Nos3 (nitric oxide synthase 3) - Rat Genome Database

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Gene: Nos3 (nitric oxide synthase 3) Rattus norvegicus
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Symbol: Nos3
Name: nitric oxide synthase 3
RGD ID: 3186
Description: Enables several functions, including Hsp90 protein binding activity; beta-catenin binding activity; and calmodulin binding activity. Involved in several processes, including cellular response to magnesium ion; cellular response to mechanical stimulus; and cellular response to organonitrogen compound. Located in several cellular components, including apical part of cell; caveola; and sarcolemma. Used to study artery disease (multiple); irritable bowel syndrome; ischemia (multiple); liver disease (multiple); and retinal disease (multiple). Biomarker of several diseases, including artery disease (multiple); kidney failure (multiple); liver disease (multiple); lung disease (multiple); and overnutrition (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); eye disease (multiple); leukemia (multiple); reproductive organ cancer (multiple); and vasculitis (multiple). Orthologous to human NOS3 (nitric oxide synthase 3); PARTICIPATES IN doxorubicin pharmacokinetics pathway; eicosanoid signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH (R)-carnitine; 1,3-dinitrobenzene; 11-deoxycorticosterone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cNOS; constitutive NOS; EC-NOS; endothelial nitric oxide synthase 3; endothelial NOS; eNos; nitric oxide synthase 3, endothelial cell; nitric oxide synthase, endothelial; NOS type III; NOSIII
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Nos3em2Mcwi   Nos3em8Mcwi   Nos3em13Mcwi  
Genetic Models: SS-Nos3em8Mcwi SS-Nos3em2Mcwi SS-Nos3em13Mcwi
Is Marker For: Strains:   WKY   DA.WF-(D4Mit11-Nos3)/Kop  
QTLs:   Tcas3   BW384_H  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8411,686,088 - 11,706,604 (-)NCBIGRCr8
mRatBN7.2410,793,834 - 10,814,170 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,793,834 - 10,814,166 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx415,940,095 - 15,960,412 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,760,284 - 11,780,599 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,112,074 - 10,132,387 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,321,908 - 7,342,404 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,320,668 - 7,342,410 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,333,272 - 7,353,767 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,158,847 - 6,179,441 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.146,158,846 - 6,179,441 (-)NCBI
Celera46,408,408 - 6,428,650 (-)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute chest syndrome  (ISO)
acute kidney failure  (IEP,ISO)
Acute Liver Failure  (IEP)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
Alzheimer's disease  (ISO)
Alzheimer's disease 1  (ISO)
angle-closure glaucoma  (ISO)
anterior ischemic optic neuropathy  (ISO)
aortic valve disease  (ISS)
arteriosclerosis  (ISO)
Arteriovenous Fistula  (IEP)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
autism spectrum disorder  (ISO)
Behcet's disease  (ISO)
bladder neck obstruction  (IEP)
Brain Hypoxia  (IEP)
brain ischemia  (IDA,IMP)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis obliterans  (IEP)
Cardiomegaly  (IEP,ISO)
cardiomyopathy  (IEP,ISO)
Cardiotoxicity  (ISO)
cardiovascular system disease  (ISO)
Carotid Artery Injuries  (IEP)
central sleep apnea  (ISO)
cerebral infarction  (ISO)
Child Behavior Disorders  (ISO)
cholestasis  (IEP)
Chronic Cerebral Hypoperfusion  (IMP)
chronic kidney disease  (IEP)
chronic obstructive pulmonary disease  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
colitis  (IEP)
congenital diaphragmatic hernia  (IEP)
congestive heart failure  (IEP,ISO)
coronary artery disease  (ISO)
coronary artery vasospasm  (ISO)
cystic fibrosis  (ISO)
diabetic angiopathy  (IEP,ISO)
Diabetic Cardiomyopathies  (IEP)
Diabetic Gastroparesis  (IEP)
Diabetic Nephropathies  (IEP,ISO)
diabetic retinopathy  (IDA,IEP,ISO)
Diaphragmatic Hernia  (IEP,ISO)
disease of cellular proliferation  (ISO)
Drug-Induced Enteropathy  (IDA)
end stage renal disease  (IEP,ISO)
endometrial carcinoma  (ISO)
Endotoxemia  (IEP)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
essential hypertension  (ISO,ISS)
Experimental Arthritis  (IEP)
Experimental Diabetes Mellitus  (IDA,IEP,ISO)
Experimental Liver Cirrhosis  (IEP,ISO)
extrahepatic cholestasis  (ISO)
familial hyperlipidemia  (IEP,ISO)
Femur Head Necrosis  (ISO)
Fetal Growth Retardation  (IEP,ISO)
gastric ulcer  (IEP,ISO)
genetic disease  (ISO)
Graft Occlusion, Vascular  (ISO)
Hemorrhagic Shock  (IEP)
Hepatic Insufficiency  (ISO)
Hepatomegaly  (ISO)
hepatopulmonary syndrome  (IEP)
high grade glioma  (ISO)
Huntington's disease  (IEP)
Hyperemia  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
Hyperoxia  (IEP)
hypertension  (IDA,IEP,ISO)
Hypertension Resistant to Conventional Therapy  (ISO)
Hypertriglyceridemia  (IEP)
hypothyroidism  (IEP)
Hypoxia  (ISO)
ileus  (IEP)
impotence  (IEP,ISO)
Insulin Resistance  (IEP,ISO)
intestinal perforation  (ISO)
Intestinal Reperfusion Injury  (IDA)
Intimal Hyperplasia  (ISO)
intracranial aneurysm  (IEP,ISO)
Intracranial Hemorrhages  (IMP)
irritable bowel syndrome  (IDA)
ischemia  (ISO)
Kidney Reperfusion Injury  (IEP)
Kuhnt-Junius degeneration  (ISO)
Left Ventricular Hypertrophy  (IEP)
leiomyoma  (ISO)
lethal congenital glycogen storage disease of heart  (ISO)
limb ischemia  (IDA,IEP,ISO)
liver cirrhosis  (IDA,IEP)
Liver Reperfusion Injury  (IEP)
long QT syndrome  (ISO)
lung disease  (IEP,ISO)
Lung Reperfusion Injury  (IMP,ISO)
lymphangioleiomyomatosis  (ISO)
Lymphatic Metastasis  (ISO)
macular retinal edema  (ISO)
male infertility  (ISO)
Metabolic Syndrome  (IDA,IMP,ISO)
migraine  (ISO)
myocardial infarction  (IDA,IEP,ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IDA,IEP,IMP,ISO)
Nasal Polyps  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
obesity  (IEP)
obstructive sleep apnea  (ISO)
oligospermia  (ISO)
ovarian cancer  (ISO)
overnutrition  (IEP)
Pain  (IMP)
Perennial Allergic Rhinitis  (ISO)
perinatal necrotizing enterocolitis  (ISO)
persistent fetal circulation syndrome  (ISS)
Phyllodes Tumor  (ISO)
placental abruption  (ISO)
polycystic kidney disease  (IEP)
portal hypertension  (IDA,IEP,ISO)
pre-eclampsia  (IEP,ISO)
Pregnancy-Induced Hypertension  (ISO)
Prenatal Exposure Delayed Effects  (IEP)
primary biliary cholangitis  (IEP,ISO)
primary open angle glaucoma  (ISO)
primary ovarian insufficiency  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulmonary edema  (IEP,ISO)
pulmonary embolism  (IEP)
pulmonary emphysema  (ISO)
pulmonary eosinophilia  (ISO)
pulmonary hypertension  (IDA,IEP,IMP,ISO)
Pulmonary Hypertension, Hypoxia-Induced  (IEP)
Radiation Pneumonitis  (ISO)
renal hypertension  (IDA)
renovascular hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
Retina Reperfusion Injury  (IDA,IEP)
retinal degeneration  (IDA,IEP)
retinopathy of prematurity  (ISO)
Right Ventricular Hypertrophy  (IDA)
Sepsis  (ISO)
sickle cell anemia  (ISO)
Spinal Cord Compression  (IEP)
Spinal Cord Injuries  (IEP)
Stomach Neoplasms  (ISO)
Stroke  (IEP,ISO)
Subarachnoid Hemorrhage  (IEP)
Sudden Hearing Loss  (ISO)
telangiectasis  (ISO)
Teratozoospermia  (ISO)
Testis Reperfusion Injury  (IEP)
Thromboembolism  (ISO)
Thrombotic Microangiopathies  (IEP)
transient cerebral ischemia  (IDA,IEP)
Transplant Rejection  (IEP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
uremia  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
vasculitis  (ISO)
Vaso-occlusive Crisis  (ISO)
Venous Thrombosis  (ISO)
Ventricular Dysfunction, Right  (IMP)
Ventricular Premature Complexes  (ISO)
Ventricular Tachycardia  (ISO)
vestibular disease  (ISO)
vulva cancer  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
11-deoxycorticosterone  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
22-Hydroxycholesterol  (ISO)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic GMP  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3-diphenyl-N-(1-phenylethyl)-1-propanamine  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (EXP,ISO)
5,6,7,8-tetrahydrobiopterin  (ISO)
5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP)
5-methoxypsoralen  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,8-diacetoxy-4-methylcoumarin  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
9,10-phenanthroquinone  (ISO)
acetylcholine  (EXP,ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
agmatine  (ISO)
AICA ribonucleotide  (EXP)
alcohol  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldrin  (ISO)
alkaloid  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
allopurinol  (EXP)
alpha-hexachlorocyclohexane  (ISO)
alpha-Zearalanol  (ISO)
aminoguanidine  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
amlodipine  (EXP)
ammonium chloride  (EXP)
anagliptin  (ISO)
ANTU  (EXP)
apocynin  (EXP,ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
atrasentan  (EXP)
atrazine  (EXP,ISO)
axitinib  (ISO)
azoxystrobin  (ISO)
BAPTA  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
benzoic acid  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
bosentan  (EXP)
bradykinin  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
Calcimycin  (EXP,ISO)
calciol  (EXP)
calcitriol  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
calmidazolium  (EXP)
camostat  (EXP)
candesartan  (EXP,ISO)
Candesartan cilexetil  (EXP)
cantharidin  (ISO)
capsaicin  (EXP,ISO)
carbon monoxide  (EXP)
carbon nanotube  (ISO)
Cardamonin  (EXP)
carvedilol  (EXP,ISO)
cetirizine  (ISO)
chelerythrine  (EXP)
chlorogenic acid  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (EXP)
chrysin  (EXP)
cilostazol  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP)
cloricromen  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (ISO)
cordycepin  (ISO)
curcumin  (ISO)
cyanidin cation  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
daidzein  (ISO)
DDE  (ISO)
Decursin  (ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
digitoxin  (ISO)
digoxin  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
edaravone  (EXP,ISO)
elemental selenium  (ISO)
enalapril  (EXP,ISO)
endosulfan  (EXP,ISO)
enzyme inhibitor  (EXP)
eplerenone  (EXP)
equol  (ISO)
erucic acid  (EXP)
esculetin  (EXP)
estriol  (ISO)
ethanol  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
everolimus  (ISO)
fenofibrate  (ISO)
fenpyroximate  (ISO)
Fexofenadine hydrochloride  (ISO)
fipronil  (EXP)
fluoranthene  (ISO)
fluorene  (ISO)
flutamide  (EXP)
fluvastatin  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
formic acid  (EXP)
formononetin  (EXP)
fosinopril  (EXP)
fructose  (EXP,ISO)
fulvestrant  (EXP,ISO)
furosemide  (EXP)
genistein  (ISO)
gentamycin  (EXP,ISO)
ginsenoside Re  (ISO)
Ginsenoside Rg5  (EXP)
gliclazide  (EXP)
glucose  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
GW 501516  (ISO)
hemin  (EXP)
hexachlorobenzene  (EXP,ISO)
hexacosan-1-ol  (EXP)
hexadecanoic acid  (EXP,ISO)
high-density lipoprotein cholesterol  (ISO)
histamine  (EXP)
homocysteine  (ISO)
hydrochlorothiazide  (EXP)
hydrogen chloride  (EXP)
hydrogen peroxide  (ISO)
icariin  (EXP,ISO)
indometacin  (EXP,ISO)
iron dextran  (EXP,ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (ISO)
isosorbide dinitrate  (ISO)
kaempferol  (EXP)
ketoconazole  (EXP)
L-arginine  (ISO)
L-ascorbic acid  (EXP,ISO)
L-erythro-7,8-dihydrobiopterin  (ISO)
lamivudine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
lead(II) chloride  (ISO)
levamisole  (ISO)
linoleic acid  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP)
luteolin  (EXP)
LY294002  (EXP,ISO)
lysophosphatidylcholine  (EXP)
Magnolol  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
manidipine  (EXP)
masoprocol  (ISO)
medroxyprogesterone acetate  (EXP,ISO)
melatonin  (ISO)
menadione  (EXP)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methacholine chloride  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
metoprolol  (EXP)
mevalonic acid  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
miquelianin  (ISO)
MK-2206  (EXP)
monocrotaline  (EXP)
myricitrin  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-desethylamiodarone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naphthalene  (ISO)
nebivolol  (EXP,ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicorandil  (ISO)
nicotine  (ISO)
nicotinic acid  (EXP,ISO)
nifedipine  (ISO)
nitrates  (EXP)
nitric oxide  (EXP,ISO)
nitrites  (EXP,ISO)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
nitroglycerin  (EXP)
nitroprusside  (ISO)
notoginsenoside R1  (ISO)
oleic acid  (ISO)
olmesartan  (EXP)
orotic acid  (ISO)
orphenadrine  (EXP)
Osajin  (ISO)
ouabain  (EXP)
ozone  (EXP)
paclitaxel  (ISO)
palytoxin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
paricalcitol  (ISO)
PD123319  (ISO)
pentaerythritol tetranitrate  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
peroxynitrous acid  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP,ISO)
phloretin  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphane  (EXP)
picoxystrobin  (ISO)
pinostrobin  (ISO)
pioglitazone  (EXP)
pirinixic acid  (EXP)
plerixafor  (ISO)
Pomiferin  (ISO)
potassium chloride  (EXP,ISO)
pravastatin  (EXP)
procymidone  (EXP)
progesterone  (EXP,ISO)
propazine  (ISO)
propiconazole  (EXP)
propranolol  (EXP)
protoporphyrin  (ISO)
puerarin  (ISO)
quercetin  (EXP,ISO)
quinapril hydrochloride  (EXP)
rac-lactic acid  (ISO)
raloxifene  (EXP)
ramipril  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
ritonavir  (ISO)
Rosavin  (ISO)
rosmarinic acid  (EXP)
rosuvastatin calcium  (EXP,ISO)
rotenone  (ISO)
roxarsone  (ISO)
salicylic acid  (EXP)
salsalate  (EXP)
sapropterin  (ISO)
sarpogrelate  (EXP)
SB 203580  (ISO)
scutellarin  (EXP)
selenium atom  (ISO)
sepiapterin  (ISO)
sibutramine  (ISO)
sildenafil citrate  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simazine  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
SKF-96365 hydrochloride  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP)
sodium azide  (ISO)
sodium chloride  (EXP)
sodium nitrate  (ISO)
Sodium salicylate  (ISO)
Soman  (EXP)
sorafenib  (EXP)
stilbenoid  (ISO)
streptozocin  (EXP)
sucrose  (EXP)
sulfadimethoxine  (EXP)
sulfur dioxide  (ISO)
superoxide  (EXP,ISO)
T-2 toxin  (ISO)
tacrolimus (anhydrous)  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (ISO)
tangeretin  (EXP)
Tanshinone I  (EXP,ISO)
tebufenpyrad  (ISO)
telmisartan  (ISO)
tenofovir disoproxil fumarate  (ISO)
terbutylazine  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetrahydrocurcumin  (ISO)
tetramethylpyrazine  (ISO)
theaflavin  (ISO)
thioacetamide  (EXP)
thymoquinone  (EXP)
thyroxine  (EXP)
Tiron  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
toluene 2,4-diisocyanate  (ISO)
torcetrapib  (EXP,ISO)
trans-caffeic acid  (ISO)
trans-cinnamic acid  (ISO)
tributylstannane  (EXP)
trichloroethene  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (ISO)
ubiquinones  (ISO)
udenafil  (EXP)
uranium atom  (EXP)
urethane  (ISO)
ursolic acid  (ISO)
valsartan  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vanillic acid  (ISO)
vitamin E  (EXP,ISO)
wortmannin  (EXP,ISO)
Y-27632  (ISO)
zidovudine  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zolmitriptan  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
aortic valve morphogenesis  (IEA,ISO)
arginine catabolic process  (IBA,IEA,ISO)
blood vessel diameter maintenance  (IEA,ISO)
blood vessel remodeling  (IEA,ISO)
bone development  (IEP)
calcium ion transport  (IEA,ISO)
cellular response to cAMP  (IEP)
cellular response to growth factor stimulus  (IEP)
cellular response to heat  (IEP)
cellular response to high density lipoprotein particle stimulus  (IEP)
cellular response to insulin stimulus  (IEP)
cellular response to low-density lipoprotein particle stimulus  (IEP)
cellular response to magnesium ion  (IEP)
cellular response to mechanical stimulus  (IMP)
cellular response to organic cyclic compound  (IEP)
cellular response to rotenone  (IEP)
cellular response to transforming growth factor beta stimulus  (IMP)
cellular response to tumor necrosis factor  (IEP)
endocardial cushion morphogenesis  (IEA,ISO)
endothelial cell migration  (IEA,ISO)
establishment of localization in cell  (IEA,ISO)
female pregnancy  (IEP)
homeostasis of number of cells within a tissue  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
lung development  (IEA,ISO)
negative regulation of biomineral tissue development  (IEA,ISO)
negative regulation of blood pressure  (IBA)
negative regulation of calcium ion transport  (IEA,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of muscle hyperplasia  (IEA,ISO)
negative regulation of potassium ion transport  (IEA,ISO)
negative regulation of smooth muscle cell proliferation  (IEA,IMP,ISO)
nitric oxide biosynthetic process  (IBA,IEA,IEP,IMP,ISO)
nitric oxide mediated signal transduction  (IBA)
nitric oxide metabolic process  (IEP)
ovulation from ovarian follicle  (IEA,ISO)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of blood vessel endothelial cell migration  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
potassium ion transport  (IEA,ISO)
pulmonary valve morphogenesis  (IEA,ISO)
regulation of nervous system process  (IEA,ISO)
regulation of sodium ion transport  (IEA,ISO)
regulation of systemic arterial blood pressure by endothelin  (IEA,ISO)
regulation of the force of heart contraction by chemical signal  (IEA,ISO)
removal of superoxide radicals  (IEA,ISO)
response to activity  (IEP)
response to amino acid  (IEP)
response to axon injury  (IEP)
response to carbohydrate  (IEP)
response to corticosterone  (IEP)
response to cytokine  (IEP)
response to erythropoietin  (IEP)
response to estradiol  (IDA,IEP)
response to ethanol  (IEP)
response to fluid shear stress  (IEA,ISO)
response to fructose  (IEP)
response to hormone  (IBA)
response to hyperoxia  (IEP)
response to hypoxia  (IEP)
response to ketone  (IEP)
response to L-arginine  (IEP)
response to lead ion  (IEP)
response to lipopolysaccharide  (IBA,IEP)
response to magnetism  (IEP)
response to mechanical stimulus  (IEP)
response to mercury ion  (IEP)
response to metal ion  (IEP)
response to nicotine  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to peptide  (IEP)
response to peptide hormone  (IEP)
response to salt  (IEP)
response to ultrasound  (IEP)
response to xenobiotic stimulus  (IEP)
retina development in camera-type eye  (IEP)
smooth muscle hyperplasia  (IEA,ISO)
vasodilation  (ISO)
ventricular septum morphogenesis  (IEA,ISO)

Cellular Component
apical part of cell  (IDA)
caveola  (IDA,IEA,ISO)
cytoplasm  (IDA,ISO)
cytoskeleton  (IEA)
cytosol  (IBA)
Golgi apparatus  (IEA,ISO)
nucleus  (IBA,IDA,IEA,ISO)
plasma membrane  (IBA,ISO)
sarcolemma  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
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41. Change in endothelial nitric oxide synthase in the rat retina following transient ischemia. Cheon EW, etal., Neuroreport. 2003 Mar 3;14(3):329-33.
42. Association of a polymorphism of the ecNOS gene with myocardial infarction in a subgroup of Turkish MI patients. Cine N, etal., Clin Genet. 2002 Jan;61(1):66-70.
43. Exercise training induces eNOS coupling and restores relaxation in coronary arteries of heart failure rats. Couto GK, etal., Am J Physiol Heart Circ Physiol. 2018 Jan 5. doi: 10.1152/ajpheart.00624.2017.
44. Cardiac oxidative stress is elevated at the onset of dilated cardiomyopathy in streptozotocin-diabetic rats. Crespo MJ, etal., J Cardiovasc Pharmacol Ther. 2008 Mar;13(1):64-71.
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50. Vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (NOS3) polymorphisms are associated with high relapse risk in childhood acute lymphoblastic leukemia (ALL). Demacq C, etal., Clin Chim Acta. 2010 Sep 6;411(17-18):1335-40. doi: 10.1016/j.cca.2010.05.025. Epub 2010 May 25.
51. TNF-a antagonism with etanercept enhances penile NOS expression, cavernosal reactivity, and testosterone levels in aged rats. Demirtas Sahin T, etal., Can J Physiol Pharmacol. 2017 Dec 20:1-8. doi: 10.1139/cjpp-2017-0113.
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68. Tetrahydrobiopterin (BH4 ): Targeting endothelial nitric oxide synthase as a potential therapy for pulmonary hypertension. Francis BN, etal., Cardiovasc Ther. 2018 Feb;36(1). doi: 10.1111/1755-5922.12312. Epub 2017 Dec 3.
69. Lack of association between an ecNOS gene polymorphism and diabetic nephropathy in type 2 diabetic patients with proliferative diabetic retinopathy. Fujita H, etal., Horm Metab Res. 2000 Feb;32(2):80-3.
70. A young girl with vasospastic angina associated with mutation in endothelial nitric oxide synthase gene--a case report. Fukuda N, etal., Angiology. 2003 Mar-Apr;54(2):233-7.
71. Molecular mechanism of limbs' postischemic revascularization improved by perindopril in diabetic rats. Gao L and Yu DM, Chin Med J (Engl). 2008 Nov 5;121(21):2129-33.
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73. Vascular invasion in human breast cancer is correlated to T-->786C polymorphism of NOS3 gene. Ghilardi G, etal., Nitric Oxide. 2003 Sep;9(2):118-22.
74. Evidence for a functional nitric oxide synthase system in brown adipocyte nucleus. Giordano A, etal., FEBS Lett. 2002 Mar 13;514(2-3):135-40.
75. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
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77. Effects of early overnutrition on the renal response to Ang II and expression of RAAS components in rat renal tissue. Granado M, etal., Nutr Metab Cardiovasc Dis. 2017 Oct;27(10):930-937. doi: 10.1016/j.numecd.2017.06.019. Epub 2017 Jul 8.
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79. Endothelial nitric oxide synthase variants in cystic fibrosis lung disease. Grasemann H, etal., Am J Respir Crit Care Med. 2003 Feb 1;167(3):390-4. Epub 2002 Aug 15.
80. Neuroprotective effect of citicoline on retinal cell damage induced by kainic acid in rats. Han YS, etal., Korean J Ophthalmol. 2005 Sep;19(3):219-26.
81. Roles of constitutive nitric oxide synthase in postischemic rat retina. Hangai M, etal., Invest Ophthalmol Vis Sci. 1999 Feb;40(2):450-8.
82. Association of nitric oxide synthase 3 (NOS3) 894 G>T polymorphism with prognostic outcomes of anthracycline in Chinese patients with acute myeloid leukaemia. He H, etal., Clin Exp Pharmacol Physiol. 2014 Jun;41(6):400-7. doi: 10.1111/1440-1681.12235.
83. Polymorphisms of the endothelial nitric oxide synthase gene in ovarian cancer. Hefler LA, etal., Gynecol Oncol. 2002 Aug;86(2):134-7.
84. TGFbeta receptor activation enhances cardiac apoptosis via SMAD activation and concomitant NO release. Heger J, etal., J Cell Physiol. 2010 Dec 29.
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87. A high-salt diet dissociates NO synthase-3 expression and NO production by the thick ascending limb. Herrera M, etal., Hypertension. 2006 Jan;47(1):95-101. Epub 2005 Dec 12.
88. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. Hildebrandt MA, etal., PLoS One. 2010 Aug 25;5(8):e12402.
89. Nitric oxide synthases in infants and children with pulmonary hypertension and congenital heart disease. Hoehn T, etal., Respir Res. 2009 Nov 13;10:110.
90. Haplotype analysis of the endothelial nitric oxide synthase gene in asthma. Holla LI, etal., Hum Immunol. 2008 Apr-May;69(4-5):306-13. Epub 2008 Apr 15.
91. Association study of promoter polymorphisms within the NOS3 gene and allergic diseases. Holla LI, etal., Int Arch Allergy Immunol. 2006;141(2):103-9. Epub 2006 Jul 12.
92. The relationship between polymorphisms in the endothelial cell nitric oxide synthase gene and the platelet GPIIIa gene with myocardial infarction and venous thromboembolism in African Americans. Hooper WC, etal., Chest. 1999 Oct;116(4):880-6.
93. Maternal Exposure to Bisphenol A Combined with High-Fat Diet-Induced Programmed Hypertension in Adult Male Rat Offspring: Effects of Resveratrol. Hsu CN, etal., Int J Mol Sci. 2019 Sep 6;20(18):4382. doi: 10.3390/ijms20184382.
94. Role of hepatic nitric oxide synthases in rats with thioacetamide-induced acute liver failure and encephalopathy. Huang HC, etal., J Chin Med Assoc. 2007 Jan;70(1):16-23.
95. Developmental regulation of nitric oxide synthase expression in rat skeletal bone. Hukkanen MV, etal., J Bone Miner Res. 1999 Jun;14(6):868-77.
96. Dynamin activates NO production in rat renal inner medullary collecting ducts via protein-protein interaction with NOS1. Hyndman KA, etal., Am J Physiol Renal Physiol. 2011 Apr 13.
97. Heat shock regulates the respiration of cardiac H9c2 cells through upregulation of nitric oxide synthase. Ilangovan G, etal., Am J Physiol Cell Physiol. 2004 Nov;287(5):C1472-81.
98. Association of the Glu298Asp polymorphism in the endothelial nitric oxide synthase gene with essential hypertension resistant to conventional therapy. Jachymova M, etal., Biochem Biophys Res Commun. 2001 Jun 8;284(2):426-30.
99. Expression of nitric oxide synthase, aquaporin 1 and aquaporin 5 in rat after bleomycin inhalation. Jang AS, etal., Intensive Care Med. 2004 Mar;30(3):489-95. Epub 2004 Feb 6.
100. Pregnancy alters nitric oxide synthase and natriuretic peptide systems in the rat left ventricle. Jankowski M, etal., J Endocrinol. 2005 Jan;184(1):209-17.
101. Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea. Jelic S, etal., Circulation. 2008 Apr 29;117(17):2270-8. Epub 2008 Apr 14.
102. Vascular inflammation in obesity and sleep apnea. Jelic S, etal., Circulation. 2010 Mar 2;121(8):1014-21. Epub 2010 Feb 16.
103. [Preventive effect of endothelial nitric oxide synthase gene transfer on chronic hypoxic pulmonary hypertension in rats]. Jin Q, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2009 Apr;21(4):222-5.
104. Receptor-mediated activation of nitric oxide synthesis by arginine in endothelial cells. Joshi MS, etal., Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):9982-7. Epub 2007 May 29.
105. Up-regulated eNOS protects blood-retinal barrier in the L-arginine treated ischemic rat retina. Ju WK, etal., Neuroreport. 2001 Aug 8;12(11):2405-9.
106. Esculetin ameliorates vascular perturbation by intervening in the occupancy of H2BK120Ub at At1, At2, Tgfß1 and Mcp1 promoter gene in thoracic aorta of IR and T2D rats. Kadakol A, etal., Biomed Pharmacother. 2017 Nov;95:1461-1468. doi: 10.1016/j.biopha.2017.09.067. Epub 2017 Sep 21.
107. Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with hypertension, alcohol intake, and cigarette smoking. Kang JH, etal., Arch Ophthalmol. 2011 Jun;129(6):773-80. doi: 10.1001/archophthalmol.2011.118.
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248. Bronchiolitis obliterans induced by intratracheal papaverine: a novel animal model. Svetlecic J, etal., Lung. 2004;182(2):119-34.
249. Association between polymorphism of the NQO1, NOS3 and NFE2L2 genes and AMD. Synowiec E, etal., Front Biosci (Landmark Ed). 2013 Jan 1;18:80-90.
250. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
251. Subcellular distribution of nitric oxide synthase isoforms in the rat duodenum. Talapka P, etal., World J Gastroenterol. 2011 Feb 28;17(8):1026-9.
252. Orthodontic force stimulates eNOS and iNOS in rat osteocytes. Tan SD, etal., J Dent Res. 2009 Mar;88(3):255-60.
253. Endothelial nitric oxide synthase gene intron 4 variable number tandem repeat polymorphism in beta-thalassemia major: relation to cardiovascular complications. Tantawy AA, etal., Blood Coagul Fibrinolysis. 2015 Jun;26(4):419-25. doi: 10.1097/MBC.0000000000000277.
254. Endothelial nitric oxide synthase gene intron 4 VNTR polymorphism in sickle cell disease: relation to vasculopathy and disease severity. Tantawy AA, etal., Pediatr Blood Cancer. 2015 Mar;62(3):389-94. doi: 10.1002/pbc.25234. Epub 2014 Sep 27.
255. eNOS4 polymorphism of the endothelial nitric oxide synthase predicts risk for severe diabetic retinopathy. Taverna MJ, etal., Diabet Med. 2002 Mar;19(3):240-5.
256. The T-786C and C774T endothelial nitric oxide synthase gene polymorphisms independently affect the onset pattern of severe diabetic retinopathy. Taverna MJ, etal., Nitric Oxide. 2005 Aug;13(1):88-92.
257. Overexpression of endothelial nitric oxide synthase suppresses features of allergic asthma in mice. Ten Broeke R, etal., Respir Res. 2006 Apr 5;7:58.
258. Polymorphisms in genes involved in the free-radical process in patients with sudden sensorineural hearing loss and Meniere's disease. Teranishi M, etal., Free Radic Res. 2013 Jul;47(6-7):498-506. doi: 10.3109/10715762.2013.793319. Epub 2013 May 7.
259. High-density lipoprotein administration attenuates liver proinflammatory response, restores liver endothelial nitric oxide synthase activity, and lowers portal pressure in cirrhotic rats. Thabut D, etal., Hepatology. 2007 Dec;46(6):1893-906.
260. Interleukin-6 sustains hepatic regeneration in cirrhotic rat. Tiberio GA, etal., Hepatogastroenterology. 2007 Apr-May;54(75):878-83.
261. Ethanol consumption increases blood pressure and alters the responsiveness of the mesenteric vasculature in rats. Tirapelli CR, etal., J Pharm Pharmacol. 2008 Mar;60(3):331-41.
262. Lack of association between polymorphisms of eight candidate genes and idiopathic dilated cardiomyopathy: the CARDIGENE study. Tiret L, etal., J Am Coll Cardiol. 2000 Jan;35(1):29-35.
263. Downregulation of endothelial nitric oxide synthase in rat aorta after prolonged hypoxia in vivo. Toporsian M, etal., Circ Res 2000 Mar 31;86(6):671-5.
264. Comparison of the effect of simvastatin, spironolactone and L-arginine on endothelial function of aorta in hereditary hypertriglyceridemic rats. Torok J, etal., Physiol Res. 2007;56 Suppl 2:S33-40. Epub 2007 Sep 5.
265. Resveratrol neuroprotective effects during focal cerebral ischemia injury via nitric oxide mechanism in rats. Tsai SK, etal., J Vasc Surg. 2007 Aug;46(2):346-53. Epub 2007 Jun 27.
266. Stromal nitric oxide synthase (NOS) expression correlates with the grade of mammary phyllodes tumour. Tse GM, etal., J Clin Pathol. 2005 Jun;58(6):600-4.
267. Oral sorbent AST-120 increases renal NO synthesis in uremic rats. Tumur Z and Niwa T, J Ren Nutr. 2008 Jan;18(1):60-4.
268. Association study of the 5' flanking regions of endothelial-nitric oxide synthase and endothelin-1 genes in familial primary open-angle glaucoma. Tunny TJ, etal., Clin Exp Pharmacol Physiol. 1998 Jan;25(1):26-9.
269. Effects of endothelial nitric oxide synthase, interleukin-6 gene polymorphisms and asymmetric dimethylarginine levels on risk factors and lesion sites in peripheral artery disease. Tuygun AK, etal., J Int Med Res. 2009 Jul-Aug;37(4):1003-10.
270. Intron 4 VNTR of endothelial nitric oxide synthase (eNOS) gene and diabetic retinopathy in type 2 patients in southern India. Uthra S, etal., Ophthalmic Genet. 2007 Jun;28(2):77-81.
271. The soy isoflavone genistein reverses oxidative and inflammatory state, neuropathic pain, neurotrophic and vasculature deficits in diabetes mouse model. Valsecchi AE, etal., Eur J Pharmacol. 2011 Jan 15;650(2-3):694-702. doi: 10.1016/j.ejphar.2010.10.060. Epub 2010 Nov 2.
272. Anti-inflammatory effects of atorvastatin improve left ventricular function in experimental diabetic cardiomyopathy. Van Linthout S, etal., Diabetologia. 2007 Sep;50(9):1977-86. Epub 2007 Jun 23.
273. Nitric oxide synthase 3 contributes to ventilator-induced lung injury. Vaporidi K, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Aug;299(2):L150-9. Epub 2010 May 7.
274. Apelin as a novel drug for treating preeclampsia. Wang C, etal., Exp Ther Med. 2017 Dec;14(6):5917-5923. doi: 10.3892/etm.2017.5304. Epub 2017 Oct 13.
275. A smoking-dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene. Wang XL, etal., Nat Med. 1996 Jan;2(1):41-5.
276. Combination analysis of NOS3, ABCB1 and IL23R polymorphisms with alcohol-induced osteonecrosis of the femoral head risk in Chinese males. Wang Y, etal., Oncotarget. 2017 May 16;8(20):33770-33778. doi: 10.18632/oncotarget.16809.
277. Thyroid hormones alter estrous cyclicity and antioxidative status in the ovaries of rats. Wei Q, etal., Anim Sci J. 2017 Dec 7. doi: 10.1111/asj.12950.
278. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics Wei W, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2007 Oct;9(5):473-8.
279. Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. Wu IC, etal., Neoplasia. 2011 Apr;13(4):386-92. doi: 10.1593/neo.101722.
280. Norepinephrine-induced nociception and vasoconstrictor hypersensitivity in rats with chronic post-ischemia pain. Xanthos DN, etal., Pain. 2007 Dec 11;.
281. Hydrogen sulfide improves endothelial dysfunction in hypertension by activating peroxisome proliferator-activated receptor delta/endothelial nitric oxide synthase signaling. Xiao L, etal., J Hypertens. 2017 Oct 27. doi: 10.1097/HJH.0000000000001605.
282. Epigenetic regulation of the endothelial nitric oxide synthase gene in persistent pulmonary hypertension of the newborn rat. Xu XF, etal., J Hypertens. 2010 Nov;28(11):2227-35.
283. Propofol reduces nitric oxide-induced apoptosis in testicular ischemia-reperfusion injury by downregulating the expression of inducible nitric oxide synthase. Yagmurdur H, etal., Acta Anaesthesiol Scand. 2008 Mar;52(3):350-7. Epub 2008 Jan 16.
284. Splenic hemodynamics and decreased endothelial nitric oxide synthase in the spleen of rats with liver cirrhosis. Yamaguchi S, etal., Life Sci. 2007 May 8;80(22):2036-44. Epub 2007 Mar 23.
285. Novel allele of the endothelial nitric oxide synthase gene polymorphism in Caucasian asthmatics. Yanamandra K, etal., Biochem Biophys Res Commun. 2005 Sep 23;335(2):545-9.
286. Titanium implants alter endothelial function and vasoconstriction via a protein kinase C-regulated pathway. Yang RS, etal., Acta Biomater. 2009 Oct;5(8):3258-64. doi: 10.1016/j.actbio.2009.05.006. Epub 2009 May 13.
287. Combined preconditioning with hypoxia and GYKI-52466 protects rats from cerebral ischemic injury by HIF-1a/eNOS pathway. Yang Y, etal., Am J Transl Res. 2017 Dec 15;9(12):5308-5319. eCollection 2017.
288. Structural-Activity Relationship of Ginsenosides from Steamed Ginseng in the Treatment of Erectile Dysfunction. Ying A, etal., Am J Chin Med. 2018 Jan 3:1-19. doi: 10.1142/S0192415X18500088.
289. Phosphorylated Endothelial NOS Ser1177 via the PI3K/Akt Pathway Is Depressed in the Brain of Stroke-Prone Spontaneously Hypertensive Rat. Yoshitomi H, etal., J Stroke Cerebrovasc Dis. 2010 Aug 31.
290. Magnesium supplementation prevents chronic cyclosporine nephrotoxicity via adjusting nitric oxide synthase activity. Yuan J, etal., Transplant Proc. 2005 May;37(4):1892-5.
291. Role of Nitric Oxide Synthase in Bladder Pathologic Remodeling and Dysfunction Resulting From Partial Outlet Obstruction. Yuan X, etal., Urology. 2011 Jan 20.
292. Intestinal endotoxemia plays a central role in development of hepatopulmonary syndrome in a cirrhotic rat model induced by multiple pathogenic factors. Zhang HY, etal., World J Gastroenterol. 2007 Dec 21;13(47):6385-95.
293. Influence of L-arginine on the expression of eNOS and COX2 in experimental pulmonary thromboembolism. Zhang J, etal., J Huazhong Univ Sci Technolog Med Sci. 2006;26(5):524-7.
294. Direct effects of lead (Pb2+) on the relaxation of in vitro cultured rat aorta to acetylcholine. Zhang LF, etal., Toxicol Lett. 2007 Apr 25;170(2):104-10. Epub 2007 Feb 20.
295. Interaction of calmodulin with its binding domain of rat cerebellar nitric oxide synthase. A multinuclear NMR study. Zhang M, etal., J Biol Chem. 1995 Sep 8;270(36):20901-7.
296. Simvastatin increases circulating endothelial progenitor cells and reduces the formation and progression of diabetic retinopathy in rats. Zhang W and Yan H, Exp Eye Res. 2012 Dec;105:1-8. doi: 10.1016/j.exer.2012.09.014. Epub 2012 Oct 8.
297. Osteopontin protects against hyperoxia-induced lung injury by inhibiting nitric oxide synthases. Zhang XF, etal., Chin Med J (Engl). 2010 Apr 5;123(7):929-35.
298. Bliverdin reductase-A improves neurological function in a germinal matrix hemorrhage rat model. Zhang Y, etal., Neurobiol Dis. 2018 Feb;110:122-132. doi: 10.1016/j.nbd.2017.11.017. Epub 2017 Dec 5.
299. Radix Cyathula officinalis Kuan inhibits arterial remodeling in spontaneously hypertensive rats. Zhao J, etal., Exp Ther Med. 2017 Dec;14(6):5395-5400. doi: 10.3892/etm.2017.5218. Epub 2017 Sep 28.
300. iNOS expression in rat aorta is increased after spinal cord transection: a possible cause of orthostatic hypotension in man. Zhao J, etal., Neurosci Lett. 2007 Mar 30;415(3):210-4. Epub 2007 Jan 14.
301. Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration. Zhao YY, etal., J Clin Invest. 2009 Jul;119(7):2009-18.
302. Perturbations in Endothelial Dysfunction-Associated Pathways in the Nitrofen-Induced Congenital Diaphragmatic Hernia Model. Zhaorigetu S, etal., J Vasc Res. 2017 Dec 8;55(1):26-34. doi: 10.1159/000484087.
303. Phytoestrogen alpha-zearalanol improves vascular function in ovariectomized hyperhomocysteinemic rats. Zhen PP, etal., Atherosclerosis. 2011 Apr;215(2):309-15. doi: 10.1016/j.atherosclerosis.2010.12.029. Epub 2011 Jan 19.
304. Down-regulation of renal endothelial nitric oxide synthase expression in experimental glomerular thrombotic microangiopathy. Zhou XJ, etal., Lab Invest. 2000 Jul;80(7):1079-87.
305. Cryptotanshinone exhibits therapeutical effects on cerebral stroke through the PI3K/AKT-eNOS signaling pathway. Zhu W, etal., Mol Med Rep. 2017 Dec;16(6):9361-9366. doi: 10.3892/mmr.2017.7824. Epub 2017 Oct 19.
Additional References at PubMed
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Genomics

Comparative Map Data
Nos3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8411,686,088 - 11,706,604 (-)NCBIGRCr8
mRatBN7.2410,793,834 - 10,814,170 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,793,834 - 10,814,166 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx415,940,095 - 15,960,412 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,760,284 - 11,780,599 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,112,074 - 10,132,387 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,321,908 - 7,342,404 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,320,668 - 7,342,410 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,333,272 - 7,353,767 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,158,847 - 6,179,441 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.146,158,846 - 6,179,441 (-)NCBI
Celera46,408,408 - 6,428,650 (-)NCBICelera
Cytogenetic Map4q11NCBI
NOS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387150,991,017 - 151,014,588 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7150,991,017 - 151,014,588 (+)EnsemblGRCh38hg38GRCh38
GRCh377150,688,105 - 150,711,676 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,319,080 - 150,342,609 (+)NCBINCBI36Build 36hg18NCBI36
Build 347150,125,794 - 150,149,323NCBI
Celera7145,245,139 - 145,269,020 (+)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7144,500,690 - 144,524,025 (+)NCBIHuRef
CHM1_17150,696,541 - 150,720,093 (+)NCBICHM1_1
T2T-CHM13v2.07152,163,824 - 152,187,711 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27150,017,398 - 150,041,276 (+)NCBI
Nos3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39524,569,772 - 24,589,472 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl524,569,808 - 24,589,472 (+)EnsemblGRCm39 Ensembl
GRCm38524,364,816 - 24,384,474 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl524,364,810 - 24,384,474 (+)EnsemblGRCm38mm10GRCm38
MGSCv37523,870,637 - 23,890,292 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36523,874,884 - 23,894,536 (+)NCBIMGSCv36mm8
Celera521,311,457 - 21,334,226 (+)NCBICelera
Cytogenetic Map5A3NCBI
cM Map511.32NCBI
Nos3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554915,438,010 - 5,460,814 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554915,438,228 - 5,457,308 (+)NCBIChiLan1.0ChiLan1.0
NOS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26187,411,083 - 187,436,160 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1739,421,347 - 39,446,540 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07142,577,334 - 142,600,702 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17154,730,009 - 154,755,233 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7154,730,009 - 154,755,233 (+)Ensemblpanpan1.1panPan2
NOS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11615,054,196 - 15,072,454 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1615,011,344 - 15,072,277 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1615,662,484 - 15,680,572 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01616,776,276 - 16,794,533 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11615,148,899 - 15,166,990 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01615,730,292 - 15,748,445 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01615,781,028 - 15,799,144 (+)NCBIUU_Cfam_GSD_1.0
Nos3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051186,457,663 - 6,476,277 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365276,427,093 - 6,446,534 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365276,427,147 - 6,445,770 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,209,158 - 6,228,943 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1186,209,218 - 6,228,912 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,579,253 - 6,602,572 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NOS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121119,174,829 - 119,196,840 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607215,144,615 - 15,167,202 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nos3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248005,600,212 - 5,619,004 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248005,600,215 - 5,619,020 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nos3
52 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:38
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000013058
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat

Markers in Region
D4Mgh28  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2410,807,902 - 10,808,048 (+)MAPPERmRatBN7.2
Rnor_6.047,336,137 - 7,336,282NCBIRnor6.0
Rnor_5.047,347,501 - 7,347,646UniSTSRnor5.0
RGSC_v3.446,172,895 - 6,173,041RGDRGSC3.4
RGSC_v3.446,172,896 - 6,173,041UniSTSRGSC3.4
RGSC_v3.146,172,895 - 6,173,041RGD
Celera46,422,456 - 6,422,601UniSTS
RH 3.4 Map43.2UniSTS
RH 3.4 Map43.2RGD
RH 2.0 Map413.9RGD
Cytogenetic Map4q11UniSTS
PMC155039P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2410,811,093 - 10,811,288 (+)MAPPERmRatBN7.2
Rnor_6.047,339,328 - 7,339,522NCBIRnor6.0
Rnor_5.047,350,692 - 7,350,886UniSTSRnor5.0
RGSC_v3.446,176,087 - 6,176,281UniSTSRGSC3.4
Celera46,425,647 - 6,425,841UniSTS
Cytogenetic Map4q11UniSTS
RH138584  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2410,813,389 - 10,813,517 (+)MAPPERmRatBN7.2
Rnor_6.047,341,624 - 7,341,751NCBIRnor6.0
Rnor_5.047,352,987 - 7,353,114UniSTSRnor5.0
RGSC_v3.446,178,665 - 6,178,792UniSTSRGSC3.4
Celera46,427,874 - 6,428,001UniSTS
RH 3.4 Map43.1UniSTS
Cytogenetic Map4q11UniSTS
Nos3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2410,794,243 - 10,794,517 (+)MAPPERmRatBN7.2
Rnor_6.047,322,498 - 7,322,771NCBIRnor6.0
Rnor_5.047,333,862 - 7,334,135UniSTSRnor5.0
RGSC_v3.446,159,257 - 6,159,530UniSTSRGSC3.4
Celera46,408,818 - 6,409,091UniSTS
Cytogenetic Map4q11UniSTS
UniSTS:166287  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2410,794,593 - 10,794,830 (+)MAPPERmRatBN7.2
Rnor_6.047,322,848 - 7,323,084NCBIRnor6.0
Rnor_5.047,334,212 - 7,334,448UniSTSRnor5.0
RGSC_v3.446,159,607 - 6,159,843UniSTSRGSC3.4
Celera46,409,168 - 6,409,404UniSTS
Cytogenetic Map4q11UniSTS


Related Rat Strains
The following Strains have been annotated to Nos3
DA.WF-(D4Mit11-Nos3)/Kop     MNS_     S     WKY    


Genetic Models
This gene Nos3 is modified in the following models/strains:
SS-Nos3em8Mcwi     SS-Nos3em2Mcwi     SS-Nos3em13Mcwi    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 36 2 2 7 2 8 5
Low 3 7 55 39 12 39 8 11 74 27 36 11 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000013058   ⟹   ENSRNOP00000013058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,794,172 - 10,814,166 (-)Ensembl
Rnor_6.0 Ensembl47,320,668 - 7,342,410 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118104   ⟹   ENSRNOP00000086104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,793,834 - 10,814,166 (-)Ensembl
RefSeq Acc Id: NM_021838   ⟹   NP_068610
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,686,268 - 11,706,581 (-)NCBI
mRatBN7.2410,793,834 - 10,814,166 (-)NCBI
Rnor_6.047,322,088 - 7,342,400 (-)NCBI
Rnor_5.047,333,272 - 7,353,767 (-)NCBI
RGSC_v3.446,158,847 - 6,179,441 (-)RGD
Celera46,408,408 - 6,428,650 (-)RGD
Sequence:
RefSeq Acc Id: XM_006235872   ⟹   XP_006235934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,686,088 - 11,706,604 (-)NCBI
mRatBN7.2410,793,964 - 10,814,170 (-)NCBI
Rnor_6.047,321,908 - 7,342,404 (-)NCBI
Rnor_5.047,333,272 - 7,353,767 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_068610   ⟸   NM_021838
- UniProtKB: A0A8I6A2Y1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235934   ⟸   XM_006235872
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A2Y1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013058   ⟸   ENSRNOT00000013058
RefSeq Acc Id: ENSRNOP00000086104   ⟸   ENSRNOT00000118104
Protein Domains
FAD-binding FR-type   Flavodoxin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62600-F1-model_v2 AlphaFold Q62600 1-1202 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692795
Promoter ID:EPDNEW_R3318
Type:single initiation site
Name:Nos3_1
Description:nitric oxide synthase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.047,342,416 - 7,342,476EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3186 AgrOrtholog
BioCyc Gene G2FUF-46034 BioCyc
Ensembl Genes ENSRNOG00000009348 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013058.5 UniProtKB/TrEMBL
  ENSRNOT00000118104 ENTREZGENE
  ENSRNOT00000118104.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.360 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.440.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Translation factors UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CysJ-like_FAD-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_FR_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavdoxin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavodoxin/NO_synth UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavoprot_Pyr_Nucl_cyt_Rdtase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavoprotein-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FNR_nucleotide-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADPH_Cyt_P450_Rdtase_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_dom_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_dom_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_dom_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OxRdtase_FAD/NAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Riboflavin_synthase-like_b-brl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24600 UniProtKB/Swiss-Prot
NCBI Gene 24600 ENTREZGENE
PANTHER NITRIC OXIDE SYNTHASE OXYGENASE UniProtKB/Swiss-Prot
  NITRIC OXIDE SYNTHASE OXYGENASE UniProtKB/Swiss-Prot
  NITRIC OXIDE SYNTHASE OXYGENASE UniProtKB/TrEMBL
  NITRIC OXIDE SYNTHASE OXYGENASE UniProtKB/TrEMBL
Pfam FAD_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavodoxin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NO_synthase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NOS3 RGD
PhenoGen Nos3 PhenoGen
PIRSF NOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS FLAVODOXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FPNCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FAD_FR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FLAVODOXIN_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009348 RatGTEx
Superfamily-SCOP SSF52218 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52343 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56512 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63380 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A2Y1 ENTREZGENE, UniProtKB/TrEMBL
  A6K568_RAT UniProtKB/TrEMBL
  F1LQC7_RAT UniProtKB/TrEMBL
  NOS3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9JJY7_RAT UniProtKB/TrEMBL
UniProt Secondary O88672 UniProtKB/Swiss-Prot
  O89041 UniProtKB/Swiss-Prot
  Q62734 UniProtKB/Swiss-Prot
  Q68GV6 UniProtKB/Swiss-Prot
  Q75NE4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Nos3  nitric oxide synthase 3      Name updated 70584 APPROVED
2001-10-23 Nos3  nitric oxide synthase 3, endothelial cell      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function produces nitric oxide (NO) 61039
gene_function catalyzes the conversion of L-arginine to L-citrulline and NO 628542
gene_process implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway 61039
gene_process involved in inhibition of vascular smooth muscle cell proliferation 628542
gene_process may play a role in lung development 728993
gene_process regulates medullary blood flow (MBF) in the renal medulla and mediates the long-term control of blood pressure 628564
gene_regulation cell inhibitory effect is mediated by p21 and p53 628542