMID:37499777 doxorubicin decreases response to substance ISO GCLC (Homo sapiens) 6480464 GCLC protein results in decreased susceptibility to Doxorubicin CTD PMID:29549912 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of GCLC mRNA and Doxorubicin results in decreased expression of GCLC protein CTD PMID:18371937 more ... doxorubicin multiple interactions ISO Gclc (Mus musculus) 6480464 ABCC1 gene mutant form promotes the reaction [Doxorubicin results in increased expression of GCLC protein] and FNDC5 protein inhibits the reaction [Doxorubicin results in decreased expression of GCLC mRNA] CTD PMID:26822305 and PMID:37499777 doxorubicin increases expression ISO Gclc (Mus musculus) 6480464 Doxorubicin results in increased expression of GCLC protein CTD PMID:26822305 doxorubicin multiple interactions ISO GCLC (Homo sapiens) 6480464 [GCLC protein co-treated with GCLM protein] promotes the reaction [GSTP1 protein results in decreased susceptibility to Doxorubicin] and GCLC protein inhibits the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin] CTD PMID:10900222 and PMID:11560771 elemental selenium multiple interactions EXP 6480464 [Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of GCLC mRNA CTD PMID:11444866 emodin increases expression EXP 6480464 Emodin results in increased expression of GCLC mRNA CTD PMID:34971761 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of GCLC mRNA CTD PMID:29391264 enzyme inhibitor multiple interactions ISO GCLC (Homo sapiens) 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GCLC protein CTD PMID:23301498 epoxiconazole increases expression ISO Gclc (Mus musculus) 6480464 epoxiconazole results in increased expression of GCLC mRNA CTD PMID:35436446 erastin multiple interactions EXP 6480464 NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLC protein] CTD PMID:32937103 erastin increases expression EXP 6480464 erastin results in increased expression of GCLC protein CTD PMID:32937103 erdosteine increases expression ISO Gclc (Mus musculus) 6480464 erdosteine results in increased expression of GCLC protein CTD PMID:26193055 etacrynic acid multiple interactions ISO GCLC (Homo sapiens) 6480464 [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Ethacrynic Acid CTD PMID:10900222 ethanol increases expression EXP 6480464 Ethanol results in increased expression of GCLC mRNA CTD PMID:10978506 ethanol increases expression ISO Gclc (Mus musculus) 6480464 Ethanol results in increased expression of GCLC mRNA CTD PMID:34995708 ethanol affects splicing ISO Gclc (Mus musculus) 6480464 Ethanol affects the splicing of GCLC mRNA CTD PMID:30319688 ethanol decreases expression ISO Gclc (Mus musculus) 6480464 Ethanol results in decreased expression of GCLC mRNA CTD PMID:27983966 ethanol multiple interactions ISO Gclc (Mus musculus) 6480464 [ethylene dichloride co-treated with Ethanol] results in increased expression of GCLC mRNA more ... CTD PMID:27983966 more ... ethanol multiple interactions EXP 6480464 [Trinitrobenzenesulfonic Acid co-treated with Ethanol] results in increased expression of GCLC mRNA CTD PMID:10830784 ethanol increases expression ISO GCLC (Homo sapiens) 6480464 Ethanol results in increased expression of GCLC mRNA CTD PMID:19133322 ethanol multiple interactions ISO GCLC (Homo sapiens) 6480464 CYP2E1 protein promotes the reaction [Ethanol results in increased expression of GCLC mRNA] CTD PMID:19133322 Ethyl acrylate increases expression ISO GCLC (Homo sapiens) 6480464 ethyl acrylate results in increased expression of GCLC mRNA CTD PMID:26198647 etoposide multiple interactions ISO GCLC (Homo sapiens) 6480464 [GCLC protein co-treated with GCLM protein] promotes the reaction [ABCC1 protein results in decreased susceptibility to Etoposide] and [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Etoposide CTD PMID:10900222 eugenol increases expression ISO GCLC (Homo sapiens) 6480464 Eugenol results in increased expression of GCLC mRNA CTD PMID:20566472 more ... farnesal increases expression ISO GCLC (Homo sapiens) 6480464 farnesal results in increased expression of GCLC mRNA CTD PMID:20491607 farrerol increases expression ISO Gclc (Mus musculus) 6480464 farrerol results in increased expression of GCLC mRNA CTD PMID:26111761 fenofibrate decreases expression EXP 6480464 Fenofibrate results in decreased expression of GCLC mRNA CTD PMID:25596134 fenofibrate multiple interactions ISO Gclc (Mus musculus) 6480464 Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of GCLC protein] CTD PMID:36905866 fenvalerate multiple interactions EXP 6480464 [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of GCLC protein CTD PMID:34896426 ferrostatin-1 multiple interactions ISO Gclc (Mus musculus) 6480464 ferrostatin-1 inhibits the reaction [Benzene results in decreased expression of GCLC mRNA] CTD PMID:35661779 fipronil increases expression EXP 6480464 fipronil results in increased expression of GCLC mRNA CTD PMID:23962444 flutamide increases expression ISO Gclc (Mus musculus) 6480464 Flutamide results in increased expression of GCLC mRNA CTD PMID:17702527 flutamide increases expression EXP 6480464 Flutamide results in increased expression of GCLC mRNA CTD PMID:24136188 flutamide affects response to substance EXP 6480464 GCLC protein affects the susceptibility to Flutamide CTD PMID:19481141 folic acid decreases expression ISO GCLC (Homo sapiens) 6480464 Folic Acid deficiency results in decreased expression of GCLC protein CTD PMID:28639913 folic acid multiple interactions ISO Gclc (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of GCLC mRNA CTD PMID:22206623 folpet increases expression ISO Gclc (Mus musculus) 6480464 folpet results in increased expression of GCLC mRNA CTD PMID:31558096 formaldehyde increases expression ISO GCLC (Homo sapiens) 6480464 Formaldehyde results in increased expression of GCLC mRNA CTD PMID:20491607 FR900359 decreases phosphorylation ISO GCLC (Homo sapiens) 6480464 FR900359 results in decreased phosphorylation of GCLC protein CTD PMID:37730182 fulvestrant multiple interactions EXP 6480464 fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein] CTD PMID:24437944 fumaraldehyde increases expression ISO GCLC (Homo sapiens) 6480464 malealdehyde results in increased expression of GCLC mRNA CTD PMID:35750087 furan multiple interactions ISO Gclc (Mus musculus) 6480464 [Bromodeoxyuridine co-treated with furan] results in increased expression of GCLC mRNA CTD PMID:24910943 furan increases expression EXP 6480464 furan results in increased expression of GCLC mRNA CTD PMID:27402187 furan increases expression ISO Gclc (Mus musculus) 6480464 furan results in increased expression of GCLC mRNA CTD PMID:24183702 and PMID:24910943 galactose decreases expression EXP 6480464 Galactose results in decreased expression of GCLC mRNA CTD PMID:25892055 galactose multiple interactions EXP 6480464 Saponins inhibits the reaction [Galactose results in decreased expression of GCLC mRNA] CTD PMID:25892055 gamma-hexachlorocyclohexane increases expression ISO GCLC (Homo sapiens) 6480464 Hexachlorocyclohexane results in increased expression of GCLC mRNA CTD PMID:26198647 gamma-linolenic acid increases activity ISO GCLC (Homo sapiens) 6480464 gamma-Linolenic Acid results in increased activity of GCLC protein CTD PMID:17092368 gamma-linolenic acid increases expression ISO GCLC (Homo sapiens) 6480464 gamma-Linolenic Acid results in increased expression of GCLC mRNA CTD PMID:17092368 gefitinib affects response to substance ISO GCLC (Homo sapiens) 6480464 GCLC protein affects the susceptibility to gefitinib CTD PMID:15496427 genistein multiple interactions EXP 6480464 [Genistein co-treated with Methoxychlor] results in increased expression of GCLC mRNA CTD PMID:21782745 genistein affects expression ISO GCLC (Homo sapiens) 6480464 Genistein affects the expression of GCLC mRNA CTD PMID:26865667 genistein increases expression EXP 6480464 Genistein results in increased expression of GCLC mRNA CTD PMID:21782745 ginsenoside Rg1 increases expression ISO Gclc (Mus musculus) 6480464 ginsenoside Rg1 results in increased expression of GCLC mRNA CTD PMID:29964319 ginsenoside Rg1 multiple interactions ISO Gclc (Mus musculus) 6480464 ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA] and NFE2L2 protein affects the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]] CTD PMID:29964319 Ginsenoside Rh4 multiple interactions ISO Gclc (Mus musculus) 6480464 ginsenoside Rh4 inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GCLC mRNA] CTD PMID:33359794 Ginsenoside Rh4 multiple interactions EXP 6480464 ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCLC mRNA] more ... CTD PMID:33359794 gliclazide multiple interactions EXP 6480464 Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA] and Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC protein] CTD PMID:21439372 glutathione multiple interactions ISO Gclc (Mus musculus) 6480464 [2-tert-butylhydroquinone results in increased activity of GCLC protein] which results in increased abundance of Glutathione more ... CTD PMID:14978233 more ... glutathione increases expression EXP 6480464 Glutathione deficiency results in increased expression of GCLC mRNA CTD PMID:15345336 and PMID:20621112 glutathione affects chemical synthesis ISO GCLC (Homo sapiens) 6480464 GCLC polymorphism affects the chemical synthesis of Glutathione CTD PMID:16599007 glutathione increases abundance ISO GCLC (Homo sapiens) 6480464 GCLC results in increased abundance of Glutathione CTD PMID:18556457 glutathione multiple interactions EXP 6480464 [HGF protein results in increased activity of GCLC protein] which results in increased chemical synthesis of Glutathione CTD PMID:10544272 glutathione multiple interactions ISO GCLC (Homo sapiens) 6480464 [[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] which results in increased abundance of Glutathione more ... CTD PMID:11673643 more ... glutathione increases abundance ISO Gclc (Mus musculus) 6480464 GCLC mRNA results in increased abundance of Glutathione and GCLC protein results in increased abundance of Glutathione CTD PMID:19914271 more ... Glutathione ethyl ester multiple interactions ISO Gclc (Mus musculus) 6480464 S-ethyl glutathione inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA] CTD PMID:17980396 glycerol 2-phosphate multiple interactions EXP 6480464 [beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA more ... CTD PMID:27028516 guggulsterone increases expression ISO Gclc (Mus musculus) 6480464 pregna-4 more ... CTD PMID:22851183 guggulsterone increases expression ISO GCLC (Homo sapiens) 6480464 pregna-4 more ... CTD PMID:22851183 hemin increases expression ISO GCLC (Homo sapiens) 6480464 Hemin results in increased expression of GCLC mRNA and Hemin results in increased expression of GCLC protein CTD PMID:16631525 and PMID:33434570 hemin multiple interactions ISO GCLC (Homo sapiens) 6480464 [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GCLC mRNA and [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GCLC protein CTD PMID:33434570 Hexachloro-1,3-butadiene decreases expression EXP 6480464 hexachlorobutadiene results in decreased expression of GCLC mRNA CTD PMID:21905055 Hexachloro-1,3-butadiene increases expression EXP 6480464 hexachlorobutadiene results in increased expression of GCLC mRNA CTD PMID:21905055 hexadecanoic acid increases expression EXP 6480464 Palmitic Acid results in increased expression of GCLC mRNA CTD PMID:28027979 hexadecanoic acid multiple interactions ISO GCLC (Homo sapiens) 6480464 [Palmitic Acid co-treated with Oleic Acid] results in decreased expression of GCLC protein and Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of GCLC protein] CTD PMID:36905866 hexane increases expression ISO GCLC (Homo sapiens) 6480464 n-hexane results in increased expression of GCLC mRNA CTD PMID:20566472 hydrogen chloride multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GCLC mRNA] CTD PMID:29618784 hydrogen chloride increases expression ISO Gclc (Mus musculus) 6480464 Hydrochloric Acid results in increased expression of GCLC mRNA CTD PMID:29618784 hydrogen peroxide affects expression ISO GCLC (Homo sapiens) 6480464 Hydrogen Peroxide affects the expression of GCLC mRNA CTD PMID:20044591 hydrogen peroxide decreases expression EXP 6480464 Hydrogen Peroxide results in decreased expression of GCLC mRNA and Hydrogen Peroxide results in decreased expression of GCLC protein CTD PMID:36305173 hydrogen peroxide multiple interactions EXP 6480464 Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA] more ... CTD PMID:24437944 and PMID:27028516 hydrogen peroxide affects expression EXP 6480464 Hydrogen Peroxide affects the expression of GCLC protein CTD PMID:24437944 hydrogen peroxide multiple interactions ISO GCLC (Homo sapiens) 6480464 4-((alpha-L-rhamnosyloxy)benzyl)isothiocyanate inhibits the reaction [Hydrogen Peroxide results in decreased expression of GCLC mRNA] more ... CTD PMID:24866057 and PMID:31521693 hydrogen peroxide decreases expression ISO GCLC (Homo sapiens) 6480464 Hydrogen Peroxide results in decreased expression of GCLC mRNA and Hydrogen Peroxide results in decreased expression of GCLC protein CTD PMID:24866057 and PMID:31521693 hydrogen peroxide increases expression ISO GCLC (Homo sapiens) 6480464 Hydrogen Peroxide results in increased expression of GCLC mRNA CTD PMID:12598062 more ... hydrogen peroxide multiple interactions ISO Gclc (Mus musculus) 6480464 GCLC protein inhibits the reaction [Hydrogen Peroxide results in decreased abundance of Glutathione] more ... CTD PMID:19914271 and PMID:31494107 hydrogen peroxide decreases response to substance ISO Gclc (Mus musculus) 6480464 GCLC protein results in decreased susceptibility to Hydrogen Peroxide CTD PMID:19914271 hydroquinone increases expression ISO Gclc (Mus musculus) 6480464 hydroquinone results in increased expression of GCLC mRNA and hydroquinone results in increased expression of GCLC protein CTD PMID:23290930 and PMID:30547568 hydroquinone increases expression ISO GCLC (Homo sapiens) 6480464 hydroquinone results in increased expression of GCLC mRNA CTD PMID:23940045 and PMID:32334435 hydroquinone affects methylation ISO GCLC (Homo sapiens) 6480464 hydroquinone affects the methylation of GCLC promoter CTD PMID:23940045 hydroquinone multiple interactions ISO GCLC (Homo sapiens) 6480464 [hydroquinone affects the methylation of GCLC promoter] which results in decreased abundance of 5-Methylcytosine more ... CTD PMID:23940045 and PMID:32334435 hypochlorous acid multiple interactions ISO Gclc (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA] more ... CTD PMID:17980396 hypochlorous acid affects expression ISO Gclc (Mus musculus) 6480464 Hypochlorous Acid affects the expression of GCLC mRNA CTD PMID:18648578 hypochlorous acid increases expression ISO Gclc (Mus musculus) 6480464 Hypochlorous Acid results in increased expression of GCLC mRNA CTD PMID:17980396 ibuprofen increases expression ISO GCLC (Homo sapiens) 6480464 Ibuprofen results in increased expression of GCLC mRNA CTD PMID:11909699 ifosfamide decreases expression ISO GCLC (Homo sapiens) 6480464 Ifosfamide results in decreased expression of GCLC mRNA CTD PMID:25596134 indometacin multiple interactions ISO GCLC (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Indomethacin results in increased expression of GCLC mRNA] more ... CTD PMID:11909699 indometacin multiple interactions ISO Gclc (Mus musculus) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Rosiglitazone co-treated with Indomethacin] results in increased expression of GCLC mRNA CTD PMID:33412187 indometacin decreases expression EXP 6480464 Indomethacin results in decreased expression of GCLC mRNA CTD PMID:36868495 indometacin increases expression ISO GCLC (Homo sapiens) 6480464 Indomethacin results in increased expression of GCLC mRNA and Indomethacin results in increased expression of GCLC protein CTD PMID:11820781 and PMID:11909699 iron atom increases activity EXP 6480464 Iron results in increased activity of GCLC protein CTD PMID:17189828 iron atom decreases expression EXP 6480464 Iron results in decreased expression of GCLC protein CTD PMID:35247364 iron atom multiple interactions EXP 6480464 leonurine inhibits the reaction [Iron results in decreased expression of GCLC protein] CTD PMID:35247364 iron atom decreases expression ISO GCLC (Homo sapiens) 6480464 Iron results in decreased expression of GCLC mRNA CTD PMID:19073151 iron atom multiple interactions ISO GCLC (Homo sapiens) 6480464 Ursodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GCLC mRNA] CTD PMID:19073151 iron trichloride multiple interactions ISO Gclc (Mus musculus) 6480464 [ferric chloride co-treated with TNF protein] results in increased expression of GCLC protein CTD PMID:19900513 iron(0) increases activity EXP 6480464 Iron results in increased activity of GCLC protein CTD PMID:17189828 iron(0) multiple interactions EXP 6480464 leonurine inhibits the reaction [Iron results in decreased expression of GCLC protein] CTD PMID:35247364 iron(0) decreases expression EXP 6480464 Iron results in decreased expression of GCLC protein CTD PMID:35247364 iron(0) multiple interactions ISO GCLC (Homo sapiens) 6480464 Ursodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GCLC mRNA] CTD PMID:19073151 iron(0) decreases expression ISO GCLC (Homo sapiens) 6480464 Iron results in decreased expression of GCLC mRNA CTD PMID:19073151 iron(2+) sulfate (anhydrous) multiple interactions ISO GCLC (Homo sapiens) 6480464 ferrous sulfate promotes the reaction [SNCA protein results in decreased expression of GCLC protein] CTD PMID:27424009 iron(2+) sulfate (anhydrous) decreases expression ISO GCLC (Homo sapiens) 6480464 ferrous sulfate results in decreased expression of GCLC protein CTD PMID:27424009 iron(III) nitrilotriacetate increases expression ISO Gclc (Mus musculus) 6480464 ferric nitrilotriacetate results in increased expression of GCLC mRNA CTD PMID:18617210 isoeugenol increases expression ISO GCLC (Homo sapiens) 6480464 isoeugenol results in increased expression of GCLC mRNA CTD PMID:20566472 isoniazide increases expression ISO Gclc (Mus musculus) 6480464 Isoniazid results in increased expression of GCLC mRNA CTD PMID:33771660 isoniazide multiple interactions EXP 6480464 chrysin inhibits the reaction [Isoniazid results in increased expression of GCLC mRNA] CTD PMID:33121995 isoniazide increases expression EXP 6480464 Isoniazid results in increased expression of GCLC mRNA CTD PMID:33121995 isoniazide multiple interactions ISO Gclc (Mus musculus) 6480464 Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GCLC mRNA] CTD PMID:24128855 isoniazide decreases expression ISO Gclc (Mus musculus) 6480464 Isoniazid results in decreased expression of GCLC mRNA CTD PMID:24128855 isoprenaline decreases expression ISO Gclc (Mus musculus) 6480464 Isoproterenol results in decreased expression of GCLC mRNA CTD PMID:21335049 isorhamnetin multiple interactions ISO GCLC (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] more ... CTD PMID:24211276 isorhamnetin multiple interactions EXP 6480464 [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA and [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC protein CTD PMID:25716194 isorhamnetin increases expression EXP 6480464 3-methylquercetin results in increased expression of GCLC mRNA and 3-methylquercetin results in increased expression of GCLC protein CTD PMID:25716194 isorhamnetin multiple interactions ISO Gclc (Mus musculus) 6480464 [3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein CTD PMID:24211276 isothiocyanate increases expression ISO Gclc (Mus musculus) 6480464 Isothiocyanates results in increased expression of GCLC protein CTD PMID:15570060 ivermectin decreases expression ISO GCLC (Homo sapiens) 6480464 Ivermectin results in decreased expression of GCLC protein CTD PMID:32959892 kaempferol increases expression ISO GCLC (Homo sapiens) 6480464 kaempferol results in increased expression of GCLC mRNA CTD PMID:11864778 kaempferol multiple interactions ISO Gclc (Mus musculus) 6480464 kaempferol affects the reaction [propacetamol affects the expression of GCLC protein] CTD PMID:29574133 kahweol multiple interactions EXP 6480464 [cafestol co-treated with kahweol] inhibits the reaction [ochratoxin A results in decreased expression of GCLC protein] CTD PMID:17110534 ketamine increases expression EXP 6480464 Ketamine results in increased expression of GCLC mRNA CTD PMID:20080153 ketamine multiple interactions EXP 6480464 Curcumin inhibits the reaction [Ketamine results in decreased expression of GCLC mRNA] and Curcumin inhibits the reaction [Ketamine results in decreased expression of GCLC protein] CTD PMID:36305173 ketamine decreases expression EXP 6480464 Ketamine results in decreased expression of GCLC mRNA and Ketamine results in decreased expression of GCLC protein CTD PMID:36305173 ketoprofen increases expression ISO GCLC (Homo sapiens) 6480464 Ketoprofen results in increased expression of GCLC mRNA CTD PMID:11909699 L-ascorbic acid multiple interactions EXP 6480464 [beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of GCLC mRNA more ... CTD PMID:27028516 and PMID:31585129 L-ascorbic acid 2-phosphate multiple interactions ISO GCLC (Homo sapiens) 6480464 [[ascorbate-2-phosphate co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of GCLC mRNA CTD PMID:34480604 L-cysteine multiple interactions EXP 6480464 Cysteine promotes the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine] CTD PMID:15115889 L-gamma-glutamyl-L-cysteine multiple interactions EXP 6480464 Buthionine Sulfoximine inhibits the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine] more ... CTD PMID:15115889 L-gamma-glutamyl-L-cysteine increases chemical synthesis EXP 6480464 GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine CTD PMID:15115889 L-methionine multiple interactions ISO Gclc (Mus musculus) 6480464 [Choline deficiency co-treated with Methionine deficiency] results in increased expression of GCLC mRNA and NFE2L2 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of GCLC mRNA] CTD PMID:20350562 lead diacetate multiple interactions ISO GCLC (Homo sapiens) 6480464 NFE2L2 mutant form inhibits the reaction [lead acetate results in increased expression of GCLC mRNA] CTD PMID:26498409 lead diacetate increases expression ISO GCLC (Homo sapiens) 6480464 lead acetate results in increased expression of GCLC mRNA CTD PMID:26498409 lead(II) chloride increases expression ISO GCLC (Homo sapiens) 6480464 lead chloride results in increased expression of GCLC mRNA CTD PMID:18654764 lead(II) chloride decreases expression ISO GCLC (Homo sapiens) 6480464 lead chloride results in decreased expression of GCLC protein CTD PMID:30359721 lead(II) chloride multiple interactions ISO GCLC (Homo sapiens) 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GCLC mRNA CTD PMID:18654764 leflunomide increases expression EXP 6480464 leflunomide results in increased expression of GCLC mRNA CTD PMID:24136188 Leonurine multiple interactions EXP 6480464 leonurine inhibits the reaction [Iron results in decreased expression of GCLC protein] CTD PMID:35247364 levofloxacin decreases expression EXP 6480464 Levofloxacin results in decreased expression of GCLC mRNA CTD PMID:24136188 linalool increases expression ISO GCLC (Homo sapiens) 6480464 linalool results in increased expression of GCLC mRNA CTD PMID:20491607 lipoic acid increases expression ISO GCLC (Homo sapiens) 6480464 Thioctic Acid results in increased expression of GCLC mRNA CTD PMID:16249512 more ... lipoic acid multiple interactions ISO GCLC (Homo sapiens) 6480464 Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLC mRNA] and Thioctic Acid results in increased expression of and results in increased activity of GCLC protein CTD PMID:26365678 lipoic acid multiple interactions ISO Gclc (Mus musculus) 6480464 Thioctic Acid inhibits the reaction [Silicon results in decreased expression of GCLC protein] CTD PMID:34252510 lipoic acid multiple interactions EXP 6480464 Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GCLC protein] more ... CTD PMID:27298056 and PMID:32061141 lipopolysaccharide multiple interactions ISO Gclc (Mus musculus) 6480464 8-oxoberberine promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of GCLC mRNA] more ... CTD PMID:35691465 liquiritigenin increases expression EXP 6480464 liquiritigenin results in increased expression of GCLC protein CTD PMID:29908794 liquiritigenin multiple interactions EXP 6480464 liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA] CTD PMID:29908794 liquiritin increases expression EXP 6480464 liquiritin results in increased expression of GCLC protein CTD PMID:29908794 liquiritin multiple interactions EXP 6480464 liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA] CTD PMID:29908794 lithocholic acid increases expression ISO Gclc (Mus musculus) 6480464 Lithocholic Acid results in increased expression of GCLC mRNA and Lithocholic Acid results in increased expression of GCLC protein CTD PMID:20977460 lithocholic acid decreases expression ISO Gclc (Mus musculus) 6480464 Lithocholic Acid results in decreased expression of GCLC mRNA CTD PMID:29794447 lithocholic acid increases expression ISO GCLC (Homo sapiens) 6480464 Lithocholic Acid results in increased expression of GCLC protein CTD PMID:17724089 lithocholic acid multiple interactions ISO GCLC (Homo sapiens) 6480464 [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA more ... CTD PMID:17724089 and PMID:20146260 lithocholic acid affects expression ISO GCLC (Homo sapiens) 6480464 Lithocholic Acid affects the expression of GCLC mRNA and Lithocholic Acid affects the expression of GCLC protein CTD PMID:20146260 lithocholic acid multiple interactions ISO Gclc (Mus musculus) 6480464 [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA more ... CTD PMID:17724089 more ... luteolin increases expression EXP 6480464 Luteolin results in increased expression of GCLC mRNA and Luteolin results in increased expression of GCLC protein CTD PMID:22864849 luteolin multiple interactions EXP 6480464 [Luteolin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide CTD PMID:22864849 LY294002 multiple interactions ISO GCLC (Homo sapiens) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cinnamaldehyde results in increased expression of GCLC protein] more ... CTD PMID:19073151 more ... LY294002 multiple interactions ISO Gclc (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]] CTD PMID:25895139 LY294002 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of GCLC protein] and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Plant Extracts results in increased expression of GCLC mRNA] CTD PMID:20399244 and PMID:25773745 LY294002 decreases expression ISO GCLC (Homo sapiens) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of GCLC mRNA CTD PMID:19073151 lycopene multiple interactions ISO Gclc (Mus musculus) 6480464 Lycopene inhibits the reaction [Atrazine results in increased expression of GCLC mRNA] and Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of GCLC mRNA] CTD PMID:35917956 more ... maneb increases expression ISO GCLC (Homo sapiens) 6480464 [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of GCLC mRNA CTD PMID:21402726 maneb increases activity EXP 6480464 Maneb results in increased activity of GCLC protein CTD PMID:15527874 melatonin multiple interactions ISO Gclc (Mus musculus) 6480464 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]] more ... CTD PMID:25550330 meloxicam multiple interactions ISO GCLC (Homo sapiens) 6480464 meloxicam inhibits the reaction [Paraquat results in decreased expression of GCLC protein] CTD PMID:20851755 menadione increases activity ISO GCLC (Homo sapiens) 6480464 Vitamin K 3 results in increased activity of GCLC protein CTD PMID:11972604 menadione increases expression ISO GCLC (Homo sapiens) 6480464 Vitamin K 3 results in increased expression of GCLC mRNA CTD PMID:11972604 and PMID:23410634 menadione increases expression ISO Gclc (Mus musculus) 6480464 Vitamin K 3 results in increased expression of GCLC mRNA CTD PMID:25270620 menadione multiple interactions ISO GCLC (Homo sapiens) 6480464 Dactinomycin inhibits the reaction [Vitamin K 3 results in increased expression of GCLC mRNA] CTD PMID:11972604 mercury atom increases expression ISO GCLC (Homo sapiens) 6480464 Mercury results in increased expression of GCLC mRNA CTD PMID:17547211 mercury atom multiple interactions EXP 6480464 [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC mRNA more ... CTD PMID:27837179 mercury atom multiple interactions ISO GCLC (Homo sapiens) 6480464 [Mercuric Chloride results in increased abundance of Mercury] which results in decreased expression of GCLC protein and GCLC gene polymorphism promotes the reaction [GSTP1 gene polymorphism affects the abundance of Mercury] CTD PMID:19515364 and PMID:30359721 mercury atom affects response to substance ISO GCLC (Homo sapiens) 6480464 GCLC gene SNP affects the susceptibility to Mercury CTD PMID:22236634 mercury dibromide increases expression ISO GCLC (Homo sapiens) 6480464 mercuric bromide results in increased expression of GCLC mRNA CTD PMID:26272509 mercury dibromide multiple interactions ISO GCLC (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLC mRNA CTD PMID:27188386 mercury dichloride decreases response to substance ISO GCLC (Homo sapiens) 6480464 GCLC protein results in decreased susceptibility to Mercuric Chloride CTD PMID:24118919 mercury dichloride multiple interactions EXP 6480464 [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC mRNA more ... CTD PMID:27837179 mercury dichloride multiple interactions ISO GCLC (Homo sapiens) 6480464 [Mercuric Chloride results in increased abundance of Mercury] which results in decreased expression of GCLC protein CTD PMID:30359721 mercury dichloride increases expression ISO GCLC (Homo sapiens) 6480464 Mercuric Chloride results in increased expression of GCLC mRNA CTD PMID:24118919 mercury(0) increases expression ISO GCLC (Homo sapiens) 6480464 Mercury results in increased expression of GCLC mRNA CTD PMID:17547211 mercury(0) multiple interactions EXP 6480464 [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC mRNA more ... CTD PMID:27837179 mercury(0) multiple interactions ISO GCLC (Homo sapiens) 6480464 [Mercuric Chloride results in increased abundance of Mercury] which results in decreased expression of GCLC protein and GCLC gene polymorphism promotes the reaction [GSTP1 gene polymorphism affects the abundance of Mercury] CTD PMID:19515364 and PMID:30359721 mercury(0) affects response to substance ISO GCLC (Homo sapiens) 6480464 GCLC gene SNP affects the susceptibility to Mercury CTD PMID:22236634 mesalamine multiple interactions ISO GCLC (Homo sapiens) 6480464 [IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with Mesalamine] results in increased expression of GCLC mRNA CTD PMID:27818126 metformin increases expression EXP 6480464 Metformin results in increased expression of GCLC mRNA CTD PMID:25596134 methapyrilene increases expression EXP 6480464 Methapyrilene results in increased expression of GCLC mRNA and Methapyrilene results in increased expression of GCLC protein CTD PMID:15890375 more ... methimazole increases expression ISO GCLC (Homo sapiens) 6480464 Methimazole results in increased expression of GCLC mRNA CTD PMID:20144635 methimazole increases expression EXP 6480464 Methimazole results in increased expression of GCLC mRNA CTD PMID:30047161 methotrexate affects expression ISO Gclc (Mus musculus) 6480464 Methotrexate affects the expression of GCLC mRNA CTD PMID:18502557 methoxychlor multiple interactions EXP 6480464 [Genistein co-treated with Methoxychlor] results in increased expression of GCLC mRNA CTD PMID:21782745 methoxychlor increases expression EXP 6480464 Methoxychlor results in increased expression of GCLC mRNA CTD PMID:21782745 methyl non-2-ynoate increases expression ISO GCLC (Homo sapiens) 6480464 2-nonynoic acid methyl ester results in increased expression of GCLC mRNA CTD PMID:20491607 methyl salicylate increases expression ISO GCLC (Homo sapiens) 6480464 methyl salicylate results in increased expression of GCLC mRNA CTD PMID:20566472 methylene blue multiple interactions ISO Gclc (Mus musculus) 6480464 [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLC mRNA and NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of GCLC mRNA] CTD PMID:24556215 methylene blue increases expression ISO Gclc (Mus musculus) 6480464 Methylene Blue results in increased expression of GCLC mRNA CTD PMID:24556215 methylisothiazolinone increases expression ISO GCLC (Homo sapiens) 6480464 2-methyl-4-isothiazolin-3-one results in increased expression of GCLC mRNA CTD PMID:30806763 methylmercury chloride increases expression ISO Gclc (Mus musculus) 6480464 methylmercuric chloride results in increased expression of GCLC mRNA CTD PMID:20061341 methylmercury chloride decreases expression EXP 6480464 methylmercuric chloride results in decreased expression of GCLC protein CTD PMID:32061141 methylmercury chloride multiple interactions EXP 6480464 Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GCLC protein] more ... CTD PMID:27298056 and PMID:32061141 methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of GCLC mRNA and methylmercuric chloride results in increased expression of GCLC protein CTD PMID:27298056 and PMID:32061141 methylmercury chloride increases expression ISO GCLC (Homo sapiens) 6480464 methylmercuric chloride results in increased expression of GCLC mRNA CTD PMID:24118919 and PMID:28001369 methylmercury chloride decreases response to substance ISO GCLC (Homo sapiens) 6480464 GCLC protein results in decreased susceptibility to methylmercuric chloride CTD PMID:24118919 Methysticin increases expression ISO Gclc (Mus musculus) 6480464 methysticin results in increased expression of GCLC mRNA CTD PMID:28448946 microcystin increases expression EXP 6480464 Microcystins analog results in increased expression of GCLC mRNA CTD PMID:24964298 microcystin multiple interactions EXP 6480464 Buthionine Sulfoximine inhibits the reaction [Microcystins analog results in increased expression of GCLC mRNA] CTD PMID:24964298 microcystin-LR increases expression ISO Gclc (Mus musculus) 6480464 cyanoginosin LR results in increased expression of GCLC mRNA CTD PMID:17654400 microcystin-LR multiple interactions ISO GCLC (Homo sapiens) 6480464 cyanoginosin LR results in decreased expression of and results in increased phosphorylation of GCLC protein and GCLC protein inhibits the reaction [cyanoginosin LR results in decreased activity of CAT protein] CTD PMID:30940545 microcystin-LR decreases expression ISO GCLC (Homo sapiens) 6480464 cyanoginosin LR results in decreased expression of GCLC mRNA CTD PMID:30940545 mifepristone multiple interactions ISO Gclc (Mus musculus) 6480464 Acetaminophen promotes the reaction [Mifepristone results in increased activity of [GCLC protein binds to GCLM protein]] and Mifepristone results in increased activity of [GCLC protein binds to GCLM protein] CTD PMID:16840778 mifepristone increases expression ISO Gclc (Mus musculus) 6480464 Mifepristone results in increased expression of GCLC protein CTD PMID:16840778 miquelianin multiple interactions EXP 6480464 [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA and [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC protein CTD PMID:25716194 MK 571 multiple interactions ISO GCLC (Homo sapiens) 6480464 [verlukast binds to and results in decreased activity of ABCC1 protein] inhibits the reaction [15-deoxy-delta(12 and 14)-prostaglandin J2 results in increased expression of GCLC protein] CTD PMID:21728338 mono(2-ethylhexyl) phthalate increases expression ISO Gclc (Mus musculus) 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of GCLC mRNA CTD PMID:34863575 monocrotaline multiple interactions EXP 6480464 liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA] and liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA] CTD PMID:29908794 monocrotaline decreases expression EXP 6480464 Monocrotaline results in decreased expression of GCLC mRNA CTD PMID:29908794 N,N-diethyl-m-toluamide multiple interactions EXP 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of GCLC mRNA CTD PMID:28659758 N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide multiple interactions ISO GCLC (Homo sapiens) 6480464 N-(3 and 5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Copper results in increased expression of GCLC mRNA] CTD PMID:19747488 N-acetyl-L-cysteine multiple interactions ISO GCLC (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [15-deoxy-delta(12 more ... CTD PMID:11820781 more ... N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [decamethrin results in increased expression of GCLC mRNA] and Acetylcysteine inhibits the reaction [decamethrin results in increased expression of GCLC protein] CTD PMID:17540521 N-acetyl-L-cysteine multiple interactions ISO Gclc (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [2' more ... CTD PMID:17980396 more ... N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases expression ISO GCLC (Homo sapiens) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GCLC mRNA and benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GCLC protein CTD PMID:30186748 and PMID:33434570 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO GCLC (Homo sapiens) 6480464 [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GCLC mRNA more ... CTD PMID:25263748 more ... N-methyl-4-phenylpyridinium multiple interactions EXP 6480464 [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC mRNA and [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC protein CTD PMID:32763437 N-methyl-4-phenylpyridinium multiple interactions ISO Gclc (Mus musculus) 6480464 [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC mRNA more ... CTD PMID:32763437 N-methylformamide affects expression ISO Gclc (Mus musculus) 6480464 methylformamide affects the expression of GCLC mRNA and methylformamide analog affects the expression of GCLC mRNA CTD PMID:17040096 N-methylnicotinate multiple interactions ISO GCLC (Homo sapiens) 6480464 trigonelline inhibits the reaction [Pyocyanine results in increased expression of GCLC mRNA] CTD PMID:24015256 N-nitrosodiethylamine multiple interactions EXP 6480464 [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCLC mRNA more ... CTD PMID:14656948 more ... N-nitrosodiethylamine increases expression ISO Gclc (Mus musculus) 6480464 Diethylnitrosamine results in increased expression of GCLC mRNA CTD PMID:35523338 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of GCLC mRNA CTD PMID:19638242 N-nitrosodimethylamine increases expression ISO GCLC (Homo sapiens) 6480464 Dimethylnitrosamine results in increased expression of GCLC mRNA CTD PMID:17547211 N-nitrosodimethylamine decreases expression EXP 6480464 Dimethylnitrosamine results in decreased expression of GCLC protein CTD PMID:23485615 N-nitrosodimethylamine multiple interactions EXP 6480464 Plant Extracts inhibits the reaction [Dimethylnitrosamine results in decreased expression of GCLC protein] CTD PMID:23485615 N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of GCLC mRNA CTD PMID:14600272 and PMID:15890375 N-tosyl-L-phenylalanyl chloromethyl ketone increases expression ISO Gclc (Mus musculus) 6480464 Tosylphenylalanyl Chloromethyl Ketone results in increased expression of GCLC mRNA CTD PMID:22851183 N-tosyl-L-phenylalanyl chloromethyl ketone increases expression ISO GCLC (Homo sapiens) 6480464 Tosylphenylalanyl Chloromethyl Ketone results in increased expression of GCLC mRNA CTD PMID:22851183 naphthalene multiple interactions ISO Gclc (Mus musculus) 6480464 Buthionine Sulfoximine inhibits the reaction [GCLC protein results in decreased susceptibility to naphthalene] more ... CTD PMID:10900227 and PMID:12805647 naphthalene decreases expression ISO Gclc (Mus musculus) 6480464 naphthalene results in decreased expression of GCLC mRNA CTD PMID:31020322 naphthalene increases expression EXP 6480464 naphthalene analog results in increased expression of GCLC mRNA and naphthalene results in increased expression of GCLC mRNA CTD PMID:24563378 and PMID:24976557 naphthalene increases activity ISO Gclc (Mus musculus) 6480464 naphthalene results in increased activity of GCLC protein CTD PMID:10900227 naphthalene decreases response to substance ISO Gclc (Mus musculus) 6480464 GCLC protein results in decreased susceptibility to naphthalene CTD PMID:10900227 and PMID:12805647 naphthalene-1,2-diol increases expression ISO GCLC (Homo sapiens) 6480464 1 and 2-dihydroxynaphthalene analog results in increased expression of GCLC mRNA CTD PMID:25807370 naproxen increases expression ISO GCLC (Homo sapiens) 6480464 Naproxen results in increased expression of GCLC mRNA CTD PMID:11909699 naringin multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of GCLC protein] more ... CTD PMID:22871521 and PMID:25773745 naringin increases expression EXP 6480464 naringin results in increased expression of GCLC mRNA and naringin results in increased expression of GCLC protein CTD PMID:22871521 and PMID:25773745 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of GCLC mRNA CTD PMID:24136188 neoastilbin multiple interactions ISO GCLC (Homo sapiens) 6480464 astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA] CTD PMID:29471006 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of GCLC mRNA CTD PMID:22110744 nickel dichloride increases expression ISO GCLC (Homo sapiens) 6480464 nickel chloride results in increased expression of GCLC mRNA CTD PMID:17547211 and PMID:21111804 nickel sulfate increases expression ISO Gclc (Mus musculus) 6480464 nickel sulfate results in increased expression of GCLC mRNA CTD PMID:16100012 nickel sulfate increases expression ISO GCLC (Homo sapiens) 6480464 nickel sulfate results in increased expression of GCLC mRNA CTD PMID:20491607 and PMID:20566472 nicotinamide multiple interactions EXP 6480464 [Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA more ... CTD PMID:21439372 nicotine multiple interactions ISO Gclc (Mus musculus) 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 nimesulide increases expression EXP 6480464 nimesulide results in increased expression of GCLC mRNA CTD PMID:24136188 nimustine increases expression ISO GCLC (Homo sapiens) 6480464 Nimustine results in increased expression of GCLC mRNA CTD PMID:9393752 nitisinone multiple interactions ISO Gclc (Mus musculus) 6480464 [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLC mRNA CTD PMID:12899938 nitric oxide decreases expression EXP 6480464 Nitric Oxide deficiency results in decreased expression of GCLC mRNA and Nitric Oxide deficiency results in decreased expression of GCLC protein CTD PMID:19631198 nitrofurantoin multiple interactions ISO GCLC (Homo sapiens) 6480464 NFE2L2 protein affects the reaction [Nitrofurantoin results in increased expression of GCLC protein] and POR protein affects the reaction [Nitrofurantoin results in increased expression of GCLC protein] CTD PMID:34021431 nitrofurantoin increases expression ISO GCLC (Homo sapiens) 6480464 Nitrofurantoin results in increased expression of GCLC protein CTD PMID:34021431 Nodularin affects expression ISO GCLC (Homo sapiens) 6480464 nodularin affects the expression of GCLC mRNA CTD PMID:30562542 Nonidet P-40 decreases expression ISO GCLC (Homo sapiens) 6480464 Nonidet P-40 results in decreased expression of GCLC mRNA CTD PMID:26552463 norswertianolin increases expression EXP 6480464 norswertianolin results in increased expression of GCLC mRNA and norswertianolin results in increased expression of GCLC protein CTD PMID:30800665 notoginsenoside R1 multiple interactions EXP 6480464 Cycloheximide inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein] more ... CTD PMID:24437944 notoginsenoside R1 increases expression EXP 6480464 notoginsenoside R1 results in increased expression of GCLC protein CTD PMID:24437944 ochratoxin A multiple interactions EXP 6480464 [cafestol co-treated with kahweol] inhibits the reaction [ochratoxin A results in decreased expression of GCLC protein] CTD PMID:17110534 ochratoxin A increases expression ISO GCLC (Homo sapiens) 6480464 ochratoxin A results in increased expression of GCLC mRNA CTD PMID:30291945 and PMID:32905824 ochratoxin A increases expression ISO Gclc (Mus musculus) 6480464 ochratoxin A results in increased expression of GCLC mRNA CTD PMID:30291945 ochratoxin A multiple interactions ISO GCLC (Homo sapiens) 6480464 AHR protein affects the reaction [ochratoxin A results in increased expression of GCLC mRNA] and NR1I2 protein affects the reaction [ochratoxin A results in increased expression of GCLC mRNA] CTD PMID:30291945 ochratoxin A affects expression EXP 6480464 ochratoxin A affects the expression of GCLC mRNA CTD PMID:32468156 ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of GCLC mRNA and ochratoxin A results in decreased expression of GCLC protein CTD PMID:16251485 more ... olanzapine increases expression ISO Gclc (Mus musculus) 6480464 Olanzapine results in increased expression of GCLC mRNA CTD PMID:37005277 oleanolic acid increases expression EXP 6480464 Oleanolic Acid results in increased expression of GCLC mRNA CTD PMID:18706400 oleanolic acid increases expression ISO Gclc (Mus musculus) 6480464 Oleanolic Acid results in increased expression of GCLC mRNA and Oleanolic Acid results in increased expression of GCLC protein CTD PMID:18706400 more ... oleic acid multiple interactions ISO GCLC (Homo sapiens) 6480464 [Palmitic Acid co-treated with Oleic Acid] results in decreased expression of GCLC protein and Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of GCLC protein] CTD PMID:36905866 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of GCLC mRNA and [Topotecan co-treated with oxaliplatin] results in decreased expression of GCLC mRNA CTD PMID:25729387 oxaliplatin decreases expression EXP 6480464 oxaliplatin results in decreased expression of GCLC mRNA CTD PMID:25729387 oxidopamine increases expression EXP 6480464 Oxidopamine results in increased expression of GCLC mRNA and Oxidopamine results in increased expression of GCLC protein CTD PMID:21397656 oxidopamine multiple interactions EXP 6480464 salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLC protein] CTD PMID:25446857 oxidopamine multiple interactions ISO GCLC (Homo sapiens) 6480464 salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLC protein] CTD PMID:25446857 oxidopamine decreases expression EXP 6480464 Oxidopamine results in decreased expression of GCLC protein CTD PMID:25446857 oxidopamine decreases expression ISO GCLC (Homo sapiens) 6480464 Oxidopamine results in decreased expression of GCLC protein CTD PMID:25446857 ozone multiple interactions ISO Gclc (Mus musculus) 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of GCLC mRNA more ... CTD PMID:17460151 more ... ozone increases expression ISO Gclc (Mus musculus) 6480464 Ozone results in increased expression of GCLC mRNA CTD PMID:17095637 p-chloromercuribenzoic acid increases expression ISO GCLC (Homo sapiens) 6480464 p-Chloromercuribenzoic Acid results in increased expression of GCLC mRNA CTD PMID:26272509 p-chloromercuribenzoic acid multiple interactions ISO GCLC (Homo sapiens) 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLC mRNA CTD PMID:27188386 para-Cresidine increases expression ISO GCLC (Homo sapiens) 6480464 cresidine results in increased expression of GCLC mRNA CTD PMID:26198647 paracetamol multiple interactions ISO GCLC (Homo sapiens) 6480464 Chlorogenic Acid promotes the reaction [Acetaminophen results in increased expression of GCLC mRNA] more ... CTD PMID:25881548 and PMID:29136249 paracetamol decreases expression ISO Gclc (Mus musculus) 6480464 Acetaminophen results in decreased expression of GCLC mRNA CTD PMID:25818464 and PMID:29355602 paracetamol decreases response to substance ISO Gclc (Mus musculus) 6480464 GCLC protein results in decreased susceptibility to Acetaminophen CTD PMID:18642143 and PMID:24661219 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of GCLC mRNA CTD PMID:26767949 paracetamol decreases expression ISO GCLC (Homo sapiens) 6480464 Acetaminophen results in decreased expression of GCLC mRNA and Acetaminophen results in decreased expression of GCLC protein CTD PMID:27761495 and PMID:37792503 paracetamol increases expression ISO Gclc (Mus musculus) 6480464 Acetaminophen results in increased expression of GCLC mRNA and Acetaminophen results in increased expression of GCLC protein CTD PMID:10915739 more ... paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of GCLC mRNA CTD PMID:11245408 more ... paracetamol affects expression ISO Gclc (Mus musculus) 6480464 Acetaminophen affects the expression of GCLC mRNA CTD PMID:15606129 more ... paracetamol affects response to substance EXP 6480464 GCLC protein affects the susceptibility to Acetaminophen CTD PMID:17573345 paracetamol decreases activity ISO Gclc (Mus musculus) 6480464 Acetaminophen results in decreased activity of GCLC protein CTD PMID:10915739 paracetamol multiple interactions ISO Gclc (Mus musculus) 6480464 [Acetaminophen co-treated with amlexanox co-treated with dorsomorphin] affects the expression of GCLC mRNA more ... CTD PMID:15122755 more ... paracetamol increases expression ISO GCLC (Homo sapiens) 6480464 Acetaminophen results in increased expression of GCLC mRNA CTD PMID:21420995 more ... paraquat increases expression ISO Gclc (Mus musculus) 6480464 Paraquat results in increased expression of GCLC mRNA CTD PMID:17215068 and PMID:31216030 paraquat multiple interactions ISO Gclc (Mus musculus) 6480464 SIRT6 promotes the reaction [Paraquat results in increased expression of GCLC mRNA] CTD PMID:31216030 paraquat increases expression EXP 6480464 Paraquat results in increased expression of GCLC mRNA CTD PMID:26598004 more ... paraquat decreases expression ISO GCLC (Homo sapiens) 6480464 Paraquat results in decreased expression of GCLC mRNA and Paraquat results in decreased expression of GCLC protein CTD PMID:20851755 and PMID:24866057 paraquat multiple interactions ISO GCLC (Homo sapiens) 6480464 [alpha-Tocopherol co-treated with Paraquat] results in increased expression of GCLC mRNA more ... CTD PMID:20851755 more ... paraquat affects expression EXP 6480464 Paraquat affects the expression of GCLC mRNA CTD PMID:16854511 perfluorobutyric acid increases expression ISO Gclc (Mus musculus) 6480464 perfluorobutyric acid results in increased expression of GCLC mRNA CTD PMID:34474067 perfluorohexanesulfonic acid multiple interactions ISO Gclc (Mus musculus) 6480464 [perfluorohexanesulfonic acid co-treated with Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of GCLC mRNA CTD PMID:32991729 perfluorononanoic acid decreases expression ISO Gclc (Mus musculus) 6480464 perfluoro-n-nonanoic acid results in decreased expression of GCLC mRNA CTD PMID:23567314 perfluorooctane-1-sulfonic acid increases expression ISO Gclc (Mus musculus) 6480464 perfluorooctane sulfonic acid results in increased expression of GCLC mRNA CTD PMID:26548598 perfluorooctane-1-sulfonic acid multiple interactions ISO Gclc (Mus musculus) 6480464 [Dietary Fats co-treated with perfluorooctane sulfonic acid] results in increased expression of GCLC mRNA more ... CTD PMID:32979393 more ... perfluorooctanoic acid decreases expression ISO Gclc (Mus musculus) 6480464 perfluorooctanoic acid results in decreased expression of GCLC mRNA CTD PMID:23567314 and PMID:30547568 perfluoroundecanoic acid decreases expression ISO Gclc (Mus musculus) 6480464 perfluoroundecanoic acid results in decreased expression of GCLC mRNA CTD PMID:23567314 permethrin multiple interactions EXP 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of GCLC mRNA CTD PMID:28659758 phenethyl caffeate multiple interactions ISO Gclc (Mus musculus) 6480464 caffeic acid phenethyl ester inhibits the reaction [Bleomycin results in decreased expression of GCLC protein] CTD PMID:23570914 phenethyl isothiocyanate increases expression ISO GCLC (Homo sapiens) 6480464 phenethyl isothiocyanate results in increased expression of GCLC mRNA CTD PMID:20442190 phenobarbital decreases expression ISO Gclc (Mus musculus) 6480464 Phenobarbital results in decreased expression of GCLC mRNA CTD PMID:19270015 phenobarbital decreases expression EXP 6480464 Phenobarbital results in decreased expression of GCLC mRNA CTD PMID:19162173 phenol increases expression ISO GCLC (Homo sapiens) 6480464 Phenol results in increased expression of GCLC mRNA CTD PMID:26198647 phenylmercury acetate increases expression ISO GCLC (Homo sapiens) 6480464 Phenylmercuric Acetate results in increased expression of GCLC mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO GCLC (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCLC mRNA CTD PMID:27188386 phlorizin decreases expression ISO Gclc (Mus musculus) 6480464 Phlorhizin results in decreased expression of GCLC mRNA CTD PMID:22538082 phloroglucinol increases expression ISO Gclc (Mus musculus) 6480464 Phloroglucinol results in increased expression of GCLC protein CTD PMID:20188716 phorbol 13-acetate 12-myristate multiple interactions ISO GCLC (Homo sapiens) 6480464 [Tetradecanoylphorbol Acetate co-treated with Rosuvastatin Calcium] results in increased expression of GCLC mRNA CTD PMID:18154958 phorbol 13-acetate 12-myristate increases expression ISO GCLC (Homo sapiens) 6480464 Tetradecanoylphorbol Acetate results in increased expression of GCLC mRNA CTD PMID:18154958 and PMID:26198647 phorbol 13-acetate 12-myristate increases expression ISO Gclc (Mus musculus) 6480464 Tetradecanoylphorbol Acetate results in increased expression of GCLC mRNA CTD PMID:17200146 phosgene affects expression ISO Gclc (Mus musculus) 6480464 Phosgene affects the expression of GCLC mRNA CTD PMID:16300373 piperonyl butoxide increases expression EXP 6480464 Piperonyl Butoxide results in increased expression of GCLC mRNA CTD PMID:15890375 pirinixic acid increases expression ISO Gclc (Mus musculus) 6480464 pirinixic acid results in increased expression of GCLC mRNA CTD PMID:17426115 pirinixic acid decreases expression ISO Gclc (Mus musculus) 6480464 pirinixic acid results in decreased expression of GCLC mRNA CTD PMID:18445702 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of GCLC mRNA CTD PMID:15890375 and PMID:19162173 Polpunonic acid increases expression ISO Gclc (Mus musculus) 6480464 maytenonic acid results in increased expression of GCLC mRNA CTD PMID:27751938 Polpunonic acid increases expression ISO GCLC (Homo sapiens) 6480464 maytenonic acid results in increased expression of GCLC mRNA CTD PMID:27751938 potassium chloride multiple interactions EXP 6480464 [Desoxycorticosterone Acetate co-treated with Sodium Chloride and Dietary co-treated with Potassium Chloride] results in decreased expression of GCLC mRNA CTD PMID:22228705 potassium chromate multiple interactions ISO Gclc (Mus musculus) 6480464 [Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of GCLC mRNA] CTD PMID:14625279 potassium dichromate multiple interactions ISO Gclc (Mus musculus) 6480464 [Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of GCLC mRNA] CTD PMID:14625279 pravastatin increases expression ISO Gclc (Mus musculus) 6480464 Pravastatin results in increased expression of GCLC mRNA CTD PMID:27225895 pravastatin decreases expression EXP 6480464 Pravastatin results in decreased expression of GCLC mRNA CTD PMID:27225895 prazosin multiple interactions ISO Gclc (Mus musculus) 6480464 Prazosin inhibits the reaction [Acetaminophen results in increased expression of GCLC mRNA] CTD PMID:18071297 pregnenolone 16alpha-carbonitrile increases expression EXP 6480464 Pregnenolone Carbonitrile results in increased expression of GCLC mRNA CTD PMID:19162173 pregnenolone 16alpha-carbonitrile decreases expression ISO Gclc (Mus musculus) 6480464 Pregnenolone Carbonitrile results in decreased expression of GCLC mRNA CTD PMID:28903501 progesterone decreases expression ISO Gclc (Mus musculus) 6480464 Progesterone results in decreased expression of GCLC mRNA CTD PMID:22238285 propacetamol affects expression ISO Gclc (Mus musculus) 6480464 propacetamol affects the expression of GCLC protein CTD PMID:29574133 propacetamol multiple interactions ISO Gclc (Mus musculus) 6480464 kaempferol affects the reaction [propacetamol affects the expression of GCLC protein] CTD PMID:29574133 propan-2-ol increases expression ISO GCLC (Homo sapiens) 6480464 2-Propanol results in increased expression of GCLC mRNA CTD PMID:20566472 propanal decreases expression ISO GCLC (Homo sapiens) 6480464 propionaldehyde results in decreased expression of GCLC mRNA CTD PMID:26079696 prostaglandin J2 increases expression EXP 6480464 9-deoxy-delta-9-prostaglandin D2 results in increased expression of GCLC mRNA and 9-deoxy-delta-9-prostaglandin D2 results in increased expression of GCLC protein CTD PMID:18332871 puerarin multiple interactions ISO Gclc (Mus musculus) 6480464 [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC mRNA more ... CTD PMID:32763437 puerarin multiple interactions EXP 6480464 [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC mRNA and [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC protein CTD PMID:32763437 pyocyanine increases expression ISO GCLC (Homo sapiens) 6480464 Pyocyanine results in increased expression of GCLC mRNA CTD PMID:24015256 pyocyanine multiple interactions ISO GCLC (Homo sapiens) 6480464 [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA and trigonelline inhibits the reaction [Pyocyanine results in increased expression of GCLC mRNA] CTD PMID:24015256 pyrazines increases expression ISO GCLC (Homo sapiens) 6480464 Pyrazines analog results in increased expression of GCLC mRNA CTD PMID:25056784 pyrethrins decreases expression EXP 6480464 Pyrethrins results in decreased expression of GCLC protein CTD PMID:34896426 Pyridostigmine bromide multiple interactions EXP 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of GCLC mRNA CTD PMID:28659758 pyrroloquinoline quinone multiple interactions EXP 6480464 PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of GCLC mRNA] CTD PMID:26276080 quercetin increases expression ISO GCLC (Homo sapiens) 6480464 Quercetin results in increased expression of GCLC mRNA and Quercetin results in increased expression of GCLC protein CTD PMID:11864778 more ... quercetin multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 protein affects the reaction [Quercetin results in increased expression of GCLC protein] CTD PMID:36584933 quercetin increases expression EXP 6480464 Quercetin results in increased expression of GCLC mRNA and Quercetin results in increased expression of GCLC protein CTD PMID:19798679 more ... quercetin multiple interactions EXP 6480464 [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA more ... CTD PMID:19798679 more ... quercetin multiple interactions ISO GCLC (Homo sapiens) 6480464 [clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA more ... CTD PMID:25881548 quercetin increases expression ISO Gclc (Mus musculus) 6480464 Quercetin results in increased expression of GCLC mRNA and Quercetin results in increased expression of GCLC protein CTD PMID:19183254 and PMID:36584933 quercetin affects expression EXP 6480464 Quercetin affects the expression of GCLC mRNA CTD PMID:18178720 rac-lactic acid increases expression ISO GCLC (Homo sapiens) 6480464 Lactic Acid results in increased expression of GCLC mRNA CTD PMID:20566472 reactive oxygen species decreases abundance ISO GCLC (Homo sapiens) 6480464 GCLC gene SNP results in decreased abundance of Reactive Oxygen Species CTD PMID:32715377 reactive oxygen species affects abundance ISO Gclc (Mus musculus) 6480464 GCLC protein affects the abundance of Reactive Oxygen Species CTD PMID:35123994 reactive oxygen species affects expression ISO GCLC (Homo sapiens) 6480464 Reactive Oxygen Species affects the expression of GCLC mRNA CTD PMID:25800948 reactive oxygen species multiple interactions EXP 6480464 [Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]] CTD PMID:22864849 reactive oxygen species multiple interactions ISO GCLC (Homo sapiens) 6480464 [[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] which results in increased abundance of Glutathione and [[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein CTD PMID:21728338 resorcinol increases expression ISO GCLC (Homo sapiens) 6480464 resorcinol results in increased expression of GCLC mRNA CTD PMID:30806763 resveratrol increases expression ISO GCLC (Homo sapiens) 6480464 resveratrol results in increased expression of GCLC mRNA CTD PMID:11909699 more ... resveratrol multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 protein affects the reaction [Resveratrol results in increased expression of GCLC protein] CTD PMID:36584933 resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA] and resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC protein] CTD PMID:21439372 resveratrol increases expression EXP 6480464 resveratrol results in increased expression of GCLC mRNA CTD PMID:15882976 resveratrol increases expression ISO Gclc (Mus musculus) 6480464 Resveratrol results in increased expression of GCLC mRNA and Resveratrol results in increased expression of GCLC protein CTD PMID:21520053 and PMID:36584933 resveratrol multiple interactions ISO GCLC (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased expression of GCLC mRNA] more ... CTD PMID:11909699 more ... rosuvastatin calcium multiple interactions ISO GCLC (Homo sapiens) 6480464 [Tetradecanoylphorbol Acetate co-treated with Rosuvastatin Calcium] results in increased expression of GCLC mRNA CTD PMID:18154958 rosuvastatin calcium increases expression ISO GCLC (Homo sapiens) 6480464 Rosuvastatin Calcium results in increased expression of GCLC mRNA CTD PMID:18154958 rotenone increases expression ISO Gclc (Mus musculus) 6480464 Rotenone results in increased expression of GCLC mRNA CTD PMID:17657281 rotenone increases expression ISO GCLC (Homo sapiens) 6480464 Rotenone results in increased expression of GCLC mRNA CTD PMID:36586010 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of GCLC mRNA CTD PMID:26276080 rotenone multiple interactions EXP 6480464 PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of GCLC mRNA] CTD PMID:26276080 rottlerin multiple interactions ISO GCLC (Homo sapiens) 6480464 rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] and rottlerin inhibits the reaction [Plant Extracts results in increased expression of GCLC protein] CTD PMID:24211276 and PMID:30626086 rottlerin multiple interactions ISO Gclc (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]] more ... CTD PMID:25895139 more ... rottlerin multiple interactions EXP 6480464 rottlerin inhibits the reaction [naringin results in increased expression of GCLC protein] CTD PMID:25773745 S-adenosyl-L-methioninate multiple interactions ISO GCLC (Homo sapiens) 6480464 S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA] and S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]] CTD PMID:20146260 S-adenosyl-L-methionine multiple interactions ISO GCLC (Homo sapiens) 6480464 S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA] and S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]] CTD PMID:20146260 S-butyl-DL-homocysteine (S,R)-sulfoximine decreases activity ISO Gclc (Mus musculus) 6480464 Buthionine Sulfoximine results in decreased activity of GCLC protein CTD PMID:15707499 and PMID:7955076 S-butyl-DL-homocysteine (S,R)-sulfoximine increases expression EXP 6480464 Buthionine Sulfoximine results in increased expression of GCLC mRNA CTD PMID:10978506 and PMID:23585199 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions ISO GCLC (Homo sapiens) 6480464 Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione] and Buthionine Sulfoximine inhibits the reaction [GCLC results in decreased susceptibility to Cadmium Chloride] CTD PMID:17724089 and PMID:18556457 S-butyl-DL-homocysteine (S,R)-sulfoximine decreases activity EXP 6480464 Buthionine Sulfoximine results in decreased activity of GCLC protein CTD PMID:12433058 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions EXP 6480464 [Buthionine Sulfoximine co-treated with Carmustine] results in decreased activity of GCLC protein more ... CTD PMID:12967637 more ... S-butyl-DL-homocysteine (S,R)-sulfoximine increases expression ISO Gclc (Mus musculus) 6480464 Buthionine Sulfoximine results in increased expression of GCLC mRNA CTD PMID:17980396 more ... S-butyl-DL-homocysteine (S,R)-sulfoximine increases activity ISO Gclc (Mus musculus) 6480464 Buthionine Sulfoximine results in increased activity of GCLC protein CTD PMID:10915739 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions ISO Gclc (Mus musculus) 6480464 [Buthionine Sulfoximine results in decreased activity of GCLC protein] inhibits the reaction [indenoindole results in increased abundance of Glutathione] more ... CTD PMID:10900227 more ... SB 203580 multiple interactions ISO GCLC (Homo sapiens) 6480464 SB 203580 inhibits the reaction [Plant Extracts results in increased expression of GCLC protein] and SB 203580 inhibits the reaction [sodium arsenite results in increased expression of GCLC protein] CTD PMID:25201354 and PMID:30626086 SB 203580 multiple interactions ISO Gclc (Mus musculus) 6480464 SB 203580 inhibits the reaction [2' more ... CTD PMID:31029725 SB 431542 multiple interactions ISO GCLC (Homo sapiens) 6480464 [LDN 193189 co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 and PMID:34480604 selenium atom multiple interactions EXP 6480464 [Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of GCLC mRNA CTD PMID:11444866 selenocystine multiple interactions ISO GCLC (Homo sapiens) 6480464 NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of GCLC mRNA] CTD PMID:22807314 selenocystine increases expression ISO GCLC (Homo sapiens) 6480464 selenocystine results in increased expression of GCLC mRNA CTD PMID:22807314 selenomethionine increases expression ISO GCLC (Homo sapiens) 6480464 Selenomethionine results in increased expression of GCLC mRNA CTD PMID:22807314 sevoflurane multiple interactions ISO Gclc (Mus musculus) 6480464 alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of GCLC protein] CTD PMID:35350913 sevoflurane decreases expression ISO Gclc (Mus musculus) 6480464 Sevoflurane results in decreased expression of GCLC protein CTD PMID:35350913 silicon atom multiple interactions ISO Gclc (Mus musculus) 6480464 Thioctic Acid inhibits the reaction [Silicon results in decreased expression of GCLC protein] CTD PMID:34252510 silicon atom decreases expression ISO Gclc (Mus musculus) 6480464 Silicon results in decreased expression of GCLC protein CTD PMID:34252510 silicon dioxide decreases expression ISO GCLC (Homo sapiens) 6480464 Silicon Dioxide analog results in decreased expression of GCLC mRNA CTD PMID:25895662 silicon dioxide decreases expression ISO Gclc (Mus musculus) 6480464 Silicon Dioxide results in decreased expression of GCLC mRNA CTD PMID:23221170 silver atom multiple interactions ISO GCLC (Homo sapiens) 6480464 NFE2L2 protein affects the reaction [Silver results in increased expression of GCLC mRNA] CTD PMID:22546375 silver atom increases expression ISO Gclc (Mus musculus) 6480464 Silver results in increased expression of GCLC mRNA CTD PMID:27131904 silver atom increases expression ISO GCLC (Homo sapiens) 6480464 Silver results in increased expression of GCLC mRNA CTD PMID:22036727 more ... silver(0) multiple interactions ISO GCLC (Homo sapiens) 6480464 NFE2L2 protein affects the reaction [Silver results in increased expression of GCLC mRNA] CTD PMID:22546375 silver(0) increases expression ISO Gclc (Mus musculus) 6480464 Silver results in increased expression of GCLC mRNA CTD PMID:27131904 silver(0) increases expression ISO GCLC (Homo sapiens) 6480464 Silver results in increased expression of GCLC mRNA CTD PMID:22036727 more ... silver(1+) nitrate decreases expression ISO GCLC (Homo sapiens) 6480464 Silver Nitrate results in decreased expression of GCLC mRNA CTD PMID:19733233 SL-327 multiple interactions ISO Gclc (Mus musculus) 6480464 SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]] CTD PMID:25550330 sodium arsenate multiple interactions ISO GCLC (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of GCLC mRNA and [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of GCLC protein CTD PMID:32525701 and PMID:33434570 sodium arsenate increases expression ISO GCLC (Homo sapiens) 6480464 sodium arsenate results in increased expression of GCLC mRNA CTD PMID:12727804 sodium arsenite increases expression ISO GCLC (Homo sapiens) 6480464 sodium arsenite results in increased expression of GCLC mRNA and sodium arsenite results in increased expression of GCLC protein CTD PMID:12441363 more ... sodium arsenite decreases expression ISO GCLC (Homo sapiens) 6480464 sodium arsenite results in decreased expression of GCLC mRNA CTD PMID:34032870 and PMID:37956786 sodium arsenite affects methylation ISO GCLC (Homo sapiens) 6480464 sodium arsenite affects the methylation of GCLC gene CTD PMID:28589171 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of GCLC mRNA and sodium arsenite results in increased expression of GCLC protein CTD PMID:12210719 and PMID:21465251 sodium arsenite affects expression EXP 6480464 sodium arsenite affects the expression of GCLC mRNA CTD PMID:25625412 sodium arsenite increases expression ISO Gclc (Mus musculus) 6480464 sodium arsenite results in increased expression of GCLC mRNA and sodium arsenite results in increased expression of GCLC protein CTD PMID:16014739 more ... sodium arsenite multiple interactions ISO Gclc (Mus musculus) 6480464 [GCLM co-treated with GCLC] inhibits the reaction [sodium arsenite results in increased activity of and results in increased cleavage of CASP3 protein] more ... CTD PMID:20006689 more ... sodium arsenite increases activity ISO GCLC (Homo sapiens) 6480464 sodium arsenite results in increased activity of GCLC protein CTD PMID:12441363 sodium arsenite multiple interactions ISO GCLC (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of GCLC protein] more ... CTD PMID:20805060 more ... sodium cholate multiple interactions ISO Gclc (Mus musculus) 6480464 [Cholesterol more ... CTD PMID:27394961 sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of GCLC mRNA CTD PMID:22561333 sodium dichromate increases expression ISO Gclc (Mus musculus) 6480464 sodium bichromate results in increased expression of GCLC mRNA CTD PMID:22155349 sodium dichromate decreases expression ISO Gclc (Mus musculus) 6480464 sodium bichromate results in decreased expression of GCLC mRNA CTD PMID:22155349 sodium dodecyl sulfate increases expression ISO GCLC (Homo sapiens) 6480464 Sodium Dodecyl Sulfate results in increased expression of GCLC mRNA CTD PMID:20566472 sodium fluoride decreases expression ISO Gclc (Mus musculus) 6480464 Sodium Fluoride results in decreased expression of GCLC mRNA CTD PMID:27862939 spironolactone multiple interactions EXP 6480464 Spironolactone inhibits the reaction [Aldosterone results in increased expression of GCLC protein] CTD PMID:24512358 and PMID:25204689 staurosporine multiple interactions ISO GCLC (Homo sapiens) 6480464 Staurosporine promotes the reaction [MYC protein binds to GCLC promoter] CTD PMID:17628013 stavudine increases expression EXP 6480464 Stavudine results in increased expression of GCLC mRNA CTD PMID:18299183 streptozocin multiple interactions EXP 6480464 [Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA more ... CTD PMID:21439372 and PMID:33639173 streptozocin multiple interactions ISO Gclc (Mus musculus) 6480464 [Dietary Fats co-treated with Streptozocin] results in decreased expression of GCLC mRNA and ginsenoside Rh4 inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GCLC mRNA] CTD PMID:33359794 streptozocin decreases expression EXP 6480464 Streptozocin results in decreased expression of GCLC mRNA and Streptozocin results in decreased expression of GCLC protein CTD PMID:33639173 styrene increases activity ISO Gclc (Mus musculus) 6480464 Styrene results in increased activity of GCLC protein CTD PMID:16971035 succimer multiple interactions ISO GCLC (Homo sapiens) 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of GCLC mRNA CTD PMID:26378955 sulfadimethoxine increases expression EXP 6480464 Sulfadimethoxine results in increased expression of GCLC mRNA CTD PMID:30047161 sulforaphane multiple interactions ISO Gclc (Mus musculus) 6480464 [sulforaphane co-treated with dibenzoylmethane] results in increased expression of GCLC mRNA more ... CTD PMID:17942926 more ... sulforaphane decreases expression ISO GCLC (Homo sapiens) 6480464 sulforaphane results in decreased expression of GCLC mRNA CTD PMID:35724838 sulforaphane decreases methylation ISO GCLC (Homo sapiens) 6480464 sulforaphane results in decreased methylation of GCLC gene CTD PMID:31838189 sulforaphane increases expression ISO Gclc (Mus musculus) 6480464 sulforaphane results in increased expression of GCLC mRNA and sulforaphane results in increased expression of GCLC protein CTD PMID:17942926 more ... sulforaphane increases expression ISO GCLC (Homo sapiens) 6480464 sulforaphane results in increased expression of GCLC mRNA and sulforaphane results in increased expression of GCLC protein CTD PMID:20442190 more ... sulforaphane increases expression EXP 6480464 sulforaphane results in increased expression of GCLC mRNA and sulforaphane results in increased expression of GCLC protein CTD PMID:21871945 and PMID:22558124 sulforaphane multiple interactions EXP 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine inhibits the reaction [sulforaphane results in increased expression of GCLC mRNA] CTD PMID:21871945 sulforaphane multiple interactions ISO GCLC (Homo sapiens) 6480464 alpha-methylepinine promotes the reaction [sulforaphane results in increased expression of GCLC mRNA] more ... CTD PMID:21871945 more ... sulindac multiple interactions ISO GCLC (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [Sulindac results in increased expression of GCLC protein] CTD PMID:11820781 sulindac increases expression ISO GCLC (Homo sapiens) 6480464 Sulindac results in increased expression of GCLC protein CTD PMID:11820781 sulindac affects expression ISO GCLC (Homo sapiens) 6480464 Sulindac affects the expression of GCLC mRNA CTD PMID:15946948 sunitinib increases expression ISO GCLC (Homo sapiens) 6480464 Sunitinib results in increased expression of GCLC mRNA CTD PMID:31533062 suprofen increases expression ISO GCLC (Homo sapiens) 6480464 Suprofen results in increased expression of GCLC mRNA CTD PMID:11909699 T-2 toxin decreases expression ISO Gclc (Mus musculus) 6480464 T-2 Toxin results in decreased expression of GCLC mRNA CTD PMID:20854872 T-2 toxin increases expression ISO Gclc (Mus musculus) 6480464 T-2 Toxin results in increased expression of GCLC mRNA CTD PMID:33508416 tamoxifen affects expression ISO Gclc (Mus musculus) 6480464 Tamoxifen affects the expression of GCLC mRNA CTD PMID:20937368 tectorigenin multiple interactions ISO Gclc (Mus musculus) 6480464 [tectorigenin co-treated with 1-Naphthylisothiocyanate] results in increased expression of GCLC protein and tectorigenin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of GCLC mRNA] CTD PMID:37348807 tert-butyl hydroperoxide multiple interactions ISO GCLC (Homo sapiens) 6480464 [Linoleic Acids and Conjugated results in increased activity of GCLC protein] which results in decreased susceptibility to tert-Butylhydroperoxide CTD PMID:17092368 tert-butyl hydroperoxide decreases expression ISO Gclc (Mus musculus) 6480464 tert-Butylhydroperoxide results in decreased expression of GCLC mRNA CTD PMID:30547568 tert-butyl hydroperoxide increases expression ISO GCLC (Homo sapiens) 6480464 tert-Butylhydroperoxide results in increased expression of GCLC mRNA CTD PMID:23410634 and PMID:27509014 tert-butyl hydroperoxide multiple interactions EXP 6480464 [Apigenin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide more ... CTD PMID:22864849 tert-butyl hydroperoxide decreases response to substance EXP 6480464 GCLC protein results in decreased susceptibility to tert-Butylhydroperoxide CTD PMID:12425961 tetrachloromethane affects expression ISO Gclc (Mus musculus) 6480464 Carbon Tetrachloride affects the expression of GCLC mRNA CTD PMID:17484886 tetrachloromethane increases expression ISO GCLC (Homo sapiens) 6480464 Carbon Tetrachloride results in increased expression of GCLC mRNA CTD PMID:32234387 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of GCLC mRNA CTD PMID:31150632 tetrachloromethane multiple interactions ISO Gclc (Mus musculus) 6480464 AK-1 compound promotes the reaction [Carbon Tetrachloride results in increased expression of GCLC mRNA] more ... CTD PMID:21725986 more ... tetrachloromethane decreases expression ISO Gclc (Mus musculus) 6480464 Carbon Tetrachloride results in decreased expression of GCLC mRNA and Carbon Tetrachloride results in decreased expression of GCLC protein CTD PMID:27477297 more ... tetrachloromethane multiple interactions EXP 6480464 diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA] and schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of GCLC mRNA] CTD PMID:24293383 and PMID:31150632 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of GCLC mRNA CTD PMID:24293383 tetrachloromethane increases expression ISO Gclc (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of GCLC mRNA and Carbon Tetrachloride results in increased expression of GCLC protein CTD PMID:10915739 more ... tetrachloromethane decreases activity ISO Gclc (Mus musculus) 6480464 Carbon Tetrachloride results in decreased activity of GCLC protein CTD PMID:10915739 tetramethylpyrazine increases expression ISO GCLC (Homo sapiens) 6480464 tetramethylpyrazine analog results in increased expression of GCLC mRNA and tetramethylpyrazine analog results in increased expression of GCLC protein CTD PMID:25056784 tetramethylpyrazine multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]] more ... CTD PMID:27477297 thapsigargin increases expression EXP 6480464 Thapsigargin results in increased expression of GCLC protein CTD PMID:35544339 thiabendazole increases activity ISO Gclc (Mus musculus) 6480464 Thiabendazole results in increased activity of GCLC protein CTD PMID:11019651 thiabendazole multiple interactions ISO Gclc (Mus musculus) 6480464 [Thiabendazole co-treated with Buthionine Sulfoximine] results in increased activity of GCLC protein CTD PMID:11019651 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of GCLC mRNA and Thioacetamide results in increased expression of GCLC protein CTD PMID:10486302 more ... thioacetamide multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of GCLC mRNA CTD PMID:28943392 titanium dioxide increases expression ISO Gclc (Mus musculus) 6480464 titanium dioxide results in increased expression of GCLC mRNA CTD PMID:23557971 titanium dioxide decreases expression ISO Gclc (Mus musculus) 6480464 titanium dioxide results in decreased expression of GCLC protein CTD PMID:28780322 titanium dioxide multiple interactions ISO Gclc (Mus musculus) 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of GCLC mRNA and Grape Seed Proanthocyanidins inhibits the reaction [titanium dioxide results in decreased expression of GCLC protein] CTD PMID:28780322 and PMID:29950665 topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of GCLC mRNA CTD PMID:25729387 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of GCLC mRNA and [Topotecan co-treated with oxaliplatin] results in decreased expression of GCLC mRNA CTD PMID:25729387 trans-isoeugenol increases expression ISO GCLC (Homo sapiens) 6480464 isoeugenol results in increased expression of GCLC mRNA CTD PMID:20566472 triacsin C increases expression ISO GCLC (Homo sapiens) 6480464 triacsin C results in increased expression of GCLC mRNA CTD PMID:16704987 tributylstannane multiple interactions ISO Gclc (Mus musculus) 6480464 PRKCD gene mutant form promotes the reaction [tributyltin results in increased expression of GCLC mRNA] CTD PMID:25895139 Trichloroacetonitrile increases expression ISO GCLC (Homo sapiens) 6480464 trichloroacetonitrile results in increased expression of GCLC mRNA CTD PMID:35842135 trichostatin A increases expression ISO GCLC (Homo sapiens) 6480464 trichostatin A results in increased expression of GCLC mRNA CTD PMID:21319187 trichostatin A multiple interactions ISO GCLC (Homo sapiens) 6480464 [Fenretinide co-treated with trichostatin A] results in increased expression of GCLC mRNA CTD PMID:21319187 trimethyltin increases expression ISO Gclc (Mus musculus) 6480464 trimethyltin results in increased expression of GCLC mRNA CTD PMID:25895139 trimethyltin multiple interactions ISO Gclc (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]] and rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA] CTD PMID:25895139 triphenyl phosphate affects expression EXP 6480464 triphenyl phosphate affects the expression of GCLC mRNA CTD PMID:30589522 Triptolide multiple interactions EXP 6480464 NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of GCLC protein] CTD PMID:25169008 Triptolide decreases expression ISO Gclc (Mus musculus) 6480464 triptolide results in decreased expression of GCLC protein CTD PMID:25169008 Triptolide decreases expression EXP 6480464 triptolide results in decreased expression of GCLC protein CTD PMID:25169008 troglitazone increases expression ISO GCLC (Homo sapiens) 6480464 troglitazone results in increased expression of GCLC mRNA CTD PMID:19140230 trovafloxacin decreases expression EXP 6480464 trovafloxacin results in decreased expression of GCLC mRNA CTD PMID:24136188 trovafloxacin multiple interactions ISO Gclc (Mus musculus) 6480464 [trovafloxacin co-treated with lipopolysaccharide and E coli O55-B5] results in decreased expression of GCLC mRNA CTD PMID:18930950 tunicamycin multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 mRNA affects the reaction [Tunicamycin results in increased expression of GCLC mRNA] CTD PMID:22959925 tunicamycin increases expression ISO GCLC (Homo sapiens) 6480464 Tunicamycin results in increased expression of GCLC mRNA CTD PMID:36586010 tunicamycin increases expression ISO Gclc (Mus musculus) 6480464 Tunicamycin results in increased expression of GCLC mRNA CTD PMID:22959925 tyloxapol decreases expression ISO Gclc (Mus musculus) 6480464 tyloxapol results in decreased expression of GCLC protein CTD PMID:36905866 tyloxapol multiple interactions ISO Gclc (Mus musculus) 6480464 Escin inhibits the reaction [tyloxapol results in decreased expression of GCLC protein] and Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of GCLC protein] CTD PMID:36905866 tyrphostin AG 1478 multiple interactions EXP 6480464 Doxorubicin promotes the reaction [RTKI cpd results in decreased expression of GCLC protein] CTD PMID:18371937 tyrphostin AG 1478 decreases expression EXP 6480464 RTKI cpd results in decreased expression of GCLC protein CTD PMID:18371937 urethane increases expression ISO GCLC (Homo sapiens) 6480464 Urethane results in increased expression of GCLC mRNA CTD PMID:28818685 ursodeoxycholic acid multiple interactions ISO GCLC (Homo sapiens) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased expression of GCLC mRNA] more ... CTD PMID:19073151 and PMID:20146260 ursodeoxycholic acid increases expression ISO Gclc (Mus musculus) 6480464 Ursodeoxycholic Acid results in increased expression of GCLC mRNA and Ursodeoxycholic Acid results in increased expression of GCLC protein CTD PMID:18687751 ursodeoxycholic acid increases expression ISO GCLC (Homo sapiens) 6480464 Ursodeoxycholic Acid results in increased expression of GCLC mRNA CTD PMID:19073151 ursodeoxycholic acid multiple interactions ISO Gclc (Mus musculus) 6480464 NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of GCLC mRNA] CTD PMID:18687751 usnic acid multiple interactions ISO GCLC (Homo sapiens) 6480464 NFE2L2 protein promotes the reaction [usnic acid results in increased expression of GCLC protein] CTD PMID:27369375 usnic acid increases expression ISO GCLC (Homo sapiens) 6480464 usnic acid results in increased expression of GCLC mRNA and usnic acid results in increased expression of GCLC protein CTD PMID:27369375 valdecoxib increases expression EXP 6480464 valdecoxib results in increased expression of GCLC mRNA CTD PMID:24136188 valproic acid increases expression ISO GCLC (Homo sapiens) 6480464 Valproic Acid results in increased expression of GCLC mRNA CTD PMID:25716160 vanillin increases expression ISO GCLC (Homo sapiens) 6480464 vanillin results in increased expression of GCLC mRNA CTD PMID:17178418 vincristine multiple interactions ISO GCLC (Homo sapiens) 6480464 [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Vincristine CTD PMID:10900222 vitamin E multiple interactions ISO Gclc (Mus musculus) 6480464 Vitamin E inhibits the reaction [Alcohols results in increased expression of GCLC mRNA] CTD PMID:18814483 vitamin E multiple interactions EXP 6480464 [Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of GCLC mRNA and Vitamin E affects the reaction [[REL binds to GCLC promoter] which affects the expression of GCLC mRNA] CTD PMID:11444866 and PMID:16298738 vitamin E affects expression EXP 6480464 Vitamin E affects the expression of GCLC mRNA and Vitamin E affects the expression of GCLC protein CTD PMID:16298738 water multiple interactions ISO Gclc (Mus musculus) 6480464 [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of GCLC mRNA CTD PMID:29335169 withaferin A multiple interactions ISO Gclc (Mus musculus) 6480464 withaferin A inhibits the reaction [Ethanol results in increased expression of GCLC mRNA] CTD PMID:34995708 XAV939 multiple interactions ISO GCLC (Homo sapiens) 6480464 [[ascorbate-2-phosphate co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of GCLC mRNA CTD PMID:34480604 yohimbine multiple interactions ISO Gclc (Mus musculus) 6480464 [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 zinc atom multiple interactions ISO GCLC (Homo sapiens) 6480464 acetyl-valyl-isoleucyl-aspartyl-aldehyde inhibits the reaction [Zinc deficiency results in increased cleavage of GCLC protein] more ... CTD PMID:23377617 zinc atom decreases expression ISO GCLC (Homo sapiens) 6480464 Zinc deficiency results in decreased expression of GCLC mRNA CTD PMID:23377617 zinc atom decreases expression EXP 6480464 Zinc deficiency results in decreased expression of GCLC mRNA and Zinc deficiency results in decreased expression of GCLC protein CTD PMID:23377617 zinc dichloride multiple interactions ISO GCLC (Homo sapiens) 6480464 zinc chloride promotes the reaction [SLC39A2 protein results in increased expression of GCLC mRNA] CTD PMID:18385089 zinc dichloride increases expression ISO GCLC (Homo sapiens) 6480464 zinc chloride results in increased expression of GCLC mRNA CTD PMID:33645215 zinc oxide multiple interactions ISO Gclc (Mus musculus) 6480464 1-(2-cyano-3 more ... CTD PMID:30500950 more ... zinc oxide increases expression ISO Gclc (Mus musculus) 6480464 Zinc Oxide analog results in increased expression of GCLC protein CTD PMID:35247504 zinc oxide decreases expression ISO Gclc (Mus musculus) 6480464 Zinc Oxide analog results in decreased expression of GCLC mRNA CTD PMID:36100149 zinc(0) multiple interactions ISO GCLC (Homo sapiens) 6480464 acetyl-valyl-isoleucyl-aspartyl-aldehyde inhibits the reaction [Zinc deficiency results in increased cleavage of GCLC protein] more ... CTD PMID:23377617 zinc(0) decreases expression EXP 6480464 Zinc deficiency results in decreased expression of GCLC mRNA and Zinc deficiency results in decreased expression of GCLC protein CTD PMID:23377617 zinc(0) decreases expression ISO GCLC (Homo sapiens) 6480464 Zinc deficiency results in decreased expression of GCLC mRNA CTD PMID:23377617
