Rho (rhodopsin) - Rat Genome Database

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Gene: Rho (rhodopsin) Rattus norvegicus
Analyze
Symbol: Rho
Name: rhodopsin
RGD ID: 3573
Description: Enables retinal binding activity and spectrin binding activity. Involved in red, far-red light phototransduction and rhodopsin mediated signaling pathway. Located in photoreceptor outer segment membrane and rough endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital stationary night blindness autosomal dominant 1; fundus albipunctatus; night blindness; retinitis pigmentosa; and retinitis pigmentosa 4. Orthologous to human RHO (rhodopsin); PARTICIPATES IN altered visual phototransduction pathway; retinitis pigmentosa pathway; retinoid cycle metabolic pathway; INTERACTS WITH 3,7-dihydropurine-6-thione; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Rhodopsin (retinitis pigmentosa 4, autosomal dominant)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84150,653,205 - 150,658,367 (+)NCBIGRCr8
mRatBN7.24148,975,597 - 148,988,693 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4148,980,611 - 148,985,773 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4155,209,107 - 155,214,199 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04150,993,130 - 150,998,222 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04149,616,029 - 149,621,121 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04147,832,136 - 147,837,298 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,832,136 - 147,837,298 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04211,115,847 - 211,121,009 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44152,057,788 - 152,062,950 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14152,302,628 - 152,307,791 (+)NCBI
Celera4137,870,273 - 137,875,435 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A homozygous p.Glu150Lys mutation in the opsin gene of two Pakistani families with autosomal recessive retinitis pigmentosa. Azam M, etal., Mol Vis. 2009 Dec 3;15:2526-34.
2. Aberrant retinal tight junction and adherens junction protein expression in an animal model of autosomal dominant Retinitis pigmentosa: the Rho(-/-) mouse. Campbell M, etal., Exp Eye Res. 2006 Sep;83(3):484-92. Epub 2006 Apr 27.
3. Caspase-7 ablation modulates UPR, reprograms TRAF2-JNK apoptosis and protects T17M rhodopsin mice from severe retinal degeneration. Choudhury S, etal., Cell Death Dis. 2013 Mar 7;4:e528. doi: 10.1038/cddis.2013.34.
4. Genes and mutations causing retinitis pigmentosa. Daiger SP, etal., Clin Genet. 2013 Aug;84(2):132-41. doi: 10.1111/cge.12203. Epub 2013 Jun 19.
5. Rhodopsin in immature rod outer segments. Dodge J, etal., Invest Ophthalmol Vis Sci. 1996 Sep;37(10):1951-6.
6. Mutations within the rhodopsin gene in patients with autosomal dominant retinitis pigmentosa. Dryja TP, etal., N Engl J Med. 1990 Nov 8;323(19):1302-7.
7. Heterozygous missense mutation in the rhodopsin gene as a cause of congenital stationary night blindness. Dryja TP, etal., Nat Genet. 1993 Jul;4(3):280-3.
8. Interaction of GABA receptor/channel rho(1) and gamma(2) subunit. Ekema GM, etal., Invest Ophthalmol Vis Sci. 2002 Jul;43(7):2326-33.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Preservation of photoreceptor morphology and function in P23H rats using an allele independent ribozyme. Gorbatyuk M, etal., Exp Eye Res. 2007 Jan;84(1):44-52. Epub 2006 Nov 1.
12. Phosphorylation of the InaD gene product, a photoreceptor membrane protein required for recovery of visual excitation. Huber A, etal., J Biol Chem 1996 May 17;271(20):11710-7.
13. Identification of an IMPDH1 mutation in autosomal dominant retinitis pigmentosa (RP10) revealed following comparative microarray analysis of transcripts derived from retinas of wild-type and Rho(-/-) mice. Kennan A, etal., Hum Mol Genet. 2002 Mar 1;11(5):547-57.
14. Transport of truncated rhodopsin and its effects on rod function and degeneration. Lee ES and Flannery JG, Invest Ophthalmol Vis Sci. 2007 Jun;48(6):2868-76.
15. AAV delivery of wild-type rhodopsin preserves retinal function in a mouse model of autosomal dominant retinitis pigmentosa. Mao H, etal., Hum Gene Ther. 2011 May;22(5):567-75. doi: 10.1089/hum.2010.140. Epub 2011 Mar 7.
16. Functional characterization of a novel c.614-622del rhodopsin mutation in a French pedigree with retinitis pigmentosa. Maubaret C, etal., Mol Vis. 2012;18:581-7. Epub 2012 Mar 2.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Rhodopsin C110Y mutation causes a type 2 autosomal dominant retinitis pigmentosa. Milla E, etal., Ophthalmic Genet. 1998 Sep;19(3):131-9.
19. Zinc-finger-based transcriptional repression of rhodopsin in a model of dominant retinitis pigmentosa. Mussolino C, etal., EMBO Mol Med. 2011 Mar;3(3):118-28. doi: 10.1002/emmm.201000119. Epub 2011 Jan 26.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. Identification of two mutations of the RHO gene in two Chinese families with retinitis pigmentosa: correlation between genotype and phenotype. Pan Z, etal., Mol Vis. 2012;18:3013-20. Epub 2012 Dec 14.
23. The giant spectrin betaV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route. Papal S, etal., Hum Mol Genet. 2013 Sep 15;22(18):3773-88. doi: 10.1093/hmg/ddt228. Epub 2013 May 23.
24. Enhanced cone dysfunction in rats homozygous for the P23H rhodopsin mutation. Pinilla I, etal., Neurosci Lett. 2005 Jul 1-8;382(1-2):16-21. Epub 2005 Mar 17.
25. Generation, characterization, and molecular cloning of the Noerg-1 mutation of rhodopsin in the mouse. Pinto LH, etal., Vis Neurosci. 2005 Sep-Oct;22(5):619-29.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Comprehensive gene review and curation RGD comprehensive gene curation
31. Rhodopsin p.N78I dominant mutation causing sectorial retinitis pigmentosa in a pedigree with intrafamilial clinical heterogeneity. Rivera-De la Parra D, etal., Gene. 2013 Apr 25;519(1):173-6. doi: 10.1016/j.gene.2013.01.048. Epub 2013 Feb 9.
32. Mice with a D190N mutation in the gene encoding rhodopsin: a model for human autosomal-dominant retinitis pigmentosa. Sancho-Pelluz J, etal., Mol Med. 2012 May 9;18:549-55. doi: 10.2119/molmed.2011.00475.
33. Addition of the chromophore to rat rhodopsin is an early post-translational event. St Jules RS, etal., Exp Eye Res. 1989 May;48(5):653-65.
34. The localization and timing of post-translational modifications of rat rhodopsin. St Jules RS, etal., Exp Eye Res. 1990 Oct;51(4):427-34.
35. Membrane receptors and transporters involved in the function and transport of vitamin A and its derivatives. Sun H Biochim Biophys Acta. 2012 Jan;1821(1):99-112. Epub 2011 Jun 17.
36. Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait. Wright AF, etal., Nat Rev Genet. 2010 Apr;11(4):273-84. doi: 10.1038/nrg2717.
Additional References at PubMed
PMID:1827795   PMID:2218504   PMID:7654522   PMID:7916602   PMID:10097103   PMID:10399916   PMID:10725384   PMID:11747369   PMID:11767049   PMID:12651948   PMID:12965217   PMID:15476589  
PMID:16723493   PMID:17272282   PMID:18411229   PMID:18654856   PMID:19332056   PMID:19934218   PMID:20592197   PMID:21052544   PMID:21212183   PMID:21444805   PMID:21765948   PMID:22183357  
PMID:22183407   PMID:22432009   PMID:22869374   PMID:22937111   PMID:23178122   PMID:23351594   PMID:23793062   PMID:23943788   PMID:24129169   PMID:24496510   PMID:24664747   PMID:25108566  
PMID:25224828   PMID:25664179   PMID:26004531   PMID:26436889   PMID:28734946   PMID:34680161  


Genomics

Comparative Map Data
Rho
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84150,653,205 - 150,658,367 (+)NCBIGRCr8
mRatBN7.24148,975,597 - 148,988,693 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4148,980,611 - 148,985,773 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4155,209,107 - 155,214,199 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04150,993,130 - 150,998,222 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04149,616,029 - 149,621,121 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04147,832,136 - 147,837,298 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,832,136 - 147,837,298 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04211,115,847 - 211,121,009 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44152,057,788 - 152,062,950 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14152,302,628 - 152,307,791 (+)NCBI
Celera4137,870,273 - 137,875,435 (+)NCBICelera
Cytogenetic Map4q42NCBI
RHO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383129,528,639 - 129,535,344 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3129,528,639 - 129,535,344 (+)EnsemblGRCh38hg38GRCh38
GRCh373129,247,482 - 129,254,187 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363130,730,172 - 130,736,877 (+)NCBINCBI36Build 36hg18NCBI36
Build 343130,730,179 - 130,736,885NCBI
Celera3127,674,318 - 127,681,023 (+)NCBICelera
Cytogenetic Map3q22.1NCBI
HuRef3126,630,783 - 126,637,404 (+)NCBIHuRef
CHM1_13129,210,611 - 129,217,316 (+)NCBICHM1_1
T2T-CHM13v2.03132,273,081 - 132,279,773 (+)NCBIT2T-CHM13v2.0
Rho
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396115,903,741 - 115,916,999 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6115,908,709 - 115,916,997 (+)EnsemblGRCm39 Ensembl
GRCm386115,926,754 - 115,940,038 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6115,931,748 - 115,940,036 (+)EnsemblGRCm38mm10GRCm38
MGSCv376115,881,945 - 115,888,848 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366115,897,546 - 115,904,449 (+)NCBIMGSCv36mm8
Celera6117,767,245 - 117,774,151 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.72NCBI
Rho
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542917,787,337 - 17,791,982 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542917,787,337 - 17,791,982 (-)NCBIChiLan1.0ChiLan1.0
RHO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22127,461,364 - 127,471,171 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13127,466,088 - 127,473,896 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03126,586,510 - 126,593,028 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13133,938,419 - 133,944,928 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3133,938,419 - 133,944,928 (+)Ensemblpanpan1.1panPan2
RHO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1205,630,735 - 5,638,906 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha205,669,643 - 5,674,903 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0205,661,948 - 5,667,219 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl205,661,632 - 5,667,315 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1205,377,793 - 5,383,047 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0205,730,818 - 5,736,090 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0205,706,443 - 5,711,705 (-)NCBIUU_Cfam_GSD_1.0
Rho
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494218,008,183 - 18,014,175 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936602894,617 - 901,664 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936602896,730 - 901,480 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RHO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1368,908,578 - 68,913,651 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11368,908,578 - 68,913,651 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21376,135,867 - 76,140,946 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RHO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12251,513,611 - 51,520,589 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2251,515,081 - 51,519,974 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041114,957,244 - 114,963,876 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rho
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624872523,912 - 527,615 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624872523,892 - 528,278 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rho
41 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:62
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000064603
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 14 4 24 2
Below cutoff 3 22 16 5 9 5 4 4 60 28 17 9 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000064603   ⟹   ENSRNOP00000061473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4148,980,611 - 148,985,773 (+)Ensembl
Rnor_6.0 Ensembl4147,832,136 - 147,837,298 (+)Ensembl
RefSeq Acc Id: NM_033441   ⟹   NP_254276
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84150,653,205 - 150,658,367 (+)NCBI
mRatBN7.24148,980,611 - 148,985,773 (+)NCBI
Rnor_6.04147,832,136 - 147,837,298 (+)NCBI
Rnor_5.04211,115,847 - 211,121,009 (+)NCBI
RGSC_v3.44152,057,788 - 152,062,950 (+)RGD
Celera4137,870,273 - 137,875,435 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_254276 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA84439 (Get FASTA)   NCBI Sequence Viewer  
  CAA87081 (Get FASTA)   NCBI Sequence Viewer  
  EDM02135 (Get FASTA)   NCBI Sequence Viewer  
  EDM02136 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061473
  ENSRNOP00000061473.1
GenBank Protein P51489 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_254276   ⟸   NM_033441
- UniProtKB: P51489 (UniProtKB/Swiss-Prot),   A0A0G2JSY7 (UniProtKB/TrEMBL),   A6IL03 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000061473   ⟸   ENSRNOT00000064603
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51489-F1-model_v2 AlphaFold P51489 1-348 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693329
Promoter ID:EPDNEW_R3854
Type:single initiation site
Name:Rho_1
Description:rhodopsin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04147,832,122 - 147,832,182EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3573 AgrOrtholog
BioCyc Gene G2FUF-43307 BioCyc
Ensembl Genes ENSRNOG00000011144 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064603 ENTREZGENE
  ENSRNOT00000064603.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Opsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Retinal_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24717 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24717 ENTREZGENE
PANTHER OPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHODOPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rho PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHODOPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011144 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSY7 ENTREZGENE, UniProtKB/TrEMBL
  A6IL03 ENTREZGENE, UniProtKB/TrEMBL
  A6IL04_RAT UniProtKB/TrEMBL
  OPSD_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Rho  Rhodopsin (retinitis pigmentosa 4, autosomal dominant)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutations in the human homolog are a major cause of retinitis pigmentosa 731249