Prps1 (phosphoribosyl pyrophosphate synthetase 1) - Rat Genome Database

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Gene: Prps1 (phosphoribosyl pyrophosphate synthetase 1) Rattus norvegicus
Analyze
Symbol: Prps1
Name: phosphoribosyl pyrophosphate synthetase 1
RGD ID: 61955
Description: Enables several functions, including magnesium ion binding activity; purine ribonucleotide binding activity; and ribose phosphate diphosphokinase activity. Involved in 5-phosphoribose 1-diphosphate biosynthetic process; AMP biosynthetic process; and animal organ regeneration. Part of ribose phosphate diphosphokinase complex. Human ortholog(s) of this gene implicated in Arts syndrome; X-linked deafness 1; X-linked recessive disease (multiple); gout; and retinitis pigmentosa. Orthologous to human PRPS1 (phosphoribosyl pyrophosphate synthetase 1); PARTICIPATES IN de novo purine biosynthetic pathway; pentose phosphate pathway; purine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: phosphoribosyl pyrophosphate synthase I; phosphoribosyl pyrophosphate synthetase I; PRS-I; ribose-phosphate pyrophosphokinase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X108,920,663 - 108,942,713 (+)NCBIGRCr8
mRatBN7.2X104,132,139 - 104,154,191 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX104,132,141 - 104,154,187 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX106,261,498 - 106,283,545 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X109,760,234 - 109,782,281 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X107,316,203 - 107,337,428 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X111,798,233 - 111,820,270 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX111,798,233 - 111,820,266 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0352,779,462 - 52,801,499 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X128,249,843 - 128,271,893 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X128,323,278 - 128,345,324 (+)NCBI
Celera343,777,612 - 43,799,661 (-)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-nicotine  (ISO)
(Z)-3-butylidenephthalide  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
chloroacetaldehyde  (ISO)
cidofovir anhydrous  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (EXP)
ivermectin  (ISO)
lead diacetate  (EXP)
methidathion  (ISO)
nefazodone  (EXP)
nicotine  (ISO)
nimesulide  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
rimonabant  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
topotecan  (EXP)
trimellitic anhydride  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expanding the phenotype of PRPS1 syndromes in females: neuropathy, hearing loss and retinopathy. Almoguera B, etal., Orphanet J Rare Dis. 2014 Dec 10;9:190. doi: 10.1186/s13023-014-0190-9.
2. The genetic and functional basis of purine nucleotide feedback-resistant phosphoribosylpyrophosphate synthetase superactivity. Becker MA, etal., J Clin Invest. 1995 Nov;96(5):2133-41.
3. Pediatric neurological syndromes and inborn errors of purine metabolism. Camici M, etal., Neurochem Int. 2010 Feb;56(3):367-78. Epub 2009 Dec 11.
4. Mutations in PRPS1 causing syndromic or nonsyndromic hearing impairment: intrafamilial phenotypic variation complicates genetic counseling. Gandia M, etal., Pediatr Res. 2015 Jul;78(1):97-102. doi: 10.1038/pr.2015.56. Epub 2015 Mar 18.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Partial reconstitution of mammalian phosphoribosylpyrophosphate synthetase in Escherichia coli cells. Coexpression of catalytic subunits with the 39-kDa associated protein leads to formation of soluble multimeric complexes of various compositions. Ishijima S, etal., Biochim Biophys Acta. 1997 Sep 26;1342(1):28-36.
7. Expression of rat phosphoribosylpyrophosphate synthetase subunits I and II in Escherichia coli. Isolation and characterization of the recombinant isoforms. Ishijima S, etal., J Biol Chem. 1991 Aug 25;266(24):15693-7.
8. Complete cDNA sequence of rat phosphoribosylpyrophosphate synthetase subunit I (PRS I). Ishijima S, etal., Nucleic Acids Res 1989 Nov 11;17(21):8860.
9. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
10. Rat liver phosphoribosyl pyrophosphate synthetase: existence of the purified enzyme as heterogeneous aggregates and identification of the catalytic subunit. Kita K, etal., J Biochem. 1989 May;105(5):736-41.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Structure of the rat PRPS1 gene encoding phosphoribosylpyrophosphate synthetase subunit I. Shimada H, etal., J Biol Chem 1990 Mar 5;265(7):3956-60.
19. Rat liver phosphoribosylpyrophosphate synthetase is activated by free Mg2+ in a manner that overcomes its inhibition by nucleotides. Sonoda T, etal., Biochim Biophys Acta. 1998 Sep 8;1387(1-2):32-40.
20. Kinetic and regulatory properties of rat liver phosphoribosylpyrophosphate synthetase complex are partly distinct from those of isolated recombinant component catalytic subunits. Sonoda T, etal., J Biochem. 1997 Sep;122(3):635-40.
21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22. Nucleotide and deduced amino acid sequences of two distinct cDNAs for rat phosphoribosylpyrophosphate synthetase. Taira M, etal., J Biol Chem 1987 Nov 5;262(31):14867-70.
Additional References at PubMed
PMID:4328836   PMID:8253776   PMID:8889548   PMID:12847698   PMID:15489334   PMID:16189514   PMID:16939420   PMID:17701896   PMID:17701900   PMID:22792159   PMID:22871113   PMID:24625528  
PMID:25416956   PMID:25502805   PMID:25910212   PMID:31515488   PMID:35352799  


Genomics

Comparative Map Data
Prps1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X108,920,663 - 108,942,713 (+)NCBIGRCr8
mRatBN7.2X104,132,139 - 104,154,191 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX104,132,141 - 104,154,187 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX106,261,498 - 106,283,545 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X109,760,234 - 109,782,281 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X107,316,203 - 107,337,428 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X111,798,233 - 111,820,270 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX111,798,233 - 111,820,266 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0352,779,462 - 52,801,499 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X128,249,843 - 128,271,893 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X128,323,278 - 128,345,324 (+)NCBI
Celera343,777,612 - 43,799,661 (-)NCBICelera
Cytogenetic MapXq32NCBI
PRPS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X107,628,510 - 107,651,026 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX107,628,428 - 107,651,993 (+)EnsemblGRCh38hg38GRCh38
GRCh37X106,871,740 - 106,894,256 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X106,758,415 - 106,780,912 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X106,677,903 - 106,700,400NCBI
CeleraX107,343,160 - 107,365,584 (+)NCBICelera
Cytogenetic MapXq22.3NCBI
HuRefX96,496,454 - 96,518,960 (+)NCBIHuRef
CHM1_1X106,782,575 - 106,805,177 (+)NCBICHM1_1
T2T-CHM13v2.0X106,065,274 - 106,087,791 (+)NCBIT2T-CHM13v2.0
Prps1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X139,357,352 - 139,376,889 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX139,357,362 - 139,376,889 (+)EnsemblGRCm39 Ensembl
GRCm38X140,456,603 - 140,476,140 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX140,456,613 - 140,476,140 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X136,991,142 - 137,010,679 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X135,802,977 - 135,822,503 (+)NCBIMGSCv36mm8
CeleraX123,716,011 - 123,735,469 (+)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX61.35NCBI
Prps1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554908,303,775 - 8,330,713 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554908,303,775 - 8,330,713 (-)NCBIChiLan1.0ChiLan1.0
PRPS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X107,104,116 - 107,126,928 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X107,107,719 - 107,130,532 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X96,720,988 - 96,743,594 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X107,094,898 - 107,117,117 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX107,094,898 - 107,117,117 (+)Ensemblpanpan1.1panPan2
PRPS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X81,150,537 - 81,171,521 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX81,150,536 - 81,212,689 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX67,269,356 - 67,290,346 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X82,796,457 - 82,817,447 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX82,796,456 - 82,817,446 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X80,256,666 - 80,277,657 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X81,968,332 - 81,989,524 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X81,759,859 - 81,781,048 (+)NCBIUU_Cfam_GSD_1.0
Prps1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X80,521,497 - 80,543,124 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364997,115,780 - 7,136,449 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364997,114,838 - 7,136,468 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRPS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX88,074,965 - 88,101,910 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X88,074,861 - 88,101,925 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X102,515,177 - 102,542,941 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRPS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X95,452,481 - 95,475,933 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606520,574,165 - 20,597,947 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Prps1
149 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:514
Count of miRNA genes:246
Interacting mature miRNAs:285
Transcripts:ENSRNOT00000029571
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat

Markers in Region
RH138795  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X104,153,874 - 104,154,036 (+)MAPPERmRatBN7.2
Rnor_6.0X111,819,954 - 111,820,115NCBIRnor6.0
Rnor_5.0352,779,617 - 52,779,778UniSTSRnor5.0
RGSC_v3.4X128,271,577 - 128,271,738UniSTSRGSC3.4
Celera343,777,767 - 43,777,928UniSTS
RH 3.4 Map21372.2UniSTS
Cytogenetic MapXq35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 50 34 19 34 8 11 74 35 34 11 8
Low 1 7 7 7 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000078582   ⟹   ENSRNOP00000071101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX104,132,141 - 104,154,187 (+)Ensembl
Rnor_6.0 EnsemblX111,798,233 - 111,820,266 (+)Ensembl
RefSeq Acc Id: NM_017243   ⟹   NP_058939
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X108,920,663 - 108,942,713 (+)NCBI
mRatBN7.2X104,132,139 - 104,154,191 (+)NCBI
Rnor_6.0X111,798,233 - 111,820,270 (+)NCBI
Rnor_5.0352,779,462 - 52,801,499 (-)NCBI
RGSC_v3.4X128,249,843 - 128,271,893 (+)RGD
Celera343,777,612 - 43,799,661 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_058939 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41959 (Get FASTA)   NCBI Sequence Viewer  
  AAA41960 (Get FASTA)   NCBI Sequence Viewer  
  AAA41963 (Get FASTA)   NCBI Sequence Viewer  
  AAH78853 (Get FASTA)   NCBI Sequence Viewer  
  CAA34555 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071101
  ENSRNOP00000071101.2
GenBank Protein P60892 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_058939   ⟸   NM_017243
- UniProtKB: Q5M8A4 (UniProtKB/Swiss-Prot),   P60892 (UniProtKB/Swiss-Prot),   A6HLR9 (UniProtKB/TrEMBL),   A0A8L2R3X1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071101   ⟸   ENSRNOT00000078582
Protein Domains
Ribose-phosphate pyrophosphokinase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P60892-F1-model_v2 AlphaFold P60892 1-318 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701956
Promoter ID:EPDNEW_R12480
Type:single initiation site
Name:Prps1_1
Description:phosphoribosyl pyrophosphate synthetase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X111,798,221 - 111,798,281EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61955 AgrOrtholog
BioCyc Gene G2FUF-1543 BioCyc
BioCyc Pathway PWY0-662 [PRPP biosynthesis] BioCyc
BioCyc Pathway Image PWY0-662 BioCyc
Ensembl Genes ENSRNOG00000060262 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078582 ENTREZGENE
  ENSRNOT00000078582.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.2020 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7190069 IMAGE-MGC_LOAD
InterPro PRib_PP_synth_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pribosyltran_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRibTrfase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRTase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rib-P_diPkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rib-P_diPkinase_bac UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  rno:314140 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93512 IMAGE-MGC_LOAD
NCBI Gene 29562 ENTREZGENE
PANTHER PTHR10210 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIBOSE-PHOSPHATE DIPHOSPHOKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pribosyl_synth UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pribosyltran_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PRPS1 RGD
PhenoGen Prps1 PhenoGen
PROSITE PRPP_SYNTHASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000060262 RatGTEx
SMART Pribosyltran_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53271 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2R3X1 ENTREZGENE, UniProtKB/TrEMBL
  A6HLR9 ENTREZGENE, UniProtKB/TrEMBL
  P60892 ENTREZGENE, UniProtKB/Swiss-Prot
  Q5M8A4 ENTREZGENE
UniProt Secondary P09329 UniProtKB/Swiss-Prot
  Q5M8A4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Prps1  phosphoribosyl pyrophosphate synthetase 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 317 amino acids 633743
gene_regulation expression increased after partial hepatectomy. 633743