Sparc (secreted protein acidic and cysteine rich) - Rat Genome Database

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Gene: Sparc (secreted protein acidic and cysteine rich) Rattus norvegicus
Analyze
Symbol: Sparc
Name: secreted protein acidic and cysteine rich
RGD ID: 3742
Description: Enables calcium ion binding activity. Involved in several processes, including response to L-ascorbic acid; response to cAMP; and response to lead ion. Located in extracellular space and vesicle. Is active in glutamatergic synapse. Biomarker of diabetic angiopathy; membranoproliferative glomerulonephritis; membranous glomerulonephritis; myocardial infarction; and stomach carcinoma. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; multiple myeloma; and osteogenesis imperfecta type 17. Orthologous to human SPARC (secreted protein acidic and cysteine rich); INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: basement-membrane protein 40; BM-40; ON; osteonectin; Secreted acidic cystein-rich glycoprotein (osteonectin); secreted acidic cysteine rich glycoprotein; secreted protein acidic and rich in cysteine; secreted protein, acidic, cysteine-rich (osteonectin)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Vetf2 Vetf10
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81040,017,065 - 40,038,816 (-)NCBIGRCr8
mRatBN7.21039,516,394 - 39,538,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1039,516,406 - 39,538,396 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1044,200,679 - 44,221,761 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01043,690,774 - 43,711,860 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01039,194,463 - 39,215,539 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01040,742,390 - 40,764,232 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,742,400 - 40,764,185 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01040,573,510 - 40,595,261 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41040,809,730 - 40,831,481 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11040,823,352 - 40,845,104 (-)NCBI
Celera1038,848,158 - 38,869,906 (-)NCBICelera
RH 3.4 Map10414.6RGD
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-camphor  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aldehydo-D-glucose  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
berberine  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
buspirone  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
calcitriol  (EXP)
camphor  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
carnosic acid  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corn oil  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
DDT  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
Ethoxyacetic acid  (ISO)
fenamidone  (ISO)
fenthion  (ISO)
fipronil  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (EXP)
gallocatechin  (EXP)
gamma-aminobutyric acid  (EXP)
gamma-Oryzanol (TN)  (EXP)
genistein  (EXP)
glucose  (ISO)
glycerol 2-phosphate  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isoflavones  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
losartan  (EXP)
magnesium atom  (ISO)
methamphetamine  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
notoginsenoside R1  (ISO)
oxaliplatin  (EXP)
p-toluidine  (EXP)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
piroxicam  (ISO)
poly(vinylpyrrolidone)  (EXP)
potassium dichromate  (ISO)
progesterone  (ISO)
raloxifene  (EXP)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
Soman  (EXP)
streptozocin  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP,ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
Trapidil  (EXP)
triacsin C  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
calcium ion binding  (IBA,IDA,IEA,ISO)
collagen binding  (IBA,IEA,ISO)
extracellular matrix binding  (IBA,IEA,ISO)
protein binding  (ISO)

References

References - curated
# Reference Title Reference Citation
1. SPARC from olfactory ensheathing cells stimulates Schwann cells to promote neurite outgrowth and enhances spinal cord repair. Au E, etal., J Neurosci. 2007 Jul 4;27(27):7208-21.
2. Secreted protein, acidic and rich in cysteine (SPARC) and thrombospondin in the developing follicle and corpus luteum of the rat. Bagavandoss P, etal., J Histochem Cytochem. 1998 Sep;46(9):1043-49.
3. Activation of SPARC expression in reactive stroma associated with human epithelial ovarian cancer. Brown TJ, etal., Gynecol Oncol. 1999 Oct;75(1):25-33.
4. Adenovirus-mediated inhibition of SPARC attenuates liver fibrosis in rats. Camino AM, etal., J Gene Med. 2008 Sep;10(9):993-1004.
5. Extracellular Ca(2+)-sensing receptors modulate matrix production and mineralization in chondrogenic RCJ3.1C5.18 cells. Chang W, etal., Endocrinology. 2002 Apr;143(4):1467-74.
6. Purification of a calcium binding protein (rat SPARC) from primary Sertoli cell-enriched culture medium. Cheng CY Biochem Biophys Res Commun. 1990 Mar 30;167(3):1393-9.
7. Relative and absolute quantification of postsynaptic density proteome isolated from rat forebrain and cerebellum. Cheng D, etal., Mol Cell Proteomics. 2006 Jun;5(6):1158-70. doi: 10.1074/mcp.D500009-MCP200. Epub 2006 Feb 28.
8. Coordinate gene expression during neonatal rat heart development. A possible role for the myocyte in extracellular matrix biogenesis and capillary angiogenesis. Engelmann GL Cardiovasc Res. 1993 Sep;27(9):1598-605.
9. Regulation of selenoprotein P mRNA expression in comparison with metallothionein and osteonectin mRNAs following cadmium and dexamethasone administration. Fujii M, etal., Kobe J Med Sci. 1997 Feb;43(1):13-23.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. SPARC gene expression is reduced in early diabetes-related kidney growth. Gilbert RE, etal., Kidney Int. 1995 Oct;48(4):1216-25.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
14. Osteonectin gene expression in fibrotic liver. Inagaki H, etal., Life Sci. 1996;58(11):927-34.
15. Gene expression and immunohistochemical localization of osteonectin in association with early bone formation in the developing mandible. Ishigaki R, etal., Histochem J. 2002 Jan-Feb;34(1-2):57-66.
16. SPARC gene expression is increased in diabetes-related mesenteric vascular hypertrophy. Jandeleit-Dahm K, etal., Microvasc Res. 2000 Jan;59(1):61-71.
17. Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma. Kaiser MF, etal., Blood. 2013 Jul 11;122(2):219-26. doi: 10.1182/blood-2013-03-487884. Epub 2013 May 22.
18. Middle East Respiratory Syndrome-Coronavirus Infection into Established hDPP4-Transgenic Mice Accelerates Lung Damage Via Activation of the Pro-Inflammatory Response and Pulmonary Fibrosis. Kim J, etal., J Microbiol Biotechnol. 2020 Mar 28;30(3):427-438. doi: 10.4014/jmb.1910.10055.
19. The expression of molecular mediators in the idiopathic cutaneous calcification and ossification. Kim SY, etal., J Cutan Pathol. 2008 Sep;35(9):826-31. doi: 10.1111/j.1600-0560.2007.00904.x. Epub 2008 Apr 18.
20. Spatially and temporally different expression of osteonectin and osteopontin in the infarct zone of experimentally induced myocardial infarction in rats. Komatsubara I, etal., Cardiovasc Pathol. 2003 Jul-Aug;12(4):186-94.
21. Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC. Kucukdereli H, etal., Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):E440-9. doi: 10.1073/pnas.1104977108. Epub 2011 Jul 25.
22. Microgravity signal ensnarls cell adhesion, cytoskeleton, and matrix proteins of rat osteoblasts: osteopontin, CD44, osteonectin, and alpha-tubulin. Kumei Y, etal., Ann N Y Acad Sci. 2006 Dec;1090:311-7.
23. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
24. Regional differences in expression of osteonectin mRNA after administration of cadmium to rats. Lee MJ, etal., Arch Toxicol 1995;69(9):590-5.
25. Gene expression profile of rat adipose tissue at the onset of high-fat-diet obesity. Li J, etal., Am J Physiol Endocrinol Metab 2002 Jun;282(6):E1334-41.
26. Osteonectin RNA and collagen alpha1(I) RNA in the developing rat maxilla. Liao H, etal., Eur J Oral Sci 1998 Jan;106 Suppl 1:418-23.
27. Appearance of osteonectin-expressing fibroblastic cells in early rat stomach carcinogenesis and stomach tumors induced with N-methyl-N'-nitro-N-nitrosoguanidine. Maeng HY, etal., Jpn J Cancer Res. 2002 Sep;93(9):960-7.
28. SPARC/osteonectin mRNA is induced in blood vessels following injury to the adult rat cerebral cortex. Mendis DB, etal., Neurochem Res. 1998 Aug;23(8):1117-23.
29. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
30. Expression of mRNA encoding extracellular matrix glycoproteins SPARC and SC1 is temporally and spatially regulated in the developing cochlea of the rat inner ear. Mothe AJ and Brown IR, Hear Res. 2001 May;155(1-2):161-74.
31. Matrix vesicles are carriers of bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), and noncollagenous matrix proteins. Nahar NN, etal., J Bone Miner Metab. 2008;26(5):514-9. Epub 2008 Aug 30.
32. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. CD34+ fibrocytes in chronic cystitis and noninvasive and invasive urothelial carcinomas of the urinary bladder. Nimphius W, etal., Virchows Arch. 2007 Feb;450(2):179-85.
34. Molecular profile of catabolic versus anabolic treatment regimens of parathyroid hormone (PTH) in rat bone: an analysis by DNA microarray. Onyia JE, etal., J Cell Biochem. 2005 May 15;95(2):403-18.
35. SPARC is expressed by mesangial cells in experimental mesangial proliferative nephritis and inhibits platelet-derived-growth-factor-medicated mesangial cell proliferation in vitro. Pichler RH, etal., Am J Pathol. 1996 Apr;148(4):1153-67.
36. SPARC is expressed in renal interstitial fibrosis and in renal vascular injury. Pichler RH, etal., Kidney Int. 1996 Dec;50(6):1978-89.
37. Expression of SPARC (secreted protein, acidic and rich in cysteine) in healing intestinal anastomoses and short bowel syndrome in rats. Puolakkainen P, etal., Dig Dis Sci. 1999 Aug;44(8):1554-64.
38. Differential expression of SPARC and thrombospondin 1 in wound repair: immunolocalization and in situ hybridization. Reed MJ, etal., J Histochem Cytochem. 1993 Oct;41(10):1467-77.
39. GOA pipeline RGD automated data pipeline
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Overexpression of SPARC protein contrasts with its transcriptional silencing by aberrant hypermethylation of SPARC CpG-rich region in endometrial carcinoma. Rodriguez-Jimenez FJ, etal., Oncol Rep. 2007 Jun;17(6):1301-7.
42. Normalization of the ovarian cancer microenvironment by SPARC. Said N, etal., Mol Cancer Res. 2007 Oct;5(10):1015-30.
43. SPARC expression in primary human renal cell carcinoma: upregulation of SPARC in sarcomatoid renal carcinoma. Sakai N, etal., Hum Pathol. 2001 Oct;32(10):1064-70.
44. Lead inhibits secretion of osteonectin/SPARC without significantly altering collagen or Hsp47 production in osteoblast-like ROS 17/2.8 cells. Sauk JJ, etal., Toxicol Appl Pharmacol. 1992 Oct;116(2):240-7.
45. Secreted protein acidic and rich in cysteine deficiency ameliorates renal inflammation and fibrosis in angiotensin hypertension. Socha MJ, etal., Am J Pathol. 2007 Oct;171(4):1104-12. Epub 2007 Aug 23.
46. Discovery of novel methylation biomarkers in cervical carcinoma by global demethylation and microarray analysis. Sova P, etal., Cancer Epidemiol Biomarkers Prev. 2006 Jan;15(1):114-23.
47. SPARC participates in the branching morphogenesis of developing fetal rat lung. Strandjord TP, etal., Am J Respir Cell Mol Biol. 1995 Sep;13(3):279-87.
48. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
49. Impaired expression of noncollagenous bone matrix protein mRNAs during fracture healing in ascorbic acid-deficient rats. Sugimoto M, etal., J Bone Miner Res. 1998 Feb;13(2):271-8.
50. The matricellular protein SPARC/osteonectin as a newly identified factor up-regulated in obesity. Tartare-Deckert S, etal., J Biol Chem. 2001 Jun 22;276(25):22231-7. Epub 2001 Apr 9.
51. Effects of parathyroid hormone on bone formation in a rat model for chronic alcohol abuse. Turner RT, etal., Alcohol Clin Exp Res. 2001 May;25(5):667-71.
52. Downregulation of SPARC expression is mediated by nitric oxide in rat mesangial cells and during endotoxemia in the rat. Walpen S, etal., J Am Soc Nephrol. 2000 Mar;11(3):468-76.
53. Analysis of the gene expression of SPARC and its prognostic value for bladder cancer. Yamanaka M, etal., J Urol. 2001 Dec;166(6):2495-9.
Additional References at PubMed
PMID:1737102   PMID:3400777   PMID:3427055   PMID:7034958   PMID:7848824   PMID:8906420   PMID:9501084   PMID:10559001   PMID:11856645   PMID:12867428   PMID:14505356   PMID:15389586  
PMID:16093428   PMID:16443258   PMID:17299058   PMID:18757743   PMID:19285050   PMID:19837135   PMID:22289652   PMID:22306863   PMID:22876197   PMID:22880013   PMID:23910024   PMID:24006456  
PMID:24245505   PMID:25340873   PMID:26110898   PMID:26420865   PMID:27068509   PMID:27339669   PMID:28499910   PMID:30424792   PMID:30560317   PMID:34876214   PMID:36241137  


Genomics

Comparative Map Data
Sparc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81040,017,065 - 40,038,816 (-)NCBIGRCr8
mRatBN7.21039,516,394 - 39,538,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1039,516,406 - 39,538,396 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1044,200,679 - 44,221,761 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01043,690,774 - 43,711,860 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01039,194,463 - 39,215,539 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01040,742,390 - 40,764,232 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,742,400 - 40,764,185 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01040,573,510 - 40,595,261 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41040,809,730 - 40,831,481 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11040,823,352 - 40,845,104 (-)NCBI
Celera1038,848,158 - 38,869,906 (-)NCBICelera
RH 3.4 Map10414.6RGD
Cytogenetic Map10q22NCBI
SPARC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385151,661,096 - 151,686,915 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5151,661,096 - 151,686,975 (-)EnsemblGRCh38hg38GRCh38
GRCh375151,040,657 - 151,066,476 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365151,021,201 - 151,046,710 (-)NCBINCBI36Build 36hg18NCBI36
Build 345151,021,203 - 151,046,710NCBI
Celera5147,122,406 - 147,147,929 (-)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5146,186,043 - 146,212,010 (-)NCBIHuRef
CHM1_15150,473,070 - 150,499,042 (-)NCBICHM1_1
T2T-CHM13v2.05152,200,073 - 152,225,896 (-)NCBIT2T-CHM13v2.0
Sparc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391155,284,985 - 55,310,906 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1155,285,326 - 55,314,009 (-)EnsemblGRCm39 Ensembl
GRCm381155,394,159 - 55,420,080 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1155,394,500 - 55,423,183 (-)EnsemblGRCm38mm10GRCm38
MGSCv371155,208,003 - 55,233,582 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361155,237,924 - 55,263,289 (-)NCBIMGSCv36mm8
Celera1159,982,920 - 59,995,424 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1133.04NCBI
Sparc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554086,099,003 - 6,122,459 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554086,100,123 - 6,122,460 (-)NCBIChiLan1.0ChiLan1.0
SPARC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24146,892,751 - 146,917,550 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15145,032,296 - 145,057,021 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05147,087,903 - 147,112,466 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15153,091,160 - 153,115,745 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5153,090,181 - 153,115,750 (-)Ensemblpanpan1.1panPan2
SPARC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1457,659,541 - 57,682,147 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl457,659,650 - 57,681,711 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha457,479,010 - 57,501,597 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0458,102,077 - 58,124,747 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl458,101,302 - 58,124,748 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1457,918,069 - 57,940,655 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0458,016,600 - 58,039,187 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0458,519,992 - 58,542,658 (+)NCBIUU_Cfam_GSD_1.0
Sparc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213112,576,762 - 112,597,465 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651511,025,724 - 11,046,849 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651511,026,156 - 11,046,812 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPARC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1671,357,586 - 71,381,161 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11671,368,164 - 71,380,972 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21677,576,864 - 77,584,734 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPARC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12354,224,003 - 54,248,869 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2354,222,838 - 54,238,006 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603423,456,066 - 23,481,034 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sparc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473337,338,284 - 37,369,804 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473337,348,993 - 37,369,804 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sparc
155 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:303
Count of miRNA genes:175
Interacting mature miRNAs:209
Transcripts:ENSRNOT00000017486
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat

Markers in Region
RH128632  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21039,516,544 - 39,516,733 (+)MAPPERmRatBN7.2
Rnor_6.01040,742,541 - 40,742,729NCBIRnor6.0
Rnor_5.01040,573,661 - 40,573,849UniSTSRnor5.0
RGSC_v3.41040,809,881 - 40,810,069UniSTSRGSC3.4
Celera1038,848,309 - 38,848,497UniSTS
RH 3.4 Map10408.7UniSTS
Cytogenetic Map10q22UniSTS
RH94599  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21039,516,435 - 39,516,593 (+)MAPPERmRatBN7.2
Rnor_6.01040,742,432 - 40,742,589NCBIRnor6.0
Rnor_5.01040,573,552 - 40,573,709UniSTSRnor5.0
RGSC_v3.41040,809,772 - 40,809,929UniSTSRGSC3.4
Celera1038,848,200 - 38,848,357UniSTS
RH 3.4 Map10414.6UniSTS
Cytogenetic Map10q22UniSTS
RH140308  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21039,516,913 - 39,517,093 (+)MAPPERmRatBN7.2
Rnor_6.01040,742,910 - 40,743,089NCBIRnor6.0
Rnor_5.01040,574,030 - 40,574,209UniSTSRnor5.0
RGSC_v3.41040,810,250 - 40,810,429UniSTSRGSC3.4
Celera1038,848,678 - 38,848,857UniSTS
RH 3.4 Map10408.0UniSTS
Cytogenetic Map10q22UniSTS
PMC151926P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21039,517,071 - 39,518,238 (+)MAPPERmRatBN7.2
Rnor_6.01040,743,068 - 40,744,234NCBIRnor6.0
Rnor_5.01040,574,188 - 40,575,354UniSTSRnor5.0
RGSC_v3.41040,810,408 - 40,811,574UniSTSRGSC3.4
Celera1038,848,836 - 38,850,002UniSTS
Cytogenetic Map10q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 24 2 3 4 8 14 26 9 3
Medium 3 19 57 41 17 41 5 7 66 21 15 2 5
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC127919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D28875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U75928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y13714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000017486   ⟹   ENSRNOP00000017486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1039,516,416 - 39,538,242 (-)Ensembl
Rnor_6.0 Ensembl1040,742,400 - 40,764,185 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098312   ⟹   ENSRNOP00000094410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1039,516,406 - 39,538,396 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099801   ⟹   ENSRNOP00000083269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1039,516,406 - 39,526,241 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115607   ⟹   ENSRNOP00000093140
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1039,517,585 - 39,538,180 (-)Ensembl
RefSeq Acc Id: NM_012656   ⟹   NP_036788
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81040,017,065 - 40,038,816 (-)NCBI
mRatBN7.21039,516,394 - 39,538,149 (-)NCBI
Rnor_6.01040,742,390 - 40,764,141 (-)NCBI
Rnor_5.01040,573,510 - 40,595,261 (-)NCBI
RGSC_v3.41040,809,730 - 40,831,481 (-)RGD
Celera1038,848,158 - 38,869,906 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_036788   ⟸   NM_012656
- Peptide Label: precursor
- UniProtKB: O08953 (UniProtKB/Swiss-Prot),   Q6GSZ4 (UniProtKB/Swiss-Prot),   P16975 (UniProtKB/Swiss-Prot),   A6HEL9 (UniProtKB/TrEMBL),   A0A8I6ALJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017486   ⟸   ENSRNOT00000017486
RefSeq Acc Id: ENSRNOP00000094410   ⟸   ENSRNOT00000098312
RefSeq Acc Id: ENSRNOP00000083269   ⟸   ENSRNOT00000099801
RefSeq Acc Id: ENSRNOP00000093140   ⟸   ENSRNOT00000115607
Protein Domains
EF-hand   Follistatin-like   Kazal-like   SPARC/Testican calcium-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16975-F1-model_v2 AlphaFold P16975 1-301 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697202
Promoter ID:EPDNEW_R7726
Type:initiation region
Name:Sparc_1
Description:secreted protein acidic and cysteine rich
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01040,764,175 - 40,764,235EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3742 AgrOrtholog
BioCyc Gene G2FUF-25080 BioCyc
Ensembl Genes ENSRNOG00000012840 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017486 ENTREZGENE
  ENSRNOT00000017486.8 UniProtKB/TrEMBL
  ENSRNOT00000098312.1 UniProtKB/TrEMBL
  ENSRNOT00000099801.1 UniProtKB/TrEMBL
  ENSRNOT00000115607.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.60.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621666 IMAGE-MGC_LOAD
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fol_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Follistatin/Osteonectin_EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Osteonectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPARC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPARC/Testican_Ca-bd-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24791 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72514 IMAGE-MGC_LOAD
NCBI Gene 24791 ENTREZGENE
PANTHER PTHR13866:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPARC OSTEONECTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FOLN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPARC_Ca_bdg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sparc PhenoGen
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KAZAL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OSTEONECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OSTEONECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012840 RatGTEx
SMART FOLN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KAZAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF100895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZWN9_RAT UniProtKB/TrEMBL
  A0A8I6ALJ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GK51_RAT UniProtKB/TrEMBL
  A0A8L2Q9I7_RAT UniProtKB/TrEMBL
  A6HEL9 ENTREZGENE, UniProtKB/TrEMBL
  A6HEM4_RAT UniProtKB/TrEMBL
  O08953 ENTREZGENE
  P16975 ENTREZGENE
  Q6GSZ4 ENTREZGENE
  SPRC_RAT UniProtKB/Swiss-Prot
UniProt Secondary O08953 UniProtKB/Swiss-Prot
  Q6GSZ4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Sparc  secreted protein acidic and cysteine rich  Sparc  secreted protein, acidic, cysteine-rich (osteonectin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Sparc  secreted protein, acidic, cysteine-rich (osteonectin)  Sparc  secreted acidic cysteine rich glycoprotein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Sparc  Secreted acidic cystein-rich glycoprotein (osteonectin)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in osteoblasts, odontoblasts, and fibroblasts during development 730043
gene_expression expression is increased 2.2 fold in SHR compared with WKY rats 1357414
gene_regulation expression increases at the onset of high-fat-diet obesity 625747