Slc10a1 (solute carrier family 10 member 1) - Rat Genome Database

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Gene: Slc10a1 (solute carrier family 10 member 1) Rattus norvegicus
Analyze
Symbol: Slc10a1
Name: solute carrier family 10 member 1
RGD ID: 3681
Description: Enables bile acid:sodium symporter activity. Involved in several processes, including bile acid and bile salt transport; bile acid signaling pathway; and response to estrogen. Located in basolateral plasma membrane. Biomarker of alcoholic hepatitis; cholestasis; and obesity. Orthologous to human SLC10A1 (solute carrier family 10 member 1); PARTICIPATES IN bile acid signaling pathway; bile acid transport pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; 1-benzylpiperazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hepatic sodium/bile acid cotransporter; Na(+)/bile acid cotransporter; Na(+)/taurocholate transport protein; NA-dependent cholate transporting protein; Ntcp; Ntcp1; SBACT; sodium-dependent bile acid cotransporter; sodium-dependent taurocholate cotransporting polypeptide; sodium/bile acid cotransporter; sodium/taurocholate cotransporting polypeptide; solute carrier family 10 (sodium/bile acid cotransporter family) member 1; Solute carrier family 10 (sodium/bile acid cotransporter family), member 1; solute carrier family 10 (sodium/bile acid cotransporter), member 1; solute carrier family 10, member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86106,344,319 - 106,357,944 (-)NCBIGRCr8
mRatBN7.26100,613,045 - 100,626,670 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6100,613,045 - 100,626,670 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6100,773,704 - 100,787,344 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06101,072,886 - 101,086,526 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06100,453,053 - 100,466,659 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06104,617,730 - 104,631,355 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6104,617,730 - 104,631,355 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06112,782,934 - 112,796,559 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46104,735,839 - 104,749,464 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16104,739,294 - 104,752,920 (-)NCBI
Celera698,468,708 - 98,482,340 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-Epidiosbulbin E acetate  (ISO)
acadesine  (EXP)
acetamide  (EXP)
acetamides  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
albuterol  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
allyl alcohol  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
Augmentin  (ISO)
azathioprine  (EXP)
aztreonam  (ISO)
benzenesulfonates  (ISO)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bosentan  (EXP,ISO)
bromosulfophthalein  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
carvedilol  (ISO)
cefalotin  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (ISO)
cholic acid  (ISO)
chrysophanol  (EXP)
ciprofibrate  (ISO)
clavulanic acid  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cocaine  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cyproconazole  (ISO)
daidzein  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dichlorine  (EXP)
dieldrin  (EXP,ISO)
dihydroartemisinin  (EXP)
dimethylarsinic acid  (ISO)
Diosbulbin B  (ISO)
dioscin  (EXP)
doxycycline  (EXP)
emodin  (EXP,ISO)
endosulfan  (ISO)
enilconazole  (ISO)
epoxiconazole  (ISO)
estrone 3-sulfate  (ISO)
ethambutol  (ISO)
ethanol  (EXP,ISO)
fenofibrate  (EXP,ISO)
fipronil  (EXP)
flavonoids  (EXP)
fluorescein 5-isothiocyanate  (ISO)
flutamide  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
fusidic acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
Geniposide  (EXP)
genistein  (EXP)
ginsenoside Rg1  (EXP)
glafenine  (EXP)
glyburide  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
guggulsterone  (EXP,ISO)
GW 4064  (EXP,ISO)
Heliotrine  (ISO)
heptachlor  (EXP,ISO)
ibuprofen  (ISO)
icariside II  (ISO)
imipenem hydrate  (ISO)
indocyanine green  (ISO)
indole-3-acetic acid  (ISO)
indoxyl sulfate  (ISO)
isoniazide  (EXP,ISO)
ketoconazole  (EXP)
lead diacetate  (ISO)
lipopolysaccharide  (EXP,ISO)
liquiritin  (ISO)
lithocholic acid  (ISO)
macitentan  (ISO)
manganese(II) chloride  (EXP)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (EXP)
methoxsalen  (EXP)
methoxychlor  (EXP)
methylarsonic acid  (ISO)
microcystin-LR  (ISO)
mirex  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-benzoylglycine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP,ISO)
neomycin  (ISO)
nifedipine  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (EXP,ISO)
oleanolic acid  (ISO)
oltipraz  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorobutanesulfonic acid  (EXP,ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perhexiline  (EXP)
phenobarbital  (EXP,ISO)
physcion  (EXP)
Picroside ii  (ISO)
piperazines  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
propiconazole  (ISO)
prothioconazole  (ISO)
Prothioconazole-desthio  (ISO)
pyrazinecarboxamide  (EXP,ISO)
pyrrolidines  (EXP)
rifampicin  (ISO)
ritonavir  (ISO)
Ro 41-5253  (ISO)
senecionine  (EXP,ISO)
Senkirkine  (ISO)
serpentine asbestos  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium atom  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sulfadimethoxine  (EXP)
sulfoglycolithocholic acid  (ISO)
sulforaphane  (ISO)
Sunset Yellow FCF  (ISO)
tamoxifen  (EXP,ISO)
tartrazine  (ISO)
taurocholic acid  (EXP,ISO)
tauroursodeoxycholic acid  (ISO)
tebuconazole  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
thioacetamide  (EXP)
tianeptine  (EXP)
ticlopidine  (EXP)
tolvaptan  (ISO)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
Yangonin  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Effect of a high-fat diet on the hepatic expression of nuclear receptors and their target genes: relevance to drug disposition. Ghoneim RH, etal., Br J Nutr. 2015 Feb 14;113(3):507-16. doi: 10.1017/S0007114514003717. Epub 2015 Jan 23.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system. Hagenbuch B, etal., Proc Natl Acad Sci U S A 1991 Dec 1;88(23):10629-33.
5. Alisma orientale extract exerts the reversing cholestasis effect by activation of farnesoid X receptor. Huo XK, etal., Phytomedicine. 2018 Mar 15;42:34-42. doi: 10.1016/j.phymed.2018.03.017. Epub 2018 Mar 8.
6. Interleukin-1beta -mediated Suppression of RXR:RAR Transactivation of the Ntcp Promoter Is JNK-dependent. Li D, etal., J Biol Chem 2002 Aug 30;277(35):31416-22.
7. Role of AMP-activated protein kinase α1 in 17α-ethinylestradiol-induced cholestasis in rats. Li X, etal., Arch Toxicol. 2017 Jan;91(1):481-494. doi: 10.1007/s00204-016-1697-8. Epub 2016 Apr 18.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump. Mita S, etal., Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G159-67. Epub 2004 Aug 5.
10. Two N-linked glycans are required to maintain the transport activity of the bile salt export pump (ABCB11) in MDCK II cells. Mochizuki K, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Mar;292(3):G818-28. doi: 10.1152/ajpgi.00415.2006. Epub 2006 Nov 2.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation. Tian J, etal., Sci Rep. 2017 Aug 21;7(1):8938. doi: 10.1038/s41598-017-09131-2.
16. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
17. Protein kinase B/Akt mediates cAMP- and cell swelling-stimulated Na+/taurocholate cotransport and Ntcp translocation. Webster CR, etal., J Biol Chem 2002 Aug 9;277(32):28578-83.
18. Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner. Xu W, etal., Toxicol Appl Pharmacol. 2017 Jan 15;315:23-34. doi: 10.1016/j.taap.2016.12.001. Epub 2016 Dec 6.
Additional References at PubMed
PMID:8662994   PMID:11279518   PMID:12477932   PMID:12547402   PMID:12631271   PMID:12842829   PMID:12883478   PMID:14684617   PMID:14701722   PMID:14711893   PMID:15361361   PMID:16027164  
PMID:16608845   PMID:17615179   PMID:17640976   PMID:17916651   PMID:19815625   PMID:20539008   PMID:21167233   PMID:23125159   PMID:24008362   PMID:25305012   PMID:26306036   PMID:27133208  
PMID:31088037   PMID:35580629  


Genomics

Comparative Map Data
Slc10a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86106,344,319 - 106,357,944 (-)NCBIGRCr8
mRatBN7.26100,613,045 - 100,626,670 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6100,613,045 - 100,626,670 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6100,773,704 - 100,787,344 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06101,072,886 - 101,086,526 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06100,453,053 - 100,466,659 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06104,617,730 - 104,631,355 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6104,617,730 - 104,631,355 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06112,782,934 - 112,796,559 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46104,735,839 - 104,749,464 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16104,739,294 - 104,752,920 (-)NCBI
Celera698,468,708 - 98,482,340 (-)NCBICelera
Cytogenetic Map6q24NCBI
SLC10A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381469,775,416 - 69,797,241 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1469,775,416 - 69,797,241 (-)EnsemblGRCh38hg38GRCh38
GRCh371470,242,133 - 70,263,958 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361469,312,305 - 69,333,707 (-)NCBINCBI36Build 36hg18NCBI36
Build 341469,312,304 - 69,333,707NCBI
Celera1450,306,664 - 50,328,118 (-)NCBICelera
Cytogenetic Map14q24.1NCBI
HuRef1450,411,110 - 50,432,563 (-)NCBIHuRef
CHM1_11470,180,694 - 70,202,147 (-)NCBICHM1_1
T2T-CHM13v2.01463,983,088 - 64,004,909 (-)NCBIT2T-CHM13v2.0
Slc10a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391280,999,959 - 81,015,479 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1280,999,957 - 81,015,479 (-)EnsemblGRCm39 Ensembl
GRCm381280,953,185 - 80,968,705 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1280,953,183 - 80,968,705 (-)EnsemblGRCm38mm10GRCm38
MGSCv371282,054,172 - 82,069,066 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361281,874,340 - 81,886,832 (-)NCBIMGSCv36mm8
Celera1282,418,707 - 82,433,538 (-)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1237.21NCBI
Slc10a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955466597,204 - 608,756 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955466597,081 - 609,254 (+)NCBIChiLan1.0ChiLan1.0
SLC10A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21570,900,139 - 70,921,237 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11470,113,183 - 70,137,836 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01450,369,663 - 50,390,984 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11469,240,602 - 69,261,904 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1469,240,602 - 69,261,904 (-)Ensemblpanpan1.1panPan2
SLC10A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1843,521,291 - 43,546,426 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl843,521,747 - 43,546,274 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha843,210,224 - 43,234,841 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0843,749,263 - 43,773,881 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl843,749,716 - 43,773,832 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1843,363,627 - 43,388,457 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0843,437,348 - 43,461,959 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0843,797,816 - 43,821,924 (-)NCBIUU_Cfam_GSD_1.0
Slc10a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864061,215,944 - 61,231,982 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649512,959,077 - 12,975,755 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649512,958,983 - 12,975,755 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC10A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl793,397,608 - 93,421,985 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1793,400,037 - 93,421,989 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2799,679,201 - 99,699,835 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC10A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12447,018,237 - 47,034,360 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2447,017,414 - 47,033,940 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605335,245,164 - 35,260,625 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc10a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473431,287,394 - 31,311,357 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473431,287,539 - 31,307,339 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc10a1
54 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:34
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000007825
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 32 29 4 29 3 2
Low 3 10 25 12 15 12 8 9 11 19 5 9 8
Below cutoff 3 2 8 10 12

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007825   ⟹   ENSRNOP00000007825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6100,613,045 - 100,626,670 (-)Ensembl
Rnor_6.0 Ensembl6104,617,730 - 104,631,355 (-)Ensembl
RefSeq Acc Id: NM_017047   ⟹   NP_058743
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,344,319 - 106,357,944 (-)NCBI
mRatBN7.26100,613,045 - 100,626,670 (-)NCBI
Rnor_6.06104,617,730 - 104,631,355 (-)NCBI
Rnor_5.06112,782,934 - 112,796,559 (-)NCBI
RGSC_v3.46104,735,839 - 104,749,464 (-)RGD
Celera698,468,708 - 98,482,340 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_058743   ⟸   NM_017047
- UniProtKB: Q5BK99 (UniProtKB/Swiss-Prot),   P26435 (UniProtKB/Swiss-Prot),   A6JDL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007825   ⟸   ENSRNOT00000007825

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26435-F1-model_v2 AlphaFold P26435 1-362 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694702
Promoter ID:EPDNEW_R5227
Type:initiation region
Name:Slc10a1_1
Description:solute carrier family 10 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06104,631,310 - 104,631,370EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3681 AgrOrtholog
BioCyc Gene G2FUF-36902 BioCyc
Ensembl Genes ENSRNOG00000005794 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055020271 UniProtKB/Swiss-Prot
  ENSRNOG00060029184 UniProtKB/Swiss-Prot
  ENSRNOG00065017546 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007825 ENTREZGENE
  ENSRNOT00000007825.4 UniProtKB/Swiss-Prot
  ENSRNOT00055034621 UniProtKB/Swiss-Prot
  ENSRNOT00060050677 UniProtKB/Swiss-Prot
  ENSRNOT00065029352 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1530.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7370832 IMAGE-MGC_LOAD
InterPro BilAc:Na_symport/Acr3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bilac:Na_transpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na+/solute_symporter_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24777 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108711 IMAGE-MGC_LOAD
NCBI Gene 24777 ENTREZGENE
PANTHER PTHR10361 UniProtKB/Swiss-Prot
  PTHR10361:SF40 UniProtKB/Swiss-Prot
  SODIUM-BILE ACID COTRANSPORTER UniProtKB/TrEMBL
  SODIUM/BILE ACID COTRANSPORTER UniProtKB/TrEMBL
Pfam SBF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SLC10A1 RGD
PhenoGen Slc10a1 PhenoGen
RatGTEx ENSRNOG00000005794 RatGTEx
  ENSRNOG00055020271 RatGTEx
  ENSRNOG00060029184 RatGTEx
  ENSRNOG00065017546 RatGTEx
UniProt A6JDL3 ENTREZGENE, UniProtKB/TrEMBL
  A6JDL4_RAT UniProtKB/TrEMBL
  A6JDL5_RAT UniProtKB/TrEMBL
  NTCP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5BK99 ENTREZGENE
UniProt Secondary Q5BK99 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Slc10a1  solute carrier family 10 member 1  Slc10a1  solute carrier family 10 (sodium/bile acid cotransporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc10a1  solute carrier family 10 (sodium/bile acid cotransporter family), member 1    solute carrier family 10, member 1  Name updated 1299863 APPROVED
2003-04-09 Slc10a1  solute carrier family 10, member 1    Solute carrier family 10 (sodium/bile acid cotransporter family), member 1  Name updated 629478 APPROVED
2002-06-10 Slc10a1  Solute carrier family 10 (sodium/bile acid cotransporter family), member 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression reduced in response to certain types of liver damage 70249
gene_regulation transporter activity is induced by cAMP via phosphoinositide 3-kinase/protein kinase B mediated signaling 727378