Gene: Psen1 (presenilin 1) Rattus norvegicus
Symbol: Psen1
Name: presenilin 1
Description: ENCODES a protein that exhibits endopeptidase activity; peptidase activity; beta-catenin binding (ortholog); INVOLVED IN membrane protein ectodomain proteolysis; negative regulation of apoptotic process; negative regulation of neuron apoptotic process; PARTICIPATES IN Alzheimer disease pathway; Notch signaling pathway; Notch signaling pathway; ASSOCIATED WITH increased apoptosis; ASSOCIATED WITH Alzheimer Disease (ortholog); Alzheimer disease type 4 (ortholog); Alzheimer Disease, Familial, 3, with Spastic Paraparesis and Apraxia (ortholog); FOUND IN cell surface; lysosomal membrane; membrane raft; INTERACTS WITH 2,6-dinitrotoluene; ammonium chloride; cypermethrin
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: presenilin-1; PS-1
Orthologs:
Latest Assembly: RGSC Genome Assembly v5.0
Position:
MapChrPositionStrandSource
RGSC Genome Assembly v6.06107,169,513 - 107,220,957+NCBI
Rat Cytogenetic Map6q31 NCBI
RGSC Genome Assembly v5.06118,324,910 - 118,373,090-NCBI
RGSC Genome Assembly v3.46107,737,543 - 107,776,357+NCBI
Rat Celera Assembly6101,163,513 - 101,199,486+NCBI
Genome Assembly 3.16107,729,188 - 107,781,021+NCBI
Model

Launch Genome Browser (GBrowse)


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (RGSC Genome Assembly v5.0)

Sequence

Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Psen1
Entrez Gene
Ensembl Gene
Genome Browser
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 3425
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2014-12-02
Status: ACTIVE