Il7 (interleukin 7) - Rat Genome Database

Name: Il7
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Il7 (interleukin 7) Rattus norvegicus

Analyze

Symbol:

Il7

Name:

interleukin 7

RGD ID:

2904

Description:

Predicted to enable cytokine activity and growth factor activity. Involved in cellular response to hypoxia and response to X-ray. Predicted to be located in extracellular space. Used to study high grade glioma. Biomarker of periodontal disease. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human IL7 (interleukin 7); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

IL-7; interleukin-7

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	IL7 (interleukin 7)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Il7 (interleukin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Il7 (interleukin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	IL7 (interleukin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	IL7 (interleukin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Il7 (interleukin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	IL7 (interleukin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	IL7 (interleukin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Il7 (interleukin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ATP4B (ATPase H+/K+ transporting subunit beta)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	IL7 (interleukin 7)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Il7 (interleukin 7)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	96,142,523 - 96,186,282 (+)	NCBI		GRCr8
mRatBN7.2	2	94,235,219 - 94,280,075 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	94,234,766 - 94,280,075 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	100,777,208 - 100,821,004 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	98,898,266 - 98,942,070 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	93,955,118 - 93,998,914 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	96,427,884 - 96,474,979 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	96,439,286 - 96,474,977 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	116,171,246 - 116,216,348 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	96,356,083 - 96,399,796 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	96,301,044 - 96,344,792 (+)	NCBI
Celera	2	89,787,744 - 89,831,293 (+)	NCBI		Celera
RH 3.4 Map	2	592.4	RGD
Cytogenetic Map	2	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

Brain Injuries (ISO)

COVID-19 (ISO)

Epidermodysplasia Verruciformis 5 (ISO)

genetic disease (ISO)

glucose intolerance (ISO)

high grade glioma (IDA)

hyperglycemia (ISO)

Insulin Resistance (ISO)

lung non-small cell carcinoma (ISO)

lymphopenia (ISO)

Metabolic Bone Diseases (ISO)

Middle East respiratory syndrome (ISO)

multiple sclerosis (ISO)

obesity (ISO)

periodontal disease (IEP)

Postmenopausal Osteoporosis (ISO)

severe acute respiratory syndrome (ISO)

Transplant Rejection (IEP)

Weight Gain (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-demecolcine (ISO)

(-)-epigallocatechin 3-gallate (ISO)

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-nitrotoluene (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

5'-S-methyl-5'-thioadenosine (ISO)

5-fluorouracil (ISO)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

anthracen-2-amine (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

azathioprine (ISO)

benzo[a]pyrene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP)

bleomycin A2 (ISO)

cadmium dichloride (EXP)

cadmium sulfate (ISO)

cannabidiol (ISO)

capsaicin (EXP)

CGP 52608 (ISO)

choline (ISO)

cisplatin (EXP,ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

crotonaldehyde (ISO)

cyclosporin A (EXP,ISO)

deoxynivalenol (ISO)

dexamethasone (ISO)

dioxygen (ISO)

doxorubicin (EXP)

emamectin benzoate (ISO)

endosulfan (EXP)

ethanol (ISO)

ferulic acid (ISO)

fragrance (ISO)

furan (EXP)

gentamycin (EXP)

imiquimod (ISO)

indometacin (ISO)

isoprenaline (EXP,ISO)

lead diacetate (ISO)

lipopolysaccharide (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

melatonin (ISO)

melphalan (ISO)

methapyrilene (ISO)

methyl carbamate (ISO)

methyl methanesulfonate (ISO)

microcystin-LR (ISO)

N-ethyl-N-nitrosourea (ISO)

nickel atom (ISO)

nickel dichloride (ISO)

nicotine (ISO)

nonanoic acid (ISO)

oxaliplatin (EXP)

oxymetholone (ISO)

paracetamol (EXP)

paraquat (EXP,ISO)

PCB138 (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

quercetin (ISO)

riddelliine (EXP)

ritonavir (ISO)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenite (ISO)

tamibarotene (ISO)

tamoxifen (ISO)

tetrachloromethane (EXP,ISO)

toluene 2,4-diisocyanate (ISO)

topotecan (EXP)

trichloroethene (EXP)

valproic acid (ISO)

vincristine (ISO)

vinorelbine (ISO)

zinc acetate (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

B cell proliferation (IEA,ISO)

bone resorption (IEA,ISO,ISS)

cellular response to hypoxia (IEP)

cytokine-mediated signaling pathway (IEA,ISO)

extrinsic apoptotic signaling pathway (IEA,ISO)

homeostasis of number of cells within a tissue (IEA,ISO)

immune response (IEA)

interleukin-7-mediated signaling pathway (ISO)

negative regulation of apoptotic process (ISS)

negative regulation of extrinsic apoptotic signaling pathway (ISO)

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (IEA,ISO)

organ growth (IEA,ISO)

positive regulation of B cell differentiation (IEA,ISO)

positive regulation of B cell proliferation (IEA,ISO,ISS)

positive regulation of chemokine production (IEA,ISO)

positive regulation of cytokine-mediated signaling pathway (IEA,ISO)

positive regulation of gene expression (ISO)

positive regulation of organ growth (IEA,ISO)

positive regulation of T cell differentiation (IEA,ISO,ISS)

regulation of gene expression (ISO)

regulation of peptidyl-tyrosine phosphorylation (IEA,ISO)

response to X-ray (IEP)

signal transduction (IEA)

T cell lineage commitment (IEA,ISO)

Cellular Component

extracellular region (ISO)

extracellular space (IEA,ISO)

Molecular Function

cytokine activity (IEA,ISO,ISS)

growth factor activity (IEA,ISO,ISS)

interleukin-7 receptor binding (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

cytokine mediated signaling pathway (IEA)

Jak-Stat signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Semiquantitative detection of cytokine messages in X-irradiated and regenerating rat thymus.	Adachi Y, etal., Radiat Res. 2005 Apr;163(4):400-7.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Biomarkers of basic activities of daily living in Alzheimer's disease.	Hall JR, etal., J Alzheimers Dis. 2012;31(2):429-37. doi: 10.3233/JAD-2012-111481.
4.	Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.	Huang C, etal., Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
5.	A Special Ingredient (VtR) Containing Oligostilbenes Isolated from Vitis thunbergii Prevents Bone Loss in Ovariectomized Mice: In Vitro and In Vivo Study.	Huang YL, etal., Evid Based Complement Alternat Med. 2013;2013:409421. doi: 10.1155/2013/409421. Epub 2013 Apr 11.
6.	High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7.	Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease.	Li Y, etal., Mol Oral Microbiol. 2010 Aug;25(4):275-92.
8.	Down-regulation of interleukin 7 mRNA by hypoxia is calcium dependent.	Lu A, etal., Neurol Res. 2009 Jun;31(5):545-9. doi: 10.1179/174313209X380928. Epub 2008 Dec 3.
9.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
10.	[The expressions of IL-7 and IL-7R and the relationship between them with lymph node metastasis and prognosis in non-small cell lung cancer].	MING J, etal., Zhongguo Fei Ai Za Zhi. 2010 Dec;13(12):1101-6. doi: 10.3779/j.issn.1009-3419.2010.12.04.
11.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
12.	Structural basis for binding multiple ligands by the common cytokine receptor gamma-chain.	Olosz F and Malek TR, J Biol Chem 2002 Apr 5;277(14):12047-52.
13.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
14.	GOA pipeline	RGD automated data pipeline
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	Comprehensive gene review and curation	RGD comprehensive gene curation
17.	Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter.	Salopek D, etal., Immunol Lett. 2008 Dec 22;121(2):134-9. doi: 10.1016/j.imlet.2008.10.002. Epub 2008 Nov 4.
18.	Regression of intracerebral rat glioma isografts by therapeutic subcutaneous immunization with interferon-gamma, interleukin-7, or B7-1-transfected tumor cells.	Visse E, etal., Cancer Gene Ther 1999 Jan-Feb;6(1):37-44.
19.	Increased expression of non-interleukin-2 T cell growth factors and their implications during liver allograft rejection in rats.	Wang WL, etal., J Gastroenterol Hepatol. 2007 Jul;22(7):1141-7. Epub 2007 May 27.

Additional References at PubMed

PMID:7671324	PMID:8950980	PMID:9252127	PMID:10429671	PMID:11418668	PMID:12431371	PMID:12490655	PMID:12970760	PMID:16797412	PMID:19249122	PMID:21178173	PMID:25666089
PMID:27023180	PMID:29581031

Genomics

Comparative Map Data

Il7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	96,142,523 - 96,186,282 (+)	NCBI		GRCr8
mRatBN7.2	2	94,235,219 - 94,280,075 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	94,234,766 - 94,280,075 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	100,777,208 - 100,821,004 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	98,898,266 - 98,942,070 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	93,955,118 - 93,998,914 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	96,427,884 - 96,474,979 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	96,439,286 - 96,474,977 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	116,171,246 - 116,216,348 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	96,356,083 - 96,399,796 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	96,301,044 - 96,344,792 (+)	NCBI
Celera	2	89,787,744 - 89,831,293 (+)	NCBI		Celera
RH 3.4 Map	2	592.4	RGD
Cytogenetic Map	2	q23	NCBI

IL7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	78,675,044 - 78,805,463 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	78,675,743 - 78,805,523 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	79,645,007 - 79,717,698 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	79,807,560 - 79,880,313 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	79,807,560 - 79,880,313	NCBI
Celera	8	75,648,737 - 75,721,711 (-)	NCBI		Celera
Cytogenetic Map	8	q21.13	NCBI
HuRef	8	75,134,557 - 75,207,310 (-)	NCBI		HuRef
CHM1_1	8	79,696,615 - 79,769,400 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	79,106,579 - 79,236,843 (-)	NCBI		T2T-CHM13v2.0

Il7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	7,637,088 - 7,678,820 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	7,635,054 - 7,678,820 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	7,572,028 - 7,613,760 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	7,569,994 - 7,613,760 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	7,572,077 - 7,613,427 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	7,555,150 - 7,596,500 (-)	NCBI		MGSCv36	mm8
Celera	3	7,588,657 - 7,629,776 (-)	NCBI		Celera
Cytogenetic Map	3	A1	NCBI
cM Map	3	2.02	NCBI

Il7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955444	2,365,077 - 2,400,953 (+)	NCBI	ChiLan1.0	ChiLan1.0

IL7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	94,468,097 - 94,546,977 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	70,095,550 - 70,175,284 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	75,254,166 - 75,337,373 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	76,894,158 - 76,967,685 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	76,895,095 - 76,966,918 (-)	Ensembl	panpan1.1		panPan2

IL7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	26,384,493 - 26,422,586 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	29	26,384,493 - 26,422,737 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	29	26,651,877 - 26,696,032 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	29	26,502,024 - 26,546,251 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	29	26,501,104 - 26,546,713 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	29	26,548,175 - 26,592,337 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	29	26,592,034 - 26,636,185 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	29	26,943,719 - 26,987,896 (-)	NCBI		UU_Cfam_GSD_1.0

Il7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	52,717,829 - 52,769,445 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936702	111,211 - 162,322 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936702	110,625 - 162,957 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IL7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	57,684,796 - 57,744,709 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	57,677,895 - 57,744,713 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	62,888,668 - 62,949,085 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

IL7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	74,230,493 - 74,292,985 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	74,231,809 - 74,292,384 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	66,940,681 - 67,051,084 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Il7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624744	12,567,661 - 12,604,074 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624744	12,562,536 - 12,604,037 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Il7
230 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	467
Count of miRNA genes:	222
Interacting mature miRNAs:	281
Transcripts:	ENSRNOT00000016091
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	5873687	102844969	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	25413423	143657569	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26917817	127469484	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	26917817	136917119	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	40067944	102785628	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	40067944	102785628	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	40067944	102785628	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	40067944	102785628	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	40067944	102785628	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	157142209	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	182042367	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	43154682	202446871	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43154682	202446871	Rat
2293676	Bmd19	Bone mineral density QTL 19	10.7	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	2	43162366	111362592	Rat
2293682	Bmd24	Bone mineral density QTL 24	8.9	0.0001	femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	2	43162366	111362592	Rat
2293671	Bss44	Bone structure and strength QTL 44	10.97	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	2	43162366	148478373	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43171017	184114403	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46123260	202447032	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56043031	202447032	Rat
1558648	Smcn1	Smooth muscle cell number QTL 1		0.039	blood vessel smooth muscle cell quantity (VT:0010525)	aorta smooth muscle cell count per unit vessel length (CMO:0001646)	2	59134147	127460910	Rat
5684990	Bmd82	Bone mineral density QTL 82	2.8		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	2	59324377	103795077	Rat
5684996	Bmd85	Bone mineral density QTL 85	4.7	0.024	tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	2	59324377	103795077	Rat
61438	Cia7	Collagen induced arthritis QTL 7	4.6	0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	2	59324377	141596857	Rat
631500	Bp99	Blood pressure QTL 99	2.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	59324719	102755241	Rat
1578777	Stresp15	Stress response QTL 15	2	0.05	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	2	59846005	104846005	Rat
2306903	Bp336	Blood pressure QTL 336		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	64366971	109366971	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118275	202447032	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
7411551	Bw131	Body weight QTL 131	29.6	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	2	67942638	112942638	Rat
1558653	Prcr1	Prostate cancer resistance QTL 1	5		prostate integrity trait (VT:0010571)	area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)	2	72532993	157142209	Rat
1359034	Bp274	Blood pressure QTL 274			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	74786664	94359546	Rat
1359034	Bp274	Blood pressure QTL 274			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	74786664	94359546	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	74786664	206665859	Rat
61465	Bp13	Blood pressure QTL 13	3.3		blood pressure trait (VT:0000183)	diastolic blood pressure (CMO:0000005)	2	76539322	102785628	Rat
61465	Bp13	Blood pressure QTL 13	3.3		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	76539322	102785628	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	76539322	150540526	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	76539322	202447032	Rat
2299162	Iddm32	Insulin dependent diabetes mellitus QTL 32	2.36		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	78665616	143657569	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	78665619	219826953	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
61392	Bp6	Blood pressure QTL 6	7		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	80270434	125270434	Rat
1598865	Bp296	Blood pressure QTL 296	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	81018907	126018907	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	81689826	221035911	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
1578772	Stresp14	Stress response QTL 14	5	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	2	82345893	130923501	Rat
7207808	Bmd89	Bone mineral density QTL 89	4.1		femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	2	88862519	133862519	Rat
2300165	Bmd49	Bone mineral density QTL 49	4.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	2	88862519	133862519	Rat
2300170	Bmd45	Bone mineral density QTL 45	12.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	2	88862519	133862519	Rat
2300185	Bmd46	Bone mineral density QTL 46	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	88862519	133862519	Rat
1598862	Glom9	Glomerulus QTL 9	3.5		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	2	92337601	137337601	Rat
1598863	Cm65	Cardiac mass QTL 65	2.3		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	92337601	137337601	Rat

Markers in Region

RH94835

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	94,276,311 - 94,276,401 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	96,472,323 - 96,472,412	NCBI	Rnor6.0
Rnor_5.0	2	116,213,692 - 116,213,781	UniSTS	Rnor5.0
RGSC_v3.4	2	96,397,184 - 96,397,273	UniSTS	RGSC3.4
Celera	2	89,828,637 - 89,828,726	UniSTS
RH 3.4 Map	2	592.4	UniSTS
Cytogenetic Map	2	q23	UniSTS

Il7

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	94,278,646 - 94,278,811 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	96,474,658 - 96,474,822	NCBI	Rnor6.0
Rnor_5.0	2	116,216,027 - 116,216,191	UniSTS	Rnor5.0
RGSC_v3.4	2	96,399,519 - 96,399,683	UniSTS	RGSC3.4
Celera	2	89,830,972 - 89,831,136	UniSTS
Cytogenetic Map	2	q23	UniSTS

RH131820

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	94,278,889 - 94,279,100 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	96,474,901 - 96,475,111	NCBI	Rnor6.0
Rnor_5.0	2	116,216,270 - 116,216,480	UniSTS	Rnor5.0
Celera	2	89,831,215 - 89,831,425	UniSTS
Cytogenetic Map	2	q23	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			8		15
Low	3	5	35	27	4	27	4	4	8	16	24	11	4
Below cutoff		26	14	14		14	4	6	11	15	13		4

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_013110	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006232139	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281372	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF010464	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF367210	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ226544	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ226549	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000016091 ⟹ ENSRNOP00000016091

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	94,243,644 - 94,280,075 (+)	Ensembl
Rnor_6.0 Ensembl	2	96,439,286 - 96,474,977 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000095233 ⟹ ENSRNOP00000097908

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	94,234,766 - 94,280,075 (+)	Ensembl

RefSeq Acc Id:

NM_013110 ⟹ NP_037242

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	96,142,640 - 96,186,282 (+)	NCBI
mRatBN7.2	2	94,235,336 - 94,278,968 (+)	NCBI
Rnor_6.0	2	96,430,768 - 96,474,979 (+)	NCBI
Rnor_5.0	2	116,171,246 - 116,216,348 (+)	NCBI
RGSC_v3.4	2	96,356,083 - 96,399,796 (+)	RGD
Celera	2	89,787,744 - 89,831,293 (+)	RGD

Sequence:

show sequence

TCCCGCAGACCATGTTCCATGTTTCTTTTAGATATATCTTTGGAATTCCTCCCCTGATCCTTGT
GCTGCTGCCGGTCACATCGTCTGACTGTCACATTAAAGACAAGGACGGTAAAGCCTTTGGGAGT
GTGCTGATGATCAGCATCAATCAACTGGACAAAATGACAGGAACTGATAGTGATTGCCCAAATA
ATGAACCAAACTTTTTTAAAAAACATCTATGTGATGATACAAAGGAAGCTGCTTTTCTAAATCG
TGCTGCTCGCAAGTTGAGGCAATTTCTTAAAATGAATATCAGTGAGGAATTCAATGACCATTTA
CTAAGAGTTTCAGACGGCACACAAACACTGGTGAACTGCACAAGCAAGGAAGAAAAAACCATAA
AGGAACAGAAAAAGAATGATCCATGTTTCCTAAAGAGACTACTGAGAGAGATAAAAACTTGTTG
GAATAAAATCTTGAACAGCAGTATATAAACAGAAAATGTAGTAGCAACCTCCAAGAAACTACTG
CCTTGCATACTTGGAGAGTTTGGAACCCTCCCAGAAGTTTCTGGATGCCTCCTGGTCAAATAAA
GCAAGCAACTGGGAAATCTACAGTGATAGACATAAGAAATGCAACTGACTCCTGCGGTCAGCAT
ATGCCTATGGAAATTTATCAACAGTACTGATTTTGTAAAGCAACCCTGTCATCTGCAATGCTTT
TAAAGCCTTTCCAAGTGTTTCTACCATTATCCAGTCTACAAACAAGGCTCTGAAGATTCAGAGT
CGCCACTGTTTTGTTAGCAACCATGCATCGGTGAACCACTGGGGGAGTGGAACTGTCCTGTGGA
AGACTGCAGATACAGGAGGGCTCCTGGTGATGGATAATGCTCTTGAAAACGAGAGTCACATCTT
AAAGCAGCAGCAGCAGCAGCAAAAAGAAGGTTAAGGCATCAACAAATGTAGTTAAATATGAATG
TATAACACATAGCTTCAGTACAGAGCATAGCAGATATTTTTAAATAAAAGTATTCTTAAAAATA
GAAATGCACTTAGTTCAAAGATACTGAACCTTAGTATTCAGTCACTTTTGTCATATATGTATAA
TAAAGCTTATATAACTGAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006232139 ⟹ XP_006232201

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	96,142,523 - 96,183,980 (+)	NCBI
mRatBN7.2	2	94,235,219 - 94,276,666 (+)	NCBI
Rnor_6.0	2	96,427,884 - 96,473,108 (+)	NCBI
Rnor_5.0	2	116,171,246 - 116,216,348 (+)	NCBI

Sequence:

show sequence

CTACTACTACTACTGCTACTACTACCACTACTGCTGCTACTACTACTACTACTGCTGCTACTAC
TCCACCACCACAACTACCTCTGTCTTCTTTGATGTGATCCTGGAGACAGAGATGGGGTTCATGC
AAATTAAGCAAGCTCCCACCCTTTAGCTATACCCCCAGTCCACTTTTACTTTGTCATTTTTAAA
GACAGGGTCTTCTCACTCATTCAACAAAGCAGGAATTGAACTTTTAATTCTCCTGCCTCTGATT
AAGTAGCTAGGGTTACAGGTCTCCACCATCAGGCCTGGAATATTACTTGATTTATTTAATTATC
AACATTCCAAAAATTCATAAAACATTCATCCTTGTCAAACTGTATATTCAGTTTCTGTTTAAAA
AGCAACAGCTGATTTAAGGTGCGGTATTGATTTTTTTTCAAAACGATACTAATTTTCTTAGACT
TCTCTCATAATACTATGTAATTCAAAGGTGTCCATTTTCACCTAACTTTTTAAATTCCAAATGC
TTTCTAAATATTCTTTTCAGAAGACATTCTTAACACTTAAGGATAGAGTCTTGGGGAAAAAAAG
TTACTTCTTCTTTCCTGGAACTTTAGATACTTTCCCTCATTTTGCTCAAATTTTGCCTATGCAC
AAGCTTTGTTCTGTCTGCCTTGCTGGTGATTGTGCCCGGAAGGAAGACAGATTTCCCCTTTTGC
ACTCTGTTGATGGATGCTTTTTCACTCCGCTCTGAAGAGTCTAGCAACAGATGGGAAAAAAGCA
GAGAGTGTGAACAATTGTAGCCCTACCTGTACCCCATGGCCAGGGAGTTTAATACAGCTACTGC
AACCCTAGGCACGTTTATAGAATTCATCTTTAACAGTCCCTGCAGTCTCATCTCTGTCTACCTC
TTATCTCCACATCGGAATTTCAATGACATTTTTGGAAGTGTGTGCCTTTCCCCCTGAGGCTCAG
TTTCCTGACTTCATTTTCCAGCTCTTCCCTGTTTTCTTTCTCATTCCTCTATTTCCCTCCTTTT
GTGAACATTCTTCCATGTTCCATCCTTGAAGCCCTGTCTTACCAAAGTAGCTCTCTTCCATCCT
GTCATACTGAGACGTTGGAGTCTAATCTCATTCTAGATAGCCCTTCTCTGTGCAGGGGAGCTGT
CTTCAGAACGCACAGCGGGGAAAGGCCAGTAGCTGCAGGGAGGATGACAAGTACCTTCAAATCT
TCTGATGCTTTGAGAAGGAGGAAAGGTTGTTGTTGGCAAGAGAGACAACACAGAGGTCTTAAAC
AGCCCTGCCATCACCGGATAGGGTTTATTTTGGAAGTGCACTGAAACGACAGGTTTATACATTG
GATGTGGAAAGGCAGAGTCCCAGCAGCAGAGGCCACAGGCCAGTGTCCAGTAGGAACTCCTACC
CTGTACCCTTTAAAGCACAGACAGTCCCTGTCTCGCTCCTTTCTCTCCGCTTCTTCTCACTGTT
AGCACCACGACAGAATCTGAAGTTCATGTCCTGATGTCAGTACAGGAACCACAAACTCCAGACA
CCTTTCTGAGGTTCCCCAGAGGGTTAAGGGCATACCCACAACCTCAGGTCATTTCCCTAGTCTA
CTGCTATACTCTATTATTCACAGGGTTCTCTTACACACAGGATTCCAAGCAGTCTTTGAAGCCA
GACTGCAGGCGGTTTTTATCCAAGTTCAGCCATGTGAACTTAGCTCTGTTACTTAAGGAAGCCT
CTGTTCCCATGCATCTTTCAACTGTAGATAAGAAAACCGTATGCCTCACAGAAAACTCCAGATG
CCAAAATACTTGTAAATTCCTGACCAACAGTACTGGCATAGAAATGCTAGATAAATGGGAGCTG
TGATCCTGATCTAGGATCGCTCTTCTTACTGGTTTGCACTACCCACCTTCACCTAGGCAGGGTT
TCTCCTGATCATGAAAAACAACTCTTATCAGGAAGCACCTCGGTAAGTCAGGTCTATTACAAAA
ACAAAACAAAACAAAACAAAACAAAAAACTTCAATGAAACAATCACGATGGATAGTTTATTAGT
CATGTCAGGAGATACCTGTTTTGAGTTAATTACGATGCAGAACTTCTATGCCACCCCTCTCCCC
AAGTAATGCTTGCTTTCCTGAAGCTACAGCTTACACACTAGACTGCGTGGGTTCACAAGAATTA
TTTGTTCTTAAAGTCTCACCTGAGCAGGTGTGCTGCACAGGAGACGGGGAAGGAAAGAAACTAG
TTAGAAGCTTAGAGGGGCAGAGGGCGTGACCCTCTTAATCATCCTTCACTTCCTTTTTTTTAAA
AGATGACTTGGCAAAGTCAGCCAGATCGGGCGGCAGAAGCAGTGACGCCTTCTCAGTGGAACTG
ACTTGCAATAGCGAGCTTTCTCTGCTGCCCATTTGTGGCTTCTGTGGACATATTAGTAACCGGT
GGTTTTAGCTCCCAGTCTCCCAGAGTTGCCAAAGCTGTTAGAAGTCATTTGGAAATGCCTATTA
GCCGAATCTTTCTGATCCAGAAGGCCAGCTGACTGCAGCAACCACTGATCCTGGTCCAGGTGCA
TGGGGAAGACGCTAAGGGTATAAACCCAAGCACTGAACCTGAAGACCCAGCGCAAAGTAGAAAC
TGAAAGTACCCTGCTTACTCTGCCGGCAGATCCTACGGAAGTTATGGCAAAGTCAGAGCGCCTG
GGTGGCCAATGATGCGTGCAGCCCCTCCTGGGATGGATGGACCAGGCGCCGCGTGGGTAAGAGG
AGTCAGCTGCCTGGACTGCCCTGCCCAGCACCAGCTTGCGGCTACTCGGAGGATGACCAGGGTC
CTGGGCGTGATTATGGGTGGCGAGAGCCGGCTCCTGCTGCAGTCCCAGTCATCATGACTACACC
CATCTCCCACAGACCATGTTCCATGTTTCTTTTAGATATATCTTTGGAATTCCTCCCCTGATCC
TTGTGCTGCTGCCGGTCACATCGTCTGACTGTCACATTAAAGACAAGGACGGTAAAGCCTTTGG
GAGTGTGCTGATGATCAGCATCAATCAACTGGACAAAATGACAGGAACTGATAGTGATTGCCCA
AATAATGAACCAAACTTTTTTAAAAAACATCTATGTGATGATACAAAGGAAGCTGCTTTTCTAA
ATCGTGCTGCTCGCAAGTTGAGGCAATTTCTTAAAATGAATATCAGTGAGGAATTCAATGACCA
TTTACTAAGAGTTTCAGACGGCACACAAACACTGGTGAACTGCACAAGCAAGGTATTCCCCTAC
TCTAGAACAAAGCCTCGGCCTTCGGGAAGCTACTCAAGCCTTGGCTGCAAAGTCACAAAGCCCA
TTTGGATCTGCTTTCAAAGATTAACCACTCAGGGACATTGAACAATGATCATGCTGGTATGTGG
GTTATGGATTCTTTTTGACATTTCCATTGTTGTTGTTTATCAGCACAGATATGAAAACATGACT
TTGTAAGGAAGCAGGTGAGCTTTCACACAGTGCATTAGGAAGCCATAGGCATTCCAATCTGAAG
TATAAAATTCAAAGTACACAAATATATGACCCAGAAGCAACATAAAAATAACAAGGGCCTTGTC
CATGAATTTAGAAAGTTTAAATATTTGTGTCTCCAGAATTCCAGAGGTAAAGGGAGGGTTTGTT
CCCACCTGCTTTTTCTGTGTTATGTATCCATGGTAATGGTCAGACAGCTCATAAACAGTTCTAG
CCATGCTCCCACTCTTGGGAGAAAGTGATGGAGTTTCTGCCTATAACCCACACATAGCCTCCTG
TATACTCTAAATTGTATGCAGGCTTCTTAAAAGTTCCACA

hide sequence

RefSeq Acc Id:

XM_063281372 ⟹ XP_063137442

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	96,142,523 - 96,185,680 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_037242	(Get FASTA)	NCBI Sequence Viewer
	XP_006232201	(Get FASTA)	NCBI Sequence Viewer
	XP_063137442	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB66350	(Get FASTA)	NCBI Sequence Viewer
	AAK53392	(Get FASTA)	NCBI Sequence Viewer
	EDM01027	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000016091.7
	ENSRNOP00000097908
	ENSRNOP00000097908.1
GenBank Protein	P56478	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_037242 ⟸ NM_013110
- Peptide Label:	precursor
- UniProtKB:	P56478 (UniProtKB/Swiss-Prot), Q91Y32 (UniProtKB/TrEMBL)
- Sequence:	show sequence MFHVSFRYIFGIPPLILVLLPVTSSDCHIKDKDGKAFGSVLMISINQLDKMTGTDSDCPNNEPN FFKKHLCDDTKEAAFLNRAARKLRQFLKMNISEEFNDHLLRVSDGTQTLVNCTSKEEKTIKEQK KNDPCFLKRLLREIKTCWNKILNSSI hide sequence

RefSeq Acc Id:	XP_006232201 ⟸ XM_006232139
- Peptide Label:	isoform X1
- Sequence:	show sequence MFHVSFRYIFGIPPLILVLLPVTSSDCHIKDKDGKAFGSVLMISINQLDKMTGTDSDCPNNEPN FFKKHLCDDTKEAAFLNRAARKLRQFLKMNISEEFNDHLLRVSDGTQTLVNCTSKVFPYSRTKP RPSGSYSSLGCKVTKPIWICFQRLTTQGH hide sequence

RefSeq Acc Id:

ENSRNOP00000016091 ⟸ ENSRNOT00000016091

RefSeq Acc Id:

ENSRNOP00000097908 ⟸ ENSRNOT00000095233

RefSeq Acc Id:	XP_063137442 ⟸ XM_063281372
- Peptide Label:	isoform X1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P56478-F1-model_v2	AlphaFold	P56478	1-154	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2904	AgrOrtholog
BioCyc Gene	G2FUF-53693	BioCyc
Ensembl Genes	ENSRNOG00000011973	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000016091.8	UniProtKB/TrEMBL
	ENSRNOT00000095233	ENTREZGENE
	ENSRNOT00000095233.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1250.50	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	IL-7	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IL-7/IL-9_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IL7_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25647	UniProtKB/TrEMBL
NCBI Gene	25647	ENTREZGENE
PANTHER	INTERLEUKIN-7	UniProtKB/Swiss-Prot
	INTERLEUKIN-7	UniProtKB/Swiss-Prot
	INTERLEUKIN-7	UniProtKB/TrEMBL
	INTERLEUKIN-7	UniProtKB/TrEMBL
Pfam	IL7	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Il7	PhenoGen
PIRSF	IL-7	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	INTERLEUKIN7	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	INTERLEUKIN_7_9	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000011973	RatGTEx
SMART	IL7	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6IH79_RAT	UniProtKB/TrEMBL
	F7FJK6_RAT	UniProtKB/TrEMBL
	IL7_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q91Y32	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Il7	Interleukin 7			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_process	increased expression decreases intracerebral brain tumor cell growth	727266

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)