Gene: Psen1 (presenilin 1) Rattus norvegicus
Symbol: Psen1
Name: presenilin 1
Description: ENCODES a protein that exhibits endopeptidase activity; peptidase activity; beta-catenin binding (ortholog); INVOLVED IN membrane protein ectodomain proteolysis; negative regulation of apoptotic process; negative regulation of neuron apoptotic process; PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; syndecan signaling pathway; ASSOCIATED WITH increased apoptosis; ASSOCIATED WITH Alzheimer Disease (ortholog); Alzheimer disease type 4 (ortholog); Alzheimer Disease, Familial, 3, with Spastic Paraparesis and Apraxia (ortholog); FOUND IN cell surface; lysosomal membrane; membrane raft; INTERACTS WITH 17beta-hydroxy-5alpha-androstan-3-one; 2,6-dinitrotoluene; 6-propyl-2-thiouracil
Type: protein-coding
Also known as: presenilin-1; PS-1
Latest Assembly: RGSC Genome Assembly v5.0
RGSC Genome Assembly v6.06107,169,513 - 107,220,957+NCBI
Rat Cytogenetic Map6q31 NCBI
RGSC Genome Assembly v5.06118,324,910 - 118,373,090-NCBI
RGSC Genome Assembly v3.46107,737,543 - 107,776,357+NCBI
Rat Celera Assembly6101,163,513 - 101,199,486+NCBI
Genome Assembly 3.16107,729,188 - 107,781,021+NCBI

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Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (RGSC Genome Assembly v5.0)


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Psen1
Entrez Gene
Ensembl Gene
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Vista + UCSC

RGD Object Information
RGD ID: 3425
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2015-05-12
Status: ACTIVE