Nos2 (nitric oxide synthase 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Nos2 (nitric oxide synthase 2) Rattus norvegicus
Analyze
Symbol: Nos2
Name: nitric oxide synthase 2
RGD ID: 3185
Description: Enables several functions, including Hsp90 protein binding activity; beta-catenin binding activity; and enzyme binding activity. Involved in several processes, including cellular response to cytokine stimulus; response to bacterium; and response to hexose. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and peroxisome. Used to study several diseases, including Alzheimer's disease; diabetic angiopathy; pleurisy; renal hypertension; and toxic shock syndrome. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); inflammatory bowel disease (multiple); liver disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); hypertension (multiple); malaria; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human NOS2 (nitric oxide synthase 2); PARTICIPATES IN endothelin signaling pathway; hypoxia inducible factor pathway; interleukin-12 signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-sesamin; (+)-Tetrandrine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: inducible nitric oxide synthase; inducible NO synthase; inducible NOS; iNos; LOC497963; Nitric oxide synthase 2 inducible; Nitric oxide synthase 2 inducible macrophage; nitric oxide synthase 2, inducible; nitric oxide synthase 2, inducible, macrophage; nitric oxide synthase, inducible; nitric oxide synthase, inducible-like; NOS type II; Nos2a; peptidyl-cysteine S-nitrosylase NOS2; similar to Nitric oxide synthase, inducible (NOS type II) (Inducible NO synthase) (Inducible NOS) (iNOS)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Nos2-ps1  
Is Marker For: Strains:   SS.LEW-(Nos2-D10M11Mit119)/Ayd   SS.MNS-(D10Mco10-Aldoc)/Jr   SS.MNS-(Aldoc-D10Mco1)/Jr  
QTLs:   Bp12   Bp76   Bp133  
Candidate Gene For: Bp12 Bp71 Bp136 Bp168 Eau9
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81064,313,335 - 64,349,221 (+)NCBIGRCr8
mRatBN7.21063,815,308 - 63,851,208 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1063,815,308 - 63,851,210 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1068,445,568 - 68,481,178 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01067,950,910 - 67,986,520 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01063,419,659 - 63,455,435 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01066,188,290 - 66,221,621 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1066,189,786 - 66,313,190 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01065,423,626 - 65,456,957 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41065,036,884 - 65,072,453 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11065,050,519 - 65,086,394 (+)NCBI
Celera1062,790,940 - 62,826,625 (+)NCBICelera
Cytogenetic Map10q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IEP)
Acute Hepatitis  (IDA)
acute kidney failure  (ISO)
Acute Liver Failure  (IEP)
Acute Lung Injury  (IMP)
acute necrotizing pancreatitis  (IEP)
Alzheimer's disease  (IDA,ISO)
amyotrophic lateral sclerosis  (ISO)
anterior uveitis  (IEP)
anti-basement membrane glomerulonephritis  (IEP)
asbestosis  (IEP,ISO)
aspiration pneumonia  (ISO)
asthma  (IEP,IMP,ISO)
atherosclerosis  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
brain edema  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (IEP)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
bronchial disease  (ISO)
Bronchial Hyperreactivity  (IEP,IMP,ISO)
bronchiolitis obliterans  (ISO)
Burns  (ISO)
Cardiovascular Abnormalities  (ISO)
cholangiocarcinoma  (ISO)
cholestasis  (ISO)
Chronic Bronchitis  (IDA)
Chronic Hepatitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (IEP,ISO)
colon adenocarcinoma  (ISO)
Colonic Neoplasms  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
cystic fibrosis  (ISO)
dementia  (ISO)
diabetic angiopathy  (IEP,IMP)
diabetic neuropathy  (ISO)
dilated cardiomyopathy  (ISO)
duodenal ulcer  (ISO)
Edema  (IEP)
Emphysema  (ISO)
Endotoxemia  (IDA,IEP,ISO)
Esophageal Neoplasms  (ISO)
Experimental Arthritis  (IMP,ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IEP,ISO)
Experimental Liver Neoplasms  (IEP)
extrahepatic cholestasis  (ISO)
extrinsic allergic alveolitis  (ISO)
Fetal Diseases  (ISO)
Fetal Growth Retardation  (IEP)
focal segmental glomerulosclerosis  (ISO)
Fungal Lung Diseases  (IEP)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (ISO)
gastroschisis  (IEP)
genetic disease  (ISO)
Hemorrhagic Shock  (IEP)
hepatic encephalopathy  (IEP)
Hepatic Insufficiency  (ISO)
hepatitis  (IEP)
hepatocellular carcinoma  (IEP)
Hepatomegaly  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
Hyperemia  (ISO)
hypertension  (IEP,ISO)
Hypothermia  (ISO)
hypothyroidism  (IEP)
impotence  (IEP)
Inflammation  (ISO)
inflammatory bowel disease  (IEP)
Insulin Resistance  (IEP,ISO)
interstitial cystitis  (IEP)
interstitial lung disease  (ISO)
intestinal disease  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (IEP)
Lewy body dementia  (ISO)
liver disease  (ISO)
lung disease  (IEP,IMP,ISO)
Lung Neoplasms  (ISO)
malaria  (ISO)
Manganese Poisoning  (ISO)
Marfan syndrome  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
middle cerebral artery infarction  (IEP,ISO)
mitochondrial metabolism disease  (ISO)
mucositis  (IEP)
Mycoplasma Infections  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Reperfusion Injury  (IEP,ISO)
myocardial stunning  (ISO)
Nasal Polyps  (ISO)
Necrosis  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephrotoxicity  (IEP)
obesity  (ISO)
obstructive sleep apnea  (ISO)
otitis media  (IEP)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
paraplegia  (IEP)
Parkinson's disease  (ISO)
Perennial Allergic Rhinitis  (ISO)
perinatal necrotizing enterocolitis  (ISO)
pleurisy  (IDA,IEP)
Pneumococcal Pneumonia  (ISO)
pneumocystosis  (IEP)
primary biliary cholangitis  (IEP,ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
pulmonary edema  (IEP)
pulmonary emphysema  (IEP,ISO)
pulmonary eosinophilia  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IEP,ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
renal hypertension  (IMP)
Reperfusion Injury  (IEP,ISO)
respiratory allergy  (IDA,ISO)
retinal disease  (ISO)
retinopathy of prematurity  (IEP)
rhinitis  (ISO)
Schistosomiasis Mansoni  (ISO)
sclerosing cholangitis  (ISO)
secondary Parkinson disease  (ISO)
Sepsis  (IEP,ISO)
silicosis  (ISO)
sleeping sickness  (IEP)
Spinal Cord Injuries  (IEP)
status epilepticus  (ISO)
Stevens-Johnson syndrome  (ISO)
Stroke  (IEP,ISO)
Subarachnoid Hemorrhage  (ISO)
Systemic Inflammatory Response Syndrome  (IEP)
systemic lupus erythematosus  (ISO)
Takayasu's arteritis  (ISO)
Thrombotic Microangiopathies  (IEP)
toxic shock syndrome  (IDA,ISO)
traumatic brain injury  (ISO)
Turner syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
uremia  (IEP)
ureteral obstruction  (ISO)
urinary tract infection  (ISO)
uveitis  (ISO)
Viral Bronchiolitis  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (ISO)
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-Erythraline  (ISO)
(+)-isoborneol  (ISO)
(+)-pilocarpine  (EXP)
(+)-sesamin  (EXP)
(+)-syringaresinol beta-D-glucoside  (ISO)
(+)-Tetrandrine  (EXP)
(-)-alpha-phellandrene  (ISO)
(-)-Arctigenin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-hinokiresinol  (ISO)
(-)-matairesinol  (ISO)
(1->4)-beta-D-glucan  (EXP)
(20S)-ginsenoside Rg3  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(9R)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione  (EXP)
(E)-roxithromycin  (EXP,ISO)
(E)-thiamethoxam  (EXP,ISO)
(R)-adrenaline  (EXP,ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,2-naphthoquinone  (ISO)
1,3,5-trinitrobenzene  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1,4-dithiothreitol  (EXP,ISO)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (ISO)
1-bromopropane  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-hydroxy-2-naphthoic acid  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
16,16-dimethylprostaglandin E2  (EXP)
17-hydroxyjolkinolide B  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,5-hexanedione  (EXP)
2,6-dichloroindophenol  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-chloroethanol  (ISO)
2-deoxy-D-glucose  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
2-naphthylamine  (ISO)
2-tert-butylhydroquinone  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic GMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,4-dihydroxybenzoic acid  (EXP,ISO)
3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea  (ISO)
3-methylcatechol  (ISO)
3-nitropropanoic acid  (EXP,ISO)
3-phenylprop-2-enal  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-amino-1,8-naphthalimide  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxynon-2-enal  (ISO)
4-methylcatechol  (ISO)
4-nitroquinoline N-oxide  (EXP)
5'-S-methyl-5'-thioadenosine  (ISO)
5,6,7-trimethoxyflavone  (ISO)
5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide  (EXP)
5-aminoimidazole-4-carboxamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-Hydroxycapric acid  (EXP,ISO)
5-Hydroxyflavone  (ISO)
5-Nitro-2-(3-phenylpropylamino)benzoic acid  (ISO)
6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine  (EXP)
6-oxoprostaglandin F1alpha  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7,8-diacetoxy-4-methylcoumarin  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
7-ketocholesterol  (ISO)
8-Br-cAMP  (EXP)
9,10-phenanthroquinone  (ISO)
9-phenanthrol  (ISO)
[6]-Shogaol  (ISO)
acetaldehyde  (ISO)
acetic acid  (EXP)
acetylcholine  (ISO)
acetylsalicylic acid  (EXP,ISO)
Aciculatin  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
actinomycin D  (EXP,ISO)
Activin A  (EXP)
adefovir pivoxil  (ISO)
adenine  (ISO)
adenosine  (EXP)
ADP  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
agmatine  (ISO)
agomelatine  (EXP)
AICA ribonucleotide  (EXP,ISO)
alachlor  (ISO)
albuterol  (EXP)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
alendronic acid  (EXP)
Alismol  (ISO)
all-trans-retinoic acid  (EXP)
all-trans-retinol  (EXP)
allantoin  (EXP,ISO)
allopurinol  (ISO)
alloxan  (ISO)
allyl alcohol  (EXP)
Aloe emodin  (ISO)
alpha-Chaconine  (ISO)
alpha-D-galactose  (ISO)
alpha-linolenic acid  (EXP)
alpha-methylhistamine  (ISO)
alpha-naphthoflavone  (EXP,ISO)
alpha-phellandrene  (ISO)
Alternaramide  (ISO)
aluminium atom  (EXP,ISO)
aluminium(0)  (EXP,ISO)
amentoflavone  (ISO)
amiloride  (ISO)
aminoguanidine  (EXP,ISO)
amlexanox  (ISO)
ammonia  (ISO)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
amobarbital  (EXP)
amphetamine  (EXP)
amphibole asbestos  (ISO)
ampicillin  (EXP)
anandamide  (ISO)
androst-4-ene-3,17-dione  (EXP)
Anemonin  (ISO)
Anemoside B4  (ISO)
aniline  (EXP)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony(0)  (EXP,ISO)
Apicularen A  (ISO)
apigenin  (EXP,ISO)
apocynin  (EXP,ISO)
arachidonyl-2'-chloroethylamide  (ISO)
Arctiin  (ISO)
aristolochic acid A  (ISO)
arjunolic acid  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asarone  (ISO)
asbestos  (ISO)
aspalathin  (ISO)
astaxanthin  (EXP,ISO)
astilbin  (ISO)
atenolol  (ISO)
atorvastatin calcium  (EXP)
ATP  (EXP,ISO)
atrazine  (EXP,ISO)
atropine  (EXP)
aureusidin  (ISO)
azathioprine  (ISO)
azetidine  (ISO)
baicalein  (ISO)
baicalin  (EXP,ISO)
Bardoxolone methyl  (ISO)
beclomethasone  (ISO)
benazepril  (EXP)
benfotiamine  (ISO)
benzamide  (EXP,ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzoic acid  (ISO)
benzyl isothiocyanate  (ISO)
berberine  (EXP,ISO)
Bergenin  (EXP)
beryllium sulfate  (ISO)
Besigomsin  (ISO)
beta-amyrin  (ISO)
beta-carotene  (EXP)
beta-D-fructofuranose 1,6-bisphosphate  (ISO)
beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-ionone  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (ISO)
bilirubin IXalpha  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
boric acid  (ISO)
BQ 123  (ISO)
bromoacetate  (ISO)
bromocriptine  (ISO)
budesonide  (EXP,ISO)
bufalin  (ISO)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfide  (ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calciol  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium dichloride  (ISO)
camphene  (EXP)
candesartan  (EXP)
Candesartan cilexetil  (EXP)
cannabidiol  (EXP,ISO)
Cannabidivarin  (ISO)
cantharidin  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
captopril  (EXP)
carbamazepine  (EXP)
carbaryl  (ISO)
carbendazim  (EXP)
CARBENOXOLONE  (ISO)
carbon atom  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (ISO)
Cardamonin  (EXP)
carfilzomib  (ISO)
carmustine  (EXP,ISO)
carnosic acid  (ISO)
carnosine  (ISO)
carrageenan  (EXP,ISO)
carvacrol  (ISO)
carvedilol  (EXP,ISO)
carveol  (ISO)
catalpol  (ISO)
catechol  (ISO)
celastrol  (ISO)
celecoxib  (EXP,ISO)
cerium trichloride  (ISO)
ceruletide  (ISO)
cetirizine  (ISO)
chaetoglobosin A  (ISO)
chalcone  (ISO)
chitosan  (EXP)
chloroethene  (ISO)
chloroform  (ISO)
chlorogenic acid  (EXP,ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (EXP,ISO)
chondroitin sulfate  (ISO)
chromium(6+)  (EXP,ISO)
chrysin  (EXP,ISO)
chrysin 5,7-dimethyl ether  (EXP)
ciglitazone  (ISO)
cilostazol  (ISO)
cirsilineol  (ISO)
Cirsimarin  (ISO)
cis-caffeic acid  (EXP,ISO)
cisplatin  (EXP,ISO)
citronellol  (EXP,ISO)
clofibrate  (EXP,ISO)
cloricromen  (EXP)
clothianidin  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
coenzyme Q10  (EXP,ISO)
coniferyl aldehyde  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
cordycepin  (ISO)
corilagin  (ISO)
corosolic acid  (ISO)
cortisol  (EXP)
cortisone  (ISO)
costunolide  (ISO)
coumarin  (EXP,ISO)
crocidolite asbestos  (EXP,ISO)
crotonaldehyde  (EXP)
cumene hydroperoxide  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyclizine  (ISO)
cycloheximide  (ISO)
Cyclopamine  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
cyproterone acetate  (EXP)
cytochalasin D  (ISO)
D-fructofuranose 1,6-bisphosphate  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
daidzein  (ISO)
dapoxetine  (EXP)
DAPT  (EXP,ISO)
DDE  (ISO)
DDT  (EXP,ISO)
Decursin  (ISO)
deguelin  (ISO)
dehydrocostus lactone  (ISO)
Dehydrodiisoeugenol  (ISO)
Delta(9)-tetrahydrocannabinolic acid  (ISO)
delta-tocotrienol  (ISO)
demethoxycurcumin  (EXP,ISO)
deoxynivalenol  (EXP,ISO)
desferrioxamine B  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazepam  (EXP,ISO)
diazinon  (ISO)
diazoxide  (EXP,ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP)
dibutylstannane  (ISO)
dichlorine  (EXP)
dichloroacetyl chloride  (ISO)
dichloromethane  (ISO)
dichlorvos  (EXP)
diclofenac  (EXP,ISO)
dieckol  (ISO)
diethyl maleate  (EXP,ISO)
diethyldithiocarbamic acid  (EXP,ISO)
Diferuloylputrescine  (ISO)
diflunisal  (EXP)
dihydrolipoic acid  (ISO)
Dihydrotanshinone I  (ISO)
dihydroxyacetone  (ISO)
dimemorfan  (EXP,ISO)
dimercaprol  (ISO)
dimethyl sulfoxide  (ISO)
Diosbulbin B  (ISO)
diosmetin  (ISO)
diosmin  (EXP)
dioxygen  (EXP,ISO)
diphenylmethane-4,4'-diisocyanate  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP,ISO)
diprotium oxide  (ISO)
dipyridamole  (EXP,ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (EXP)
dizocilpine maleate  (EXP)
dobutamine  (ISO)
domperidone  (ISO)
donepezil hydrochloride  (ISO)
dopamine  (EXP,ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
DPCPX  (ISO)
drospirenone  (ISO)
ebselen  (EXP,ISO)
edaravone  (EXP,ISO)
elemental carbon  (ISO)
elemental selenium  (ISO)
ellagic acid  (EXP,ISO)
emamectin benzoate  (ISO)
emodin  (EXP)
enalapril  (EXP,ISO)
endosulfan  (EXP,ISO)
entinostat  (ISO)
enzyme inhibitor  (EXP)
erucic acid  (EXP)
esculetin  (ISO)
estriol  (ISO)
etacrynic acid  (EXP)
ethanol  (EXP,ISO)
Ethyl pyruvate  (EXP,ISO)
ethylmalonic acid  (EXP)
etoposide  (EXP,ISO)
eugenol  (ISO)
eupatilin  (ISO)
Evodiamine  (ISO)
fasudil  (EXP)
fenofibrate  (EXP,ISO)
fenoldopam  (EXP)
ferric ammonium citrate  (ISO)
ferroheme b  (ISO)
ferrostatin-1  (EXP)
ferulic acid  (ISO)
Fexofenadine hydrochloride  (ISO)
Fidarestat  (ISO)
finasteride  (EXP)
fipronil  (EXP)
fisetin  (EXP,ISO)
Flavokawain A  (ISO)
flavone  (ISO)
flavonoids  (EXP,ISO)
flavonol  (ISO)
flufenamic acid  (EXP,ISO)
fluoxetine  (ISO)
flurbiprofen  (EXP,ISO)
fluvastatin  (ISO)
fluvoxamine  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
formic acid  (EXP)
Fraxinellone  (ISO)
fructose  (EXP,ISO)
fucoxanthin  (ISO)
fulvestrant  (EXP,ISO)
gabapentin  (EXP)
gadodiamide hydrate  (ISO)
gadolinium trichloride  (EXP)
galactose  (ISO)
galangin  (EXP)
gallic acid  (EXP,ISO)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (ISO)
geldanamycin  (EXP,ISO)
gemfibrozil  (ISO)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (ISO)
gentamycin  (EXP,ISO)
Geraniin  (ISO)
geraniol  (EXP,ISO)
gingerol  (ISO)
ginkgolide B  (EXP)
Ginkgolide C  (EXP)
ginsenoside C-K  (EXP)
ginsenoside Re  (ISO)
ginsenoside Rg1  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
Glutathione ethyl ester  (EXP,ISO)
glyburide  (EXP,ISO)
glycitein  (ISO)
glycochenodeoxycholic acid  (EXP)
glycyrol  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (EXP)
GW 1929  (ISO)
GW 7647  (ISO)
haloperidol  (ISO)
halothane  (EXP)
Harpagide  (ISO)
helenalin  (ISO)
heme b  (ISO)
hemin  (EXP,ISO)
herbimycin  (EXP)
hesperetin  (EXP,ISO)
hesperidin  (EXP,ISO)
hexachlorobenzene  (ISO)
hexacosan-1-ol  (EXP)
hexadecanoic acid  (EXP,ISO)
hinokiflavone  (ISO)
histamine  (EXP,ISO)
homocysteine  (ISO)
homoeriodictyol  (ISO)
Honokiol  (ISO)
HU-308  (EXP,ISO)
hyaluronic acid  (ISO)
hydrogen chloride  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxamic acid  (EXP)
hydroxychloroquine  (ISO)
hypoxanthine  (ISO)
Ibudilast  (EXP)
ibuprofen  (EXP,ISO)
icariin  (EXP,ISO)
icariside II  (ISO)
ifosfamide  (EXP)
Imipenem-cilastatin  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
iodixanol  (EXP)
iopromide  (EXP)
irinotecan  (ISO)
iron atom  (EXP,ISO)
iron dextran  (EXP)
iron trichloride  (EXP)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) nitrilotriacetate  (EXP,ISO)
isoeugenol  (ISO)
isoflurane  (EXP)
isoliquiritigenin  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (ISO)
isothiocyanate  (ISO)
ivermectin  (ISO)
jaspamide  (EXP,ISO)
kaempferol  (ISO)
kaempferol 3-O-beta-D-glucoside  (ISO)
kainic acid  (EXP,ISO)
keto-D-fructose 1,6-bisphosphate  (ISO)
KN-93  (ISO)
Kukoamine B  (ISO)
L-1,4-dithiothreitol  (EXP,ISO)
L-arginine  (EXP)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (EXP)
L-gamma-glutamyl-L-cysteine  (ISO)
L-methionine  (EXP,ISO)
L-proline betaine  (ISO)
lactacystin  (ISO)
Lafutidine  (EXP)
lamotrigine  (EXP)
latrunculin B  (EXP,ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
lentinan  (ISO)
leukotriene B4  (ISO)
leukotriene C4  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
lignan  (ISO)
linoleic acid  (EXP)
linsidomine  (ISO)
linuron  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP,ISO)
lipoxin A4  (ISO)
liquiritigenin  (EXP,ISO)
liquiritin  (EXP,ISO)
lisinopril dihydrate  (EXP)
lithium atom  (EXP)
lithium chloride  (ISO)
lithium hydride  (EXP)
loganin  (ISO)
lornoxicam  (ISO)
losartan  (EXP)
lovastatin  (EXP,ISO)
loxoprofen  (EXP)
luteolin  (EXP,ISO)
LY294002  (EXP,ISO)
lycorine  (ISO)
lysophosphatidylcholine  (EXP)
m-xylene  (EXP)
Macrosphelide B  (ISO)
magnesium atom  (EXP)
Magnolol  (EXP,ISO)
malathion  (EXP)
malonaldehyde  (ISO)
malvidin 3-O-beta-D-glucoside  (ISO)
mancozeb  (ISO)
maneb  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP,ISO)
manumycin A  (ISO)
Maprotiline  (EXP)
mechlorethamine  (EXP,ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
mercaptoethanol  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
mesalamine  (EXP,ISO)
metformin  (EXP,ISO)
methacholine chloride  (ISO)
methamphetamine  (ISO)
methimazole  (EXP)
methoctramine tetrahydrochloride  (EXP)
methotrexate  (EXP,ISO)
methoxychlor  (ISO)
methylene blue  (EXP,ISO)
methylglyoxal  (EXP)
methylmalonic acid  (EXP)
methylmercury chloride  (ISO)
metoclopramide  (ISO)
metoprolol  (EXP)
metronidazole  (EXP)
mevalonic acid  (EXP,ISO)
mevinphos  (EXP)
miconazole  (EXP)
microcystin-LR  (EXP,ISO)
mifepristone  (EXP,ISO)
minocycline  (EXP,ISO)
miquelianin  (ISO)
monascin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP,ISO)
monosodium L-glutamate  (EXP)
monotropein  (ISO)
montelukast  (EXP)
morin  (EXP,ISO)
morphine  (ISO)
Morroniside  (ISO)
mycotoxin  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N-[3-(aminomethyl)benzyl]acetamidine  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-feruloyltyramine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naltrexone  (ISO)
naproxen  (EXP)
Narciclasine  (ISO)
naringin  (EXP,ISO)
neoastilbin  (ISO)
neoechinulin A  (ISO)
neohesperidin dihydrochalcone  (ISO)
neomycin  (ISO)
nerolidol  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP,ISO)
nicorandil  (ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (EXP)
nifedipine  (ISO)
nilotinib  (EXP)
nimesulide  (EXP,ISO)
nitrates  (EXP,ISO)
nitric oxide  (EXP,ISO)
nitrites  (EXP,ISO)
nitrobenzenes  (EXP)
nitroflurbiprofen  (EXP,ISO)
nitrogen dioxide  (EXP,ISO)
nitroglycerin  (EXP,ISO)
nitroprusside  (ISO)
Nivalenol  (ISO)
Nonylphenol  (EXP,ISO)
notoginsenoside R1  (EXP,ISO)
NS-398  (ISO)
O-(chloroacetylcarbamoyl)fumagillol  (EXP)
O-acetyl-L-carnitine  (EXP)
o-anisidine  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP,ISO)
oleuropein  (EXP)
oligopeptide  (ISO)
onapristone  (EXP)
organoselenium compound  (EXP,ISO)
orlistat  (EXP)
oroxylin A  (EXP,ISO)
Osajin  (ISO)
oxcarbazepine  (EXP)
oxidopamine  (EXP,ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-tolualdehyde  (ISO)
paclitaxel  (EXP)
paeoniflorin  (EXP,ISO)
Paeonol  (ISO)
palytoxin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
parthenolide  (EXP)
patchouli alcohol  (ISO)
PD-166866  (EXP)
pefloxacin  (ISO)
pelargonidin  (ISO)
pentanal  (ISO)
Pentoxifylline  (EXP)
peptidoglycan  (ISO)
perflubutane  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perindopril  (ISO)
peroxynitrous acid  (ISO)
phenanthridone  (EXP)
Phenelzine  (ISO)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (ISO)
phenylephrine  (EXP,ISO)
phenylpropane  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (EXP,ISO)
pifithrin-?  (EXP)
pimobendan  (ISO)
Pinacidil  (ISO)
pinostrobin  (EXP)
pioglitazone  (EXP,ISO)
pipoxolan  (ISO)
pirfenidone  (ISO)
pirinixic acid  (EXP,ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
platycodin D  (ISO)
poly(I:C)  (EXP,ISO)
polymyxin B2  (EXP,ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
potassium chloride  (EXP,ISO)
potassium cyanide  (EXP)
potassium dichromate  (EXP)
Praeruptorin A  (ISO)
pravastatin  (ISO)
prazosin  (EXP,ISO)
prednisolone  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
prilocaine  (ISO)
pristane  (ISO)
prodigiosin  (EXP,ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
propanil  (ISO)
propazine  (ISO)
propofol  (EXP,ISO)
prostaglandin A1  (ISO)
prostaglandin E1  (EXP)
prostaglandin E2  (EXP,ISO)
Protolichesterinic acid  (ISO)
protoporphyrin  (ISO)
prunetin  (ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
Punicalagin  (EXP)
putrescine  (ISO)
pyrazines  (ISO)
pyrimethamine  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quercitrin  (EXP)
radicicol  (EXP)
raloxifene  (EXP,ISO)
ranitidine  (EXP)
Ranitidine bismuth citrate  (ISO)
reactive nitrogen species  (ISO)
reactive oxygen species  (EXP,ISO)
Rebamipide  (EXP)
resiniferatoxin  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (EXP,ISO)
Ro 31-8220  (ISO)
rofecoxib  (EXP)
rolipram  (EXP)
Rosavin  (ISO)
rosmarinic acid  (EXP)
rosuvastatin calcium  (EXP)
rotenone  (EXP,ISO)
Rutecarpine  (ISO)
rutin  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-allylcysteine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP,ISO)
S-nitrosoglutathione  (ISO)
saccharin  (ISO)
salicylic acid  (EXP)
salubrinal  (ISO)
Salvianolic acid A  (EXP,ISO)
salvianolic acid B  (EXP)
Sanggenon C  (ISO)
saxagliptin  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
scoparone  (ISO)
scopolamine  (ISO)
scutellarin  (EXP)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
selenomethionine  (ISO)
senecionine  (ISO)
serotonin  (ISO)
serpentine asbestos  (EXP,ISO)
sevoflurane  (EXP,ISO)
sildenafil citrate  (EXP,ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simazine  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium chromate  (ISO)
sodium fluoride  (EXP)
sodium hydrogensulfite  (ISO)
sodium nitrate  (EXP)
sodium propionate  (ISO)
Sodium salicylate  (ISO)
sodium stibogluconate  (ISO)
Sophocarpine  (ISO)
Sophoricoside  (ISO)
sorafenib  (EXP)
sorbinil  (ISO)
soyasaponin I  (ISO)
Soyasaponin II  (ISO)
spermine  (ISO)
SR 144528  (ISO)
staurosporine  (EXP)
sterigmatocystin  (EXP,ISO)
stigmasterol  (ISO)
streptozocin  (EXP,ISO)
Sucralfate  (EXP)
sucrose  (ISO)
sulfasalazine  (EXP,ISO)
sulforaphane  (EXP,ISO)
sulfur dioxide  (EXP)
sunitinib  (ISO)
superoxide  (ISO)
T-2 toxin  (ISO)
tacrine  (ISO)
tacrolimus hydrate  (EXP,ISO)
tadalafil  (EXP)
tamibarotene  (EXP)
tamoxifen  (ISO)
tanespimycin  (EXP)
tangeretin  (EXP)
Tanshinone I  (ISO)
taurine  (EXP,ISO)
taurocholic acid  (EXP)
tauroursodeoxycholic acid  (ISO)
telmisartan  (EXP,ISO)
tenofovir disoproxil fumarate  (EXP)
tephrosin  (ISO)
terbutylazine  (ISO)
tert-butanol  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
tetrachloro-1,4-benzoquinone  (ISO)
tetrachloromethane  (EXP,ISO)
tetrahydrocurcumin  (ISO)
tetramethylpyrazine  (EXP,ISO)
thalidomide  (EXP)
thallium  (EXP)
Theaflavin 3,3'-digallate  (EXP)
theophylline  (EXP)
thiacloprid  (EXP)
thiamethoxam  (EXP,ISO)
thioacetamide  (EXP,ISO)
thiopental  (EXP)
thiourea  (ISO)
thyroxine  (EXP)
Tiopronin  (EXP)
tiquizium bromide  (EXP)
Tiron  (EXP)
titanium atom  (ISO)
titanium dioxide  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
topiramate  (EXP)
trans-caffeic acid  (EXP,ISO)
trans-chalcone  (ISO)
trans-isoeugenol  (ISO)
trazodone  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triciribine  (EXP)
triclosan  (ISO)
trimethyltin  (ISO)
trioxsalen  (ISO)
triptonide  (ISO)
triptorelin  (EXP)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
Tropicamide  (EXP)
trovafloxacin  (ISO)
tungsten  (EXP)
tunicamycin  (ISO)
U-73122  (ISO)
ubiquinone-0  (ISO)
uranium atom  (EXP)
urethane  (EXP)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (ISO)
usnic acid  (EXP,ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vanadium atom  (EXP,ISO)
vanadium(0)  (EXP,ISO)
vancomycin  (ISO)
vanillin  (EXP)
veliparib  (ISO)
Vicanicin  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
Vitisin A  (ISO)
vorinostat  (ISO)
water  (ISO)
WIN 55212-2  (EXP)
withaferin A  (EXP)
wogonin  (EXP,ISO)
wortmannin  (EXP,ISO)
xanthohumol  (EXP)
xanthones  (ISO)
Y-27632  (EXP,ISO)
yohimbine  (EXP)
Z-Val-Phe-H  (ISO)
zerumbone  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc molecular entity  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP,ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP)
zoledronic acid  (ISO)
zolmitriptan  (EXP)
zonisamide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
arginine catabolic process  (IBA,IEA,ISO)
blood vessel remodeling  (IMP)
cellular response to cytokine stimulus  (IDA)
cellular response to interleukin-1  (IEP)
cellular response to lipopolysaccharide  (IEA,IEP,ISO)
cellular response to lithium ion  (IEP)
cellular response to organic cyclic compound  (IDA)
cellular response to redox state  (IEP)
cellular response to tumor necrosis factor  (IEP)
cellular response to type II interferon  (IEA,ISO)
cellular response to vitamin D  (IEP)
cellular response to xenobiotic stimulus  (IEA,ISO)
cGMP-mediated signaling  (IDA)
circadian rhythm  (IEA,ISO)
defense response to bacterium  (IBA,IEA,ISO,ISS)
defense response to Gram-negative bacterium  (IEP)
endothelial cell proliferation  (IEP)
G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger  (IDA)
glycoside metabolic process  (IEP)
inflammatory response  (IBA)
intracellular signal transduction  (IMP)
negative regulation of blood pressure  (IBA)
negative regulation of gene expression  (IEA,ISO)
negative regulation of protein catabolic process  (IEA,ISO)
nitric oxide biosynthetic process  (IBA,IDA,IEA,ISO,TAS)
nitric oxide mediated signal transduction  (IBA)
ovulation from ovarian follicle  (ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of interleukin-6 production  (IEA,ISO,ISS)
positive regulation of interleukin-8 production  (IEA,ISO,ISS)
positive regulation of killing of cells of another organism  (IEA,ISO)
prostaglandin secretion  (IEA,ISO,ISS)
regulation of blood pressure  (IMP)
regulation of cell population proliferation  (IEA,ISO)
regulation of cytokine production involved in inflammatory response  (IEA,ISO,ISS)
regulation of insulin secretion  (IEA,ISO)
response to activity  (IEP)
response to bacterium  (ISO)
response to dexamethasone  (IEP)
response to estradiol  (IEP)
response to fructose  (IEP)
response to glucose  (IEP)
response to hormone  (IBA,IEP)
response to hypoxia  (IEA,ISO)
response to immobilization stress  (IEP)
response to lipopolysaccharide  (IBA,IEP,ISO)
response to mechanical stimulus  (IEP)
response to oxygen-glucose deprivation  (IEP)
response to tumor necrosis factor  (IMP)
retinoic acid receptor signaling pathway  (IEP)
superoxide metabolic process  (IEA,ISO,ISS)

Cellular Component
cortical cytoskeleton  (IEA,ISO)
cytoplasm  (IDA,ISO)
cytosol  (IBA,IDA,IEA,ISO)
extracellular space  (IDA)
nucleus  (IBA,IDA)
perinuclear region of cytoplasm  (IDA,IEA,ISO)
peroxisome  (IDA,IEA,ISO)
plasma membrane  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Effects of inducible nitric oxide synthase inhibitors on asthma depending on administration schedule. Abe M, etal., Free Radic Biol Med. 2006 Mar 15;40(6):1083-95. Epub 2005 Nov 21.
2. Complete coding sequence of inducible nitric oxide synthase from human heart and skeletal muscle of patients with chronic heart failure. Adams V, etal., Nitric Oxide. 1998;2(4):242-9.
3. Deletion of UCP2 in iNOS deficient mice reduces the severity of the disease during experimental autoimmune encephalomyelitis. Aheng C, etal., PLoS One. 2011;6(8):e22841. Epub 2011 Aug 8.
4. Immunohistochemical localization of inducible nitric oxide synthase and 3-nitrotyrosine in rat liver tumors induced by N-nitrosodiethylamine. Ahn B, etal., Carcinogenesis. 1999 Jul;20(7):1337-44.
5. Cardiovascular responses and neurotransmitter changes during static muscle contraction following blockade of inducible nitric oxide synthase (iNOS) within the ventrolateral medulla. Ally A, etal., Brain Res. 2006 May 23;1090(1):123-33. Epub 2006 May 2.
6. Cerebral and peripheral changes occurring in nitric oxide (NO) synthesis in a rat model of sleeping sickness: identification of brain iNOS expressing cells. Amrouni D, etal., PLoS One. 2010 Feb 16;5(2):e9211.
7. Biochemical and genetic alterations of oxidant/antioxidant status of the brain in rats treated with dexamethasone: protective roles of melatonin and acetyl-L: -carnitine. Assaf N, etal., J Physiol Biochem. 2011 Oct 11.
8. Insidious role of nitric oxide in migration/invasion of colon cancer cells by upregulating MMP-2/9 via activation of cGMP-PKG-ERK signaling pathways. Babykutty S, etal., Clin Exp Metastasis. 2012 Jun;29(5):471-92. doi: 10.1007/s10585-012-9464-6. Epub 2012 Mar 15.
9. Toll-like receptor 4 and inducible nitric oxide synthase gene polymorphisms are associated with Type 2 diabetes. Bagarolli RA, etal., J Diabetes Complications. 2009 Apr 21.
10. Ammonia reduction with Ornithine phenylacetate restores brain eNOS activity via the DDAH-ADMA pathway in bile duct ligated cirrhotic rats. Balasubramaniyan V, etal., Am J Physiol Gastrointest Liver Physiol. 2011 Sep 8.
11. Isoflurane favorably modulates guanosine triphosphate cyclohydrolase-1 and endothelial nitric oxide synthase during myocardial ischemia and reperfusion injury in rats. Baotic I, etal., Anesthesiology. 2015 Sep;123(3):582-9. doi: 10.1097/ALN.0000000000000778.
12. Association of inducible nitric oxide synthase with asthma severity, total serum immunoglobulin E and blood eosinophil levels. Batra J, etal., Thorax. 2007 Jan;62(1):16-22.
13. p38 MAPK-mediated transcriptional activation of inducible nitric-oxide synthase in glial cells. Roles of nuclear factors, nuclear factor kappa B, cAMP response element-binding protein, CCAAT/enhancer-binding protein-beta, and activating transcription factor-2. Bhat NR, etal., J Biol Chem 2002 Aug 16;277(33):29584-92.
14. Role of nitric oxide synthases in elastase-induced emphysema. Boyer L, etal., Lab Invest. 2010 Oct 18.
15. Arginase inhibition in airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin. Bratt JM, etal., Toxicol Appl Pharmacol. 2010 Jan 1;242(1):1-8. Epub 2009 Oct 2.
16. Aerosol gene transfer with inducible nitric oxide synthase reduces hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats. Budts W, etal., Circulation. 2000 Dec 5;102(23):2880-5.
17. Cannabinoid-mediated inhibition of inducible nitric oxide production by rat microglial cells: evidence for CB1 receptor participation. Cabral GA, etal., Adv Exp Med Biol 2001;493:207-14.
18. Anti-inflammatory effects of low molecular weight heparin derivative in a rat model of carrageenan-induced pleurisy. Ceccarelli M, etal., J Cell Mol Med. 2009 Aug;13(8B):2704-12.
19. Curcumin attenuates airway hyperreactivity induced by ischemia-reperfusion of the pancreas in rats. Chen KH, etal., Transplant Proc. 2010 Apr;42(3):744-7.
20. [Apoptosis related genes--Bcl-2, bax and iNOS, expressed in the olfactory epithelium of mice infected with influenza virus]. Chen Z, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007 Jun;21(11):510-2.
21. Microarray studies on effects of Pneumocystis carinii infection on global gene expression in alveolar macrophages. Cheng BH, etal., BMC Microbiol. 2010 Apr 8;10:103.
22. A crucial role of nitric oxide in acute lung injury secondary to the acute necrotizing pancreatitis. Cheng S, etal., Hum Exp Toxicol. 2010 Apr;29(4):329-37. Epub 2010 Feb 9.
23. Elevated nitric oxide synthase activity concurrent with antigen-induced airway hyperresponsiveness in rats. Chiba Y, etal., Exp Lung Res. 2000 Oct-Nov;26(7):535-49.
24. Expression of nitric oxide synthase and aquaporin-3 in cyclophosphamide treated rat bladder. Cho KH, etal., Int Neurourol J. 2010 Oct;14(3):149-56. Epub 2010 Oct 31.
25. Lymphatic-borne IL-1beta and the inducible isoform of nitric oxide synthase trigger the bronchial hyporesponsiveness after intestinal ischema/reperfusion in rats. Coelho FR, etal., Shock. 2007 Dec;28(6):694-9.
26. Implication of TNF-alpha convertase (TACE/ADAM17) in inducible nitric oxide synthase expression and inflammation in an experimental model of colitis. Colon AL, etal., Cytokine 2001 Dec 21;16(6):220-6.
27. NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease. Colton CA, etal., Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12867-72. Epub 2006 Aug 14.
28. Inducible nitric oxide synthase (iNOS) in immune-mediated demyelination and Wallerian degeneration of the rat peripheral nervous system. Conti G, etal., Exp Neurol. 2004 Jun;187(2):350-8.
29. The Neuroprotective Effect of Agmatine After Focal Cerebral Ischemia in Diabetic Rats. Cui H, etal., J Neurosurg Anesthesiol. 2011 Oct 11.
30. Fructose-1,6-bisphosphate inhibits the expression of inducible nitric oxide synthase caused by oxygen-glucose deprivation through the inhibition of glutamate release in rat forebrain slices. Cárdenas A, etal., Naunyn Schmiedebergs Arch Pharmacol. 2000 Sep;362(3):208-12. doi: 10.1007/s002100000286.
31. Upregulation of AT1R and iNOS in the rostral ventrolateral medulla (RVLM) is essential for the sympathetic hyperactivity and hypertension in the 2K-1C Wistar rat model. de Oliveira-Sales EB, etal., Am J Hypertens. 2010 Jul;23(7):708-15. Epub 2010 Apr 1.
32. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. Deng AY and Rapp JP, J Clin Invest 1995 May;95(5):2170-7
33. Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats. Deng Y and Rapp JP, Nat Genet 1992 Jul;1(4):267-72
34. Exhaled NO and iNOS expression in sputum cells of healthy, obese and OSA subjects. Depalo A, etal., J Intern Med. 2008 Jan;263(1):70-8.
35. Retinoic acid inhibits expression of TNF-alpha and iNOS in activated rat microglia. Dheen ST, etal., Glia. 2005 Apr 1;50(1):21-31.
36. Association study of ACE and eNOS single nucleotide polymorphisms with Henoch-Schonlein purpura nephritis. Di B, etal., Mol Med Rep. 2012 Nov;6(5):1171-7. doi: 10.3892/mmr.2012.1032. Epub 2012 Aug 10.
37. Blockade of kinin B(1) receptor reverses plasma fatty acids composition changes and body and tissue fat gain in a rat model of insulin resistance. Dias JP and Couture R, Diabetes Obes Metab. 2011 Oct 24. doi: 10.1111/j.1463-1326.2011.01521.x.
38. The role of NOS in the impairment of spatial memory and damaged neurons in rats injected with amyloid beta 25-35 into the temporal cortex. Diaz A, etal., Pharmacol Biochem Behav. 2010 Dec 14.
39. Dual role of inducible nitric oxide synthase in acute asbestos-induced lung injury. Dorger M, etal., Free Radic Biol Med. 2002 Aug 15;33(4):491-501.
40. Early inflammatory response to asbestos exposure in rat and hamster lungs: role of inducible nitric oxide synthase. Dorger M, etal., Toxicol Appl Pharmacol. 2002 Jun 1;181(2):93-105.
41. Production of nitric oxide by airways neutrophils in the initial phase of murine asthma. Fernandes PD, etal., Int Immunopharmacol. 2007 Jan;7(1):96-102. Epub 2006 Oct 3.
42. The Effect of Combining an ACE Inhibitor and a VDR Activator on Glomerulosclerosis, Proteinuria and Renal Oxidative Stress in Uremic Rats. Finch JL, etal., Am J Physiol Renal Physiol. 2011 Sep 28.
43. Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic cancer. Franco L, etal., Prostaglandins Other Lipid Mediat. 2004 Jan;73(1-2):51-8.
44. High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearance. Frank JA, etal., Am J Physiol Lung Cell Mol Physiol 2003 May;284(5):L791-8.
45. Post-lung transplant bronchiolitis obliterans syndrome (BOS) is characterized by increased exhaled nitric oxide levels and epithelial inducible nitric oxide synthase. Gabbay E, etal., Am J Respir Crit Care Med. 2000 Dec;162(6):2182-7.
46. Cloning and expression of inducible nitric oxide synthase from rat astrocytes. Galea E, etal., J Neurosci Res 1994 Feb 15;37(3):406-14.
47. Multiple organ inflammatory response to portosystemic shunt in the rat. Garcia C, etal., Cytokine. 2011 Oct 3.
48. Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Garrett MR, etal., Genome Res 1998 Jul;8(7):711-23
49. The association of minocycline and the probiotic Escherichia coli Nissle 1917 results in an additive beneficial effect in a DSS model of reactivated colitis in mice. Garrido-Mesa N, etal., Biochem Pharmacol. 2011 Sep 16.
50. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
51. Evidence for a functional nitric oxide synthase system in brown adipocyte nucleus. Giordano A, etal., FEBS Lett. 2002 Mar 13;514(2-3):135-40.
52. Nitric oxide signaling via nuclearized endothelial nitric-oxide synthase modulates expression of the immediate early genes iNOS and mPGES-1. Gobeil F Jr, etal., J Biol Chem. 2006 Jun 9;281(23):16058-67. Epub 2006 Mar 30.
53. Persistent Cryptococcus neoformans pulmonary infection in the rat is associated with intracellular parasitism, decreased inducible nitric oxide synthase expression, and altered antibody responsiveness to cryptococcal polysaccharide. Goldman DL, etal., Infect Immun. 2000 Feb;68(2):832-8.
54. Overexpression of inducible nitric oxide synthase and cyclooxygenase-2 in rat zinc-deficient lung: Involvement of a NF-kappaB dependent pathway. Gomez NN, etal., Nitric Oxide. 2006 Feb;14(1):30-8. Epub 2005 Oct 26.
55. Evaluation of Nitric Oxide (NO) and Nitric Oxide Synthases (NOS) in the Amniotic Fluid in an Experimental Gastroschisis Rat Model. Goncalves FL, etal., Eur J Pediatr Surg. 2011 Sep 29.
56. Anti-inflammatory activities and mechanisms of action of the petroleum ether fraction of Rosa multiflora Thunb. hips. Guo D, etal., J Ethnopharmacol. 2011 Oct 13.
57. Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes. Guo H, etal., Am J Physiol Cell Physiol 2003 Apr;284(4):C1090-9.
58. Attenuation of cAMP accumulation in adult rat cardiac fibroblasts by IL-1beta and NO: role of cGMP-stimulated PDE2. Gustafsson AB and Brunton LL, Am J Physiol Cell Physiol 2002 Aug;283(2):C463-71.
59. Pulmonary vascular iNOS induction participates in the onset of chronic hypoxic pulmonary hypertension. Hampl V, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L11-20. Epub 2005 Aug 19.
60. Antibacterial and Anti-inflammatory Activity of Traditional Chinese Herb Pairs, Angelica sinensis and Sophora flavescens. Han C and Guo J, Inflammation. 2011 Oct 6.
61. Selective modulation of endogenous nitric oxide formation in ischemia/reperfusion injury in isolated rat hearts--effects on regional myocardial flow and enzyme release. Han H, etal., Basic Res Cardiol. 2003 May;98(3):165-74.
62. Glucagon regulates hepatic inducible nitric oxide synthesis in vivo. Harbrecht BG, etal., Shock. 2004 Aug;22(2):157-62.
63. Nitric oxide synthases in infants and children with pulmonary hypertension and congenital heart disease. Hoehn T, etal., Respir Res. 2009 Nov 13;10:110.
64. Analysis of the inducible nitric oxide synthase gene polymorphisms in Czech patients with atopic diseases. Holla LI, etal., Clin Exp Allergy. 2006 Dec;36(12):1592-601.
65. Effect of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. leaf and MAPK signal transduction pathway on inducible nitric oxide synthase expression in alveolar macrophage of chronic bronchitis rats. Huang Y, etal., Am J Chin Med. 2009;37(6):1099-111.
66. Oxidative injury due to chronic nitric oxide synthase inhibition in rat: effect of regular exercise on the heart. Husain K and Hazelrigg SR, Biochim Biophys Acta 2002 May 21;1587(1):75-82.
67. Heat shock regulates the respiration of cardiac H9c2 cells through upregulation of nitric oxide synthase. Ilangovan G, etal., Am J Physiol Cell Physiol. 2004 Nov;287(5):C1472-81.
68. Oleuropein aglycone, an olive oil compound, ameliorates development of arthritis caused by injection of collagen type II in the mice. Impellizzeri D, etal., J Pharmacol Exp Ther. 2011 Aug 31.
69. Expression of nitric oxide synthase, aquaporin 1 and aquaporin 5 in rat after bleomycin inhalation. Jang AS, etal., Intensive Care Med. 2004 Mar;30(3):489-95. Epub 2004 Feb 6.
70. Inducible nitric oxide synthase expression of tumor and stromal cells is associated with the progression of 7,12-dimethylbenzanthracene-induced rat mammary tumors. Jang TJ and Kim DK, Cancer Lett 2002 Aug 28;182(2):121-6.
71. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. Janssen R, etal., J Infect Dis. 2007 Sep 15;196(6):826-34. Epub 2007 Aug 10.
72. Enhanced antiviral antibody secretion and attenuated immunopathology during influenza virus infection in nitric oxide synthase-2-deficient mice. Jayasekera JP, etal., J Gen Virol. 2006 Nov;87(Pt 11):3361-71.
73. Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea. Jelic S, etal., Circulation. 2008 Apr 29;117(17):2270-8. Epub 2008 Apr 14.
74. Angiotensin II differentially regulates interleukin-1-beta-inducible NO synthase (iNOS) and vascular cell adhesion molecule-1 (VCAM-1) expression: role of p38 MAPK. Jiang B, etal., J Biol Chem. 2004 May 7;279(19):20363-8. Epub 2004 Mar 3.
75. iNOS regulation by calcium/calmodulin-dependent protein kinase II in vascular smooth muscle. Jones RJ, etal., Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2634-42. Epub 2007 Feb 9.
76. Cloning and expression of cytokine-inducible nitric oxide synthase cDNA from rat islets of Langerhans. Karlsen AE, etal., Diabetes 1995 Jul;44(7):753-8.
77. Expression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic adenocarcinoma: correlation with microvessel density. Kasper HU, etal., World J Gastroenterol. 2004 Jul 1;10(13):1918-22.
78. NOS2 polymorphisms associated with the susceptibility to pulmonary arterial hypertension with systemic sclerosis: contribution to the transcriptional activity. Kawaguchi Y, etal., Arthritis Res Ther. 2006;8(4):R104.
79. Superoxide dismutase analog (Tempol: 4-hydroxy-2, 2, 6, 6-tetramethylpiperidine 1-oxyl) treatment restores erectile function in diabetes-induced impotence. Kawakami T, etal., Int J Impot Res. 2009 Jun 25.
80. Influence of N-methyl-D-aspartate receptors on ouabain activation of nuclear factor-kappaB in the rat hippocampus. Kawamoto EM, etal., J Neurosci Res. 2011 Oct 18. doi: 10.1002/jnr.22745.
81. Endothelial dysfunction in the early- and late-stage type-2 diabetic Goto-Kakizaki rat aorta. Kazuyama E, etal., Mol Cell Biochem. 2009 Jun 20.
82. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
83. Inhibition of endothelin-1-mediated up-regulation of iNOS by bosentan ameliorates endotoxin-induced liver injury in cirrhosis. Keller S, etal., Shock. 2006 Mar;25(3):306-13.
84. Corticosteroids affect nitric oxide generation, total free radicals production, and nitric oxide synthase activity in monocytes of asthmatic patients. Khanduja KL, etal., Mol Cell Biochem. 2011 Jan;346(1-2):31-7. Epub 2010 Sep 15.
85. Triamcinolone acetonide prevents enhancement of hypoxia-induced neuronal and inducible nitric oxide synthases in the retinas of rats with oxygen-induced retinopathy. Kim SJ, etal., Korean J Ophthalmol. 2012 Dec;26(6):455-61. doi: 10.3341/kjo.2012.26.6.455. Epub 2012 Nov 12.
86. Overexpression of inducible nitric oxide synthase in the kidney of the spontaneously hypertensive rat. Kumar U, etal., Clin Exp Hypertens. 2005 Jan;27(1):17-31.
87. Antioxidative and anti-inflammatory effects of phenolic compounds from the roots of Ulmus macrocarpa. Kwon JH, etal., Arch Pharm Res. 2011 Sep;34(9):1459-66. Epub 2011 Oct 6.
88. Inducible nitric oxide synthase, but not xanthine oxidase, is highly expressed in interstitial pneumonias and granulomatous diseases of human lung. Lakari E, etal., Am J Clin Pathol. 2002 Jan;117(1):132-42.
89. Specific inhibition of nitric oxide synthases at different time points in a murine model of pulmonary sepsis. Lange M, etal., Biochem Biophys Res Commun. 2010 Dec 22.
90. Defective Nitric Oxide Production by Alveolar Macrophages during Pneumocystis Pneumonia. Lasbury ME, etal., Am J Respir Cell Mol Biol. 2010 Jun 17.
91. Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in Mdr2-/- mice. Latasa MU, etal., PLoS One. 2010 Dec 29;5(12):e15690. doi: 10.1371/journal.pone.0015690.
92. Regulation of Sertoli-germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)/beta-catenin (CATNB) signaling pathway: an in vitro and in vivo study. Lee NP, etal., Biol Reprod. 2005 Sep;73(3):458-71. Epub 2005 Apr 27.
93. Suppression of hepatic cytochrome p450-mediated drug metabolism during the late stage of sepsis in rats. Lee SH and Lee SM, Shock. 2005 Feb;23(2):144-9.
94. Role of nitric oxide in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice. Lee YS, etal., J Virol. 2009 Aug;83(16):8004-11. Epub 2009 Jun 17.
95. Importance of cytokines, nitric oxide, and apoptosis in the pathological process of necrotizing pancreatitis in rats. Leindler L, etal., Pancreas. 2004 Aug;29(2):157-61.
96. Role of inducible nitric oxide synthase pathway on methotrexate-induced intestinal mucositis in rodents. Leitao RF, etal., BMC Gastroenterol. 2011 Aug 16;11:90.
97. Lack of association between NOS2 pentanucleotide repeat polymorphism and asthma phenotypes or exhaled nitric oxide concentration. Leung TF, etal., Pediatr Pulmonol. 2006 Jul;41(7):649-55.
98. Reciprocal regulation between proinflammatory cytokine-induced iNOS and connexin43 in bladder smooth muscle cells. Li K, etal., J Biol Chem. 2011 Sep 29.
99. Nitric oxide synthase and intermittent hypoxia-induced spatial learning deficits in the rat. Li RC, etal., Neurobiol Dis. 2004 Oct;17(1):44-53.
100. Ischemia and reperfusion of liver induces eNOS and iNOS expression: effects of a NO donor and NOS inhibitor. Lin HI, etal., Chin J Physiol. 2004 Sep 30;47(3):121-7.
101. Formaldehyde induces lung inflammation by an oxidant and antioxidant enzymes mediated mechanism in the lung tissue. Lino-dos-Santos-Franco A, etal., Toxicol Lett. 2011 Dec 15;207(3):278-85. doi: 10.1016/j.toxlet.2011.09.026. Epub 2011 Oct 1.
102. Expression of VEGF, iNOS, and eNOS is increased in cochlea of diabetic rat. Liu F, etal., Acta Otolaryngol. 2008 Apr 14:1-9.
103. Contribution of nitric oxide to the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats. Liu H, etal., Gastroenterology. 2000 May;118(5):937-44.
104. Increased nitric oxide synthase expression in aorta of cirrhotic rats. Liu H, etal., Life Sci. 1999;64(19):1753-9.
105. Hemorrhagic shock-induced vascular hyporeactivity in the rat: relationship to gene expression of nitric oxide synthase, endothelin-1, and select cytokines in corresponding organs. Liu LM and Dubick MA, J Surg Res. 2005 May 15;125(2):128-36.
106. Activation of Liver X Receptors Attenuates Endotoxin-Induced Liver Injury in Mice with Nonalcoholic Fatty Liver Disease. Liu Y, etal., Dig Dis Sci. 2011 Sep 23.
107. Monomeric inducible nitric oxide synthase localizes to peroxisomes in hepatocytes. Loughran PA, etal., Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13837-42. Epub 2005 Sep 19.
108. Role of neuronal nitric oxide synthase and inducible nitric oxide synthase in intestinal injury in neonatal rats. Lu H, etal., World J Gastroenterol. 2006 Jul 21;12(27):4364-8.
109. Protective Effects of Ulinastatin on Acute Liver Failure Induced by Lipopolysaccharide/D: -Galactosamine. Lu J, etal., Dig Dis Sci. 2011 Oct 15.
110. Expression of iNOS mRNA associated with suppression of colonic contraction in rat colitis. Lundberg S, etal., Acta Physiol (Oxf). 2006 Aug;187(4):489-94.
111. JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Lv N, etal., Exp Cell Res. 2009 Jul 15;315(12):2064-71. doi: 10.1016/j.yexcr.2009.04.021. Epub 2009 May 3.
112. Aberrant expression of NOS isoforms in Alzheimer's disease is structurally related to nitrotyrosine formation. Lüth HJ, etal., Brain Res. 2002 Oct 25;953(1-2):135-43.
113. Simvastatin attenuates expression of cytokine-inducible nitric-oxide synthase in embryonic cardiac myoblasts. Madonna R, etal., J Biol Chem. 2005 Apr 8;280(14):13503-11. Epub 2005 Feb 10.
114. Decreased haem oxygenase-1 and increased inducible nitric oxide synthase in the lung of severe COPD patients. Maestrelli P, etal., Eur Respir J. 2003 Jun;21(6):971-6.
115. Mangiferin decreases inflammation and oxidative damage in rat brain after stress. Marquez L, etal., Eur J Nutr. 2011 Oct 7.
116. Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia. Marriott HM, etal., J Immunol. 2006 Nov 1;177(9):6480-8.
117. IL-10 receptor and coreceptor expression in quiescent and activated hepatic stellate cells. Mathurin P, etal., Am J Physiol Gastrointest Liver Physiol 2002 Jun;282(6):G981-90.
118. Inducible nitric oxide synthase and blood pressure. Mattson DL, etal., Hypertension 1998 Jan;31(1):15-20.
119. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
120. Inducible NO synthase expression is low in airway epithelium from young children with cystic fibrosis. Moeller A, etal., Thorax. 2006 Jun;61(6):514-20. Epub 2006 Mar 3.
121. Regulation of the urea cycle enzyme genes in nitric oxide synthesis. Mori M, etal., J Inherit Metab Dis. 1998;21 Suppl 1:59-71.
122. Selective Inhibition of Protein Kinase C {beta}2 Attenuates Inducible Nitric Oxide Synthase Mediated Cardiovascular Abnormalities in Streptozotocin -Diabetic Rats. Nagareddy PR, etal., Diabetes. 2009 Jul 8.
123. Effects of lithium on lipopolysaccharide-induced inflammation in rat primary glia cells. Nahman S, etal., Innate Immun. 2011 Oct 12.
124. Changes in nitric oxide and expression of nitric oxide synthase in spinal cord after acute traumatic injury in rats. Nakahara S, etal., J Neurotrauma 2002 Nov;19(11):1467-74.
125. Transient ischemia-induced paresis and complete paraplegia displayed distinct reactions of microglia and macrophages. Nakata T, etal., Brain Res. 2011 Sep 8.
126. TNF-alpha modulates iNOS expression in an experimental rat model of indomethacin-induced jejunoileitis. Nandi J, etal., Mol Cell Biochem. 2010 Mar;336(1-2):17-24. Epub 2009 Oct 3.
127. Reciprocal regulation of iNOS and PARP-1 during allergen-induced eosinophilia. Naura AS, etal., Eur Respir J. 2009 Feb;33(2):252-62. Epub 2008 Oct 1.
128. Requirement for inducible nitric oxide synthase in chronic allergen exposure-induced pulmonary fibrosis but not inflammation. Naura AS, etal., J Immunol. 2010 Sep 1;185(5):3076-85. Epub 2010 Jul 28.
129. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
130. Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-kappaB. Nishida M, etal., Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6662-7. doi: 10.1073/pnas.1017640108. Epub 2011 Apr 4.
131. Relationship between inducible nitric oxide synthase expression and angiogenesis in primary gallbladder carcinoma tissue. Niu XJ, etal., World J Gastroenterol. 2004 Mar 1;10(5):725-8.
132. Neuronal expression of inducible nitric oxide synthase in hypothyroid rat. NO_AUTHOR Neuro Endocrinol Lett. 2010 Dec 5;31(6).
133. Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma. North ML, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L911-20. Epub 2009 Mar 13.
134. Vitamin D and calcium co-therapy mitigates pre-established cadmium nephropathy by regulating renal calcium homeostatic molecules and improving anti-oxidative and anti-inflammatory activities in rat. Obaid AA, etal., J Trace Elem Med Biol. 2023 May 24;79:127221. doi: 10.1016/j.jtemb.2023.127221.
135. Expression of nitric oxide synthases in nasal mucosa from a mouse model of allergic rhinitis. Oh SJ, etal., Ann Otol Rhinol Laryngol. 2003 Oct;112(10):899-903.
136. Suppressed expression of GTP cyclohydrolase I mRNA and accelerated expression of inducible nitric oxide synthase mRNA in endomyocardial biopsy specimens from patients with dilated cardiomyopathy. Ohtsuki M, etal., Clin Chim Acta. 2005 Mar;353(1-2):103-7. doi: 10.1016/j.cccn.2004.10.004.
137. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
138. A conserved aspartate (Asp-1393) regulates NADPH reduction of neuronal nitric-oxide synthase: implications for catalysis. Panda K, etal., J Biol Chem 2004 Apr 30;279(18):18323-33. Epub 2004 Feb 13.
139. Evaluation of Morroniside, Iridoid Glycoside from Corni Fructus, on Diabetes-Induced Alterations such as Oxidative Stress, Inflammation, and Apoptosis in the Liver of Type 2 Diabetic db/db Mice. Park CH, etal., Biol Pharm Bull. 2011;34(10):1559-65.
140. (CCTTT)n polymorphism of NOS2A in nasal polyposis and asthma: a case-control study. Pascual M, etal., J Investig Allergol Clin Immunol. 2008;18(4):239-44.
141. Upregulation of iNOS expression and phosphorylation of eIF-2alpha are paralleled by suppression of protein synthesis in rat hypothalamus in a closed head trauma model. Petrov T, etal., J Neurotrauma. 2001 Aug;18(8):799-812.
142. Nitrative and oxidative DNA damage in intrahepatic cholangiocarcinoma patients in relation to tumor invasion. Pinlaor S, etal., World J Gastroenterol. 2005 Aug 14;11(30):4644-9.
143. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
144. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
145. Upregulation of the production of interferon-gamma and the gene expression of the inducible nitric oxide synthase after excimer laser ablation in rat corneas. Prada J and Ngo-Tu T, Clin Experiment Ophthalmol. 2011 Apr;39(3):277-9. doi: 10.1111/j.1442-9071.2010.02451.x.
146. Systemic L-Citrulline Prevents Cerebral Vasospasm in Haptoglobin 2-2 Transgenic Mice After Subarachnoid Hemorrhage. Pradilla G, etal., Neurosurgery. 2011 Sep 12.
147. Effect of nitric oxide synthase (NOS) inhibition on macro- and microcirculation in a model of rat endotoxic shock. Pullamsetti SS, etal., Thromb Haemost. 2006 Apr;95(4):720-7.
148. Immunosuppressants accelerate microvascular thrombus formation in vivo: Role of endothelial cell activation. Puschel A, etal., Surgery. 2011 Oct 22.
149. Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke. Raza SS, etal., Brain Res. 2011 Aug 27.
150. GOA pipeline RGD automated data pipeline
151. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
152. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
153. Effect of exogenous melatonin on hepatic energetic status during ischemia/reperfusion: possible role of tumor necrosis factor-alpha and nitric oxide. Rodriguez-Reynoso S, etal., J Surg Res. 2001 Oct;100(2):141-9.
154. Anti-inflammatory effects of celecoxib in rat lungs with smoke-induced emphysema. Roh GS, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Aug;299(2):L184-91. Epub 2010 May 14.
155. A microarray study of gene expression profiles in nasal polyps. Rostkowska-Nadolska B, etal., Auris Nasus Larynx. 2011 Feb;38(1):58-64. Epub 2010 Jun 15.
156. Chromosome 17 and the inducible nitric oxide synthase gene in human essential hypertension. Rutherford S, etal., Hum Genet 2001 Oct;109(4):408-15.
157. Spleen tyrosine kinase promotes acute neutrophil-mediated glomerular injury via activation of JNK and p38 MAPK in rat nephrotoxic serum nephritis. Ryan J, etal., Lab Invest. 2011 Dec;91(12):1727-38. doi: 10.1038/labinvest.2011.137. Epub 2011 Sep 5.
158. Nitric oxide synthase localization in the rat neutrophils: immunocytochemical, molecular, and biochemical studies. Saini R, etal., J Leukoc Biol. 2006 Mar;79(3):519-28. Epub 2005 Dec 30.
159. Pulmonary expression of iNOS and HO-1 protein is upregulated in a rat model of prehepatic portal hypertension. Schroeder RA, etal., Dig Dis Sci. 2000 Dec;45(12):2405-10.
160. Inducible NOS Inhibition Reverses Tobacco-Smoke-Induced Emphysema and Pulmonary Hypertension in Mice. Seimetz M, etal., Cell. 2011 Oct 14;147(2):293-305.
161. Expression of inducible nitric oxide synthase and its involvement in pulmonary granulomatous inflammation in rats. Setoguchi K, etal., Am J Pathol. 1996 Dec;149(6):2005-22.
162. Role of angiotensin II on dihydrofolate reductase, GTP-cyclohydrolase 1 and nitric oxide synthase expressions in renal ischemia-reperfusion. Seujange Y, etal., Am J Nephrol. 2008;28(4):692-700. doi: 10.1159/000126927. Epub 2008 Apr 11.
163. Pulmonary hypertension in human newborns with congenital diaphragmatic hernia is associated with decreased vascular expression of nitric-oxide synthase. Shehata SM, etal., Cell Biochem Biophys. 2006;44(1):147-55.
164. Role of inducible nitric oxide synthase on the development of virus-associated asthma exacerbation which is dependent on Th1 and Th17 cell responses. Shin TS, etal., Exp Mol Med. 2010 Oct 31;42(10):721-30.
165. Liver-specific Inducible Nitric-oxide Synthase Expression Is Sufficient to Cause Hepatic Insulin Resistance and Mild Hyperglycemia in Mice. Shinozaki S, etal., J Biol Chem. 2011 Oct 7;286(40):34959-75. Epub 2011 Aug 16.
166. PGE1-induced NO reduces apoptosis by D-galactosamine through attenuation of NF-kappaB and NOS-2 expression in rat hepatocytes. Siendones E, etal., Hepatology. 2004 Dec;40(6):1295-303.
167. Relationship between iNOS expression and aortic cell proliferation and apoptosis in an elastase-induced model of aorta aneurysm and the effect of 1400 W administration. Sigala F, etal., Surgery. 2005 Apr;137(4):447-56.
168. Intrauterine growth restriction and shallower implantation site in rats with maternal hyperinsulinemia are associated with altered NOS expression. Skarzinski G, etal., Placenta. 2009 Oct;30(10):898-906. Epub 2009 Aug 25.
169. Fructose-1,6-bisphosphate after hypoxic ischemic injury is protective to the neonatal rat brain. Sola A, etal., Brain Res. 1996 Nov 25;741(1-2):294-9. doi: 10.1016/s0006-8993(96)00984-5.
170. Relative contributions of advanced glycation and nitric oxide synthase inhibition to aminoguanidine-mediated renoprotection in diabetic rats. Soulis T, etal., Diabetologia. 1997 Oct;40(10):1141-51.
171. Peroxisomal localization of inducible nitric oxide synthase in hepatocytes. Stolz DB, etal., Hepatology. 2002 Jul;36(1):81-93.
172. Inhibition of inducible nitric oxide synthase attenuates acute endotoxin-induced lung injury in rats. Su CF, etal., Clin Exp Pharmacol Physiol. 2007 Apr;34(4):339-46.
173. Induction of NOS and nitrotyrosine expression in the rat striatum following experimental hepatic encephalopathy. Suarez I, etal., Metab Brain Dis. 2009 Sep;24(3):395-408.
174. Regulation of inducible nitric oxide synthase activity/expression in rat hearts from ghrelin-treated rats. Sudar E, etal., J Physiol Biochem. 2010 Nov 24.
175. Prevention of neural tube defects by loss of function of inducible nitric oxide synthase in fetuses of a mouse model of streptozotocin-induced diabetes. Sugimura Y, etal., Diabetologia. 2009 May;52(5):962-71. Epub 2009 Mar 13.
176. Inducible nitric oxide synthase plays a role in LPS-induced hyperglycemia and insulin resistance. Sugita H, etal., Am J Physiol Endocrinol Metab 2002 Feb;282(2):E386-94.
177. Site- and cell-type- specific induction of intestinal inducible nitric oxide synthase in a rat model of endotoxemia. Takahashi T, etal., Med Chem. 2005 Nov;1(6):643-7.
178. Transiently, paralleled upregulation of arginase and nitric oxide synthase and the effect of both enzymes on the pathology of asthma. Takemoto K, etal., Am J Physiol Lung Cell Mol Physiol. 2007 Dec;293(6):L1419-26. Epub 2007 Sep 21.
179. Subcellular distribution of nitric oxide synthase isoforms in the rat duodenum. Talapka P, etal., World J Gastroenterol. 2011 Feb 28;17(8):1026-9.
180. Vascular contribution of adrenomedullin to microcirculatory improvement in experimental colitis. Talero E, etal., Eur J Pharmacol. 2011 Sep 19.
181. Orthodontic force stimulates eNOS and iNOS in rat osteocytes. Tan SD, etal., J Dent Res. 2009 Mar;88(3):255-60.
182. Bromocriptine methylate suppresses glial inflammation and moderates disease progression in a mouse model of amyotrophic lateral sclerosis. Tanaka K, etal., Exp Neurol. 2011 Nov;232(1):41-52. Epub 2011 Aug 16.
183. Diacerhein improves glucose tolerance and insulin sensitivity in mice on a high-fat diet. Tobar N, etal., Endocrinology. 2011 Nov;152(11):4080-93. Epub 2011 Sep 6.
184. Differential expression of cytokine genes and iNOS induced by nonviable nontypeable Haemophilus influenzae or its LOS mutants during acute otitis media in the rat. Tong HH, etal., Int J Pediatr Otorhinolaryngol. 2008 Aug;72(8):1183-91. Epub 2008 Jun 3.
185. Preventive and therapeutic effects of caffeic acid against inflammatory injury in striatum of MPTP-treated mice. Tsai SJ, etal., Eur J Pharmacol. 2011 Sep 29.
186. Beneficial effects of magnolol in a rodent model of endotoxin shock. Tsai YC, etal., Eur J Pharmacol. 2010 Sep 1;641(1):67-73. Epub 2010 May 25.
187. Donor simvastatin treatment abolishes rat cardiac allograft ischemia/reperfusion injury and chronic rejection through microvascular protection. Tuuminen R, etal., Circulation. 2011 Sep 6;124(10):1138-50. Epub 2011 Aug 15.
188. Inducible nitric oxide synthase gene deficiency counteracts multiple manifestations of peripheral neuropathy in a streptozotocin-induced mouse model of diabetes. Vareniuk I, etal., Diabetologia. 2008 Nov;51(11):2126-33. Epub 2008 Sep 19.
189. NOS2A, TLR4, and IFNGR1 interactions influence pulmonary tuberculosis susceptibility in African-Americans. Velez DR, etal., Hum Genet. 2009 Nov;126(5):643-53. Epub 2009 Jul 3.
190. Dynamics of neuroinflammation in the macrosphere model of arterio-arterial embolic focal ischemia: an approximation to human stroke patterns. Walberer M, etal., Exp Transl Stroke Med. 2010 Dec 20;2(1):22.
191. Intact nitric oxide synthase II gene is required for interferon-beta-mediated suppression of growth and metastasis of pancreatic adenocarcinoma. Wang B, etal., Cancer Res. 2001 Jan 1;61(1):71-5.
192. Genetic disruption of host interferon-gamma drastically enhances the metastasis of pancreatic adenocarcinoma through impaired expression of inducible nitric oxide synthase. Wang B, etal., Oncogene. 2001 Oct 18;20(47):6930-7.
193. A novel model system for studying the double-edged roles of nitric oxide production in pancreatic cancer growth and metastasis. Wang B, etal., Oncogene. 2003 Mar 27;22(12):1771-82.
194. Anti-inflammation effects of corn silk in a rat model of carrageenin-induced pleurisy. Wang GQ, etal., Inflammation. 2012 Jun;35(3):822-7.
195. Expression and role of inducible nitric oxide synthase in ischemia-reperfusion liver in rats. Wang LM, etal., Hepatobiliary Pancreat Dis Int. 2003 May;2(2):252-8.
196. [Effect of 17beta-estradiol on myocardial inducible NOS and endothelial NOS activities after ischemia-reperfusion in rat heart model]. Wang XD, etal., Zhonghua Yi Xue Za Zhi. 2007 Jul 3;87(25):1789-91.
197. (Z)2-(5-(4-methoxybenzylidene)-2, 4-dioxothiazolidin-3-yl) acetic acid protects rats from CCl(4) -induced liver injury. Wang ZL, etal., J Gastroenterol Hepatol. 2012 May;27(5):966-73. doi: 10.1111/j.1440-1746.2011.06913.x.
198. Increased nitric oxide production and GFAP expression in the brains of influenza A/NWS virus infected mice. Watanabe C, etal., Neurochem Res. 2008 Jun;33(6):1017-23. Epub 2007 Dec 14.
199. The involvement of glucose metabolism in the regulation of inducible nitric oxide synthase gene expression in glial cells: possible role of glucose-6-phosphate dehydrogenase and CCAAT/enhancing binding protein. Won JS, etal., J Neurosci 2003 Aug 20;23(20):7470-8.
200. iNOS enhances rat intestinal apoptosis after ischemia-reperfusion. Wu B, etal., Free Radic Biol Med. 2002 Sep 1;33(5):649-58.
201. Tetrandrine down-regulates ERK/NF-kappaB signaling and inhibits activation of mesangial cells. Wu CJ, etal., Toxicol In Vitro. 2011 Oct 7.
202. Phosphatidylinositol 3-kinase inhibitor suppresses inducible nitric oxide synthase expression in bronchiole epithelial cells in asthmatic rats. Xia X, etal., Mol Cell Biochem. 2011 Aug 17.
203. The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies. Xu W, etal., Neuroreport 2000 Feb 7;11(2):297-9.
204. Aldose reductase deficiency protects from autoimmune- and endotoxin-induced uveitis in mice. Yadav UC, etal., Invest Ophthalmol Vis Sci. 2011 Oct 17;52(11):8076-85. Print 2011.
205. Accelerated ubiquitination and proteasome degradation of a genetic variant of inducible nitric oxide synthase. Ying WZ and Sanders PW, Biochem J. 2003 Dec 15;376(Pt 3):789-94.
206. Association between the expression of inducible nitric oxide synthase by chondrocytes and its nitric oxide-generating activity in adjuvant arthritis in rats. Yonekura Y, etal., Nitric Oxide 2003 May;8(3):164-9.
207. Enhanced iNOS expression in leukocytes and circulating endothelial cells is associated with the progression of coronary artery lesions in acute Kawasaki disease. Yu X, etal., Pediatr Res. 2004 Apr;55(4):688-94. Epub 2004 Feb 5.
208. Inducible nitric oxide synthase mediates retinal DNA damage in Goto-Kakizaki rat retina. Yuasa I, etal., Jpn J Ophthalmol. 2008 Jul-Aug;52(4):314-22. Epub 2008 Sep 5.
209. Nasal mucosal expression of nitric oxide synthases in patients with allergic rhinitis and its relation to asthma. Yuksel H, etal., Ann Allergy Asthma Immunol. 2008 Jan;100(1):12-6.
210. Cannabinoid Type 2 Receptor Activation Downregulates Stroke-Induced Classic and Alternative Brain Macrophage/Microglial Activation Concomitant to Neuroprotection. Zarruk JG, etal., Stroke. 2011 Oct 20.
211. Role of inducible nitric oxide synthase-derived nitric oxide in silica-induced pulmonary inflammation and fibrosis. Zeidler P, etal., J Toxicol Environ Health A. 2004 Jul 9;67(13):1001-26.
212. Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway. Zhang CL, etal., Int J Biol Sci. 2015 Apr 25;11(6):643-51. doi: 10.7150/ijbs.10785. eCollection 2015.
213. Correlated expression of inducible nitric oxide synthase and P53, Bax in benign and malignant diseased gallbladder. Zhang M, etal., Ann Anat. 2003 Dec;185(6):549-54.
214. Protective effects of IL-4 on Bacillus Calmette-Guerin and lipopolysaccharide induced immunological liver injury in mice. Zhang NN, etal., Inflamm Res. 2011 Sep 24.
215. Lipopolysaccharide induced activin A-follistatin imbalance affects cardiac fibrosis. Zhang WQ, etal., Chin Med J (Engl). 2012 Jun;125(12):2205-12.
216. Osteopontin protects against hyperoxia-induced lung injury by inhibiting nitric oxide synthases. Zhang XF, etal., Chin Med J (Engl). 2010 Apr 5;123(7):929-35.
217. Cooperation of the inducible nitric oxide synthase and cytochrome P450 1A1 in mediating lung inflammation and mutagenicity induced by diesel exhaust particles. Zhao H, etal., Environ Health Perspect. 2006 Aug;114(8):1253-8.
218. iNOS expression in rat aorta is increased after spinal cord transection: a possible cause of orthostatic hypotension in man. Zhao J, etal., Neurosci Lett. 2007 Mar 30;415(3):210-4. Epub 2007 Jan 14.
219. A20-binding inhibitor of NF-{kappa}B (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein {beta} activation and protects from inflammatory disease. Zhou J, etal., Proc Natl Acad Sci U S A. 2011 Oct 19.
220. Down-regulation of renal endothelial nitric oxide synthase expression in experimental glomerular thrombotic microangiopathy. Zhou XJ, etal., Lab Invest. 2000 Jul;80(7):1079-87.
221. 1,25-Dihydroxyvitamin D3 prevented allergic asthma in a rat model by suppressing the expression of inducible nitric oxide synthase. Zhou Y, etal., Allergy Asthma Proc. 2008 May-Jun;29(3):258-67.
222. Extracellular cysteine (Cys)/cystine (CySS) redox regulates metabotropic glutamate receptor 5 activity. Zhu JW, etal., Biochimie. 2011 Sep 22.
Additional References at PubMed
PMID:1383204   PMID:7504305   PMID:7516453   PMID:7519448   PMID:7544003   PMID:7680561   PMID:7682072   PMID:7682706   PMID:7693462   PMID:8383325   PMID:8913516   PMID:9271491  
PMID:9284131   PMID:9535415   PMID:9916929   PMID:10395902   PMID:11606502   PMID:11731407   PMID:11732991   PMID:11744809   PMID:11761337   PMID:11779605   PMID:11781814   PMID:11793955  
PMID:11914582   PMID:11954827   PMID:11976930   PMID:11989973   PMID:12020959   PMID:12097323   PMID:12132579   PMID:12191972   PMID:12381419   PMID:12391089   PMID:12408753   PMID:12473856  
PMID:12514219   PMID:12533773   PMID:12578118   PMID:12597521   PMID:12621123   PMID:12621312   PMID:12624428   PMID:12627879   PMID:12637249   PMID:12646421   PMID:12694879   PMID:12716655  
PMID:12761356   PMID:12789530   PMID:12810568   PMID:12817292   PMID:12853118   PMID:12882997   PMID:12898012   PMID:12918117   PMID:12933833   PMID:12950447   PMID:12954642   PMID:12960105  
PMID:12960352   PMID:14500471   PMID:14522818   PMID:14572769   PMID:14598260   PMID:14622153   PMID:14625460   PMID:14630716   PMID:14656765   PMID:14660484   PMID:14713577   PMID:14988399  
PMID:15005272   PMID:15030977   PMID:15033467   PMID:15033774   PMID:15050899   PMID:15086472   PMID:15094475   PMID:15115662   PMID:15141302   PMID:15193775   PMID:15222038   PMID:15223606  
PMID:15228594   PMID:15234218   PMID:15240426   PMID:15256225   PMID:15333612   PMID:15371096   PMID:15512981   PMID:15518712   PMID:15526382   PMID:15583003   PMID:15591777   PMID:15609089  
PMID:15618882   PMID:15631944   PMID:15637745   PMID:15683716   PMID:15716603   PMID:15740979   PMID:15777779   PMID:15826818   PMID:15869603   PMID:15883033   PMID:15954866   PMID:15978623  
PMID:15994093   PMID:16006547   PMID:16012955   PMID:16020391   PMID:16044358   PMID:16100462   PMID:16115393   PMID:16118472   PMID:16122953   PMID:16129699   PMID:16148131   PMID:16172008  
PMID:16210135   PMID:16213908   PMID:16239401   PMID:16257923   PMID:16309587   PMID:16339820   PMID:16343770   PMID:16373578   PMID:16404609   PMID:16469935   PMID:16484312   PMID:16544099  
PMID:16619262   PMID:16636306   PMID:16680016   PMID:16707097   PMID:16771677   PMID:16771680   PMID:16771681   PMID:16777990   PMID:16864944   PMID:16893173   PMID:16923814   PMID:16935907  
PMID:16938490   PMID:16978658   PMID:16980043   PMID:17009099   PMID:17039356   PMID:17047412   PMID:17049356   PMID:17072978   PMID:17174337   PMID:17216200   PMID:17227955   PMID:17234889  
PMID:17278014   PMID:17318081   PMID:17337591   PMID:17395621   PMID:17428462   PMID:17442632   PMID:17447001   PMID:17487460   PMID:17499222   PMID:17537544   PMID:17561811   PMID:17604059  
PMID:17607161   PMID:17621420   PMID:17658518   PMID:17669705   PMID:17681838   PMID:17721804   PMID:17723228   PMID:17822843   PMID:17850874   PMID:17892518   PMID:17906944   PMID:17916350  
PMID:17928287   PMID:17941794   PMID:17951367   PMID:17959843   PMID:17974582   PMID:17976576   PMID:17994107   PMID:17997045   PMID:18003616   PMID:18004231   PMID:18025219   PMID:18028947  
PMID:18031380   PMID:18063323   PMID:18067590   PMID:18091741   PMID:18096265   PMID:18161049   PMID:18171908   PMID:18205920   PMID:18217711   PMID:18248896   PMID:18261260   PMID:18283562  
PMID:18289732   PMID:18301327   PMID:18313411   PMID:18330484   PMID:18343708   PMID:18358626   PMID:18411229   PMID:18436211   PMID:18465431   PMID:18497305   PMID:18519240   PMID:18555096  
PMID:18579559   PMID:18585382   PMID:18592153   PMID:18633193   PMID:18635878   PMID:18662246   PMID:18677292   PMID:18688715   PMID:18708911   PMID:18753331   PMID:18769055   PMID:18791161  
PMID:18791856   PMID:18805549   PMID:18818569   PMID:18842497   PMID:18927216   PMID:18980714   PMID:19033879   PMID:19084437   PMID:19111870   PMID:19146971   PMID:19323834   PMID:19387904  
PMID:19391111   PMID:19398497   PMID:19412649   PMID:19431205   PMID:19460002   PMID:19513610   PMID:19535378   PMID:19539668   PMID:19588257   PMID:19661445   PMID:19683231   PMID:19688109  
PMID:19741170   PMID:19809194   PMID:19811424   PMID:19841289   PMID:19847761   PMID:19899328   PMID:19915306   PMID:19932725   PMID:19942298   PMID:19958762   PMID:19959193   PMID:20008826  
PMID:20018145   PMID:20034558   PMID:20044475   PMID:20046028   PMID:20052412   PMID:20056078   PMID:20079239   PMID:20083630   PMID:20104578   PMID:20143141   PMID:20155797   PMID:20178365  
PMID:20225207   PMID:20232214   PMID:20378828   PMID:20399619   PMID:20418118   PMID:20430051   PMID:20541824   PMID:20543082   PMID:20543091   PMID:20605598   PMID:20607198   PMID:20643487  
PMID:20649597   PMID:20683700   PMID:20817067   PMID:20853596   PMID:20871153   PMID:20926651   PMID:20970480   PMID:21062286   PMID:21139581   PMID:21158118   PMID:21162919   PMID:21166162  
PMID:21166207   PMID:21171340   PMID:21171372   PMID:21174802   PMID:21193589   PMID:21206533   PMID:21206910   PMID:21207846   PMID:21208419   PMID:21221803   PMID:21354186   PMID:21417589  
PMID:21419083   PMID:21439977   PMID:21443142   PMID:21480981   PMID:21499897   PMID:21539866   PMID:21545834   PMID:21555119   PMID:21559512   PMID:21620800   PMID:21685692   PMID:21693187  
PMID:21700708   PMID:21741974   PMID:21743335   PMID:21751490   PMID:21752327   PMID:21943492   PMID:22004609   PMID:22038823   PMID:22073225   PMID:22160804   PMID:22198001   PMID:22226057  
PMID:22229510   PMID:22339544   PMID:22362050   PMID:22365956   PMID:22391324   PMID:22480838   PMID:22486744   PMID:22493895   PMID:22513471   PMID:22575044   PMID:22638860   PMID:22672990  
PMID:22808474   PMID:22837686   PMID:22860427   PMID:22898625   PMID:22909987   PMID:22941198   PMID:22995863   PMID:23012479   PMID:23086649   PMID:23138875   PMID:23219970   PMID:23250488  
PMID:23306170   PMID:23324998   PMID:23406748   PMID:23406756   PMID:23428131   PMID:23484128   PMID:23515587   PMID:23613625   PMID:23643992   PMID:23665321   PMID:23686852   PMID:23691079  
PMID:23702479   PMID:23737493   PMID:23869893   PMID:23872130   PMID:23953569   PMID:23973463   PMID:23977158   PMID:24014650   PMID:24141017   PMID:24312512   PMID:24372242   PMID:24486487  
PMID:24673524   PMID:24760104   PMID:24768712   PMID:24780316   PMID:24815141   PMID:24815143   PMID:24870610   PMID:25023789   PMID:25038487   PMID:25051763   PMID:25071345   PMID:25095383  
PMID:25150084   PMID:25187725   PMID:25191931   PMID:25216050   PMID:25234194   PMID:25242580   PMID:25272454   PMID:25365698   PMID:25400168   PMID:25404055   PMID:25466668   PMID:25470921  
PMID:25527626   PMID:25562655   PMID:25595132   PMID:25644387   PMID:25687488   PMID:25701093   PMID:25988879   PMID:26046347   PMID:26084225   PMID:26191216   PMID:26378818   PMID:26396497  
PMID:26448619   PMID:26527422   PMID:26600052   PMID:26608376   PMID:26647858   PMID:26663724   PMID:26774797   PMID:26797190   PMID:26821579   PMID:26854976   PMID:26879172   PMID:26924260  
PMID:26927554   PMID:27026409   PMID:27110744   PMID:27116881   PMID:27139232   PMID:27306339   PMID:27371683   PMID:27649096   PMID:27665951   PMID:27832994   PMID:27904147   PMID:27909743  
PMID:28009008   PMID:28025796   PMID:28087117   PMID:28132600   PMID:28231612   PMID:28387444   PMID:28471344   PMID:28505146   PMID:28534083   PMID:28694192   PMID:28707183   PMID:28871498  
PMID:28887183   PMID:28942508   PMID:29023053   PMID:29128398   PMID:29229115   PMID:29308569   PMID:29393230   PMID:29441689   PMID:29451295   PMID:30193054   PMID:30227089   PMID:30447304  
PMID:30736955   PMID:30871034   PMID:30911278   PMID:31463706   PMID:32131490   PMID:32204021   PMID:32497615   PMID:32617655   PMID:32654546   PMID:32676275   PMID:33123916   PMID:33212839  
PMID:34842278   PMID:34923198   PMID:35584107   PMID:36402067   PMID:36513147   PMID:37054808   PMID:37515488   PMID:38095803  


Genomics

Comparative Map Data
Nos2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81064,313,335 - 64,349,221 (+)NCBIGRCr8
mRatBN7.21063,815,308 - 63,851,208 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1063,815,308 - 63,851,210 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1068,445,568 - 68,481,178 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01067,950,910 - 67,986,520 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01063,419,659 - 63,455,435 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01066,188,290 - 66,221,621 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1066,189,786 - 66,313,190 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01065,423,626 - 65,456,957 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41065,036,884 - 65,072,453 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11065,050,519 - 65,086,394 (+)NCBI
Celera1062,790,940 - 62,826,625 (+)NCBICelera
Cytogenetic Map10q25NCBI
NOS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381727,756,766 - 27,800,529 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1727,756,766 - 27,800,529 (-)EnsemblGRCh38hg38GRCh38
GRCh371726,083,792 - 26,127,555 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361723,107,919 - 23,151,682 (-)NCBINCBI36Build 36hg18NCBI36
Build 341723,107,919 - 23,151,682NCBI
Celera1722,945,649 - 22,989,408 (-)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1722,290,738 - 22,334,499 (-)NCBIHuRef
CHM1_11726,146,509 - 26,190,263 (-)NCBICHM1_1
T2T-CHM13v2.01728,698,170 - 28,741,926 (-)NCBIT2T-CHM13v2.0
Nos2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,811,613 - 78,851,052 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1178,811,613 - 78,851,080 (+)EnsemblGRCm39 Ensembl
GRCm381178,920,787 - 78,960,226 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,920,787 - 78,960,254 (+)EnsemblGRCm38mm10GRCm38
MGSCv371178,734,361 - 78,773,626 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361178,737,054 - 78,776,319 (+)NCBIMGSCv36mm8
Celera1188,553,193 - 88,592,780 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.74NCBI
Nos2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554815,201,234 - 5,231,961 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554815,197,957 - 5,232,406 (+)NCBIChiLan1.0ChiLan1.0
NOS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21936,665,413 - 36,702,609 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11738,548,858 - 38,586,077 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01728,984,295 - 29,021,516 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11729,477,285 - 29,519,412 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1729,471,510 - 29,617,093 (+)Ensemblpanpan1.1panPan2
NOS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1942,171,821 - 42,210,217 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl942,171,821 - 42,208,588 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha941,328,978 - 41,365,802 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0942,989,630 - 43,028,666 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl942,989,281 - 43,028,662 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1941,770,831 - 41,807,631 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0942,065,650 - 42,102,448 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0942,142,975 - 42,179,774 (-)NCBIUU_Cfam_GSD_1.0
Nos2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560241,174,060 - 41,203,217 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365384,052,448 - 4,097,051 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365384,052,277 - 4,097,051 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1244,174,948 - 44,218,146 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11244,174,944 - 44,219,875 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21246,022,454 - 46,067,376 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NOS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11621,533,011 - 21,576,645 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1621,533,484 - 21,574,257 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660758,565,314 - 8,606,749 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nos2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624786489,311 - 528,271 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624786491,944 - 530,427 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nos2
952 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:148
Count of miRNA genes:123
Interacting mature miRNAs:132
Transcripts:ENSRNOT00000016133, ENSRNOT00000073138
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105379738566979128Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
1331839Eae18bExperimental allergic encephalomyelitis QTL 18b5.80.03nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)106124830367785171Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631526Bp76Blood pressure QTL 760.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106134541366743655Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat

Markers in Region
D10Mco38  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01066,856,300 - 66,856,515NCBIRnor5.0
Rnor_5.01065,425,266 - 65,425,481NCBIRnor5.0
Rnor_5.01065,339,106 - 65,339,321NCBIRnor5.0
Rnor_5.01066,856,301 - 66,856,515NCBIRnor5.0
Rnor_5.01065,425,266 - 65,425,480NCBIRnor5.0
Rnor_5.01065,339,106 - 65,339,320NCBIRnor5.0
RGSC_v3.41065,121,873 - 65,122,086UniSTSRGSC3.4
RGSC_v3.41065,121,872 - 65,122,086RGDRGSC3.4
RGSC_v3.41065,068,360 - 65,068,574RGDRGSC3.4
RGSC_v3.41065,068,361 - 65,068,574UniSTSRGSC3.4
RGSC_v3.11065,081,983 - 65,082,197RGD
Celera1062,822,533 - 62,822,746UniSTS
Celera1062,872,201 - 62,872,414UniSTS
Cytogenetic Map10q25UniSTS
D10Mco39  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01065,420,852 - 65,421,123NCBIRnor5.0
Rnor_5.01066,861,588 - 66,861,859NCBIRnor5.0
Rnor_5.01065,333,768 - 65,334,045NCBIRnor5.0
RGSC_v3.41065,073,634 - 65,073,904RGDRGSC3.4
RGSC_v3.41065,127,176 - 65,127,452RGDRGSC3.4
RGSC_v3.11065,140,799 - 65,141,075RGD
Cytogenetic Map10q25UniSTS
D10Mco40  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10q25UniSTS
D10Wox24  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21063,813,614 - 63,813,752 (+)MAPPERmRatBN7.2
Rnor_6.01066,186,597 - 66,186,734NCBIRnor6.0
Rnor_5.01065,458,513 - 65,458,650UniSTSRnor5.0
RGSC_v3.41065,035,191 - 65,035,328UniSTSRGSC3.4
Celera1062,789,247 - 62,789,384UniSTS
Cytogenetic Map10q25UniSTS
D10Mco42  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21063,813,395 - 63,813,732 (+)MAPPERmRatBN7.2
Rnor_6.01066,186,378 - 66,186,714NCBIRnor6.0
Rnor_5.01065,458,533 - 65,458,869UniSTSRnor5.0
RGSC_v3.41065,034,972 - 65,035,308UniSTSRGSC3.4
RGSC_v3.11065,048,593 - 65,048,931RGD
Celera1062,789,028 - 62,789,364UniSTS
Cytogenetic Map10q25UniSTS
M84373  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21063,850,817 - 63,851,006 (+)MAPPERmRatBN7.2
mRatBN7.21063,850,817 - 63,851,006 (-)MAPPERmRatBN7.2
mRatBN7.21063,903,954 - 63,904,143 (+)MAPPERmRatBN7.2
Rnor_6.01066,313,290 - 66,313,478NCBIRnor6.0
Rnor_6.01064,763,096 - 64,763,284NCBIRnor6.0
Rnor_5.01065,335,099 - 65,335,287UniSTSRnor5.0
Rnor_5.01066,860,349 - 66,860,537UniSTSRnor5.0
RGSC_v3.41065,072,394 - 65,072,582UniSTSRGSC3.4
RGSC_v3.41065,125,937 - 65,126,125UniSTSRGSC3.4
Celera1062,876,218 - 62,876,406UniSTS
Celera1062,826,566 - 62,826,754UniSTS
Cytogenetic Map10q25UniSTS
D11Bhm163  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21063,828,503 - 63,828,577 (+)MAPPERmRatBN7.2
Rnor_6.01066,290,976 - 66,291,049NCBIRnor6.0
Rnor_6.01066,201,486 - 66,201,559NCBIRnor6.0
Rnor_5.01065,357,528 - 65,357,601UniSTSRnor5.0
Rnor_5.01065,443,688 - 65,443,761UniSTSRnor5.0
RGSC_v3.41065,050,080 - 65,050,153UniSTSRGSC3.4
Celera1062,804,136 - 62,804,209UniSTS
Cytogenetic Map10q25UniSTS
RH132839  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21063,850,974 - 63,851,135 (-)MAPPERmRatBN7.2
mRatBN7.21063,904,111 - 63,904,274 (-)MAPPERmRatBN7.2
mRatBN7.21063,904,111 - 63,904,274 (+)MAPPERmRatBN7.2
Rnor_6.01066,313,447 - 66,313,609NCBIRnor6.0
Rnor_6.01064,762,967 - 64,763,127NCBIRnor6.0
Rnor_5.01065,334,968 - 65,335,130UniSTSRnor5.0
Rnor_5.01066,860,506 - 66,860,666UniSTSRnor5.0
RGSC_v3.41065,072,551 - 65,072,711UniSTSRGSC3.4
RGSC_v3.41065,126,094 - 65,126,256UniSTSRGSC3.4
Celera1062,876,375 - 62,876,537UniSTS
Celera1062,826,723 - 62,826,883UniSTS
Cytogenetic Map10q25UniSTS
RH94571  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21063,903,869 - 63,903,965 (+)MAPPERmRatBN7.2
mRatBN7.21063,850,733 - 63,850,828 (-)MAPPERmRatBN7.2
mRatBN7.21063,903,869 - 63,903,965 (-)MAPPERmRatBN7.2
mRatBN7.21063,850,733 - 63,850,828 (+)MAPPERmRatBN7.2
Rnor_6.01064,763,274 - 64,763,368NCBIRnor6.0
Rnor_6.01066,313,206 - 66,313,300NCBIRnor6.0
Rnor_5.01066,860,265 - 66,860,359UniSTSRnor5.0
Rnor_5.01065,335,277 - 65,335,371UniSTSRnor5.0
RGSC_v3.41065,072,310 - 65,072,404UniSTSRGSC3.4
Celera1062,826,482 - 62,826,576UniSTS
Cytogenetic Map10q25UniSTS


Related Rat Strains
The following Strains have been annotated to Nos2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system reproductive system respiratory system
High
Medium
Low
Below cutoff 1 3 7 10 1 1 4 7

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB290142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB290143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF006619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF006620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF042085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ230486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY211532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D12520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D14051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D44591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D83661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D84101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L12562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L36063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S71597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U03699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U14523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U16359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U26686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U27572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U48829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U63549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U85270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z69839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000016133   ⟹   ENSRNOP00000016133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1063,819,752 - 63,851,210 (+)Ensembl
Rnor_6.0 Ensembl1066,285,433 - 66,313,190 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000073138   ⟹   ENSRNOP00000067662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1063,815,308 - 63,850,877 (+)Ensembl
Rnor_6.0 Ensembl1066,189,786 - 66,313,190 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093575   ⟹   ENSRNOP00000089741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1063,822,943 - 63,851,210 (+)Ensembl
RefSeq Acc Id: NM_012611   ⟹   NP_036743
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81064,313,335 - 64,348,904 (+)NCBI
mRatBN7.21063,815,308 - 63,850,877 (+)NCBI
Rnor_6.01066,188,290 - 66,221,621 (+)NCBI
Rnor_5.01065,423,626 - 65,456,957 (-)NCBI
RGSC_v3.41065,036,884 - 65,072,453 (+)RGD
Celera1062,790,940 - 62,826,625 (+)RGD
Sequence:
RefSeq Acc Id: XM_039085203   ⟹   XP_038941131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81064,316,118 - 64,349,221 (+)NCBI
mRatBN7.21063,818,091 - 63,851,208 (+)NCBI
RefSeq Acc Id: NP_036743   ⟸   NM_012611
- UniProtKB: Q64558 (UniProtKB/Swiss-Prot),   Q64005 (UniProtKB/Swiss-Prot),   Q63267 (UniProtKB/Swiss-Prot),   P97774 (UniProtKB/Swiss-Prot),   O60604 (UniProtKB/Swiss-Prot),   O60591 (UniProtKB/Swiss-Prot),   O35766 (UniProtKB/Swiss-Prot),   O35765 (UniProtKB/Swiss-Prot),   Q06518 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_038941131   ⟸   XM_039085203
- Peptide Label: isoform X1
- UniProtKB: F1LSH9 (UniProtKB/TrEMBL),   A0A8I6AAZ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000067662   ⟸   ENSRNOT00000073138
RefSeq Acc Id: ENSRNOP00000016133   ⟸   ENSRNOT00000016133
RefSeq Acc Id: ENSRNOP00000089741   ⟸   ENSRNOT00000093575
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q06518-F1-model_v2 AlphaFold Q06518 1-1147 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3185 AgrOrtholog
BioCyc Gene G2FUF-24039 BioCyc
BioCyc Pathway PWY-4983 [nitric oxide biosynthesis II (mammals)] BioCyc
BioCyc Pathway Image PWY-4983 BioCyc
Ensembl Genes ENSRNOG00000057443 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055025134 UniProtKB/Swiss-Prot
  ENSRNOG00060019106 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016133.7 UniProtKB/TrEMBL
  ENSRNOT00000073138 ENTREZGENE
  ENSRNOT00000073138.3 UniProtKB/TrEMBL
  ENSRNOT00000093575.2 UniProtKB/TrEMBL
  ENSRNOT00055043587 UniProtKB/Swiss-Prot
  ENSRNOT00060033771 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.360 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.440.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Translation factors UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CysJ-like_FAD-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_FR_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavdoxin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavodoxin/NO_synth UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavoprot_Pyr_Nucl_cyt_Rdtase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavoprotein-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FNR_nucleotide-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADPH_Cyt_P450_Rdtase_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_dom_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_dom_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_dom_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OxRdtase_FAD/NAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Riboflavin_synthase-like_b-brl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24599 UniProtKB/Swiss-Prot
NCBI Gene 24599 ENTREZGENE
PANTHER NITRIC OXIDE SYNTHASE OXYGENASE UniProtKB/Swiss-Prot
  NITRIC OXIDE SYNTHASE OXYGENASE UniProtKB/Swiss-Prot
  NITRIC OXIDE SYNTHASE OXYGENASE UniProtKB/TrEMBL
  NITRIC OXIDE SYNTHASE OXYGENASE UniProtKB/TrEMBL
Pfam FAD_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavodoxin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NO_synthase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nos2 PhenoGen
PIRSF NOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS FLAVODOXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FPNCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FAD_FR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FLAVODOXIN_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000057443 RatGTEx
  ENSRNOG00055025134 RatGTEx
  ENSRNOG00060019106 RatGTEx
Superfamily-SCOP SSF52218 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52343 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56512 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63380 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AAZ6 ENTREZGENE, UniProtKB/TrEMBL
  A1IMB0_RAT UniProtKB/TrEMBL
  F1LSH9 ENTREZGENE, UniProtKB/TrEMBL
  M0RDG2_RAT UniProtKB/TrEMBL
  NOS2_RAT UniProtKB/Swiss-Prot
  O35765 ENTREZGENE
  O35766 ENTREZGENE
  O60591 ENTREZGENE
  O60604 ENTREZGENE
  P97774 ENTREZGENE
  Q06518 ENTREZGENE
  Q63267 ENTREZGENE
  Q64005 ENTREZGENE
  Q64558 ENTREZGENE
  Q6XS76_RAT UniProtKB/TrEMBL
UniProt Secondary O35765 UniProtKB/Swiss-Prot
  O35766 UniProtKB/Swiss-Prot
  O60591 UniProtKB/Swiss-Prot
  O60604 UniProtKB/Swiss-Prot
  P97774 UniProtKB/Swiss-Prot
  Q63267 UniProtKB/Swiss-Prot
  Q64005 UniProtKB/Swiss-Prot
  Q64558 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Nos2  nitric oxide synthase 2  LOC497963  similar to Nitric oxide synthase, inducible (NOS type II) (Inducible NO synthase) (Inducible NOS) (iNOS)  Data merged from RGD:1598227 737654 PROVISIONAL
2015-12-10 Nos2  nitric oxide synthase 2  Nos2  nitric oxide synthase 2, inducible  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-20 Nos2  nitric oxide synthase 2, inducible  Nos2  nitric oxide synthase 2, inducible, macrophage  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-30 Nos2  nitric oxide synthase 2, inducible, macrophage  Nos2  nitric oxide synthase 2, inducible  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC497963  similar to Nitric oxide synthase, inducible (NOS type II) (Inducible NO synthase) (Inducible NOS) (iNOS)      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Nos2  nitric oxide synthase 2      Symbol and Name updated 629477 APPROVED
2003-03-06 Nos2  nitric oxide synthase 2  Nos2a    Data merged from RGD:67381 628472 PROVISIONAL
2002-06-10 Nos2a        Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Nos2  nitric oxide synthase 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may play a role in tumor progression 625548
gene_disease reduction in activity increases susceptibilty to the hypertensive actions of ANG II 625570
gene_domains promoter region contains binding site for many transcription factors like NFkB, C/EBP, and CRE; the CRE domain also has the ability to bind other transcription factors 625570
gene_domains promoter region contains binding site for many transcription factors like NFkB, C/EBP,and CRE, the CRE domain also has the ability to bind other transcription factors 625570
gene_drugs SB203580 was able to inhibit the activation of the promoter 625570
gene_drugs aminoguanidine reduces calcium-independent enzyme activity in renal medulla in rats maintained in high salt 625570
gene_expression expressed in inflammatory and immune cells 625570
gene_expression low level of expression in carcinoma, atypical mammary tumor and normal mammary tisssue 625548
gene_expression various levels of expression in epithelial, stromal or endothelial cells of different types of mammary tumors 625548
gene_expression expressed in the juxtaglomerular apparatus 625570
gene_expression expressed in inflammatory and immune cells and is controlled by p38 MAPK 625570
gene_function catalyses synthesis of nitric oxide from amino acid L-arginine and oxygen molecules 625548
gene_other activity in the outer medulla of SS (Dahl S) rats was significantly lower than wild type BN rats 625570
gene_pathway in primary glial cells induction involves MAPK (mitogen-activated protein kinase) cascades and liposaccharides 625570
gene_process generates high concentrations of nitric oxide for long time periods 625548
gene_process activation leads to a Pde2a mediated decrease in cAMP level in cardiac fibroblasts 625635
gene_process may have a role in the control of arterial pressure by renal tubular effects 625570
gene_regulation controlled by p38 MAPK 625570
gene_regulation human homolog expression increased in tumors of ovary, uterus, breast and brain 625548
gene_regulation expression induced by cytokines 625548
gene_regulation upregulation of expression in lipopolysaccharide treated hepatic tissue and invasive carcinomas from dimethylbenzanthracene (DMBA)-treated mammary glands 625548
gene_regulation induction in primary glial cells involves MAPK (mitogen-activated protein kinase) cascades and liposaccharides 625570
gene_regulation MAPK signaling mediates the endotoxin and cytokine stimulation of the promoter 625570
gene_regulation expression in the juxtaglomerular apparatus during low-salt diet is greatly reduced by a direct feedback inhibition through ANG II 625570
gene_regulation MAPK signalling mediates the endotoxin and cytokine stimulation of the promoter 625570
gene_regulation beta2-adrenergic response (cAMP elevation, cAMP-dependent protein kinase activation) stabilizes mRNA 625570
gene_regulation interleukin (IL)-1b increases mRNA expression in cardiac fibroblasts 625570