Musk (muscle associated receptor tyrosine kinase)

Gene: Musk (muscle associated receptor tyrosine kinase) Rattus norvegicus

Analyze

Symbol:

Musk

Name:

muscle associated receptor tyrosine kinase

RGD ID:

3211

Description:

Enables protein kinase binding activity and protein tyrosine kinase activity. Involved in several processes, including positive regulation of synaptic assembly at neuromuscular junction; positive regulation of synaptic transmission; and regulation of gene expression. Located in cell projection; external side of plasma membrane; and neuromuscular junction. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 9 and fetal akinesia deformation sequence syndrome 1. Orthologous to human MUSK (muscle associated receptor tyrosine kinase); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH 1-naphthyl isothiocyanate; acetamide; ammonium chloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

muscle specific kinase (neural fold/somite kinase 1); muscle, skeletal receptor tyrosine protein kinase; muscle, skeletal, receptor tyrosine kinase; muscle-specific kinase receptor; muscle-specific tyrosine kinase receptor MuSK; muscle-specific tyrosine protein kinase receptor; Nsk1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	77,853,560 - 77,967,653 (+)	NCBI		GRCr8
mRatBN7.2	5	73,058,427 - 73,169,696 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	73,058,121 - 73,171,932 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	74,950,396 - 75,053,703 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	76,772,006 - 76,875,299 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	76,744,136 - 76,847,436 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	75,392,790 - 75,498,694 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	75,392,790 - 75,498,694 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	79,542,952 - 79,649,636 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	76,273,430 - 76,388,614 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	76,278,542 - 76,393,727 (+)	NCBI
Celera	5	71,894,778 - 71,996,416 (+)	NCBI		Celera
Cytogenetic Map	5	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital myasthenic syndrome (ISO)

congenital myasthenic syndrome 4C (ISO)

congenital myasthenic syndrome 9 (ISO,ISS)

Congenital Myasthenic Syndrome, with Facial Dysmorphism, associated with Acetylcholine Receptor Deficiency (ISO)

Experimental Autoimmune Myasthenia Gravis (IDA)

fetal akinesia deformation sequence syndrome (ISO)

fetal akinesia deformation sequence syndrome 1 (ISO)

genetic disease (ISO)

myasthenia gravis (ISO)

respiratory failure (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-naphthyl isothiocyanate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

acetamide (EXP)

ammonium chloride (EXP)

asbestos (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

capsaicin (EXP)

chlorpyrifos (ISO)

cocaine (EXP)

dextran sulfate (ISO)

gentamycin (EXP)

naproxen (EXP)

paracetamol (EXP)

sarin (ISO)

sodium arsenite (ISO)

sumatriptan (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

valproic acid (ISO)

XL147 (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IEA)

cell surface receptor protein tyrosine kinase signaling pathway (IEA)

cochlea development (IEP)

enzyme-linked receptor protein signaling pathway (ISO)

long-term synaptic potentiation (IMP)

memory (IMP)

motor neuron apoptotic process (ISO)

negative regulation of gene expression (IDA)

neuromuscular junction development (IEA,IEP,ISO,ISS)

positive regulation of ERK1 and ERK2 cascade (IBA)

positive regulation of gene expression (IMP)

positive regulation of motor neuron apoptotic process (ISO)

positive regulation of neuron projection development (IBA,IEA)

positive regulation of peptidyl-tyrosine phosphorylation (IDA)

positive regulation of protein geranylgeranylation (ISO)

positive regulation of protein phosphorylation (IDA,IEA,IMP,ISO)

positive regulation of Rac protein signal transduction (ISO)

positive regulation of skeletal muscle acetylcholine-gated channel clustering (ISO)

positive regulation of synaptic assembly at neuromuscular junction (IMP)

positive regulation of synaptic transmission, cholinergic (IMP)

protein autophosphorylation (IDA)

receptor clustering (IMP,ISO)

regulation of DNA-templated transcription (ISO)

regulation of synaptic assembly at neuromuscular junction (ISO,ISS)

response to axon injury (IEP)

response to electrical stimulus (IMP)

response to muscle activity (IEP)

retina development in camera-type eye (IEP)

skeletal muscle acetylcholine-gated channel clustering (ISO)

Cellular Component

cell projection (IDA)

external side of plasma membrane (IDA)

membrane (ISO)

neuromuscular junction (IDA,ISO)

plasma membrane (IEA,ISO,ISS)

postsynaptic membrane (ISO)

receptor complex (IBA,IEA,ISO)

synapse (IEA,ISO)

Molecular Function

ATP binding (IEA)

metal ion binding (IEA)

PDZ domain binding (ISO)

protein binding (IPI,ISO)

protein kinase binding (IPI)

protein tyrosine kinase activity (IDA,ISO)

transmembrane receptor protein tyrosine kinase activity (IBA,IEA)

Wnt-protein binding (IBA,IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylcholine signaling pathway via nicotinic acetylcholine receptor (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization.	Bergamin E, etal., Mol Cell. 2010 Jul 9;39(1):100-9. doi: 10.1016/j.molcel.2010.06.007.
2.	Localization and regulation of MuSK at the neuromuscular junction.	Bowen DC, etal., Dev Biol. 1998 Jul 15;199(2):309-19.
3.	Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction.	Cheusova T, etal., Genes Dev. 2006 Jul 1;20(13):1800-16.
4.	Identification of developmentally regulated expression of MuSK in astrocytes of the rodent retina.	Cheusova T, etal., J Neurochem. 2006 Oct;99(2):450-7. Epub 2006 Aug 8.
5.	Long-lasting treatment effect of rituximab in MuSK myasthenia.	Díaz-Manera J, etal., Neurology. 2012 Jan 17;78(3):189-93. doi: 10.1212/WNL.0b013e3182407982. Epub 2012 Jan 4.
6.	MuSK expressed in the brain mediates cholinergic responses, synaptic plasticity, and memory formation.	Garcia-Osta A, etal., J Neurosci. 2006 Jul 26;26(30):7919-32.
7.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
9.	Restoration of synapse formation in Musk mutant mice expressing a Musk/Trk chimeric receptor.	Herbst R, etal., Development 2002 Dec;129(23):5449-60.
10.	Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference.	Kong XC, etal., EMBO Rep. 2004 Feb;5(2):183-8. Epub 2004 Jan 16.
11.	Rapsyn carboxyl terminal domains mediate muscle specific kinase-induced phosphorylation of the muscle acetylcholine receptor.	Lee Y, etal., Neuroscience. 2008 Jun 2;153(4):997-1007. Epub 2008 Mar 18.
12.	Activity-dependent gene regulation in conditionally-immortalized muscle precursor cell lines.	Macpherson PC, etal., J Cell Biochem. 2004 Mar 1;91(4):821-39.
13.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
14.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
15.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
16.	Muscle-like nicotinic receptor accessory molecules in sensory hair cells of the inner ear.	Osman AA, etal., Mol Cell Neurosci. 2008 Jun;38(2):153-69. Epub 2008 Mar 4.
17.	GOA pipeline	RGD automated data pipeline
18.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
20.	Crystal structure of the agrin-responsive immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK.	Stiegler AL, etal., J Mol Biol. 2006 Dec 1;364(3):424-33. Epub 2006 Sep 12.
21.	14-3-3 gamma associates with muscle specific kinase and regulates synaptic gene transcription at vertebrate neuromuscular synapse.	Strochlic L, etal., Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18189-94. Epub 2004 Dec 16.
22.	Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation.	Till JH, etal., Structure. 2002 Sep;10(9):1187-96.
23.	MuSK autoantibodies in myasthenia gravis detected by cell based assay--A multinational study.	Tsonis AI, etal., J Neuroimmunol. 2015 Jul 15;284:10-7. doi: 10.1016/j.jneuroim.2015.04.015. Epub 2015 Apr 27.
24.	Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury.	Valenzuela DM, etal., Neuron 1995 Sep;15(3):573-84.
25.	The neuromuscular junction: selective remodeling of synaptic regulators at the nerve/muscle interface.	Witzemann V, etal., Mech Dev. 2013 Jun-Aug;130(6-8):402-11. doi: 10.1016/j.mod.2012.09.004. Epub 2012 Sep 29.
26.	Rin-like, a novel regulator of endocytosis, acts as guanine nucleotide exchange factor for Rab5a and Rab22.	Woller B, etal., Biochim Biophys Acta. 2011 Jun;1813(6):1198-210. doi: 10.1016/j.bbamcr.2011.03.005. Epub 2011 Mar 17.
27.	Delayed synapsing muscles are more severely affected in an experimental model of MuSK-induced myasthenia gravis.	Xu K, etal., Neuroscience. 2006 Dec;143(3):655-9. Epub 2006 Nov 1.

Additional References at PubMed

PMID:8653786	PMID:10320756	PMID:11312299	PMID:11323662	PMID:11395002	PMID:12165471	PMID:14622576	PMID:14678832	PMID:16331983	PMID:16794080	PMID:17119023	PMID:17576800
PMID:18848351	PMID:18957220	PMID:19038220	PMID:19664639	PMID:20053883	PMID:22210232	PMID:23382219	PMID:25537362	PMID:29604268

Genomics

Comparative Map Data

Musk
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	77,853,560 - 77,967,653 (+)	NCBI		GRCr8
mRatBN7.2	5	73,058,427 - 73,169,696 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	73,058,121 - 73,171,932 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	74,950,396 - 75,053,703 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	76,772,006 - 76,875,299 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	76,744,136 - 76,847,436 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	75,392,790 - 75,498,694 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	75,392,790 - 75,498,694 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	79,542,952 - 79,649,636 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	76,273,430 - 76,388,614 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	76,278,542 - 76,393,727 (+)	NCBI
Celera	5	71,894,778 - 71,996,416 (+)	NCBI		Celera
Cytogenetic Map	5	q24	NCBI

MUSK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	110,668,791 - 110,806,558 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	110,668,779 - 110,806,558 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	113,431,071 - 113,568,838 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	112,470,960 - 112,603,099 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	110,510,693 - 110,642,833	NCBI
Celera	9	83,932,761 - 84,062,557 (+)	NCBI		Celera
Cytogenetic Map	9	q31.3	NCBI
HuRef	9	83,032,852 - 83,161,644 (+)	NCBI		HuRef
CHM1_1	9	113,577,505 - 113,709,694 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	122,838,447 - 122,978,207 (+)	NCBI		T2T-CHM13v2.0

Musk
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	58,285,742 - 58,377,848 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	58,285,962 - 58,374,303 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	58,285,729 - 58,377,848 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	58,285,960 - 58,374,303 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	58,298,834 - 58,387,175 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	58,380,016 - 58,468,357 (+)	NCBI		MGSCv36	mm8
Celera	4	58,198,854 - 58,290,062 (+)	NCBI		Celera
Cytogenetic Map	4	B3	NCBI
cM Map	4	31.87	NCBI

Musk
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955419	16,387,770 - 16,484,266 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955419	16,387,770 - 16,484,266 (-)	NCBI	ChiLan1.0	ChiLan1.0

MUSK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	28,609,032 - 28,747,000 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	28,616,248 - 28,749,362 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	81,814,766 - 81,947,341 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	109,980,748 - 110,107,480 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	109,980,748 - 110,107,480 (+)	Ensembl	panpan1.1		panPan2

MUSK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	65,552,320 - 65,642,165 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	65,551,889 - 65,642,349 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	63,954,775 - 64,044,628 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	66,682,701 - 66,788,272 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	66,682,615 - 66,772,740 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	65,202,004 - 65,291,277 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	65,223,782 - 65,329,259 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	65,913,828 - 66,003,578 (+)	NCBI		UU_Cfam_GSD_1.0

Musk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	180,764,116 - 180,884,300 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936559	2,387,027 - 2,486,552 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936559	2,387,019 - 2,486,685 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MUSK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	251,650,710 - 251,756,608 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	251,650,151 - 251,758,538 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	282,535,445 - 282,564,190 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MUSK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	28,739,094 - 28,872,247 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666035	13,886,470 - 14,018,232 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Musk
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624758	733,919 - 829,075 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624758	733,380 - 829,192 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Musk
619 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	29
Count of miRNA genes:	29
Interacting mature miRNAs:	29
Transcripts:	ENSRNOT00000048457
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	1	90450412	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	1	131345958	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	729470	86724018	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
7394712	Emca13	Estrogen-induced mammary cancer QTL 13			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	9823266	99753708	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	12789751	113558310	Rat
1358353	Srcrtb2	Stress Responsive Cort Basal QTL 2	3.48	0.003	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	18873947	74251464	Rat
6903292	Stl28	Serum triglyceride level QTL 28	2.6	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	5	28515489	73515489	Rat
6903306	Scl35	Serum cholesterol QTL 35	2.6	0.0073	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	28515489	73515489	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	31663789	131345958	Rat
1598807	Glom12	Glomerulus QTL 12	2.7		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	33215665	78215665	Rat
1298067	Scl15	Serum cholesterol level QTL 15	4.8	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	33215665	78215665	Rat
1302786	Kidm8	Kidney mass QTL 8	28.15		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	33215665	78215665	Rat
1576317	Eutr2	Estrogen induced uterine response QTL 2		0.01	uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	34730116	104251008	Rat
2316959	Gluco59	Glucose level QTL 59	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	34944474	113558310	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	35189153	141643988	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	40128307	148607290	Rat
1331773	Scl26	Serum cholesterol level QTL 26	3.065		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	43726656	86724018	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	43726656	129132602	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
1300115	Hrtrt7	Heart rate QTL 7	2.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	47869062	90099692	Rat
9589025	Epfw7	Epididymal fat weight QTL 7	20.66	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	5	49463600	94463600	Rat
7411561	Bw134	Body weight QTL 134	24	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	49463600	94463600	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	50328551	141643988	Rat
2303615	Vencon7	Ventilatory control QTL 7		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	5	50983895	95983895	Rat
2303574	Gluco42	Glucose level QTL 42	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	53496719	98496719	Rat
61359	Eaex	Experimental allergic encephalomyelitis QTL x	3		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	5	55715622	100715622	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55805606	132207589	Rat
1358895	Bp254	Blood pressure QTL 254	3.6	0.0003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	58829236	128034027	Rat
61426	Scl2	Serum cholesterol level QTL 2	7.3	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	59793399	143070159	Rat
2316954	Rf57	Renal function QTL 57	0		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	59793528	90450144	Rat
2316957	Pur21	Proteinuria QTL 21	6.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	5	59793528	113558156	Rat
61386	Bp49	Blood pressure QTL 49	16.6		cerebrum integrity trait (VT:0010549)	brain infarction volume (CMO:0001013)	5	60293434	98603051	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
2290005	Mcs24	Mammary carcinoma susceptibility QTL 24			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	64719390	109719390	Rat
2306971	Anxrr21	Anxiety related response QTL 21	9.47		fear/anxiety-related behavior trait (VT:1000241)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	5	66174080	124160948	Rat
2312671	Scl64	Serum cholesterol level QTL 64		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	68984307	104251008	Rat
61380	Edpm5	Estrogen-dependent pituitary mass QTL 5	4.5	0.92	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	5	68984307	104251008	Rat
1357396	Bw44	Body weight QTL 44	4.19		body mass (VT:0001259)	body weight (CMO:0000012)	5	68984307	104251008	Rat
1357402	Bw46	Body weight QTL 46	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	68984307	104251008	Rat
2302381	Bw84	Body weight QTL 84	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	68984307	104251008	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	69540295	151018848	Rat

Markers in Region

AW535152

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	73,101,390 - 73,101,543 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	75,433,374 - 75,433,526	NCBI	Rnor6.0
Rnor_5.0	5	79,584,316 - 79,584,468	UniSTS	Rnor5.0
RGSC_v3.4	5	76,318,555 - 76,318,707	UniSTS	RGSC3.4
Celera	5	71,935,703 - 71,935,855	UniSTS
RH 3.4 Map	5	499.6	UniSTS
Cytogenetic Map	5	q24	UniSTS

AU048759

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	73,123,531 - 73,123,676 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	75,456,078 - 75,456,220	NCBI	Rnor6.0
Rnor_5.0	5	79,607,020 - 79,607,162	UniSTS	Rnor5.0
RGSC_v3.4	5	76,340,856 - 76,340,998	UniSTS	RGSC3.4
Celera	5	71,957,789 - 71,957,921	UniSTS
Cytogenetic Map	5	q24	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium							1	1			2		1
Low	3	11	2	2	11	2	7	9	2	22	22	9	7
Below cutoff		30	47	32	8	32		1	42	11	16	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031061	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063288470	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474039	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U34985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000048457 ⟹ ENSRNOP00000041075

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	73,058,121 - 73,170,732 (+)	Ensembl
Rnor_6.0 Ensembl	5	75,392,790 - 75,498,694 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000111211 ⟹ ENSRNOP00000085490

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	73,058,614 - 73,171,932 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000118034 ⟹ ENSRNOP00000093853

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	73,058,614 - 73,171,932 (+)	Ensembl

RefSeq Acc Id:

NM_031061 ⟹ NP_112323

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	77,853,736 - 77,964,338 (+)	NCBI
mRatBN7.2	5	73,058,635 - 73,169,244 (+)	NCBI
Rnor_6.0	5	75,392,790 - 75,498,694 (+)	NCBI
Rnor_5.0	5	79,542,952 - 79,649,636 (+)	NCBI
RGSC_v3.4	5	76,273,430 - 76,388,614 (+)	RGD
Celera	5	71,894,778 - 71,996,416 (+)	RGD

Sequence:

show sequence

CAAACAGTCATTAGTGGACGACTCTATTGTAATAAACTGTGCTTTAAAATGTAAACCAGGGAGC
GTTTTTTTTCCTCACATTGTCCAGAAGCAACCTTTCTTCCTGAGCCTGGATTAATCATGAGAGA
GCTCGTCAACATTCCACTGTTACAGATGCTCACCCTGGTTGCCTTCAGCGGGACCGAGAAACTT
CCAAAAGCCCCTGTCATCACCACGCCTCTTGAAACTGTAGATGCCTTAGTTGAAGAAGTGGCGA
CTTTCATGTGCGCCGTGGAATCCTACCCTCAGCCTGAAATTTCTTGGACCAGAAATAAAATTCT
CATCAAGCTGTTTGACACCCGCTACAGCATCCGAGAGAACGGTCAGCTCCTCACCATCCTGAGT
GTGGAGGACAGTGATGATGGCATCTACTGCTGCACAGCCAACAATGGAGTGGGAGGAGCGGTGG
AAAGTTGTGGCGCCCTGCAAGTGAAGATGAAGCCTAAAATAACTCGTCCTCCCATCAATGTAAA
AATAATTGAGGGATTGAAAGCAGTCCTACCGTGCACTACGATGGGTAACCCCAAGCCATCCGTG
TCCTGGATTAAGGGGGACAGTGCTCTCAGGGAAAATTCCAGGATTGCAGTTCTTGAATCTGGGA
GTTTAAGGATCCATAATGTGCAAAAGGAAGACGCAGGACAGTACCGATGTGTGGCAAAAAACAG
CCTGGGCACAGCTTACTCCAAACTGGTGAAGCTGGAAGTGGAGGTTTTTGCAAGAATCCTGCGT
GCTCCTGAATCCCACAATGTCACCTTTGGTTCCTTTGTAACCCTACGCTGCACAGCAATAGGCA
TGCCTGTCCCCACCATCAGCTGGATTGAAAACGGAAATGCTGTTTCTTCAGGTTCCATTCAAGA
GAATGTGAAAGACCGAGTGATTGACTCAAGACTCCAGCTCTTTATCACAAAGCCAGGACTCTAC
ACATGCATAGCTACCAATAAGCATGGAGAGAAATTCAGTACCGCAAAGGCTGCAGCCACTGTCA
GTATAGCAGAATGGAGCAAATCACAGAAAGAAAGCAAAGGCTACTGTGCCCAGTACAGAGGGGA
GGTGTGTGATGCCGTCCTGGTGAAAGACTCTCTTGTCTTCTTCAACACCTCCTATCCCGACCCT
GAGGAGGCCCAAGAGCTGCTGATCCACACTGCGTGGAATGAACTCAAGGCTGTGAGCCCACTCT
GCCGACCAGCTGCCGAGGCTCTGCTGTGTAATCACCTCTTCCAGGAGTGCAGCCCTGGAGTGCT
ACCTACTCCTATGCCCATTTGCAGAGAGTACTGCTTGGCAGTAAAGGAGCTCTTCTGTGCAAAG
GAATGGCTGGCAATGGAAGGGAAGACCCACCGCGGACTCTACAGATCCGGGATGCATTTCCTCC
CGGTCCCGGAGTGCAGCAAGCTTCCCAGCATGCACCAGGACCCCACAGCCTGCACAAGACTGCC
GTATTTAGATTATAAAAAAGAAAACATAACAACATTCCCGTCCATAACGTCCTCCAAGCCGAGC
GTGGACATTCCAAACCTGCCTGCCTCCACGTCTTCCTTCGCCGTCTCGCCTGCGTACTCCATGA
CTGTCATCATCTCCATCATGTCCTGCTTTGCGGTGTTTGCTCTCCTCACCATCACTACTCTCTA
TTGCTGCCGAAGGAGGAGAGAGTGGAAAAATAAGAAAAGAGAGTCGGCAGCGGTGACCCTCACC
ACATTGCCTTCCGAGCTCCTGCTGGACAGGCTGCATCCCAACCCCATGTACCAGAGGATGCCAC
TCCTTCTGAATCCCAAGTTGCTCAGCCTGGAGTATCCGAGGAATAACATCGAGTATGTCAGAGA
CATCGGAGAGGGAGCGTTTGGAAGGGTCTTTCAAGCGAGGGCCCCAGGCTTGCTTCCTTATGAA
CCCTTCACTATGGTGGCTGTGAAGATGCTGAAGGAGGAGGCCTCCGCAGATATGCAGGCAGACT
TTCAGAGGGAGGCAGCCCTCATGGCGGAGTTTGACAACCCCAACATTGTGAAGCTCTTAGGTGT
GTGTGCTGTTGGGAAGCCAATGTGCCTGCTCTTTGAATATATGGCCTATGGTGACCTCAATGAG
TTCCTCCGAAGCATGTCCCCTCACACTGTGTGCAGCCTCAGCCACAGTGACCTGTCCACGAGGG
CTCGGGTGTCCAGCCCTGGTCCTCCACCCCTGTCTTGTGCGGAACAGCTCTGTATTGCCAGGCA
AGTGGCAGCTGGCATGGCCTACCTGTCGGAGCGCAAGTTTGTCCATCGGGACTTAGCTACCAGG
AACTGCCTGGTTGGAGAGAACATGGTGGTGAAAATTGCAGACTTTGGCCTCTCTAGGAACATCT
ACTCCGCAGACTACTACAAAGCTGATGGAAACGATGCTATACCTATCCGCTGGATGCCACCCGA
GTCTATCTTCTACAACCGCTACACCACGGAGTCAGATGTGTGGGCTTATGGCGTGGTCCTCTGG
GAGATCTTCTCCTATGGACTGCAGCCCTACTATGGAATGGCCCATGAGGAGGTCATTTACTATG
TGAGAGATGGTAACATCCTTGCCTGCCCTGAGAACTGTCCCTTGGAACTGTACAACCTTATGCG
CCTATGTTGGAGCAAGCTGCCTGCAGACAGACCCAGCTTCTGCAGTATCCACCGGATCCTGCAG
CGCATGTGCGAGAGAGCAGAGGGAACGGTAGGCGTCTAAGGTTGACCATGCTCAAACAACACCC
AGGAGGATCTTTTCAGACTGCGAGCTGGAGGGATCCTAAAGCAGAGGGCGNATAAGNNCAGATA
GGAAGAGTTTATCTCAGGCAGCACGTNCAGTTGGTTGTT

hide sequence

RefSeq Acc Id:

XM_063288470 ⟹ XP_063144540

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	77,853,560 - 77,967,653 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_112323	(Get FASTA)	NCBI Sequence Viewer
	XP_063144540	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA90956	(Get FASTA)	NCBI Sequence Viewer
	EDL91656	(Get FASTA)	NCBI Sequence Viewer
	EDL91657	(Get FASTA)	NCBI Sequence Viewer
	EDL91658	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000041075
	ENSRNOP00000041075.6
	ENSRNOP00000085490.1
	ENSRNOP00000093853.1
GenBank Protein	Q62838	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_112323 ⟸ NM_031061
- Peptide Label:	precursor
- UniProtKB:	Q62838 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MRELVNIPLLQMLTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEISWTRN KILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPI NVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSALRENSRIAVLESGSLRIHNVQKEDAGQYRCVA KNSLGTAYSKLVKLEVEVFARILRAPESHNVTFGSFVTLRCTAIGMPVPTISWIENGNAVSSGS IQENVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATVSIAEWSKSQKESKGYCAQY RGEVCDAVLVKDSLVFFNTSYPDPEEAQELLIHTAWNELKAVSPLCRPAAEALLCNHLFQECSP GVLPTPMPICREYCLAVKELFCAKEWLAMEGKTHRGLYRSGMHFLPVPECSKLPSMHQDPTACT RLPYLDYKKENITTFPSITSSKPSVDIPNLPASTSSFAVSPAYSMTVIISIMSCFAVFALLTIT TLYCCRRRREWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEY VRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKL LGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCI ARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKADGNDAIPIRWM PPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYN LMRLCWSKLPADRPSFCSIHRILQRMCERAEGTVGV hide sequence

RefSeq Acc Id:

ENSRNOP00000041075 ⟸ ENSRNOT00000048457

RefSeq Acc Id:

ENSRNOP00000085490 ⟸ ENSRNOT00000111211

RefSeq Acc Id:

ENSRNOP00000093853 ⟸ ENSRNOT00000118034

RefSeq Acc Id:	XP_063144540 ⟸ XM_063288470
- Peptide Label:	isoform X1

Protein Domains

FZ Ig-like Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q62838-F1-model_v2	AlphaFold	Q62838	1-868	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3211	AgrOrtholog
BioCyc Gene	G2FUF-41182	BioCyc
Ensembl Genes	ENSRNOG00000033567	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000048457	ENTREZGENE
	ENSRNOT00000048457.6	UniProtKB/TrEMBL
	ENSRNOT00000111211.1	UniProtKB/TrEMBL
	ENSRNOT00000118034.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.2000.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.60.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Frizzled_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Frizzled_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig_I-set	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig_sub	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig_sub2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_kinase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_kinase_cat_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:81725	UniProtKB/Swiss-Prot
NCBI Gene	Musk	ENTREZGENE
PANTHER	MUSCLE, SKELETAL RECEPTOR TYROSINE-PROTEIN KINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TYROSINE-PROTEIN KINASE RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	I-set	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PF01392	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pkinase_Tyr	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	MUSK	RGD
PhenoGen	Musk	PhenoGen
PIRSF	TyrPK_CSF1-R	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	TYRKINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	IG_LIKE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PS50038	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000033567	RatGTEx
SMART	IGc2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM00409	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TyrKc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF56112	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6AL77_RAT	UniProtKB/TrEMBL
	A0A8I6GCY4_RAT	UniProtKB/TrEMBL
	A6KDU7_RAT	UniProtKB/TrEMBL
	A6KDU8_RAT	UniProtKB/TrEMBL
	A6KDU9_RAT	UniProtKB/TrEMBL
	F1LMK4_RAT	UniProtKB/TrEMBL
	MUSK_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-04-27	Musk	muscle associated receptor tyrosine kinase	Musk	muscle, skeletal, receptor tyrosine kinase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2003-04-09	Musk	muscle, skeletal, receptor tyrosine kinase			Symbol and Name updated	629477	APPROVED
2003-03-06	Musk	muscle, skeletal, receptor tyrosine kinase	Nsk1		Data merged from RGD:621698	628472	PROVISIONAL
2002-08-07	Nsk1				Symbol and Name status set to provisional	70820	PROVISIONAL
2001-11-29	Musk	muscle, skeletal, receptor tyrosine kinase			Symbol and Name updated to reflect Human and Mouse nomenclature	68913	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_disease	human homolog maps within the region of the Fukuyama muscular dystrophy locus	633425

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations