Gria4 (glutamate ionotropic receptor AMPA type subunit 4) - Rat Genome Database

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Gene: Gria4 (glutamate ionotropic receptor AMPA type subunit 4) Rattus norvegicus
Analyze
Symbol: Gria4
Name: glutamate ionotropic receptor AMPA type subunit 4
RGD ID: 61863
Description: Enables AMPA glutamate receptor activity and identical protein binding activity. Involved in chemical synaptic transmission; positive regulation of glutamatergic synaptic transmission; and response to fungicide. Located in several cellular components, including dendritic spine; neuronal cell body; and postsynaptic density. Part of AMPA glutamate receptor complex and kainate selective glutamate receptor complex. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic active zone membrane. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human GRIA4 (glutamate ionotropic receptor AMPA type subunit 4); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AMPA-selective glutamate receptor 4; GluA4; GluR-D; Glur4; glutamate receptor 4; glutamate receptor ionotropic AMPA4 (alpha 4); glutamate receptor, ionotrophic, AMPA 4; glutamate receptor, ionotropic, 4; glutamate receptor, ionotropic, AMPA 4; glutamate receptor, ionotropic, AMPA4; glutamate receptor, ionotropic, AMPA4 (alpha 4)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr889,845,421 - 10,320,021 (-)NCBIGRCr8
mRatBN7.281,562,118 - 2,035,035 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl81,562,119 - 2,034,979 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx85,549,528 - 6,002,818 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.083,847,265 - 4,300,576 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.081,793,462 - 2,275,720 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.081,548,145 - 2,045,874 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl81,548,146 - 2,045,817 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.081,676,489 - 2,069,626 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.081,542,036 - 1,606,502 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48956,325 - 1,438,314 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18957,189 - 1,438,021 (-)NCBI
Celera81,445,037 - 1,902,161 (-)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning of a novel glutamate receptor subunit, GluR5: expression in the nervous system during development. Bettler B, etal., Neuron 1990 Nov;5(5):583-95.
2. Enhanced efficacy without further cleft closure: reevaluating twist as a source of agonist efficacy in AMPA receptors. Birdsey-Benson A, etal., J Neurosci. 2010 Jan 27;30(4):1463-70. doi: 10.1523/JNEUROSCI.4558-09.2010.
3. AMPA receptor phosphorylation during synaptic plasticity. Boehm J and Malinow R, Biochem Soc Trans. 2005 Dec;33(Pt 6):1354-6.
4. Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit. Effect on receptor phosphorylation. Correia SS, etal., J Biol Chem. 2003 Feb 21;278(8):6307-13. Epub 2002 Dec 5.
5. Comparative dynamics of NMDA- and AMPA-glutamate receptor N-terminal domains. Dutta A, etal., Structure. 2012 Nov 7;20(11):1838-49. doi: 10.1016/j.str.2012.08.012. Epub 2012 Sep 6.
6. Presynaptic localization of an AMPA-type glutamate receptor in corticostriatal and thalamostriatal axon terminals. Fujiyama F, etal., Eur J Neurosci. 2004 Dec;20(12):3322-30. doi: 10.1111/j.1460-9568.2004.03807.x.
7. Molecular cloning and development analysis of a new glutamate receptor subunit isoform in cerebellum. Gallo V, etal., J Neurosci. 1992 Mar;12(3):1010-23. doi: 10.1523/JNEUROSCI.12-03-01010.1992.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Correlating AMPA receptor activation and cleft closure across subunits: crystal structures of the GluR4 ligand-binding domain in complex with full and partial agonists. Gill A, etal., Biochemistry. 2008 Dec 30;47(52):13831-41. doi: 10.1021/bi8013196.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Role of dimer interface in activation and desensitization in AMPA receptors. Gonzalez J, etal., Proc Natl Acad Sci U S A. 2010 May 25;107(21):9891-6. doi: 10.1073/pnas.0911854107. Epub 2010 May 10.
12. Structure and organization of heteromeric AMPA-type glutamate receptors. Herguedas B, etal., Science. 2016 Apr 29;352(6285):aad3873. doi: 10.1126/science.aad3873. Epub 2016 Mar 10.
13. The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. Hirbec H, etal., J Biol Chem. 2002 May 3;277(18):15221-4. Epub 2002 Mar 12.
14. Determinants of antagonist binding at the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit, GluR-D. Role of the conserved arginine 507 and glutamate 727 residues. Jouppila A, etal., Eur J Biochem 2002 Dec;269(24):6261-70.
15. AMPA receptor subunit-specific regulation by a distinct family of type II TARPs. Kato AS, etal., Neuron. 2008 Sep 25;59(6):986-96. doi: 10.1016/j.neuron.2008.07.034.
16. A family of AMPA-selective glutamate receptors. Keinanen K, etal., Science 1990 Aug 3;249(4968):556-60.
17. Ionotropic glutamate receptors are expressed in GABAergic terminals in the rat superficial dorsal horn. Lu CR, etal., J Comp Neurol. 2005 May 30;486(2):169-78.
18. The structure and function of glutamate receptor ion channels. Madden DR Nat Rev Neurosci. 2002 Feb;3(2):91-101.
19. Positive association of the AMPA receptor subunit GluR4 gene (GRIA4) haplotype with schizophrenia: linkage disequilibrium mapping using SNPs evenly distributed across the gene region. Makino C, etal., Am J Med Genet B Neuropsychiatr Genet 2003 Jan 1;116(1):17-22.
20. The origin of the alkaline inactivation of pepsinogen. McPhie P, Biochemistry. 1975 Dec 2;14(24):5253-6.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Differential synaptic distribution of AMPA receptor subunits in the ventral posterior and reticular thalamic nuclei of the rat. Mineff EM and Weinberg RJ, Neuroscience. 2000;101(4):969-82. doi: 10.1016/s0306-4522(00)00421-8.
23. Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate. Nakatsu Y, etal., Toxicol Appl Pharmacol. 2009 Oct 15;240(2):292-8. Epub 2009 Jul 7.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Characterization of the functional role of the N-glycans in the AMPA receptor ligand-binding domain. Pasternack A, etal., J Neurochem. 2003 Mar;84(5):1184-92. doi: 10.1046/j.1471-4159.2003.01611.x.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers. Rossmann M, etal., EMBO J. 2011 Mar 2;30(5):959-71. doi: 10.1038/emboj.2011.16. Epub 2011 Feb 11.
30. Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors. Schwenk J, etal., Science. 2009 Mar 6;323(5919):1313-9. doi: 10.1126/science.1167852.
31. Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Sommer B, etal., Science 1990 Sep 28;249(4976):1580-5.
32. Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5. Soto D, etal., Nat Neurosci. 2009 Mar;12(3):277-85. doi: 10.1038/nn.2266. Epub 2009 Feb 22.
33. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
34. Rapid and bi-directional regulation of AMPA receptor phosphorylation and trafficking by JNK. Thomas GM, etal., EMBO J. 2008 Jan 23;27(2):361-72. doi: 10.1038/sj.emboj.7601969. Epub 2008 Jan 10.
35. Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting. Wyszynski M, etal., Neuron 2002 Mar 28;34(1):39-52.
36. Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption. Zhao WQ, etal., J Biol Chem. 2010 Mar 5;285(10):7619-32. doi: 10.1074/jbc.M109.057182. Epub 2009 Dec 23.
37. Postnatal synaptic potentiation: delivery of GluR4-containing AMPA receptors by spontaneous activity. Zhu JJ, etal., Nat Neurosci. 2000 Nov;3(11):1098-106.
Additional References at PubMed
PMID:1309749   PMID:7992055   PMID:8889548   PMID:10027300   PMID:10688364   PMID:12477932   PMID:12574408   PMID:12911624   PMID:14706873   PMID:15883194   PMID:17873364   PMID:18765917  
PMID:19052206   PMID:19200070   PMID:19439609   PMID:20131911   PMID:21172611   PMID:21700703   PMID:21857658   PMID:22632720   PMID:23296627   PMID:23375774   PMID:24769233   PMID:27157711  
PMID:27714514  


Genomics

Comparative Map Data
Gria4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr889,845,421 - 10,320,021 (-)NCBIGRCr8
mRatBN7.281,562,118 - 2,035,035 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl81,562,119 - 2,034,979 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx85,549,528 - 6,002,818 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.083,847,265 - 4,300,576 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.081,793,462 - 2,275,720 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.081,548,145 - 2,045,874 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl81,548,146 - 2,045,817 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.081,676,489 - 2,069,626 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.081,542,036 - 1,606,502 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48956,325 - 1,438,314 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18957,189 - 1,438,021 (-)NCBI
Celera81,445,037 - 1,902,161 (-)NCBICelera
Cytogenetic Map8q11NCBI
GRIA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811105,609,616 - 105,982,090 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11105,609,535 - 105,982,090 (+)EnsemblGRCh38hg38GRCh38
GRCh3711105,480,800 - 105,852,817 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611104,986,010 - 105,358,029 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411104,986,934 - 105,355,676NCBI
Celera11102,645,046 - 103,017,070 (+)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef11101,412,072 - 101,783,915 (+)NCBIHuRef
CHM1_111105,364,023 - 105,735,685 (+)NCBICHM1_1
T2T-CHM13v2.011105,613,870 - 105,986,693 (+)NCBIT2T-CHM13v2.0
Gria4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3994,417,893 - 4,796,250 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl94,417,896 - 4,796,234 (-)EnsemblGRCm39 Ensembl
GRCm3894,417,893 - 4,796,234 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl94,417,896 - 4,796,234 (-)EnsemblGRCm38mm10GRCm38
MGSCv3794,417,893 - 4,796,234 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3694,417,896 - 4,796,142 (-)NCBIMGSCv36mm8
Celera3117,909,944 - 118,286,524 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Gria4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554128,307,091 - 8,644,598 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554128,306,187 - 8,644,156 (+)NCBIChiLan1.0ChiLan1.0
GRIA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29106,355,155 - 106,730,387 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111107,443,410 - 107,824,127 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011100,498,632 - 100,873,764 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111103,982,785 - 104,357,629 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11103,983,862 - 104,355,280 (+)Ensemblpanpan1.1panPan2
GRIA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1526,272,008 - 26,642,819 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl526,272,970 - 26,642,100 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha526,197,215 - 26,574,534 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0526,300,625 - 26,678,461 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl526,299,273 - 26,678,282 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1526,351,009 - 26,721,522 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0526,236,451 - 26,607,672 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0526,386,039 - 26,759,919 (-)NCBIUU_Cfam_GSD_1.0
Gria4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494788,776,461 - 89,111,029 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365512,425,080 - 2,760,189 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365512,426,840 - 2,760,042 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl935,442,091 - 35,805,357 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1935,442,060 - 35,803,989 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2939,465,051 - 39,839,043 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRIA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1197,003,564 - 97,377,850 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl197,004,515 - 97,378,597 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604328,501,572 - 28,878,171 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gria4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624784429,084 - 793,138 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624784428,295 - 792,593 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gria4
2611 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:77
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000009542
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)813402289Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat

Markers in Region
D8Rat228  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.081,751,561 - 1,751,680NCBIRnor5.0
RGSC_v3.481,127,280 - 1,127,498RGDRGSC3.4
RGSC_v3.481,127,281 - 1,127,498UniSTSRGSC3.4
RGSC_v3.181,127,280 - 1,127,498RGD
SHRSP x BN Map81.0UniSTS
SHRSP x BN Map81.0RGD
FHH x ACI Map81.11RGD
Cytogenetic Map8q11UniSTS
D8Got3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.281,798,512 - 1,798,770 (+)MAPPERmRatBN7.2
Rnor_6.081,813,140 - 1,813,397NCBIRnor6.0
Rnor_5.081,834,282 - 1,834,539UniSTSRnor5.0
RGSC_v3.481,194,468 - 1,194,725RGDRGSC3.4
RGSC_v3.481,194,469 - 1,194,726UniSTSRGSC3.4
RGSC_v3.181,194,468 - 1,194,725RGD
Celera81,680,170 - 1,680,427UniSTS
RH 2.0 Map80.0RGD
Cytogenetic Map8q11UniSTS
AW531802  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.281,921,117 - 1,921,268 (+)MAPPERmRatBN7.2
mRatBN7.2154,615,370 - 4,615,517 (-)MAPPERmRatBN7.2
Rnor_6.081,933,354 - 1,933,504NCBIRnor6.0
Rnor_5.081,956,740 - 1,956,890UniSTSRnor5.0
Celera81,800,389 - 1,800,539UniSTS
Celera15250 - 399UniSTS
RH 3.4 Map1568.9UniSTS
Cytogenetic Map15p16UniSTS
Cytogenetic Map8q11UniSTS
UniSTS:25220  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.281,645,744 - 1,645,780 (+)MAPPERmRatBN7.2
mRatBN7.21670,197,622 - 70,198,235 (+)MAPPERmRatBN7.2
Rnor_6.081,631,735 - 1,631,770NCBIRnor6.0
Rnor_6.01675,193,146 - 75,193,758NCBIRnor6.0
Rnor_5.081,656,117 - 1,656,153NCBIRnor5.0
Rnor_5.01674,810,871 - 74,811,403NCBIRnor5.0
RGSC_v3.41674,874,971 - 74,875,583UniSTSRGSC3.4
RGSC_v3.481,039,345 - 1,039,380UniSTSRGSC3.4
Celera81,527,912 - 1,527,947UniSTS
Celera1668,076,960 - 68,077,572UniSTS
Cytogenetic Map8q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 62 9
Low 4 16 8 8 8 8 10 10 23 2 8
Below cutoff 2 36 30 22 17 22 3 2 17 9 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001113184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001113185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010053935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010053936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010053937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC107267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC128948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY158020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF390245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF390683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF413680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB761818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK598329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV726151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M36421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M38063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M85037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000009542   ⟹   ENSRNOP00000009542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl81,562,119 - 2,034,979 (-)Ensembl
Rnor_6.0 Ensembl81,548,146 - 2,045,817 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078765   ⟹   ENSRNOP00000068876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl81,623,212 - 2,034,979 (-)Ensembl
Rnor_6.0 Ensembl81,609,205 - 2,045,817 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081171   ⟹   ENSRNOP00000068940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl81,562,119 - 2,034,979 (-)Ensembl
Rnor_6.0 Ensembl81,548,146 - 2,045,817 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111725   ⟹   ENSRNOP00000081710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl81,625,181 - 2,034,979 (-)Ensembl
RefSeq Acc Id: NM_001113184   ⟹   NP_001106655
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr889,847,051 - 10,319,881 (-)NCBI
mRatBN7.281,562,118 - 2,034,979 (-)NCBI
Rnor_6.081,548,145 - 2,045,817 (-)NCBI
Rnor_5.081,542,036 - 1,606,502 (-)NCBI
Rnor_5.081,676,489 - 2,069,626 (-)NCBI
RGSC_v3.48956,325 - 1,438,314 (-)RGD
Celera81,445,037 - 1,902,161 (-)RGD
Sequence:
RefSeq Acc Id: NM_001113185   ⟹   NP_001106656
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr889,908,137 - 10,319,881 (-)NCBI
mRatBN7.281,623,211 - 2,034,979 (-)NCBI
Rnor_6.081,609,204 - 2,045,817 (-)NCBI
Rnor_5.081,542,036 - 1,606,502 (-)NCBI
Rnor_5.081,676,489 - 2,069,626 (-)NCBI
RGSC_v3.48956,325 - 1,438,314 (-)RGD
Celera81,505,395 - 1,902,161 (-)NCBI
Sequence:
RefSeq Acc Id: NM_017263   ⟹   NP_058959
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr889,847,051 - 10,319,881 (-)NCBI
mRatBN7.281,562,118 - 2,034,979 (-)NCBI
Rnor_6.081,548,145 - 2,045,817 (-)NCBI
Rnor_5.081,542,036 - 1,606,502 (-)NCBI
Rnor_5.081,676,489 - 2,069,626 (-)NCBI
RGSC_v3.48956,325 - 1,438,314 (-)RGD
Celera81,445,037 - 1,902,161 (-)RGD
Sequence:
RefSeq Acc Id: XM_017595510   ⟹   XP_017450999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr889,848,042 - 10,320,021 (-)NCBI
mRatBN7.281,563,111 - 2,035,035 (-)NCBI
Rnor_6.081,549,189 - 2,045,872 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595511   ⟹   XP_017451000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr889,848,042 - 10,320,021 (-)NCBI
mRatBN7.281,563,111 - 2,035,035 (-)NCBI
Rnor_6.081,549,189 - 2,045,872 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080969   ⟹   XP_038936897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr889,870,840 - 10,320,021 (-)NCBI
mRatBN7.281,585,908 - 2,035,034 (-)NCBI
RefSeq Acc Id: XM_063265031   ⟹   XP_063121101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr889,845,421 - 10,320,021 (-)NCBI
RefSeq Acc Id: XM_063265032   ⟹   XP_063121102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr889,845,421 - 10,320,021 (-)NCBI
RefSeq Acc Id: XM_063265033   ⟹   XP_063121103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr889,845,421 - 10,320,021 (-)NCBI
RefSeq Acc Id: XR_010053935
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr889,850,880 - 10,320,021 (-)NCBI
RefSeq Acc Id: XR_010053936
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr889,850,880 - 10,320,021 (-)NCBI
RefSeq Acc Id: XR_010053937
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr889,850,880 - 10,320,021 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_058959   ⟸   NM_017263
- Peptide Label: isoform 1 precursor
- UniProtKB: Q64241 (UniProtKB/Swiss-Prot),   P19493 (UniProtKB/Swiss-Prot),   A0A0G2JU28 (UniProtKB/TrEMBL),   A6KQJ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001106655   ⟸   NM_001113184
- Peptide Label: isoform 2 precursor
- UniProtKB: Q64241 (UniProtKB/Swiss-Prot),   P19493 (UniProtKB/Swiss-Prot),   G3V6W1 (UniProtKB/TrEMBL),   A6KQJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001106656   ⟸   NM_001113185
- Peptide Label: isoform 3 precursor
- UniProtKB: Q566D4 (UniProtKB/TrEMBL),   A0A8I5ZUN6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451000   ⟸   XM_017595511
- Peptide Label: isoform X2
- UniProtKB: Q64241 (UniProtKB/Swiss-Prot),   P19493 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017450999   ⟸   XM_017595510
- Peptide Label: isoform X3
- UniProtKB: Q64241 (UniProtKB/Swiss-Prot),   P19493 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009542   ⟸   ENSRNOT00000009542
RefSeq Acc Id: ENSRNOP00000068940   ⟸   ENSRNOT00000081171
RefSeq Acc Id: ENSRNOP00000068876   ⟸   ENSRNOT00000078765
RefSeq Acc Id: XP_038936897   ⟸   XM_039080969
- Peptide Label: isoform X6
- UniProtKB: Q64241 (UniProtKB/Swiss-Prot),   P19493 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000081710   ⟸   ENSRNOT00000111725
RefSeq Acc Id: XP_063121102   ⟸   XM_063265032
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063121103   ⟸   XM_063265033
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063121101   ⟸   XM_063265031
- Peptide Label: isoform X1
Protein Domains
Ionotropic glutamate receptor C-terminal   Ionotropic glutamate receptor L-glutamate and   Receptor ligand binding region

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19493-F1-model_v2 AlphaFold P19493 1-902 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61863 AgrOrtholog
BIND 144347
BioCyc Gene G2FUF-31834 BioCyc
Ensembl Genes ENSRNOG00000006957 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009542 ENTREZGENE
  ENSRNOT00000009542.6 UniProtKB/TrEMBL
  ENSRNOT00000078765 ENTREZGENE
  ENSRNOT00000078765.2 UniProtKB/TrEMBL
  ENSRNOT00000081171 ENTREZGENE
  ENSRNOT00000081171.2 UniProtKB/TrEMBL
  ENSRNOT00000111725.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Periplasmic binding protein-like II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glu/Gly-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iono_rcpt_met UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ionotropic_Glu_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iontro_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Solute-binding_3/MltF_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29629 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29629 ENTREZGENE
PANTHER GLUTAMATE RECEPTOR 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IONOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SBP_bac_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gria4 PhenoGen
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006957 RatGTEx
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PBPe UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC233174
UniProt A0A0G2JU28 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZUN6 ENTREZGENE, UniProtKB/TrEMBL
  A6KQJ6 ENTREZGENE, UniProtKB/TrEMBL
  A6KQJ7 ENTREZGENE, UniProtKB/TrEMBL
  G3V6W1 ENTREZGENE, UniProtKB/TrEMBL
  GRIA4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q566D4 ENTREZGENE, UniProtKB/TrEMBL
  Q64241 ENTREZGENE
  Q80ZF6_RAT UniProtKB/TrEMBL
UniProt Secondary Q64241 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Gria4  glutamate ionotropic receptor AMPA type subunit 4  Gria4  glutamate receptor, ionotropic, AMPA 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-16 Gria4  glutamate receptor, ionotropic, AMPA 4  Gria4  glutamate receptor, ionotrophic, AMPA 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Gria4  glutamate receptor, ionotropic, AMPA4   Gria4  glutamate receptor, ionotropic, 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gria4  glutamate receptor, ionotropic, 4      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference