Fkbp1b (FKBP prolyl isomerase 1B) - Rat Genome Database

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Gene: Fkbp1b (FKBP prolyl isomerase 1B) Rattus norvegicus
Analyze
Symbol: Fkbp1b
Name: FKBP prolyl isomerase 1B
RGD ID: 61835
Description: Enables FK506 binding activity and cyclic nucleotide binding activity. Involved in several processes, including positive regulation of axon regeneration; response to hydrogen peroxide; and response to vitamin E. Predicted to be located in Z disc; membrane; and sarcoplasmic reticulum. Predicted to be part of calcium channel complex. Predicted to be active in sarcoplasmic reticulum membrane. Biomarker of cardiomyopathy and congestive heart failure. Human ortholog(s) of this gene implicated in Graves' disease. Orthologous to human FKBP1B (FKBP prolyl isomerase 1B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 12.6 kDa FK506-binding protein; 12.6 kDa FKBP; calstabin-2; FK506 binding protein 1B; FK506 binding protein 1b (12.6 kDa); FK506-binding protein 1B; FKBP-12.6; FKBP-1B; immunophilin FKBP12.6; peptidyl-prolyl cis-trans isomerase FKBP1B; PPIase FKBP1B; rotamase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8633,551,583 - 33,570,055 (-)NCBIGRCr8
mRatBN7.2627,832,128 - 27,850,600 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl627,838,802 - 27,848,653 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx628,131,312 - 28,140,929 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0628,447,216 - 28,456,831 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0627,921,773 - 27,931,386 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0629,975,863 - 29,987,252 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl629,977,797 - 29,987,451 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0639,899,242 - 39,908,337 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera627,309,253 - 27,318,232 (-)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,4-dichloroaniline  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acetylcholine  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
atenolol  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (EXP)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
carvedilol  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dantrolene  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
diisopropyl fluorophosphate  (EXP)
diuron  (ISO)
dofetilide  (EXP)
dorsomorphin  (ISO)
folic acid  (ISO)
halothane  (ISO)
indometacin  (ISO)
isoprenaline  (EXP)
L-methionine  (ISO)
metoprolol  (ISO)
nickel sulfate  (ISO)
ochratoxin A  (EXP)
paracetamol  (ISO)
phenylmercury acetate  (ISO)
propanal  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
ryanodine  (ISO)
SB 431542  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Oral administration of a nonimmunosuppressant FKBP-12 ligand speeds nerve regeneration. Gold BG, etal., Neuroreport. 1998 Feb 16;9(3):553-8.
3. Decreased FKBP12.6 expression and enhanced endothelin receptor signaling associated with arrhymogenesis in myocardial infarction rats. He H, etal., Phytother Res. 2008 Aug;22(8):1115-24.
4. Down-regulation of FKBP12.6 and SERCA2a contributes to acute heart failure in septic shock and is related to an up-regulated endothelin signalling pathway. He HB, etal., J Pharm Pharmacol. 2007 Jul;59(7):977-84.
5. Endothelin receptor antagonist CPU0213 and vitamin E reverse downregulation of FKBP12.6 and SERCA2a: a role of hyperphosphorylation of PKCepsilon. Li N, etal., Eur J Pharmacol. 2008 Sep 4;591(1-3):211-8. Epub 2008 Jun 27.
6. Spinal Cord Injury Leads to Hyperoxidation and Nitrosylation of Skeletal Muscle Ryanodine Receptor-1 Associated with Upregulation of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4. Liu XH, etal., J Neurotrauma. 2017 Jun 15;34(12):2069-2074. doi: 10.1089/neu.2016.4763. Epub 2017 Feb 27.
7. Evidence of association between FKBP1B and thyroid autoimmune disorders in a large Tunisian family. Maalej A, etal., Autoimmunity. 2004 May;37(3):237-9.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Abrupt changes in FKBP12.6 and SERCA2a expression contribute to sudden occurrence of ventricular fibrillation on reperfusion and are prevented by CPU86017. Na T, etal., Acta Pharmacol Sin. 2007 Jun;28(6):773-82.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca2+ from islet microsomes. Noguchi N, etal., J Biol Chem 1997 Feb 7;272(6):3133-6.
12. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
13. Total triterpene acids, active ingredients from Fructus Corni, attenuate diabetic cardiomyopathy by normalizing ET pathway and expression of FKBP12.6 and SERCA2a in streptozotocin-rats. Qi MY, etal., J Pharm Pharmacol. 2008 Dec;60(12):1687-94.
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:7513996   PMID:7592869   PMID:10830164   PMID:11237759   PMID:12443530   PMID:12837242   PMID:14592808   PMID:14605212   PMID:15024040   PMID:16213210   PMID:16481613   PMID:16672364  
PMID:17921453   PMID:18466757   PMID:19226252   PMID:19578067   PMID:19805579   PMID:20080623   PMID:20431056   PMID:21289178   PMID:21788490   PMID:22087651   PMID:22363773   PMID:24053175  
PMID:26224869   PMID:29255009  


Genomics

Comparative Map Data
Fkbp1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8633,551,583 - 33,570,055 (-)NCBIGRCr8
mRatBN7.2627,832,128 - 27,850,600 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl627,838,802 - 27,848,653 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx628,131,312 - 28,140,929 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0628,447,216 - 28,456,831 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0627,921,773 - 27,931,386 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0629,975,863 - 29,987,252 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl629,977,797 - 29,987,451 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0639,899,242 - 39,908,337 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera627,309,253 - 27,318,232 (-)NCBICelera
Cytogenetic Map6q14NCBI
FKBP1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38224,033,206 - 24,063,681 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl224,049,701 - 24,063,681 (+)EnsemblGRCh38hg38GRCh38
GRCh37224,272,611 - 24,286,551 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36224,126,132 - 24,140,055 (+)NCBINCBI36Build 36hg18NCBI36
Build 34224,184,278 - 24,198,199NCBI
Celera224,112,915 - 24,126,882 (+)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef224,011,446 - 24,025,414 (+)NCBIHuRef
CHM1_1224,201,974 - 24,215,941 (+)NCBICHM1_1
T2T-CHM13v2.0224,067,904 - 24,098,366 (+)NCBIT2T-CHM13v2.0
Fkbp1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39124,883,174 - 4,891,736 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl124,883,174 - 4,891,591 (-)EnsemblGRCm39 Ensembl
GRCm38124,833,176 - 4,841,573 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl124,833,174 - 4,841,591 (-)EnsemblGRCm38mm10GRCm38
MGSCv37124,839,980 - 4,848,401 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36124,855,524 - 4,863,925 (-)NCBIMGSCv36mm8
Celera124,764,579 - 4,773,000 (-)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map122.09NCBI
Fkbp1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554696,263,271 - 6,277,767 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554696,263,271 - 6,274,823 (+)NCBIChiLan1.0ChiLan1.0
FKBP1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212102,454,794 - 102,469,102 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A102,458,758 - 102,473,066 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A24,047,287 - 24,065,765 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A24,145,893 - 24,162,842 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A24,145,893 - 24,159,082 (+)Ensemblpanpan1.1panPan2
FKBP1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11718,534,295 - 18,544,973 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1718,534,741 - 18,544,943 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1718,433,090 - 18,443,766 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01718,809,188 - 18,819,365 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1718,705,120 - 18,715,320 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11718,545,586 - 18,556,272 (+)NCBIUMICH_Zoey_3.1
UU_Cfam_GSD_1.01718,595,511 - 18,606,198 (+)NCBIUU_Cfam_GSD_1.0
Fkbp1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629262,916,727 - 62,923,563 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364937,916,002 - 7,922,796 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364937,916,002 - 7,922,747 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FKBP1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3114,623,532 - 114,634,628 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13114,623,529 - 114,636,200 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23121,888,309 - 121,899,459 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FKBP1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11483,606,511 - 83,620,289 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1483,606,454 - 83,620,205 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604528,546,085 - 28,559,863 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fkbp1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247386,382,983 - 6,394,051 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247386,383,003 - 6,394,051 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fkbp1b
70 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:49
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000071784
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat

Markers in Region
RH133671  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2627,839,107 - 27,839,321 (-)MAPPERmRatBN7.2
Rnor_6.0629,986,997 - 29,987,210NCBIRnor6.0
Rnor_5.0639,899,284 - 39,899,497UniSTSRnor5.0
Celera627,308,799 - 27,309,012UniSTS
RH 3.4 Map6117.7UniSTS
RH94771  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2627,840,723 - 27,840,788 (-)MAPPERmRatBN7.2
Rnor_6.0629,985,530 - 29,985,594NCBIRnor6.0
Rnor_5.0639,900,900 - 39,900,964UniSTSRnor5.0
Celera627,310,415 - 27,310,479UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 54 17
Low 3 26 23 14 7 14 4 4 20 18 40 10 4
Below cutoff 13 20 13 12 13 4 5 1 1 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001401262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005505573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D86642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000071784   ⟹   ENSRNOP00000067023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl627,838,802 - 27,848,653 (-)Ensembl
Rnor_6.0 Ensembl629,977,797 - 29,987,451 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119856   ⟹   ENSRNOP00000092320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl627,839,691 - 27,848,653 (-)Ensembl
RefSeq Acc Id: NM_001401262   ⟹   NP_001388191
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,558,517 - 33,568,129 (-)NCBI
mRatBN7.2627,839,066 - 27,848,680 (-)NCBI
RefSeq Acc Id: NM_001401263   ⟹   NP_001388192
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,558,517 - 33,568,129 (-)NCBI
mRatBN7.2627,839,066 - 27,848,680 (-)NCBI
RefSeq Acc Id: NM_022675   ⟹   NP_073166
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,558,517 - 33,568,129 (-)NCBI
mRatBN7.2627,839,066 - 27,848,680 (-)NCBI
Rnor_6.0629,977,893 - 29,986,756 (+)NCBI
Rnor_5.0639,899,242 - 39,908,337 (-)NCBI
Celera627,309,253 - 27,318,232 (-)RGD
Sequence:
RefSeq Acc Id: XM_017594336   ⟹   XP_017449825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,558,519 - 33,570,055 (-)NCBI
mRatBN7.2627,839,066 - 27,850,600 (-)NCBI
Rnor_6.0629,975,863 - 29,987,252 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112798   ⟹   XP_038968726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,551,583 - 33,568,291 (-)NCBI
mRatBN7.2627,832,128 - 27,848,833 (-)NCBI
RefSeq Acc Id: XM_039112799   ⟹   XP_038968727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,559,198 - 33,568,306 (-)NCBI
mRatBN7.2627,839,748 - 27,848,830 (-)NCBI
RefSeq Acc Id: XM_039112800   ⟹   XP_038968728
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,558,519 - 33,569,936 (-)NCBI
mRatBN7.2627,839,744 - 27,850,224 (-)NCBI
RefSeq Acc Id: XM_039112802   ⟹   XP_038968730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,551,583 - 33,568,288 (-)NCBI
mRatBN7.2627,833,180 - 27,848,809 (-)NCBI
RefSeq Acc Id: XM_039112803   ⟹   XP_038968731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,551,583 - 33,568,289 (-)NCBI
mRatBN7.2627,832,749 - 27,848,810 (-)NCBI
RefSeq Acc Id: XM_039112805   ⟹   XP_038968733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,558,519 - 33,568,277 (-)NCBI
mRatBN7.2627,839,601 - 27,848,800 (-)NCBI
RefSeq Acc Id: XM_039112806   ⟹   XP_038968734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,551,583 - 33,569,929 (-)NCBI
mRatBN7.2627,833,180 - 27,850,219 (-)NCBI
RefSeq Acc Id: XM_063262379   ⟹   XP_063118449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,559,195 - 33,570,040 (-)NCBI
RefSeq Acc Id: XM_063262380   ⟹   XP_063118450
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,559,195 - 33,570,049 (-)NCBI
RefSeq Acc Id: XM_063262381   ⟹   XP_063118451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,558,519 - 33,570,048 (-)NCBI
RefSeq Acc Id: XR_005505573
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8633,551,583 - 33,568,288 (-)NCBI
mRatBN7.2627,832,128 - 27,848,808 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_073166   ⟸   NM_022675
- Peptide Label: isoform 1
- UniProtKB: P97534 (UniProtKB/Swiss-Prot),   A6HAJ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449825   ⟸   XM_017594336
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: ENSRNOP00000067023   ⟸   ENSRNOT00000071784
RefSeq Acc Id: XP_038968726   ⟸   XM_039112798
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038968731   ⟸   XM_039112803
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038968734   ⟸   XM_039112806
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038968730   ⟸   XM_039112802
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038968733   ⟸   XM_039112805
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038968728   ⟸   XM_039112800
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038968727   ⟸   XM_039112799
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000092320   ⟸   ENSRNOT00000119856
RefSeq Acc Id: NP_001388191   ⟸   NM_001401262
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001388192   ⟸   NM_001401263
- Peptide Label: isoform 3
RefSeq Acc Id: XP_063118451   ⟸   XM_063262381
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063118450   ⟸   XM_063262380
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063118449   ⟸   XM_063262379
- Peptide Label: isoform X6
Protein Domains
PPIase FKBP-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97534-F1-model_v2 AlphaFold P97534 1-108 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694479
Promoter ID:EPDNEW_R5002
Type:initiation region
Name:Fkbp1b_1
Description:FK506 binding protein 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0629,977,785 - 29,977,845EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61835 AgrOrtholog
BioCyc Gene G2FUF-38263 BioCyc
Ensembl Genes ENSRNOG00000047143 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055018861 UniProtKB/Swiss-Prot
  ENSRNOG00060012567 UniProtKB/Swiss-Prot
  ENSRNOG00065022664 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000071784 ENTREZGENE
  ENSRNOT00000071784.3 UniProtKB/Swiss-Prot
  ENSRNOT00000119856.1 UniProtKB/TrEMBL
  ENSRNOT00055032149 UniProtKB/Swiss-Prot
  ENSRNOT00060021315 UniProtKB/Swiss-Prot
  ENSRNOT00065038734 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.50.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PPIase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPIase_FKBP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:58950 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 58950 ENTREZGENE
PANTHER PEPTIDYL-PROLYL CIS-TRANS ISOMERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FKBP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB FKBP1B RGD
PhenoGen Fkbp1b PhenoGen
PROSITE FKBP_PPIASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047143 RatGTEx
  ENSRNOG00055018861 RatGTEx
  ENSRNOG00060012567 RatGTEx
  ENSRNOG00065022664 RatGTEx
Superfamily-SCOP FKBP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC208795
UniProt A0A8I6GJN8_RAT UniProtKB/TrEMBL
  A6HAJ4 ENTREZGENE, UniProtKB/TrEMBL
  FKB1B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-11-09 Fkbp1b  FKBP prolyl isomerase 1B  Fkbp1b  FK506 binding protein 1B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-01 Fkbp1b  FK506 binding protein 1B  Fkbp1b  FK506 binding protein 1b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Fkbp1b  FK506 binding protein 1b      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression found in pancreatic islets of Langerhans 61587
gene_physical_interaction binds selectively to ryanodine receptor 2(RyR2), also binds cyclic ADP-ribose 61587
gene_process effects the release of intracellular calcium, my be important for insulin secretion 61587