Aoc1 (amine oxidase, copper containing 1)

Gene: Aoc1 (amine oxidase, copper containing 1) Rattus norvegicus

Analyze

Symbol:

Aoc1

Name:

amine oxidase, copper containing 1

RGD ID:

61296

Description:

Enables diamine oxidase activity and organic cyclic compound binding activity. Involved in cellular response to copper ion starvation and response to antibiotic. Located in bicellular tight junction. Orthologous to human AOC1 (amine oxidase copper containing 1); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; INTERACTS WITH (R)-adrenaline; (S)-timolol (anhydrous); 1-naphthyl isothiocyanate.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Abp; Abp1; amiloride binding protein 1; amiloride binding protein 1 (amine oxidase, copper-containing); amiloride-binding protein; amiloride-binding protein 1; amiloride-sensitive amine oxidase; amiloride-sensitive amine oxidase [copper-containing]; amine oxidase copper domain-containing protein 1; DAO; diamine oxidase; histaminase

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AOC1 (amine oxidase copper containing 1)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Aoc1 (amine oxidase, copper-containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Aoc1 (amine oxidase copper containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AOC1 (amine oxidase copper containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AOC1 (amine oxidase copper containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Aoc1 (amine oxidase copper containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AOC1 (amine oxidase copper containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AOC1 (amine oxidase copper containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Aoc1 (amine oxidase copper containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	AOC1 (amine oxidase copper containing 1)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Aoc1 (amine oxidase, copper-containing 1)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	aoc1 (amine oxidase copper containing 1)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	aoc1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Is Marker For:

QTLs: Bp45 Bw10

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	79,143,126 - 79,162,705 (+)	NCBI		GRCr8
mRatBN7.2	4	77,812,260 - 77,831,846 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	77,812,260 - 77,831,840 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	83,019,777 - 83,039,389 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	78,795,250 - 78,814,860 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	77,235,544 - 77,255,152 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	78,496,043 - 78,515,582 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	78,496,043 - 78,515,584 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	143,183,686 - 143,203,225 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	76,957,477 - 76,977,643 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	77,247,444 - 77,253,779 (+)	NCBI
Celera	4	72,749,277 - 72,768,814 (+)	NCBI		Celera
Cytogenetic Map	4	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

Cardiomegaly (ISO)

Experimental Diabetes Mellitus (IEP)

genetic disease (ISO)

hypertension (ISO)

long QT syndrome (ISO)

Prostatic Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(R)-adrenaline (EXP)

(S)-timolol (anhydrous) (EXP)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-D (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

4-(ethoxymethylene)-2-phenyloxazol-5-one (EXP)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

actinomycin D (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

Allylamine (EXP)

amiloride (EXP,ISO)

aminoguanidine (EXP,ISO)

ammonium chloride (EXP)

Benzamil (EXP,ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (ISO)

bisphenol A (ISO)

cadmium dichloride (EXP)

calcium atom (ISO)

calcium(0) (ISO)

chloroprene (EXP)

chlorpyrifos (ISO)

choline (ISO)

chromium(6+) (ISO)

clofibrate (ISO)

colforsin daropate hydrochloride (EXP)

copper atom (ISO)

copper(0) (ISO)

curcumin (EXP,ISO)

cycloheximide (EXP)

cyclosporin A (ISO)

D-glucose (ISO)

deoxynivalenol (ISO)

diethylstilbestrol (ISO)

dioxygen (ISO)

ethylisopropylamiloride (EXP,ISO)

folic acid (ISO)

fructose (ISO)

gamma-aminobutyric acid (EXP)

genistein (ISO)

glucose (ISO)

glycidyl methacrylate (ISO)

histamine (ISO)

hydralazine (ISO)

indometacin (EXP)

isoprenaline (EXP)

L-methionine (ISO)

methotrexate (EXP,ISO)

methoxychlor (EXP)

N(tele)-methylhistamine (ISO)

N-acetyl-L-cysteine (EXP)

N-nitrosodiethylamine (EXP)

nickel sulfate (ISO)

O-methyleugenol (ISO)

ozone (ISO)

paracetamol (ISO)

paraquat (EXP)

perfluorononanoic acid (ISO)

Phenylamil (EXP,ISO)

PhIP (EXP)

pirinixic acid (EXP)

putrescine (EXP,ISO)

Salidroside (ISO)

simvastatin (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

spermidine (EXP)

tacrolimus hydrate (ISO)

terbutaline (EXP)

theophylline (EXP,ISO)

titanium dioxide (EXP,ISO)

trichloroethene (EXP)

trimellitic anhydride (EXP,ISO)

valproic acid (ISO)

vancomycin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amine metabolic process (IBA,IEA)

biological_process (ND)

putrescine metabolic process (ISO,ISS)

response to antibiotic (IBA,IEA)

Cellular Component

bicellular tight junction (IDA)

extracellular exosome (ISO)

extracellular space (ISO,ISS)

plasma membrane (IBA,IEA,ISO,ISS)

Molecular Function

calcium ion binding (ISO)

copper ion binding (IBA,IEA,ISO,ISS)

diamine oxidase activity (IBA,IDA,IEA,ISO)

heparin binding (ISO,ISS)

histamine oxidase activity (ISO,ISS)

methylputrescine oxidase activity (IEA)

organic cyclic compound binding (IPI)

primary amine oxidase activity (IBA,IEA,ISO)

propane-1,3-diamine oxidase activity (IEA)

protein binding (ISO)

protein homodimerization activity (ISO)

putrescine oxidase activity (IDA,ISO,ISS)

quinone binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

alkaptonuria pathway (ISO)

arginine and proline metabolic pathway (IEA)

disulfiram pharmacodynamics pathway (ISO)

dopamine beta-hydroxylase deficiency pathway (ISO)

hawkinsinuria pathway (ISO)

histidine metabolic pathway (IEA,ISO)

histidinemia pathway (ISO)

tryptophan metabolic pathway (IEA)

tyrosine metabolic pathway (ISO)

tyrosinemia type I pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Inhibition of diamine oxidase activity by metronidazole.	Befani O, etal., Biochem Biophys Res Commun. 1995 Jul 17;212(2):589-94.
2.	Plasma diamine oxidase activities in renal dialysis patients, a human with spontaneous copper deficiency and marginally copper deficient rats.	DiSilvestro RA, etal., Clin Biochem. 1997 Oct;30(7):559-63.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers.	Ippolito JE, etal., Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12505-10. Epub 2006 Aug 8.
6.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
7.	Increased plasma post-heparin diamine oxidase activity and plant sterol levels in streptozotocin diabetic rat.	Kojima H, etal., Biochem Biophys Res Commun. 1992 Jul 15;186(1):398-404.
8.	Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18.	Kovacs P, etal., Biochem Biophys Res Commun 1997 Jun 18;235(2):343-8
9.	Molecular cloning and functional expression of different molecular forms of rat amiloride-binding proteins.	Lingueglia E, etal., Eur J Biochem 1993 Sep 1;216(2):679-87.
10.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
11.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
12.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
13.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
14.	GOA pipeline	RGD automated data pipeline
15.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
17.	Comprehensive gene review and curation	RGD comprehensive gene curation
18.	Effects of cardiopulmonary bypass on tight junction protein expressions in intestinal mucosa of rats.	Sun YJ, etal., World J Gastroenterol. 2008 Oct 14;14(38):5868-75.
19.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:2217167	PMID:8023885	PMID:8144586	PMID:12072962	PMID:12477932	PMID:16846222	PMID:19764817	PMID:21082674	PMID:22024144	PMID:23376485	PMID:23413254	PMID:23533145

Genomics

Comparative Map Data

Aoc1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	79,143,126 - 79,162,705 (+)	NCBI		GRCr8
mRatBN7.2	4	77,812,260 - 77,831,846 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	77,812,260 - 77,831,840 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	83,019,777 - 83,039,389 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	78,795,250 - 78,814,860 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	77,235,544 - 77,255,152 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	78,496,043 - 78,515,582 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	78,496,043 - 78,515,584 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	143,183,686 - 143,203,225 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	76,957,477 - 76,977,643 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	77,247,444 - 77,253,779 (+)	NCBI
Celera	4	72,749,277 - 72,768,814 (+)	NCBI		Celera
Cytogenetic Map	4	q24	NCBI

AOC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	150,852,120 - 150,861,504 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	150,824,627 - 150,861,504 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	150,549,605 - 150,558,592 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	150,180,506 - 150,189,312 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	149,987,239 - 149,996,025	NCBI
Celera	7	145,106,596 - 145,115,402 (+)	NCBI		Celera
Cytogenetic Map	7	q36.1	ENTREZGENE
HuRef	7	144,361,610 - 144,370,427 (+)	NCBI		HuRef
CHM1_1	7	150,557,803 - 150,566,593 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	152,025,287 - 152,034,270 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	149,878,851 - 149,887,665 (+)	NCBI

Aoc1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	48,872,189 - 48,886,122 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	48,849,830 - 48,886,122 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	48,895,255 - 48,909,188 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	48,872,896 - 48,909,188 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	48,845,254 - 48,859,186 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	48,824,840 - 48,838,774 (+)	NCBI		MGSCv36	mm8
Celera	6	49,405,009 - 49,418,946 (+)	NCBI		Celera
Cytogenetic Map	6	B2.3	NCBI
cM Map	6	23.78	NCBI

Aoc1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955491	5,316,476 - 5,326,305 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955491	5,316,482 - 5,326,262 (+)	NCBI	ChiLan1.0	ChiLan1.0

AOC1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	187,267,472 - 187,277,116 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	39,278,074 - 39,286,395 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	142,434,732 - 142,443,050 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	154,586,931 - 154,595,248 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	154,563,523 - 154,595,248 (+)	Ensembl	panpan1.1		panPan2

AOC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	14,955,528 - 14,963,283 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	14,958,658 - 15,036,651 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	15,563,706 - 15,571,546 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	16,671,139 - 16,678,130 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	16	15,049,911 - 15,057,763 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	15,631,448 - 15,639,287 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	15,681,981 - 15,689,844 (+)	NCBI		UU_Cfam_GSD_1.0

Aoc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	6,590,547 - 6,597,512 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936527	6,308,682 - 6,312,815 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936527	6,309,210 - 6,312,869 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AOC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	6,309,594 - 6,320,974 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	6,309,583 - 6,321,016 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	6,738,053 - 6,749,392 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AOC1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	119,037,498 - 119,046,875 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	119,038,356 - 119,047,279 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666072	15,014,229 - 15,018,767 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Aoc1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624800	5,739,034 - 5,749,608 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624800	5,739,076 - 5,749,567 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Aoc1
109 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	48
Count of miRNA genes:	47
Interacting mature miRNAs:	47
Transcripts:	ENSRNOT00000059136
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	5214602	78882945	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5214602	146446691	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	10814170	91360527	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	11320076	180699135	Rat
8655906	Rf60	Renal function QTL 60	3.8		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	4	29494195	81006281	Rat
12798520	Anxrr55	Anxiety related response QTL 55	4.45	0.01	locomotor behavior trait (VT:0001392)	number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)	4	32583980	114627242	Rat
8552782	Vie1	Viral induced encephalitis QTL 1	26.4		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	34430484	82490359	Rat
8552801	Bw143	Body weight QTL 143	7.3		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	4	34430484	82490359	Rat
8552809	Vie5	Viral induced encephalitis QTL 5	25.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	34430484	82490359	Rat
8655961	Kidm43	Kidney mass QTL 43	18		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	36303261	103194984	Rat
1358352	Srcrt3	Stress Responsive Cort QTL 3	2.29		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	38465774	146803430	Rat
1300139	Hrtrt6	Heart rate QTL 6	2.85		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	39524264	116179656	Rat
61445	Strs3	Sensitivity to stroke QTL 3	3		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	4	40433388	85433388	Rat
8694439	Bw168	Body weight QTL 168	9.57	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	40433414	85433414	Rat
6893678	Bw108	Body weight QTL 108	2.6	0.006	body mass (VT:0001259)	body weight (CMO:0000012)	4	43457976	88457976	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	44463720	155883716	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	44463908	148090542	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	44463908	148090542	Rat
2312567	Glom19	Glomerulus QTL 19	1.9	0.006	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	4	45456990	146803430	Rat
1298082	Stresp4	Stress response QTL 4			blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	50119848	146803430	Rat
4889969	Bss96	Bone structure and strength QTL 96	4.9		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	4	56647776	78882945	Rat
4889972	Bss97	Bone structure and strength QTL 97	5.6		tibia size trait (VT:0100001)	tibia total bone volume (CMO:0001724)	4	56647776	78882945	Rat
5685009	Bmd86	Bone mineral density QTL 86	3.7		tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	4	56647776	78882945	Rat
5685012	Bmd87	Bone mineral density QTL 87	5.1		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	4	56647776	78882945	Rat
70200	Alc18	Alcohol consumption QTL 18	9.2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	4	56647873	149491524	Rat
1641833	Alc21	Alcohol consumption QTL 21	8.6	0.0001	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	56698790	126192555	Rat
634311	Sach7	Saccharin preference QTL 7			taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	57114432	81266970	Rat
631546	Bp86	Blood pressure QTL 86	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	57114432	91360801	Rat
61336	Bp21	Blood pressure QTL 21	4.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	57114705	78881294	Rat
1358363	Sradr3	Stress Responsive Adrenal Weight QTL 3	6.19		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	4	57486946	102486946	Rat
1558651	Swd3	Spike wave discharge measurement QTL 3	4.62	0.000024	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge frequency (CMO:0001742)	4	58432133	92991462	Rat
631671	Iddm11	Insulin dependent diabetes mellitus QTL 11	3.6	0.0012	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	58635877	78886137	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	59948935	154902892	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	59948935	154902892	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	59948935	154902892	Rat
1578657	Bss12	Bone structure and strength QTL 12	8.9		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	4	60220938	105220938	Rat
1578658	Bss13	Bone structure and strength QTL 13	8		femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	4	60220938	105220938	Rat
2300179	Bmd50	Bone mineral density QTL 50	5.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	4	60928534	105928534	Rat
1549843	Bw53	Body weight QTL 53		0.0001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	61697658	103194791	Rat
1549839	Bw52	Body weight QTL 52		0.0001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	61697658	115089733	Rat
61418	Pia5	Pristane induced arthritis QTL 5	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	62277855	128289560	Rat
6478743	Anxrr40	Anxiety related response QTL 40		0.83076	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	62753847	107753847	Rat
6478772	Anxrr49	Anxiety related response QTL 49		0.15488	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	62753847	107753847	Rat
6478684	Anxrr30	Anxiety related response QTL 30		0.00087	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	62753847	107753847	Rat
631651	Bp124	Blood pressure QTL 124	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	62879517	107879517	Rat
7394826	Bw126	Body weight QTL 126		0.002	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	62933269	87483707	Rat
8552807	Vie4	Viral induced encephalitis QTL 4	7.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	62933508	82490359	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	62933508	114921294	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	62933508	114921294	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	62933508	114921294	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	percent change in mean arterial blood pressure (CMO:0002035)	4	62933508	114921294	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	percent change in systolic blood pressure (CMO:0000747)	4	62933508	114921294	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	absolute change in pulse pressure (CMO:0001882)	4	62933508	114921294	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	4	62933508	114921294	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	64528739	157573521	Rat
2312569	Pur19	Proteinuria QTL 19	3.4	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	4	65882107	96130297	Rat
61330	Eau1	Experimental allergic uveoretinitis QTL 1		0.0003	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	4	70362013	132642728	Rat
634344	Hcar7	Hepatocarcinoma resistance QTL 7	7.8		liver integrity trait (VT:0010547)	liver tumorous lesion area to total liver area ratio (CMO:0001075)	4	70808386	115808386	Rat
634344	Hcar7	Hepatocarcinoma resistance QTL 7	7.8		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	4	70808386	115808386	Rat
631646	Stl4	Serum triglyceride level QTL 4	6.5	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	4	73169846	132642728	Rat
724522	Bp146	Blood pressure QTL 146	2.2	0.0021	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	73630210	118630210	Rat
2302051	Pia28	Pristane induced arthritis QTL 28	5.3	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)	4	73630210	118630210	Rat
70167	Bw22	Body weight QTL 22	3.1		body mass (VT:0001259)	body weight (CMO:0000012)	4	76647384	117676292	Rat
1357342	Bw40	Body weight QTL 40		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	4	76647384	117676292	Rat

Markers in Region

RH128193

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	77,831,492 - 77,831,672 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	78,515,230 - 78,515,409	NCBI	Rnor6.0
Rnor_5.0	4	143,202,873 - 143,203,052	UniSTS	Rnor5.0
RGSC_v3.4	4	76,977,295 - 76,977,474	UniSTS	RGSC3.4
Celera	4	72,768,466 - 72,768,645	UniSTS
RH 3.4 Map	4	499.61	UniSTS
Cytogenetic Map	4	q24	UniSTS

RH129281

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	77,824,783 - 77,824,966 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	78,508,521 - 78,508,703	NCBI	Rnor6.0
Rnor_5.0	4	143,196,164 - 143,196,346	UniSTS	Rnor5.0
RGSC_v3.4	4	76,970,586 - 76,970,768	UniSTS	RGSC3.4
Celera	4	72,761,757 - 72,761,939	UniSTS
Cytogenetic Map	4	q24	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium	3		6		6						1
Low			10	8	13	8		22		17	10
Below cutoff		6	18	17		17	1	22	12	9

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022935	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006236471	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006236472	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762920	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286668	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC127409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC100144	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220353	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228794	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230036	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X73911	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X73912	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000059136 ⟹ ENSRNOP00000055909

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	77,812,260 - 77,831,840 (+)	Ensembl
Rnor_6.0 Ensembl	4	78,496,043 - 78,515,577 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000082905 ⟹ ENSRNOP00000070272

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	4	78,513,459 - 78,515,584 (+)	Ensembl

RefSeq Acc Id:

NM_022935 ⟹ NP_075224

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	79,143,126 - 79,162,705 (+)	NCBI
mRatBN7.2	4	77,812,260 - 77,831,841 (+)	NCBI
Rnor_6.0	4	78,496,043 - 78,515,578 (+)	NCBI
Rnor_5.0	4	143,183,686 - 143,203,225 (+)	NCBI
RGSC_v3.4	4	76,957,477 - 76,977,643 (+)	RGD
Celera	4	72,749,277 - 72,768,814 (+)	RGD

Sequence:

show sequence

GTGCACTGGAGAGGCTAGAAAAGGGTGTCAGATCGAGTTGTGAACCACTATGTGAGTGCCAGGA
CTGAACCTTGGTCCTCTGGGAGAACAGCAACTGCTTTTAACCACTGAGCCATCTCTTCAGCCCC
AATTTCCCCTTGATCTGAAGAAGAAAGAGCCAGGTCTCTAACAGAGCTATGAGGCTTGCACAAA
TGTGTCTGGCCTTCGGCTGGGCAGCTGTCATATTGGTTCTACAGACGGTAGACACGGCATCTGC
TGTGAGGACTCCTTATGACAAAGCGAGGGTATTTGCAGACCTGAGCCCCCAGGAGATAAAGGCT
GTTCACAGCTTCCTGATGAACAGGGAGGAGCTGGGGCTGCAGCCGTCCAAGGAACCGACTTTGG
CCAAAAACTCTGTGTTTCTCATTGAGATGCTACTGCCCAAGAAGAAGCATGTGTTGAAATTTCT
GGATGAAGGAAGAAAAGGTCCTAACCGGGAAGCTAGGGCTGTCATCTTCTTCGGTGCCCAGGAC
TACCCCAATGTCACTGAGTTTGCTGTGGGGCCCCTGCCACGGCCCTACTATATTCGAGCACTAT
CCCCCAGGCCAGGGCACCATCTGTCCTGGTCATCCAGGCCCATCTCCACAGCAGAGTACGACCT
CCTCTACCACACGCTGAAGAGAGCCACCATGCCTCTGCACCAGTTTTTCCTTGACACCACTGGC
TTCTCATTCCTAGGCTGTGACGACCGATGCTTGACTTTTACTGACGTAGCTCCACGTGGTGTGG
CGTCTGGTCAGCGTAGAAGCTGGTTTATTGTGCAGCGCTATGTGGAAGGCTATTTCCTTCATCC
TACAGGGCTGGAGATCCTATTGGATCATGGGAGCACAGATGTCCAGGACTGGAGAGTGGAGCAG
CTCTGGTATAACGGCAAGTTCTACAACAACCCAGAGGAACTGGCTCGGAAATACGCAGTTGGAG
AAGTGGACACGGTGGTCCTCGAGGACCCACTGCCCAATGGCACAGAGAAGCCCCCACTCTTTTC
TTCCTACAAACCCCGGGGGGAATTCCATACACCAGTCAATGTTGCTGGCCCCCACGTTGTCCAG
CCCAGCGGCCCCCGATATAAACTAGAGGGCAACACTGTGCTCTATGGAGGTTGGAGCTTCTCTT
ATCGGCTAAGATCCTCTTCTGGGCTGCAGATCTTCAATGTGCTCTTTGGAGGTGAGCGTGTTGC
CTACGAGGTCAGTGTGCAGGAGGCTGTGGCACTGTATGGAGGACACACACCTGCAGGCATGCAG
ACTAAGTACATTGATGTTGGCTGGGGCCTGGGCAGTGTCACTCACGAGTTGGCCCCTGGCATTG
ACTGTCCAGAGACTGCTACTTTCCTGGATGCCTTCCACTATTACGACAGCGATGGCCCTGTCCA
TTATCCACATGCTCTGTGCCTCTTTGAGATGCCCACAGGGGTGCCCCTGAGGCGCCACTTTAAC
TCAAACTTTAAAGGTGGCTTCAACTTCTATGCGGGTTTGAAGGGATATGTGCTGGTGCTACGGA
CGACATCAACTGTCTATAATTATGATTACATCTGGGATTTCATCTTCTACTCTAACGGGGTGAT
GGAGGCCAAGATGCACGCCACTGGCTATGTCCATGCGACCTTCTACACTCCTGAGGGACTGCGC
CATGGCACTCGCTTACAAACCCACCTGCTTGGTAACATCCACACCCACCTGGTGCACTACCGTG
TTGACATGGACGTGGCAGGCACCAAGAACAGCTTCCAGACACTGACGATGAAGCTGGAAAACCT
CACCAATCCCTGGAGCCCAAGTCACTCCCTGGTCCAGCCCACACTCGAGCAGACCCAGTACTCC
CAGGAGCACCAGGCTGCATTCCGCTTCGGACAGACTCTGCCCAAGTACCTGCTCTTTAGCAGCC
CCCAAAAGAACTGCTGGGGTCACAGGCGCAGCTACCGCCTGCAGATCCATTCTATGGCTGAGCA
GGTGCTGCCACCAGGTTGGCAGGAGGAGCGGGCTGTCACTTGGGCCAGGTATCCTTTGGCTGTA
ACAAAGTATCGGGAATCTGAGCGCTACAGCAGCAGCCTCTACAACCAGAATGACCCCTGGGATC
CCCCCGTGGTCTTTGAGGAGTTCCTTCGGAACAACGAGAACATTGAAGATGAGGATTTGGTGGC
CTGGGTGACAGTGGGCTTCCTGCACATCCCTCACTCAGAAGATGTCCCCAACACAGCCACACCT
GGAAACTCTGTGGGCTTCTTGCTCCGGCCCTTCAACTTCTTCCCAGAGGACCCATCCCTGGCTT
CTAGAGACACTGTGATAGTGTGGCCCCAGGACAAGGGCCTCAACCGTGTCCAGCGCTGGATCCC
TGAGGACAGGCGCTGCTTGGTGTCTCCTCCTTTCAGCTATAATGGGACCTACAAGCCTGTGTGA
TGGGTCAGACCCCAGCCTCTGCAGCACAGCCCCAGAGCCTCACAAAGACAGGGAAAACAAACAA
ACGAAACTTCTGTCTCTACCCTGTATGCTACCTTTTAGCTCTACTCGTGTTTCATTACCATACC
TGCCACAGACTTCCAAGACCATTGCAAAGGAAGGACCACAATTTTCTGCCGGTGGTTCGGTGGT
TTGGAGGGTGGTGTTTTTTAAATATTTGAGGTGTTTATCTTCCTATCAGGAGACTTTAGAGAAA
TTGTCTCACCTCAGTGATGGGAGGGAGTAAGGAAACTGTCATATGAAAATCTAATAAAATGACA
CCTTTGCTCTTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006236471 ⟹ XP_006236533

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	79,158,614 - 79,162,705 (+)	NCBI
mRatBN7.2	4	77,827,740 - 77,831,846 (+)	NCBI
Rnor_6.0	4	78,509,121 - 78,515,582 (+)	NCBI
Rnor_5.0	4	143,183,686 - 143,203,225 (+)	NCBI

Sequence:

show sequence

GACACTTGTACTTCAGCCAGAAGCACCTAGCACCTTTCCAGGGAGGAACCCCATGGGCTATAGG
TCCCCAGCTGGGTTGACCCTCCCTGTGGGGCGGGGTCCAATACCTTCAAGAAGACTTCTGGGGT
CAGTGGCCAGGAGCAAAGTCTGGAAGCCGGGGAGCCACGGAGCAGAGCACACAGAGCTATGAGG
CTTGCACAAATGTGTCTGGCCTTCGGCTGGGCAGCTGTCATATTGGTTCTACAGACGGTAGACA
CGGCATCTGCTGTGAGGACTCCTTATGACAAAGCGAGGGTATTTGCAGACCTGAGCCCCCAGGA
GATAAAGGCTGTTCACAGCTTCCTGATGAACAGGGAGGAGCTGGGGCTGCAGCCGTCCAAGGAA
CCGACTTTGGCCAAAAACTCTGTGTTTCTCATTGAGATGCTACTGCCCAAGAAGAAGCATGTGT
TGAAATTTCTGGATGAAGGAAGAAAAGGTCCTAACCGGGAAGCTAGGGCTGTCATCTTCTTCGG
TGCCCAGGACTACCCCAATGTCACTGAGTTTGCTGTGGGGCCCCTGCCACGGCCCTACTATATT
CGAGCACTATCCCCCAGGCCAGGGCACCATCTGTCCTGGTCATCCAGGCCCATCTCCACAGCAG
AGTACGACCTCCTCTACCACACGCTGAAGAGAGCCACCATGCCTCTGCACCAGTTTTTCCTTGA
CACCACTGGCTTCTCATTCCTAGGCTGTGACGACCGATGCTTGACTTTTACTGACGTAGCTCCA
CGTGGTGTGGCGTCTGGTCAGCGTAGAAGCTGGTTTATTGTGCAGCGCTATGTGGAAGGCTATT
TCCTTCATCCTACAGGGCTGGAGATCCTATTGGATCATGGGAGCACAGATGTCCAGGACTGGAG
AGTGGAGCAGCTCTGGTATAACGGCAAGTTCTACAACAACCCAGAGGAACTGGCTCGGAAATAC
GCAGTTGGAGAAGTGGACACGGTGGTCCTCGAGGACCCACTGCCCAATGGCACAGAGAAGCCCC
CACTCTTTTCTTCCTACAAACCCCGGGGGGAATTCCATACACCAGTCAATGTTGCTGGCCCCCA
CGTTGTCCAGCCCAGCGGCCCCCGATATAAACTAGAGGGCAACACTGTGCTCTATGGAGGTTGG
AGCTTCTCTTATCGGCTAAGATCCTCTTCTGGGCTGCAGATCTTCAATGTGCTCTTTGGAGGTG
AGCGTGTTGCCTACGAGGTCAGTGTGCAGGAGGCTGTGGCACTGTATGGAGGACACACACCTGC
AGGCATGCAGACTAAGTACATTGATGTTGGCTGGGGCCTGGGCAGTGTCACTCACGAGTTGGCC
CCTGGCATTGACTGTCCAGAGACTGCTACTTTCCTGGATGCCTTCCACTATTACGACAGCGATG
GCCCTGTCCATTATCCACATGCTCTGTGCCTCTTTGAGATGCCCACAGGGGTGCCCCTGAGGCG
CCACTTTAACTCAAACTTTAAAGGTGGCTTCAACTTCTATGCGGGTTTGAAGGGATATGTGCTG
GTGCTACGGACGACATCAACTGTCTATAATTATGATTACATCTGGGATTTCATCTTCTACTCTA
ACGGGGTGATGGAGGCCAAGATGCACGCCACTGGCTATGTCCATGCGACCTTCTACACTCCTGA
GGGACTGCGCCATGGCACTCGCTTACAAACCCACCTGCTTGGTAACATCCACACCCACCTGGTG
CACTACCGTGTTGACATGGACGTGGCAGGCACCAAGAACAGCTTCCAGACACTGACGATGAAGC
TGGAAAACCTCACCAATCCCTGGAGCCCAAGTCACTCCCTGGTCCAGCCCACACTCGAGCAGAC
CCAGTACTCCCAGGAGCACCAGGCTGCATTCCGCTTCGGACAGACTCTGCCCAAGTACCTGCTC
TTTAGCAGCCCCCAAAAGAACTGCTGGGGTCACAGGCGCAGCTACCGCCTGCAGATCCATTCTA
TGGCTGAGCAGGTGCTGCCACCAGGTTGGCAGGAGGAGCGGGCTGTCACTTGGGCCAGGTATCC
TTTGGCTGTAACAAAGTATCGGGAATCTGAGCGCTACAGCAGCAGCCTCTACAACCAGAATGAC
CCCTGGGATCCCCCCGTGGTCTTTGAGGAGTTCCTTCGGAACAACGAGAACATTGAAGATGAGG
ATTTGGTGGCCTGGGTGACAGTGGGCTTCCTGCACATCCCTCACTCAGAAGATGTCCCCAACAC
AGCCACACCTGGAAACTCTGTGGGCTTCTTGCTCCGGCCCTTCAACTTCTTCCCAGAGGACCCA
TCCCTGGCTTCTAGAGACACTGTGATAGTGTGGCCCCAGGACAAGGGCCTCAACCGTGTCCAGC
GCTGGATCCCTGAGGACAGGCGCTGCTTGGTGTCTCCTCCTTTCAGCTATAATGGGACCTACAA
GCCTGTGTGATGGGTCAGACCCCAGCCTCTGCAGCACAGCCCCAGAGCCTCACAAAGACAGGGA
AAACAAACAAACGAAACTTCTGTCTCTACCCTGTATGCTACCTTTTAGCTCTACTCGTGTTTCA
TTACCATACCTGCCACAGACTTCCAAGACCATTGCAAAGGAAGGACCACAATTTTCTGCCGGTG
GTTCGGTGGTTTGGAGGGTGGTGTTTTTTAAATATTTGAGGTGTTTATCTTCCTATCAGGAGAC
TTTAGAGAAATTGTCTCACCTCAGTGATGGGAGGGAGTAAGGAAACTGTCATATGAAAATCTAA
TAAAATGACACCTTTGCTCTTTAGACA

hide sequence

RefSeq Acc Id:

XM_063286668 ⟹ XP_063142738

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	79,156,270 - 79,162,705 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_075224	(Get FASTA)	NCBI Sequence Viewer
	XP_006236533	(Get FASTA)	NCBI Sequence Viewer
	XP_063142738	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI00145	(Get FASTA)	NCBI Sequence Viewer
	CAA52116	(Get FASTA)	NCBI Sequence Viewer
	CAA52117	(Get FASTA)	NCBI Sequence Viewer
	EDL88223	(Get FASTA)	NCBI Sequence Viewer
	EDL88224	(Get FASTA)	NCBI Sequence Viewer
	EDL88225	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000055909
	ENSRNOP00000055909.1
GenBank Protein	P36633	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_075224 ⟸ NM_022935
- Peptide Label:	precursor
- UniProtKB:	Q63973 (UniProtKB/Swiss-Prot), P36633 (UniProtKB/Swiss-Prot), Q498N2 (UniProtKB/TrEMBL), F6WEU8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRLAQMCLAFGWAAVILVLQTVDTASAVRTPYDKARVFADLSPQEIKAVHSFLMNREELGLQPS KEPTLAKNSVFLIEMLLPKKKHVLKFLDEGRKGPNREARAVIFFGAQDYPNVTEFAVGPLPRPY YIRALSPRPGHHLSWSSRPISTAEYDLLYHTLKRATMPLHQFFLDTTGFSFLGCDDRCLTFTDV APRGVASGQRRSWFIVQRYVEGYFLHPTGLEILLDHGSTDVQDWRVEQLWYNGKFYNNPEELAR KYAVGEVDTVVLEDPLPNGTEKPPLFSSYKPRGEFHTPVNVAGPHVVQPSGPRYKLEGNTVLYG GWSFSYRLRSSSGLQIFNVLFGGERVAYEVSVQEAVALYGGHTPAGMQTKYIDVGWGLGSVTHE LAPGIDCPETATFLDAFHYYDSDGPVHYPHALCLFEMPTGVPLRRHFNSNFKGGFNFYAGLKGY VLVLRTTSTVYNYDYIWDFIFYSNGVMEAKMHATGYVHATFYTPEGLRHGTRLQTHLLGNIHTH LVHYRVDMDVAGTKNSFQTLTMKLENLTNPWSPSHSLVQPTLEQTQYSQEHQAAFRFGQTLPKY LLFSSPQKNCWGHRRSYRLQIHSMAEQVLPPGWQEERAVTWARYPLAVTKYRESERYSSSLYNQ NDPWDPPVVFEEFLRNNENIEDEDLVAWVTVGFLHIPHSEDVPNTATPGNSVGFLLRPFNFFPE DPSLASRDTVIVWPQDKGLNRVQRWIPEDRRCLVSPPFSYNGTYKPV hide sequence

RefSeq Acc Id:	XP_006236533 ⟸ XM_006236471
- Peptide Label:	isoform X1
- UniProtKB:	Q63973 (UniProtKB/Swiss-Prot), P36633 (UniProtKB/Swiss-Prot), Q498N2 (UniProtKB/TrEMBL), F6WEU8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRLAQMCLAFGWAAVILVLQTVDTASAVRTPYDKARVFADLSPQEIKAVHSFLMNREELGLQPS KEPTLAKNSVFLIEMLLPKKKHVLKFLDEGRKGPNREARAVIFFGAQDYPNVTEFAVGPLPRPY YIRALSPRPGHHLSWSSRPISTAEYDLLYHTLKRATMPLHQFFLDTTGFSFLGCDDRCLTFTDV APRGVASGQRRSWFIVQRYVEGYFLHPTGLEILLDHGSTDVQDWRVEQLWYNGKFYNNPEELAR KYAVGEVDTVVLEDPLPNGTEKPPLFSSYKPRGEFHTPVNVAGPHVVQPSGPRYKLEGNTVLYG GWSFSYRLRSSSGLQIFNVLFGGERVAYEVSVQEAVALYGGHTPAGMQTKYIDVGWGLGSVTHE LAPGIDCPETATFLDAFHYYDSDGPVHYPHALCLFEMPTGVPLRRHFNSNFKGGFNFYAGLKGY VLVLRTTSTVYNYDYIWDFIFYSNGVMEAKMHATGYVHATFYTPEGLRHGTRLQTHLLGNIHTH LVHYRVDMDVAGTKNSFQTLTMKLENLTNPWSPSHSLVQPTLEQTQYSQEHQAAFRFGQTLPKY LLFSSPQKNCWGHRRSYRLQIHSMAEQVLPPGWQEERAVTWARYPLAVTKYRESERYSSSLYNQ NDPWDPPVVFEEFLRNNENIEDEDLVAWVTVGFLHIPHSEDVPNTATPGNSVGFLLRPFNFFPE DPSLASRDTVIVWPQDKGLNRVQRWIPEDRRCLVSPPFSYNGTYKPV hide sequence

RefSeq Acc Id:

ENSRNOP00000070272 ⟸ ENSRNOT00000082905

RefSeq Acc Id:

ENSRNOP00000055909 ⟸ ENSRNOT00000059136

RefSeq Acc Id:	XP_063142738 ⟸ XM_063286668
- Peptide Label:	isoform X1
- UniProtKB:	F6WEU8 (UniProtKB/TrEMBL), Q498N2 (UniProtKB/TrEMBL)

Protein Domains

Copper amine oxidase catalytic Copper amine oxidase N2-terminal Copper amine oxidase N3-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P36633-F1-model_v2	AlphaFold	P36633	1-746	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61296	AgrOrtholog
BioCyc Gene	G2FUF-44935	BioCyc
BioCyc Pathway	PWY-6181 [histamine degradation]	BioCyc
BioCyc Pathway Image	PWY-6181	BioCyc
Ensembl Genes	ENSRNOG00000008575	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000059136	ENTREZGENE
	ENSRNOT00000059136.3	UniProtKB/TrEMBL
Gene3D-CATH	2.70.98.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.10.450.40	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7460184	IMAGE-MGC_LOAD
InterPro	Cu_amine_oxidase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cu_amine_oxidase_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cu_amine_oxidase_C_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cu_amine_oxidase_N-reg	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cu_amine_oxidase_N2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cu_amine_oxidase_N3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:65029	UniProtKB/TrEMBL
MGC_CLONE	MGC:114316	IMAGE-MGC_LOAD
NCBI Gene	65029	ENTREZGENE
PANTHER	AMILORIDE-SENSITIVE AMINE OXIDASE [COPPER-CONTAINING]	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10638	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Cu_amine_oxid	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cu_amine_oxidN2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cu_amine_oxidN3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Aoc1	PhenoGen
PRINTS	CUDAOXIDASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	COPPER_AMINE_OXID_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	COPPER_AMINE_OXID_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000008575	RatGTEx
Superfamily-SCOP	SSF49998	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF54416	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC219547
UniProt	AOC1_RAT	UniProtKB/Swiss-Prot
	F6WEU8	ENTREZGENE, UniProtKB/TrEMBL
	P36633	ENTREZGENE
	Q498N2	ENTREZGENE, UniProtKB/TrEMBL
	Q63973	ENTREZGENE
UniProt Secondary	Q63973	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-07-09	Aoc1	amine oxidase, copper containing 1	Abp1	amiloride binding protein 1 (amine oxidase, copper-containing)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-11-17	Abp1	amiloride binding protein 1 (amine oxidase, copper-containing)		amiloride binding protein 1	Name updated	1299863	APPROVED
2001-06-22	Abp	Amiloride binding protein			Symbol and Name withdrawn	67952	WITHDRAWN
2001-06-22	Abp1	Amiloride binding protein 1			Symbol and Name updated to reflect Human and Mouse nomenclature	67952	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_function	catalyzes the degradation of compounds such as putrescine or histamine	724707
gene_mapping	mapped between Lyp and Npy genes, 0.2 cM distal to Lyp	631162

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways