Rnf4 (ring finger protein 4) - Rat Genome Database

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Gene: Rnf4 (ring finger protein 4) Rattus norvegicus
Analyze
Symbol: Rnf4
Name: ring finger protein 4
RGD ID: 3583
Description: Enables several functions, including SUMO polymer binding activity; TBP-class protein binding activity; and nuclear receptor binding activity. Involved in several processes, including cellular response to gamma radiation; cellular response to hydroxyurea; and protein ubiquitination. Located in nucleoplasm. Colocalizes with PML body. Orthologous to human RNF4 (ring finger protein 4); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: E3 ubiquitin ligase RNF4; E3 ubiquitin-protein ligase RNF4; MGC72476; RING-type E3 ubiquitin transferase RNF4; small nuclear ring finger protein; SNURF
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81480,625,864 - 80,647,138 (-)NCBIGRCr8
mRatBN7.21476,401,292 - 76,423,270 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,401,299 - 76,422,566 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1480,855,542 - 80,874,657 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01482,096,173 - 82,115,286 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01478,541,415 - 78,560,532 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01481,658,400 - 81,679,756 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1481,660,354 - 81,679,082 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01482,345,311 - 82,366,467 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41482,092,024 - 82,112,036 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11482,093,652 - 82,114,081 (-)NCBI
Celera1475,327,677 - 75,346,979 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
caffeine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
colforsin daropate hydrochloride  (EXP)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenpyroximate  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
hydrogen cyanide  (ISO)
hydroxyurea  (EXP)
hypochlorous acid  (ISO)
L-methionine  (ISO)
levofloxacin  (EXP)
Methylazoxymethanol acetate  (EXP)
Mono-carboxy isooctyl phthalate  (ISO)
nefazodone  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
progesterone  (EXP)
pyrogallol  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
triticonazole  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO,ISS)
microtubule end  (IEA,ISO)
nuclear body  (ISO)
nucleoplasm  (IDA,ISO)
nucleus  (IDA,ISO)
PML body  (IBA,IDA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Differentially expressed genes in L6 rat skeletal muscle myoblasts after incubation with inflammatory cytokines. Adams V, etal., Cytokine. 2001 Mar 21;13(6):342-8.
2. Purification and identification of endogenous polySUMO conjugates. Bruderer R, etal., EMBO Rep. 2011 Feb;12(2):142-8. doi: 10.1038/embor.2010.206. Epub 2011 Jan 21.
3. Plasma clearance, tissue uptake and expression of pituitary peptide 23/pancreatitis-associated protein in the rat. Chakraborty C, etal., J Endocrinol. 1995 Jun;145(3):461-9.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Arsenic-induced SUMO-dependent recruitment of RNF4 into PML nuclear bodies. Geoffroy MC, etal., Mol Biol Cell. 2010 Dec;21(23):4227-39. doi: 10.1091/mbc.E10-05-0449. Epub 2010 Oct 13.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Transcriptional coregulator SNURF (RNF4) possesses ubiquitin E3 ligase activity. Hakli M, etal., FEBS Lett. 2004 Feb 27;560(1-3):56-62.
8. The RING finger protein SNURF is a bifunctional protein possessing DNA binding activity. Hakli M, etal., J Biol Chem. 2001 Jun 29;276(26):23653-60. Epub 2001 Apr 23.
9. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
10. Small nuclear RING finger protein expression during gonad development: regulation by gonadotropins and estrogen in the postnatal ovary. Hirvonen-Santti SJ, etal., Endocrinology. 2004 May;145(5):2433-44. Epub 2004 Jan 28.
11. Down-regulation of estrogen receptor beta and transcriptional coregulator SNURF/RNF4 in testicular germ cell cancer. Hirvonen-Santti SJ, etal., Eur Urol. 2003 Dec;44(6):742-7; discussion 747.
12. Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen. Hu XV, etal., Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15087-92. doi: 10.1073/pnas.1009025107. Epub 2010 Aug 9.
13. Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription. Moilanen AM, etal., Mol Cell Biol 1998 Sep;18(9):5128-39.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Push back to respond better: regulatory inhibition of the DNA double-strand break response. Panier S and Durocher D, Nat Rev Mol Cell Biol. 2013 Oct;14(10):661-72. doi: 10.1038/nrm3659. Epub 2013 Sep 4.
16. Mechanism of ubiquitylation by dimeric RING ligase RNF4. Plechanovova A, etal., Nat Struct Mol Biol. 2011 Aug 21;18(9):1052-9. doi: 10.1038/nsmb.2108.
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. SNURF-SNRPN and UBE3A transcript levels in patients with Angelman syndrome. Runte M, etal., Hum Genet. 2004 May;114(6):553-61. Epub 2004 Mar 10.
20. RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Tatham MH, etal., Nat Cell Biol. 2008 May;10(5):538-46. doi: 10.1038/ncb1716. Epub 2008 Apr 13.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. Expression of the nuclear RING finger protein SNURF/RNF4 during rat testis development suggests a role in spermatid maturation. Yan W, etal., Mech Dev. 2002 Oct;118(1-2):247-53.
23. SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage. Yin Y, etal., Genes Dev. 2012 Jun 1;26(11):1196-208. doi: 10.1101/gad.189274.112.
Additional References at PubMed
PMID:10822263   PMID:10849425   PMID:12477932   PMID:12885770   PMID:15489334   PMID:20212317   PMID:21059884   PMID:22842904   PMID:24714598   PMID:24882209   PMID:26148049   PMID:28612051  
PMID:31873223  


Genomics

Comparative Map Data
Rnf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81480,625,864 - 80,647,138 (-)NCBIGRCr8
mRatBN7.21476,401,292 - 76,423,270 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,401,299 - 76,422,566 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1480,855,542 - 80,874,657 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01482,096,173 - 82,115,286 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01478,541,415 - 78,560,532 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01481,658,400 - 81,679,756 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1481,660,354 - 81,679,082 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01482,345,311 - 82,366,467 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41482,092,024 - 82,112,036 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11482,093,652 - 82,114,081 (-)NCBI
Celera1475,327,677 - 75,346,979 (-)NCBICelera
Cytogenetic Map14q21NCBI
RNF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3842,469,106 - 2,515,857 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl42,462,220 - 2,515,857 (+)EnsemblGRCh38hg38GRCh38
GRCh3742,470,833 - 2,517,584 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3642,440,605 - 2,487,382 (+)NCBINCBI36Build 36hg18NCBI36
Build 3442,438,037 - 2,484,812NCBI
Celera42,381,995 - 2,428,665 (+)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef42,410,726 - 2,457,392 (+)NCBIHuRef
CHM1_142,468,951 - 2,515,567 (+)NCBICHM1_1
T2T-CHM13v2.042,467,864 - 2,514,631 (+)NCBIT2T-CHM13v2.0
Rnf4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39534,493,594 - 34,510,789 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl534,493,633 - 34,512,973 (+)EnsemblGRCm39 Ensembl
GRCm38534,336,250 - 34,353,445 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl534,336,289 - 34,355,629 (+)EnsemblGRCm38mm10GRCm38
MGSCv37534,679,039 - 34,696,079 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36534,653,247 - 34,670,287 (+)NCBIMGSCv36mm8
Celera531,806,911 - 31,824,034 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.87NCBI
Rnf4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555141,511,062 - 1,523,714 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555141,501,943 - 1,525,689 (+)NCBIChiLan1.0ChiLan1.0
RNF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v232,806,077 - 2,853,304 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan142,763,804 - 2,789,272 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v042,614,918 - 2,661,785 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.142,518,559 - 2,565,970 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl42,540,612 - 2,563,937 (+)Ensemblpanpan1.1panPan2
RNF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1361,721,752 - 61,759,797 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl361,723,124 - 61,759,730 (-)EnsemblCanFam3.1canFam3CanFam3.1
Rnf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528567,323,348 - 67,354,145 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493647721,025,040 - 21,055,821 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl81,353,658 - 1,380,634 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.181,353,532 - 1,380,637 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28917,478 - 945,481 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RNF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12746,245,786 - 46,290,671 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660512,616,728 - 2,662,730 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnf4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475525,141,567 - 25,153,942 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475525,139,637 - 25,163,586 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rnf4
144 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:864
Count of miRNA genes:294
Interacting mature miRNAs:362
Transcripts:ENSRNOT00000019555
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat

Markers in Region
BI277880  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21476,402,837 - 76,402,934 (+)MAPPERmRatBN7.2
Rnor_6.01481,659,946 - 81,660,042NCBIRnor6.0
Rnor_5.01482,346,857 - 82,346,953UniSTSRnor5.0
RGSC_v3.41482,091,637 - 82,091,733UniSTSRGSC3.4
Celera1475,327,290 - 75,327,386UniSTS
Cytogenetic Map14q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000019555   ⟹   ENSRNOP00000019555
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1481,660,441 - 81,672,351 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077799   ⟹   ENSRNOP00000074121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,401,303 - 76,413,585 (-)Ensembl
Rnor_6.0 Ensembl1481,660,354 - 81,679,082 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095762   ⟹   ENSRNOP00000096496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,401,299 - 76,422,566 (-)Ensembl
RefSeq Acc Id: NM_019182   ⟹   NP_062055
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,627,794 - 80,647,138 (-)NCBI
mRatBN7.21476,403,225 - 76,422,564 (-)NCBI
Rnor_6.01481,660,333 - 81,679,653 (-)NCBI
Rnor_5.01482,345,311 - 82,366,467 (-)NCBI
RGSC_v3.41482,092,024 - 82,112,036 (-)RGD
Celera1475,327,677 - 75,346,979 (-)RGD
Sequence:
RefSeq Acc Id: XM_063272992   ⟹   XP_063129062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,625,864 - 80,639,968 (-)NCBI
RefSeq Acc Id: XR_010057355
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,625,864 - 80,639,968 (-)NCBI
RefSeq Acc Id: NP_062055   ⟸   NM_019182
- UniProtKB: O88846 (UniProtKB/Swiss-Prot),   A6IK32 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074121   ⟸   ENSRNOT00000077799
RefSeq Acc Id: ENSRNOP00000019555   ⟸   ENSRNOT00000019555
RefSeq Acc Id: ENSRNOP00000096496   ⟸   ENSRNOT00000095762
RefSeq Acc Id: XP_063129062   ⟸   XM_063272992
- Peptide Label: isoform X1
Protein Domains
RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88846-F1-model_v2 AlphaFold O88846 1-194 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699404
Promoter ID:EPDNEW_R9926
Type:multiple initiation site
Name:Rnf4_1
Description:ring finger protein 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01481,679,070 - 81,679,130EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3583 AgrOrtholog
BioCyc Gene G2FUF-15289 BioCyc
Ensembl Genes ENSRNOG00000013930 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055016978 UniProtKB/Swiss-Prot
  ENSRNOG00060016549 UniProtKB/Swiss-Prot
  ENSRNOG00065028885 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000077799.2 UniProtKB/TrEMBL
  ENSRNOT00000095762.1 UniProtKB/Swiss-Prot
  ENSRNOT00055028879 UniProtKB/Swiss-Prot
  ENSRNOT00060028458 UniProtKB/Swiss-Prot
  ENSRNOT00065049898 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623495 IMAGE-MGC_LOAD
InterPro RING-HC_RNF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNF4-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72476 IMAGE-MGC_LOAD
NCBI Gene 29274 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE RNF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING FINGER DOMAIN-CONTAINING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam zf-RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rnf4 PhenoGen
PROSITE ZF_RING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013930 RatGTEx
  ENSRNOG00055016978 RatGTEx
  ENSRNOG00060016549 RatGTEx
  ENSRNOG00065028885 RatGTEx
SMART RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC209613
UniProt A0A0G2K799_RAT UniProtKB/TrEMBL
  A6IK32 ENTREZGENE, UniProtKB/TrEMBL
  A6IK33_RAT UniProtKB/TrEMBL
  O88846 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Rnf4  ring finger protein 4       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction displays hormone-dependent binding to the androgen receptor 69969