Wt1 (WT1 transcription factor) - Rat Genome Database

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Gene: Wt1 (WT1 transcription factor) Rattus norvegicus
Analyze
Symbol: Wt1
Name: WT1 transcription factor
RGD ID: 3974
Description: Enables sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nuclear speck. Human ortholog(s) of this gene implicated in several diseases, including Denys-Drash syndrome; Frasier syndrome; malignant mesothelioma; nephroblastoma (multiple); and nephrotic syndrome type 4. Orthologous to human WT1 (WT1 transcription factor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-ethoxyethanol; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Wilms tumor 1; Wilms tumor protein homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83112,019,721 - 112,068,454 (+)NCBIGRCr8
mRatBN7.2391,566,540 - 91,613,653 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl391,567,001 - 91,613,643 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx395,059,051 - 95,105,563 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03103,657,999 - 103,704,505 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03101,489,766 - 101,536,390 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0395,133,221 - 95,180,574 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl395,133,713 - 95,180,564 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03101,756,056 - 101,802,601 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4390,529,704 - 90,577,280 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1390,463,925 - 90,472,651 (+)NCBI
Celera390,623,287 - 90,669,803 (+)NCBICelera
RH 3.4 Map3720.19RGD
Cytogenetic Map3q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
acute promyelocytic leukemia  (ISO)
Alzheimer's disease  (ISO)
aniridia  (ISO)
aniridia 1  (ISO)
atypical hemolytic-uremic syndrome  (ISO)
B-cell acute lymphoblastic leukemia  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
benign familial hematuria  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Chromosome 11p Deletion Syndrome  (ISO)
chronic kidney disease  (ISO)
chronic myeloid leukemia  (ISO)
Colonic Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO,ISS)
Denys-Drash syndrome  (ISO,ISS)
Diaphragmatic Hernia  (ISO)
Diffuse Mesangial Sclerosis  (ISO)
disorder of sexual development  (ISO)
endometrial cancer  (ISO)
focal segmental glomerulosclerosis  (ISO)
Frasier syndrome  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
glomerulonephritis  (ISO)
gonadal dysgenesis  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
intellectual disability  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
leukemia  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
Male Genital Neoplasms  (ISO)
malignant mesothelioma  (ISO)
Meacham Winn Culler Syndrome  (ISO)
Mesothelioma  (ISO)
nephroblastoma  (ISO)
nephrotic syndrome  (ISO)
nephrotic syndrome type 1  (ISO)
nephrotic syndrome type 2  (ISO)
nephrotic syndrome type 4  (ISO)
neurilemmoma  (ISO)
osteosarcoma  (ISO)
ovarian cancer  (ISO)
ovarian serous carcinoma  (ISO)
pancreatic cancer  (ISO)
Peritoneal Neoplasms  (ISO)
primary ovarian insufficiency  (ISO)
proteinuria  (ISO)
renal Wilms' tumor  (ISO)
WAGR syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-naringenin  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
3,7-dihydropurine-6-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
acetic acid  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
amphibole asbestos  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromochloroacetic acid  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
caffeine  (EXP)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dapagliflozin  (EXP)
demethoxycurcumin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
dieldrin  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (ISO)
diuron  (EXP)
ergosta-4,6,8(14),22-tetraen-3-one  (ISO)
ethanol  (EXP)
fenvalerate  (EXP)
flavonoids  (EXP)
formaldehyde  (EXP)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
losartan  (ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercaptopurine  (EXP)
methapyrilene  (ISO)
nickel subsulfide  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
Pachymic acid  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (EXP)
potassium dichromate  (ISO)
progesterone  (ISO)
prostaglandin E2  (ISO)
purine-6-thiol  (EXP)
pyrethrins  (EXP)
quercetin  (ISO)
resmethrin  (ISO)
resveratrol  (ISO)
rosuvastatin calcium  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
spironolactone  (EXP)
staurosporine  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenylstannane  (EXP)
valproic acid  (ISO)
vitamin E  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal cortex formation  (ISO,ISS)
adrenal gland development  (IEA,ISO,ISS)
apoptotic process  (ISO)
branching involved in ureteric bud morphogenesis  (IEA,ISO,ISS)
camera-type eye development  (ISO,ISS)
cardiac muscle cell fate commitment  (ISO)
cellular response to cAMP  (IEA,ISO)
cellular response to gonadotropin stimulus  (IEA,ISO,ISS)
diaphragm development  (ISO,ISS)
epithelial cell differentiation  (ISO,ISS)
flagellated sperm motility  (ISO)
germ cell development  (ISO,ISS)
glomerular basement membrane development  (IEA,ISO,ISS)
glomerulus development  (ISO,ISS)
gonad development  (ISO,ISS)
heart development  (ISO,ISS)
kidney development  (ISO)
male genitalia development  (ISO,ISS)
male gonad development  (IEA,ISO)
mesenchymal cell apoptotic process involved in metanephros development  (ISO)
mesenchymal to epithelial transition  (ISO,ISS)
mesonephros development  (ISO)
metanephric comma-shaped body morphogenesis  (ISO)
metanephric epithelium development  (IEA,ISO)
metanephric mesenchyme development  (ISO,ISS)
metanephric S-shaped body morphogenesis  (IEA,ISO,ISS)
metanephros development  (ISO)
negative regulation of apoptotic process  (IBA,IEA,ISO,ISS)
negative regulation of cell growth  (IEA,ISO,ISS)
negative regulation of cell population proliferation  (IBA,IEA,ISO,ISS)
negative regulation of DNA-templated transcription  (ISO,ISS)
negative regulation of female gonad development  (ISO,ISS)
negative regulation of gene expression via chromosomal CpG island methylation  (IEA,ISO)
negative regulation of mesenchymal cell apoptotic process involved in metanephros development  (ISO)
negative regulation of metanephric glomerular mesangial cell proliferation  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of translation  (ISO,ISS)
podocyte development  (ISO)
podocyte differentiation  (ISO,ISS)
positive regulation of apoptotic process  (ISO,ISS)
positive regulation of DNA-templated transcription  (IDA,ISO,ISS)
positive regulation of gene expression  (IEA,ISO)
positive regulation of heart growth  (ISO,ISS)
positive regulation of male gonad development  (ISO,ISS)
positive regulation of metanephric ureteric bud development  (ISO,ISS)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,IMP,ISO)
posterior mesonephric tubule development  (ISO,ISS)
regulation of animal organ formation  (ISO,ISS)
regulation of DNA-templated transcription  (IEA,ISO,ISS)
regulation of gene expression  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO,ISS)
RNA splicing  (ISO,ISS)
seminiferous tubule development  (ISO)
Sertoli cell development  (ISO)
sex determination  (IEA,ISO,ISS)
single fertilization  (ISO)
spermatogenesis  (ISO)
thorax and anterior abdomen determination  (ISO,ISS)
tissue development  (ISS)
ureteric bud development  (ISO,ISS)
vasculogenesis  (ISO,ISS)
visceral serous pericardium development  (IEA,ISO,ISS)

Cellular Component
cytoplasm  (IEA,ISO,ISS)
cytosol  (IEA,ISO)
nuclear speck  (IEA,ISO,ISS)
nucleolus  (IEA)
nucleoplasm  (ISO,ISS)
nucleus  (ISO)

References

References - curated
# Reference Title Reference Citation
1. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2. Pathologically decreased expression of miR-193a contributes to metastasis by targeting WT1-E-cadherin axis in non-small cell lung cancers. Chen J, etal., J Exp Clin Cancer Res. 2016 Nov 7;35(1):173. doi: 10.1186/s13046-016-0450-8.
3. Homozygous somatic Wt1 point mutations in sporadic unilateral Wilms tumor. Coppes MJ, etal., Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1416-9.
4. A necropsy case of Denys-Drash syndrome with a WT1 mutation in exon 7. Fukuzawa R, etal., J Med Genet. 2002 Aug;39(8):e48.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Expression of the 11p13 Wilms' tumor gene, WT1, correlates with histologic category of Wilms' tumor. Gerald WL, etal., Am J Pathol. 1992 May;140(5):1031-7.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Combination of MUC5ac and WT-1 immunohistochemistry is useful in distinguishing pancreatic ductal carcinoma from ovarian serous carcinoma in effusion cytology. Han L, etal., Diagn Cytopathol. 2009 Oct 23.
9. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
10. Dual usages of single Wilms' tumor 1 immunohistochemistry in evaluation of breast tumors: a preliminary study of 30 cases. Li JH and Man YG, Cancer Biomark. 2009;5(3):109-16.
11. The Wilms' tumor gene product WT1 mediates the down-regulation of the rat epidermal growth factor receptor by nerve growth factor in PC12 cells. Liu XW, etal., J Biol Chem 2001 Feb 16;276(7):5068-73.
12. Wilms' tumor suppressor (WT1) is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer's disease. Lovell MA, etal., Brain Res. 2003 Sep 5;983(1-2):84-96.
13. Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70. Maheswaran S, etal., Genes Dev. 1998 Apr 15;12(8):1108-20.
14. Physical and functional interaction between WT1 and p53 proteins. Maheswaran S, etal., Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5100-4.
15. Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genes. Metsuyanim S, etal., Stem Cells. 2008 Jul;26(7):1808-17. doi: 10.1634/stemcells.2007-0322. Epub 2008 May 8.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Immunohistochemical detection of WT1 protein in endometrial cancer. Ohno S, etal., Anticancer Res. 2009 May;29(5):1691-5.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Therapeutic potential of human induced pluripotent stem cells and renal progenitor cells in experimental chronic kidney disease. Ribeiro PC, etal., Stem Cell Res Ther. 2020 Dec 9;11(1):530. doi: 10.1186/s13287-020-02060-4.
23. Adenomatoid tumors of the female and male genital tracts: a clinicopathological and immunohistochemical study of 44 cases. Sangoi AR, etal., Mod Pathol. 2009 Sep;22(9):1228-35. Epub 2009 Jun 19.
24. Molecular cloning of rat Wilms' tumor complementary DNA and a study of messenger RNA expression in the urogenital system and the brain. Sharma PM, etal., Cancer Res 1992 Nov 15;52(22):6407-12.
Additional References at PubMed
PMID:1332065   PMID:1662794   PMID:7585606   PMID:7588596   PMID:7720589   PMID:7856737   PMID:7926762   PMID:8119964   PMID:8132626   PMID:8306891   PMID:8395349   PMID:8530339  
PMID:8889548   PMID:9118800   PMID:9178767   PMID:9765217   PMID:9784496   PMID:9815658   PMID:9927198   PMID:10077614   PMID:10101119   PMID:10322633   PMID:11278547   PMID:11509181  
PMID:11889045   PMID:11912180   PMID:12151099   PMID:12609742   PMID:12665546   PMID:12738801   PMID:12802290   PMID:14678822   PMID:14681305   PMID:14701728   PMID:15063178   PMID:15518539  
PMID:15520190   PMID:15716344   PMID:15961562   PMID:16264195   PMID:16338327   PMID:16418481   PMID:16467207   PMID:16934801   PMID:17430890   PMID:17457373   PMID:17537799   PMID:17848411  
PMID:18496514   PMID:18618131   PMID:19050011   PMID:19205749   PMID:19301398   PMID:19457926   PMID:21072664   PMID:21390327   PMID:21443142   PMID:21654746   PMID:21719793   PMID:21778682  
PMID:22431408   PMID:23042785   PMID:23107969   PMID:23229934   PMID:25258363   PMID:27009470   PMID:28315733   PMID:29025062   PMID:30242881   PMID:34554376   PMID:38182143  


Genomics

Comparative Map Data
Wt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83112,019,721 - 112,068,454 (+)NCBIGRCr8
mRatBN7.2391,566,540 - 91,613,653 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl391,567,001 - 91,613,643 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx395,059,051 - 95,105,563 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03103,657,999 - 103,704,505 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03101,489,766 - 101,536,390 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0395,133,221 - 95,180,574 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl395,133,713 - 95,180,564 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03101,756,056 - 101,802,601 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4390,529,704 - 90,577,280 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1390,463,925 - 90,472,651 (+)NCBI
Celera390,623,287 - 90,669,803 (+)NCBICelera
RH 3.4 Map3720.19RGD
Cytogenetic Map3q33NCBI
WT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381132,387,775 - 32,435,539 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1132,387,775 - 32,435,564 (-)EnsemblGRCh38hg38GRCh38
GRCh371132,409,321 - 32,457,085 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361132,365,901 - 32,413,663 (-)NCBINCBI36Build 36hg18NCBI36
Build 341132,365,896 - 32,413,653NCBI
Celera1132,556,060 - 32,603,819 (-)NCBICelera
Cytogenetic Map11p13NCBI
HuRef1132,104,249 - 32,152,010 (-)NCBIHuRef
CHM1_11132,409,251 - 32,457,017 (-)NCBICHM1_1
T2T-CHM13v2.01132,523,264 - 32,571,024 (-)NCBIT2T-CHM13v2.0
Wt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392104,956,874 - 105,003,959 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2104,956,874 - 105,003,961 (+)EnsemblGRCm39 Ensembl
GRCm382105,126,529 - 105,173,614 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2105,126,529 - 105,173,616 (+)EnsemblGRCm38mm10GRCm38
MGSCv372104,966,686 - 105,013,771 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362104,927,368 - 104,974,451 (+)NCBIMGSCv36mm8
Celera2106,361,212 - 106,408,919 (+)NCBICelera
Cytogenetic Map2E3NCBI
cM Map255.06NCBI
Wt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547610,464,616 - 10,504,473 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547610,464,688 - 10,504,473 (-)NCBIChiLan1.0ChiLan1.0
WT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2934,594,171 - 34,645,602 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11134,598,573 - 34,650,053 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01132,349,807 - 32,398,494 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11132,238,720 - 32,282,879 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1132,238,720 - 32,287,249 (-)Ensemblpanpan1.1panPan2
WT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11835,099,660 - 35,148,767 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1835,103,934 - 35,148,000 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1834,713,394 - 34,762,525 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01835,710,611 - 35,759,846 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1835,710,238 - 35,759,076 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11835,281,214 - 35,330,461 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01834,861,742 - 34,911,460 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01835,497,531 - 35,546,777 (+)NCBIUU_Cfam_GSD_1.0
Wt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494732,287,144 - 32,334,902 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365335,411,848 - 5,459,693 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365335,411,949 - 5,459,693 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl228,411,803 - 28,455,997 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1228,411,467 - 28,456,007 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2230,902,160 - 30,946,266 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2p14-q11NCBI
WT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1132,750,300 - 32,801,832 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038129,915,480 - 129,964,047 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476620,900,676 - 20,937,202 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476620,899,546 - 20,937,084 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wt1
179 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:268
Count of miRNA genes:100
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000017591, ENSRNOT00000067940
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat

Markers in Region
D3Rat26  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2391,609,794 - 91,609,953 (+)MAPPERmRatBN7.2
Rnor_6.0395,176,716 - 95,176,874NCBIRnor6.0
Rnor_5.03101,798,743 - 101,798,901UniSTSRnor5.0
RGSC_v3.4390,573,422 - 90,573,580UniSTSRGSC3.4
RGSC_v3.4390,573,349 - 90,573,782RGDRGSC3.4
RGSC_v3.1390,469,850 - 90,470,008RGD
Celera390,665,945 - 90,666,103UniSTS
RH 3.4 Map3724.0RGD
RH 3.4 Map3724.0UniSTS
RH 2.0 Map3471.1RGD
SHRSP x BN Map347.2698RGD
Cytogenetic Map3q32UniSTS
RH142234  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map3720.19UniSTS
Cytogenetic Map3q32UniSTS
GDB:371639  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2391,567,304 - 91,567,469 (+)MAPPERmRatBN7.2
Rnor_6.0395,133,828 - 95,133,992NCBIRnor6.0
Rnor_5.03101,756,608 - 101,756,772UniSTSRnor5.0
RGSC_v3.4390,529,819 - 90,529,983UniSTSRGSC3.4
Celera390,623,402 - 90,623,566UniSTS
Cytogenetic Map3q32UniSTS
GDB:371627  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2391,566,730 - 91,566,939 (+)MAPPERmRatBN7.2
Rnor_6.0395,133,254 - 95,133,462NCBIRnor6.0
Rnor_5.03101,756,034 - 101,756,242UniSTSRnor5.0
RGSC_v3.4390,529,245 - 90,529,453UniSTSRGSC3.4
Celera390,622,828 - 90,623,036UniSTS
Cytogenetic Map3q32UniSTS
PMC186395P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2391,566,261 - 91,566,383 (+)MAPPERmRatBN7.2
Rnor_6.0395,132,785 - 95,132,906NCBIRnor6.0
Rnor_5.03101,755,565 - 101,755,686UniSTSRnor5.0
RGSC_v3.4390,528,776 - 90,528,897UniSTSRGSC3.4
Celera390,622,359 - 90,622,480UniSTS
Cytogenetic Map3q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 26 6 6 6 6 26 40
Low 17 37 26 8 26 2 9 1 11
Below cutoff 3 14 9 5 9 6 6 36 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA899753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO382418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X69716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000067940   ⟹   ENSRNOP00000060038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl391,567,190 - 91,613,643 (+)Ensembl
Rnor_6.0 Ensembl395,133,713 - 95,180,564 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099117   ⟹   ENSRNOP00000078611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl391,567,001 - 91,613,643 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102019   ⟹   ENSRNOP00000086555
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl391,571,221 - 91,613,643 (+)Ensembl
RefSeq Acc Id: NM_031534   ⟹   NP_113722
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83112,022,009 - 112,068,454 (+)NCBI
mRatBN7.2391,567,190 - 91,613,653 (+)NCBI
Rnor_6.0395,133,713 - 95,180,574 (+)NCBI
Rnor_5.03101,756,056 - 101,802,601 (+)NCBI
RGSC_v3.4390,529,704 - 90,577,280 (+)RGD
Celera390,623,287 - 90,669,803 (+)RGD
Sequence:
RefSeq Acc Id: XM_006234620   ⟹   XP_006234682
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83112,019,778 - 112,068,454 (+)NCBI
mRatBN7.2391,566,540 - 91,613,653 (+)NCBI
Rnor_6.0395,133,320 - 95,180,574 (+)NCBI
Rnor_5.03101,756,056 - 101,802,601 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234621   ⟹   XP_006234683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83112,019,786 - 112,068,454 (+)NCBI
mRatBN7.2391,566,540 - 91,613,653 (+)NCBI
Rnor_6.0395,133,222 - 95,180,574 (+)NCBI
Rnor_5.03101,756,056 - 101,802,601 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234622   ⟹   XP_006234684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83112,019,721 - 112,068,454 (+)NCBI
mRatBN7.2391,566,713 - 91,613,653 (+)NCBI
Rnor_6.0395,133,221 - 95,180,574 (+)NCBI
Rnor_5.03101,756,056 - 101,802,601 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591476   ⟹   XP_017446965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83112,025,808 - 112,068,454 (+)NCBI
mRatBN7.2391,571,009 - 91,613,653 (+)NCBI
Rnor_6.0395,134,173 - 95,180,574 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591477   ⟹   XP_017446966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83112,025,806 - 112,068,454 (+)NCBI
mRatBN7.2391,571,007 - 91,613,653 (+)NCBI
Rnor_6.0395,134,173 - 95,180,574 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104288   ⟹   XP_038960216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83112,022,473 - 112,068,454 (+)NCBI
mRatBN7.2391,567,665 - 91,613,653 (+)NCBI
RefSeq Acc Id: XM_039104289   ⟹   XP_038960217
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83112,025,809 - 112,068,454 (+)NCBI
mRatBN7.2391,571,009 - 91,613,653 (+)NCBI
RefSeq Acc Id: XM_063283110   ⟹   XP_063139180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83112,022,472 - 112,068,454 (+)NCBI
RefSeq Acc Id: XM_063283112   ⟹   XP_063139182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83112,022,471 - 112,068,454 (+)NCBI
RefSeq Acc Id: XM_063283113   ⟹   XP_063139183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83112,022,471 - 112,068,454 (+)NCBI
RefSeq Acc Id: XM_063283114   ⟹   XP_063139184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83112,040,911 - 112,068,454 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_113722   ⟸   NM_031534
- UniProtKB: P49952 (UniProtKB/Swiss-Prot),   A6HNW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234683   ⟸   XM_006234621
- Peptide Label: isoform X1
- UniProtKB: P49952 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006234684   ⟸   XM_006234622
- Peptide Label: isoform X3
- UniProtKB: P49952 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006234682   ⟸   XM_006234620
- Peptide Label: isoform X2
- UniProtKB: P49952 (UniProtKB/Swiss-Prot),   D3ZJ55 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446965   ⟸   XM_017591476
- Peptide Label: isoform X7
- UniProtKB: A6HNW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446966   ⟸   XM_017591477
- Peptide Label: isoform X10
- UniProtKB: A6HNW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000060038   ⟸   ENSRNOT00000067940
RefSeq Acc Id: XP_038960216   ⟸   XM_039104288
- Peptide Label: isoform X4
- UniProtKB: A6HNW3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960217   ⟸   XM_039104289
- Peptide Label: isoform X6
- UniProtKB: A0A8I6GE58 (UniProtKB/TrEMBL),   A6HNW3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000086555   ⟸   ENSRNOT00000102019
RefSeq Acc Id: ENSRNOP00000078611   ⟸   ENSRNOT00000099117
RefSeq Acc Id: XP_063139182   ⟸   XM_063283112
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063139183   ⟸   XM_063283113
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063139180   ⟸   XM_063283110
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063139184   ⟸   XM_063283114
- Peptide Label: isoform X11
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49952-F1-model_v2 AlphaFold P49952 1-448 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692269
Promoter ID:EPDNEW_R2794
Type:single initiation site
Name:Wt1_1
Description:Wilms tumor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0395,133,803 - 95,133,863EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3974 AgrOrtholog
BioCyc Gene G2FUF-48524 BioCyc
Ensembl Genes ENSRNOG00000013074 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067940.4 UniProtKB/TrEMBL
  ENSRNOT00000099117 ENTREZGENE
  ENSRNOT00000099117.1 UniProtKB/TrEMBL
  ENSRNOT00000102019.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Wilms_tumour_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24883 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24883 ENTREZGENE
PANTHER KRUEPPEL-LIKE FACTOR 17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam WT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Wt1 PhenoGen
PRINTS WILMSTUMOUR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013074 RatGTEx
SMART ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZLA2_RAT UniProtKB/TrEMBL
  A0A8I6GE58 ENTREZGENE, UniProtKB/TrEMBL
  A6HNW2 ENTREZGENE, UniProtKB/TrEMBL
  A6HNW3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZJ55 ENTREZGENE, UniProtKB/TrEMBL
  P49952 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 Wt1  WT1 transcription factor  Wt1  Wilms tumor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Wt1  Wilms tumor 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease involved in the development of Wilms tumor 61791
gene_expression mRNA expressed in kidney glomeruli, testis, spinal chord and area postrema in the brain 730080
gene_function transcriptional factor that interacts with TCC repeats in epidermal growth factor 61791
gene_physical_interaction binds to TCC repeat sequences of epidermal growth factor promoter 727305
gene_process involved in the nerve growth factor-induced down regulation of EGF receptor 61791