Enables sodium:proton antiporter activity. Involved in several processes, including regulation of pH; response to glucocorticoid; and sodium ion transport. Located in apical plasma membrane; brush border membrane; and recycling endosome membrane. Used to study hypertension. Biomarker of obesity and renovascular hypertension. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 8. Orthologous to human SLC9A3 (solute carrier family 9 member A3); PARTICIPATES IN endothelin signaling pathway; bile acid transport pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
[piperine co-treated with Cimetidine co-treated with Pyruvates] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of SLC9A3 protein]
[piperine co-treated with Cimetidine co-treated with Pyruvates] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of SLC9A3 protein]
[sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of SLC9A3 mRNA
[bisphenol A co-treated with Fulvestrant] results in increased methylation of SLC9A3 gene and [bisphenol S co-treated with Fulvestrant] results in decreased methylation of SLC9A3 gene
[3-(2-(3-guanidino-2-methyl-3-oxo-propenyl)-5-methylphenyl)-N-isopropylidene-2-methyl-acrylamide dihydrochloride results in decreased activity of SLC9A3 protein] which results in increased secretion of Bicarbonates and [5-dimethylamiloride results in decreased activity of SLC9A3 protein] which results in increased secretion of Bicarbonates
[sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of SLC9A3 mRNA
[piperine co-treated with Cimetidine co-treated with Pyruvates] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of SLC9A3 protein]
[manganese tetrakis-(N-methyl-2 pyridyl) porphyrin affects the abundance of [Reactive Oxygen Species co-treated with Reactive Nitrogen Species]] which affects the expression of SLC9A3
[manganese tetrakis-(N-methyl-2 pyridyl) porphyrin affects the abundance of [Reactive Oxygen Species co-treated with Reactive Nitrogen Species]] which affects the expression of SLC9A3
[Plant Extracts co-treated with Resveratrol] results in decreased expression of SLC9A3 mRNA and [Resveratrol results in increased expression of SLC9A3 protein] which results in increased uptake of Sodium Chloride
[sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of SLC9A3 mRNA
[sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of SLC9A3 mRNA
[3-(2-(3-guanidino-2-methyl-3-oxo-propenyl)-5-methylphenyl)-N-isopropylidene-2-methyl-acrylamide dihydrochloride results in decreased activity of SLC9A3 protein] which results in decreased transport of Sodium
Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated by inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein kinase II.
ER function in the adult male rat: short- and long-term effects of the antiestrogen ICI 182,780 on the testis and efferent ductules, without changes in testosterone.
Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins.
Dopamine D3 receptor-mediated inhibition of Na+/H+ exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells.
Peroxisome proliferator-activated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents.
activity is regulated by physiological stimuli, glucorticoids, aldosterone, and other neurohormones and also by signal transduction pathways that involve protein kinase C, cAMP, cGMP, intracellular calcium and accessory proteins such as NHE regulatory fac
