Kcna1 (potassium voltage-gated channel subfamily A member 1) - Rat Genome Database

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Gene: Kcna1 (potassium voltage-gated channel subfamily A member 1) Rattus norvegicus
Analyze
Symbol: Kcna1
Name: potassium voltage-gated channel subfamily A member 1
RGD ID: 2949
Description: Enables delayed rectifier potassium channel activity; voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Involved in several processes, including nervous system development; neuronal action potential; and neuronal signal transduction. Located in several cellular components, including apical plasma membrane; main axon; and neuronal cell body. Part of voltage-gated potassium channel complex. Is active in calyx of Held; glutamatergic synapse; and synaptic membrane. Used to study episodic ataxia type 1 and visual epilepsy. Human ortholog(s) of this gene implicated in episodic ataxia type 1. Orthologous to human KCNA1 (potassium voltage-gated channel subfamily A member 1); INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IA; Kcna; Kcpvd; Kv1.1; potassium (K+) channel protein voltage dependent; potassium channel, voltage gated shaker related subfamily A, member 1; potassium voltage gated channel shaker related subfamily member 1; Potassium voltage gated channel, shaker related subfamily, member 1; potassium voltage-gated channel, shaker-related subfamily, member 1; RBKI; RCK1; voltage-gated potassium channel subunit Kv1.1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Kcna1Adms  
Genetic Models: F344-Kcna1Adms/Kyo
Candidate Gene For: Bp116
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84161,150,378 - 161,160,051 (-)NCBIGRCr8
mRatBN7.24159,464,223 - 159,472,905 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4159,464,188 - 159,472,682 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4165,699,172 - 165,700,917 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04161,482,081 - 161,483,826 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04160,116,108 - 160,117,853 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04159,190,781 - 159,192,526 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4159,190,804 - 159,192,526 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04226,188,851 - 226,190,596 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44163,011,777 - 163,013,522 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14163,254,845 - 163,259,290 (-)NCBI
Celera4148,186,141 - 148,187,886 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. The brain Kv1.1 potassium channel: in vitro and in vivo studies on subunit assembly and posttranslational processing. Deal KK, etal., J Neurosci. 1994 Mar;14(3 Pt 2):1666-76.
2. Two heteromeric Kv1 potassium channels differentially regulate action potential firing. Dodson PD, etal., J Neurosci. 2002 Aug 15;22(16):6953-61.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. Huang CY, etal., J Comp Neurol. 2012 Nov 1;520(16):3650-72. doi: 10.1002/cne.23119.
6. Kcna1-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures. Ishida S, etal., Brain Res. 2012 Jan 30;1435:154-66. doi: 10.1016/j.brainres.2011.11.023. Epub 2011 Nov 13.
7. Distinct roles of Kv1 and Kv3 potassium channels at the calyx of Held presynaptic terminal. Ishikawa T, etal., J Neurosci. 2003 Nov 12;23(32):10445-53.
8. Phosphorylation by protein kinase A of RCK1 K+ channels expressed in Xenopus oocytes. Ivanina T, etal., Biochemistry. 1994 Jul 26;33(29):8786-92.
9. KCNE1 and KCNE2 inhibit forward trafficking of homomeric N-type voltage-gated potassium channels. Kanda VA, etal., Biophys J. 2011 Sep 21;101(6):1354-63. doi: 10.1016/j.bpj.2011.08.015. Epub 2011 Sep 20.
10. Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. Kim E, etal., Nature. 1995 Nov 2;378(6552):85-8.
11. Subunit composition determines Kv1 potassium channel surface expression. Manganas LN and Trimmer JS, J Biol Chem. 2000 Sep 22;275(38):29685-93.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Contactin-associated protein (Caspr) 2 interacts with carboxypeptidase E in the CNS. Oiso S, etal., J Neurochem. 2009 Apr;109(1):158-67. Epub 2009 Jan 23.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Subunit composition and novel localization of K+ channels in spinal cord. Rasband MN and Trimmer JS, J Comp Neurol. 2001 Jan 1;429(1):166-76.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexes. Rhodes KJ, etal., J Neurosci. 1997 Nov 1;17(21):8246-58.
20. The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1. Schulte U, etal., Neuron. 2006 Mar 2;49(5):697-706.
21. Kv1.1 and Kv1.3 channels contribute to the delayed-rectifying K+ conductance in rat choroid plexus epithelial cells. Speake T, etal., Am J Physiol Cell Physiol 2004 Mar;286(3):C611-20. Epub 2003 Nov 5.
22. Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. Stuhmer W, etal., EMBO J 1989 Nov;8(11):3235-44.
23. Kv1.1/1.2 channels are downstream effectors of nitric oxide on synaptic GABA release to preautonomic neurons in the paraventricular nucleus. Yang Q, etal., Neuroscience. 2007 Oct 26;149(2):315-27. Epub 2007 Aug 8.
Additional References at PubMed
PMID:2539643   PMID:3191911   PMID:8046438   PMID:8361541   PMID:9736643   PMID:10585425   PMID:10884227   PMID:12879861   PMID:12907802   PMID:12944270   PMID:12963709   PMID:15361858  
PMID:15949244   PMID:16122713   PMID:16306173   PMID:16331678   PMID:16624997   PMID:17023663   PMID:17136396   PMID:17315199   PMID:17520476   PMID:17855588   PMID:18053989   PMID:18222921  
PMID:18466331   PMID:18760366   PMID:18806782   PMID:19074135   PMID:19118603   PMID:19307729   PMID:19472219   PMID:19696788   PMID:19715983   PMID:19779067   PMID:19912772   PMID:20805574  
PMID:20974108   PMID:21233214   PMID:21371023   PMID:21483673   PMID:21903165   PMID:21966978   PMID:22871113   PMID:23413915   PMID:23473320   PMID:23725331   PMID:23836929   PMID:23903368  
PMID:25270294   PMID:25931508   PMID:26348848   PMID:29476059   PMID:35053355   PMID:36750122  


Genomics

Comparative Map Data
Kcna1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84161,150,378 - 161,160,051 (-)NCBIGRCr8
mRatBN7.24159,464,223 - 159,472,905 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4159,464,188 - 159,472,682 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4165,699,172 - 165,700,917 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04161,482,081 - 161,483,826 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04160,116,108 - 160,117,853 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04159,190,781 - 159,192,526 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4159,190,804 - 159,192,526 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04226,188,851 - 226,190,596 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44163,011,777 - 163,013,522 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14163,254,845 - 163,259,290 (-)NCBI
Celera4148,186,141 - 148,187,886 (-)NCBICelera
Cytogenetic Map4q42NCBI
KCNA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38124,909,905 - 4,918,256 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl124,909,905 - 4,918,256 (+)EnsemblGRCh38hg38GRCh38
GRCh37125,019,071 - 5,027,422 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36124,889,334 - 4,897,683 (+)NCBINCBI36Build 36hg18NCBI36
Build 34124,890,805 - 4,892,293NCBI
Celera126,640,916 - 6,649,264 (+)NCBICelera
Cytogenetic Map12p13.32NCBI
HuRef124,875,853 - 4,884,200 (+)NCBIHuRef
CHM1_1125,018,738 - 5,027,087 (+)NCBICHM1_1
T2T-CHM13v2.0124,916,952 - 4,925,303 (+)NCBIT2T-CHM13v2.0
Kcna1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396126,613,426 - 126,622,764 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6126,617,360 - 126,623,347 (-)EnsemblGRCm39 Ensembl
GRCm386126,636,463 - 126,645,801 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6126,640,397 - 126,646,384 (-)EnsemblGRCm38mm10GRCm38
MGSCv376126,586,481 - 126,595,819 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366126,606,016 - 126,610,415 (-)NCBIMGSCv36mm8
Celera6128,306,063 - 128,315,400 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map661.57NCBI
Kcna1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554132,703,030 - 2,711,612 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554132,703,030 - 2,711,612 (+)NCBIChiLan1.0ChiLan1.0
KCNA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21010,458,271 - 10,468,092 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11210,455,043 - 10,464,850 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0125,027,333 - 5,037,136 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1124,949,464 - 4,957,811 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl124,950,938 - 4,952,425 (+)Ensemblpanpan1.1panPan2
KCNA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12739,928,347 - 39,936,753 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2739,933,825 - 39,935,312 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha276,745,890 - 6,747,377 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02740,289,956 - 40,291,443 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2740,289,873 - 40,292,984 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12740,179,028 - 40,180,515 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02740,203,981 - 40,205,468 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0276,156,901 - 6,158,388 (+)NCBIUU_Cfam_GSD_1.0
LOC101959799
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721327,488,417 - 27,489,932 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004937109142,711 - 144,198 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004937109142,711 - 144,257 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl565,561,962 - 65,565,116 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1565,556,837 - 65,565,880 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2567,763,338 - 67,770,194 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1114,956,824 - 4,963,732 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl114,956,856 - 4,958,343 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660633,283,565 - 3,291,460 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcna1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248601,915,344 - 1,923,062 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248601,915,108 - 1,923,071 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcna1
22 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:63
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000026731
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat

Markers in Region
PMC20739P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.44163,013,325 - 163,014,269UniSTSRGSC3.4
Cytogenetic Map4q42UniSTS
RH138013  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.04159,192,816 - 159,193,289NCBIRnor6.0
Rnor_5.04226,190,676 - 226,191,041NCBIRnor5.0
RGSC_v3.44163,014,427 - 163,015,044UniSTSRGSC3.4
Celera4148,188,044 - 148,188,662UniSTS
RH 3.4 Map4999.2UniSTS
Cytogenetic Map4q42UniSTS
PMC20739P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24159,470,926 - 159,471,130 (+)MAPPERmRatBN7.2
Rnor_6.04159,192,329 - 159,192,532NCBIRnor6.0
Rnor_5.04226,190,399 - 226,190,602UniSTSRnor5.0
RGSC_v3.44163,013,325 - 163,013,528UniSTSRGSC3.4
Celera4148,187,689 - 148,187,892UniSTS
Cytogenetic Map4q42UniSTS
UniSTS:143652  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24159,470,836 - 159,470,951 (+)MAPPERmRatBN7.2
Rnor_6.04159,192,239 - 159,192,353NCBIRnor6.0
Rnor_5.04226,190,309 - 226,190,423UniSTSRnor5.0
RGSC_v3.44163,013,235 - 163,013,349UniSTSRGSC3.4
Celera4148,187,599 - 148,187,713UniSTS
Cytogenetic Map4q42UniSTS
GDB:435453  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24159,469,970 - 159,470,718 (+)MAPPERmRatBN7.2
Rnor_6.04159,191,373 - 159,192,120NCBIRnor6.0
Rnor_5.04226,189,443 - 226,190,190UniSTSRnor5.0
RGSC_v3.44163,012,369 - 163,013,116UniSTSRGSC3.4
Celera4148,186,733 - 148,187,480UniSTS
Cytogenetic Map4q42UniSTS
PMC20739P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24159,470,941 - 159,471,130 (+)MAPPERmRatBN7.2
Rnor_6.04159,192,344 - 159,192,532NCBIRnor6.0
Rnor_5.04226,190,414 - 226,190,602UniSTSRnor5.0
RGSC_v3.44163,013,340 - 163,013,528UniSTSRGSC3.4
Celera4148,187,704 - 148,187,892UniSTS
Cytogenetic Map4q42UniSTS


Genetic Models
This gene Kcna1 is modified in the following models/strains:
F344-Kcna1Adms/Kyo    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 25
Low 13 2 8 2 7 7 43 11 2 7
Below cutoff 10 13 8 7 8 1 3 6 12 25 6 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026731   ⟹   ENSRNOP00000026731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4159,190,804 - 159,192,526 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101523   ⟹   ENSRNOP00000081659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4159,464,188 - 159,472,682 (-)Ensembl
RefSeq Acc Id: NM_173095   ⟹   NP_775118
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84161,155,529 - 161,157,274 (-)NCBI
mRatBN7.24159,469,379 - 159,471,124 (-)NCBI
Rnor_6.04159,190,781 - 159,192,526 (-)NCBI
Rnor_5.04226,188,851 - 226,190,596 (-)NCBI
RGSC_v3.44163,011,777 - 163,013,522 (-)RGD
Celera4148,186,141 - 148,187,886 (-)RGD
Sequence:
RefSeq Acc Id: XM_039107020   ⟹   XP_038962948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84161,150,378 - 161,160,051 (-)NCBI
mRatBN7.24159,464,223 - 159,472,905 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_775118   ⟸   NM_173095
- UniProtKB: P10499 (UniProtKB/Swiss-Prot),   A6ILV6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026731   ⟸   ENSRNOT00000026731
RefSeq Acc Id: XP_038962948   ⟸   XM_039107020
- Peptide Label: isoform X1
- UniProtKB: P10499 (UniProtKB/Swiss-Prot),   A6ILV6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000081659   ⟸   ENSRNOT00000101523
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10499-F1-model_v2 AlphaFold P10499 1-495 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2949 AgrOrtholog
BioCyc Gene G2FUF-42969 BioCyc
Ensembl Genes ENSRNOG00000019750 Ensembl
  ENSRNOG00000064052 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055010711 UniProtKB/Swiss-Prot
  ENSRNOG00060016588 UniProtKB/Swiss-Prot
  ENSRNOG00065033451 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000101523.1 UniProtKB/Swiss-Prot
  ENSRNOT00055018095 UniProtKB/Swiss-Prot
  ENSRNOT00060028402 UniProtKB/Swiss-Prot
  ENSRNOT00065057508 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv1.1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24520 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24520 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11537 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcna1 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KV11CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KVCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHAKERCHANEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019750 RatGTEx
  ENSRNOG00000064052 RatGTEx
  ENSRNOG00055010711 RatGTEx
  ENSRNOG00060016588 RatGTEx
  ENSRNOG00065033451 RatGTEx
SMART BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP POZ domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6ILV6 ENTREZGENE, UniProtKB/TrEMBL
  KCNA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcna1  potassium voltage-gated channel subfamily A member 1  Kcna1  potassium channel, voltage gated shaker related subfamily A, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-02-26 Kcna1  potassium channel, voltage gated shaker related subfamily A, member 1  Kcna1  potassium voltage-gated channel, shaker-related subfamily, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Kcna1  potassium voltage-gated channel, shaker-related subfamily, member 1  Kcna  Potassium voltage gated channel, shaker related subfamily, member 1  Symbol and Name updated 625702 APPROVED
2001-10-23 Kcna  Potassium voltage gated channel, shaker related subfamily, member 1channel protein, voltage dependent      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED
2001-10-23 Kcna  Potassium (K+) channel protein, voltage dependent      Name withdrawn 68913 WITHDRAWN
2001-10-23 Kcna  Potassium voltage gated channel, shaker related subfamily, member 1      Name updated 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the apical membrane of the epithelial cells 1300201
gene_expression expressed in choroid plexus epithelial cells 1300201