Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of EPN2 mRNA] | CTD | PMID:31150632 | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | EPN2 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EPN2 mRNA | CTD | PMID:22079256 | 1,2-dimethylhydrazine | increases expression | ISO | Epn2 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of EPN2 mRNA | CTD | PMID:22206623 | 1-naphthyl isothiocyanate | increases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in increased expression of EPN2 mRNA | CTD | PMID:30723492 | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | ISO | EPN2 (Homo sapiens) | 6480464 | Dihydrotestosterone results in increased expression of EPN2 mRNA | CTD | PMID:29581250 | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:27291303 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Epn2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of EPN2 mRNA | CTD | PMID:18691609 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Epn2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of EPN2 mRNA | CTD | PMID:21570461 and PMID:26377647 | 2-ethoxyethanol | increases expression | EXP | | 6480464 | 2-ethoxyethanol results in increased expression of EPN2 mRNA | CTD | PMID:19643169 | 2-hydroxypropanoic acid | decreases expression | ISO | EPN2 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of EPN2 mRNA | CTD | PMID:30851411 | 2-methoxyethanol | increases expression | EXP | | 6480464 | methyl cellosolve results in increased expression of EPN2 mRNA | CTD | PMID:19643169 | 2-methylcholine | affects expression | ISO | EPN2 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of EPN2 mRNA | CTD | PMID:21179406 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | EPN2 (Homo sapiens) | 6480464 | [bisphenol S co-treated with Fulvestrant] results in decreased methylation of EPN2 gene | CTD | PMID:31601247 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Epn2 (Mus musculus) | 6480464 | bisphenol S affects the methylation of EPN2 gene | CTD | PMID:31683443 | 4,4'-sulfonyldiphenol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of EPN2 mRNA | CTD | PMID:36041667 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of EPN2 mRNA | CTD | PMID:24780913 | aflatoxin B1 | increases expression | ISO | Epn2 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of EPN2 mRNA | CTD | PMID:19770486 | Aflatoxin B2 alpha | increases methylation | ISO | EPN2 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of EPN2 intron | CTD | PMID:30157460 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of EPN2 mRNA | CTD | PMID:16483693 | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of EPN2 gene | CTD | PMID:28931070 | benzo[a]pyrene | increases expression | ISO | Epn2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of EPN2 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | affects methylation | ISO | EPN2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of EPN2 intron | CTD | PMID:30157460 | benzo[a]pyrene | decreases methylation | ISO | EPN2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of EPN2 5' UTR | CTD | PMID:27901495 | benzo[b]fluoranthene | decreases expression | ISO | Epn2 (Mus musculus) | 6480464 | benzo(b)fluoranthene results in decreased expression of EPN2 mRNA | CTD | PMID:26377693 | benzo[e]pyrene | increases methylation | ISO | EPN2 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of EPN2 intron | CTD | PMID:30157460 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of EPN2 mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of EPN2 mRNA | CTD | PMID:36041667 | bisphenol A | multiple interactions | ISO | EPN2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of EPN2 gene | CTD | PMID:31601247 | bisphenol F | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of EPN2 mRNA | CTD | PMID:36041667 | Brodifacoum | decreases expression | EXP | | 6480464 | bromfenacoum results in decreased expression of EPN2 protein | CTD | PMID:28903499 | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of EPN2 mRNA | CTD | PMID:19167457 | carbamazepine | affects expression | ISO | EPN2 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of EPN2 mRNA | CTD | PMID:24752500 | carbon nanotube | decreases expression | ISO | Epn2 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | EPN2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to EPN2 gene] | CTD | PMID:28238834 | chlorpyrifos | decreases expression | ISO | Epn2 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of EPN2 mRNA | CTD | PMID:32715474 | chlorpyrifos | increases expression | ISO | Epn2 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of EPN2 mRNA | CTD | PMID:37019170 | choline | multiple interactions | ISO | Epn2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EPN2 gene | CTD | PMID:20938992 | chromium(6+) | affects expression | ISO | Epn2 (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of EPN2 mRNA | CTD | PMID:28472532 | cobalt dichloride | decreases expression | ISO | EPN2 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of EPN2 mRNA | CTD | PMID:19320972 and PMID:19376846 | decabromodiphenyl ether | increases expression | EXP | | 6480464 | decabromobiphenyl ether results in increased expression of EPN2 mRNA | CTD | PMID:23640034 | diclofenac | affects expression | ISO | EPN2 (Homo sapiens) | 6480464 | Diclofenac affects the expression of EPN2 mRNA | CTD | PMID:24752500 | doxorubicin | decreases expression | ISO | EPN2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of EPN2 mRNA | CTD | PMID:29803840 | elemental selenium | increases expression | ISO | EPN2 (Homo sapiens) | 6480464 | Selenium results in increased expression of EPN2 mRNA | CTD | PMID:19244175 | ethanol | affects splicing | ISO | Epn2 (Mus musculus) | 6480464 | Ethanol affects the splicing of EPN2 mRNA | CTD | PMID:30319688 | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of EPN2 mRNA | CTD | PMID:30307764 | ferric oxide | increases expression | ISO | Epn2 (Mus musculus) | 6480464 | ferric oxide analog results in increased expression of EPN2 mRNA | CTD | PMID:25086211 | folic acid | multiple interactions | ISO | Epn2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EPN2 gene | CTD | PMID:20938992 | FR900359 | affects phosphorylation | ISO | EPN2 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of EPN2 protein | CTD | PMID:37730182 | fulvestrant | multiple interactions | ISO | EPN2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of EPN2 gene and [bisphenol S co-treated with Fulvestrant] results in decreased methylation of EPN2 gene | CTD | PMID:31601247 | hydralazine | multiple interactions | ISO | EPN2 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of EPN2 mRNA | CTD | PMID:17183730 | ivermectin | decreases expression | ISO | EPN2 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of EPN2 protein | CTD | PMID:32959892 | L-methionine | multiple interactions | ISO | Epn2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EPN2 gene | CTD | PMID:20938992 | menadione | affects expression | ISO | EPN2 (Homo sapiens) | 6480464 | Vitamin K 3 affects the expression of EPN2 mRNA | CTD | PMID:20044591 | methapyrilene | increases methylation | ISO | EPN2 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of EPN2 intron | CTD | PMID:30157460 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of EPN2 mRNA | CTD | PMID:25729387 | paracetamol | affects expression | ISO | Epn2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of EPN2 mRNA | CTD | PMID:17562736 | paraquat | increases expression | ISO | Epn2 (Mus musculus) | 6480464 | Paraquat results in increased expression of EPN2 mRNA | CTD | PMID:21371552 | pentachlorophenol | increases expression | ISO | Epn2 (Mus musculus) | 6480464 | Pentachlorophenol results in increased expression of EPN2 mRNA | CTD | PMID:23892564 | potassium chromate | decreases expression | ISO | EPN2 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of EPN2 mRNA | CTD | PMID:22079256 | potassium chromate | multiple interactions | ISO | EPN2 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EPN2 mRNA | CTD | PMID:22079256 | rac-lactic acid | decreases expression | ISO | EPN2 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of EPN2 mRNA | CTD | PMID:30851411 | resveratrol | multiple interactions | ISO | EPN2 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of EPN2 mRNA | CTD | PMID:23557933 | selenium atom | increases expression | ISO | EPN2 (Homo sapiens) | 6480464 | Selenium results in increased expression of EPN2 mRNA | CTD | PMID:19244175 | sodium arsenate | increases expression | ISO | Epn2 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of EPN2 mRNA | CTD | PMID:30953684 | Soman | decreases expression | EXP | | 6480464 | Soman results in decreased expression of EPN2 mRNA | CTD | PMID:19281266 | tamoxifen | increases expression | ISO | Epn2 (Mus musculus) | 6480464 | Tamoxifen results in increased expression of EPN2 mRNA | CTD | PMID:25123088 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of EPN2 mRNA] | CTD | PMID:31150632 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of EPN2 mRNA | CTD | PMID:31150632 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of EPN2 mRNA | CTD | PMID:25729387 | trichloroethene | increases methylation | EXP | | 6480464 | Trichloroethylene results in increased methylation of EPN2 gene | CTD | PMID:27618143 | trimellitic anhydride | decreases expression | ISO | Epn2 (Mus musculus) | 6480464 | trimellitic anhydride results in decreased expression of EPN2 mRNA | CTD | PMID:19042947 | troglitazone | decreases expression | ISO | Epn2 (Mus musculus) | 6480464 | troglitazone results in decreased expression of EPN2 mRNA | CTD | PMID:28973697 | valproic acid | multiple interactions | ISO | EPN2 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of EPN2 mRNA | CTD | PMID:17183730 | valproic acid | increases methylation | ISO | EPN2 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of EPN2 gene | CTD | PMID:29154799 | valproic acid | increases expression | ISO | EPN2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of EPN2 mRNA | CTD | PMID:23179753 and PMID:28001369 | valproic acid | affects expression | ISO | EPN2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of EPN2 mRNA | CTD | PMID:25979313 | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of EPN2 mRNA | CTD | PMID:19015723 | vitamin E | increases expression | ISO | EPN2 (Homo sapiens) | 6480464 | Vitamin E results in increased expression of EPN2 mRNA | CTD | PMID:19244175 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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