Grin2c (glutamate ionotropic receptor NMDA type subunit 2C) - Rat Genome Database

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Gene: Grin2c (glutamate ionotropic receptor NMDA type subunit 2C) Rattus norvegicus
Analyze
Symbol: Grin2c
Name: glutamate ionotropic receptor NMDA type subunit 2C
RGD ID: 2739
Description: Enables NMDA glutamate receptor activity; PDZ domain binding activity; and monoatomic cation channel activity. Involved in ionotropic glutamate receptor signaling pathway; modulation of chemical synaptic transmission; and regulation of monoatomic cation transmembrane transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of NMDA selective glutamate receptor complex. Predicted to be active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human GRIN2C (glutamate ionotropic receptor NMDA type subunit 2C); PARTICIPATES IN Alzheimer's disease pathway; amyotrophic lateral sclerosis pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GluN2C; glutamate [NMDA] receptor subunit epsilon-3; Glutamate receptor ionotropic N-methyl D-aspartate 2C; glutamate receptor ionotropic, NMDA 2C; glutamate receptor, ionotropic, N-methyl D-aspartate 2C; glutamate receptor, ionotropic, NMDA2C; N-methyl D-aspartate receptor subtype 2C; NMDA glutamate receptor; NMDAR2C; NR2C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810100,987,410 - 101,006,064 (-)NCBIGRCr8
mRatBN7.210100,488,430 - 100,507,083 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10100,488,431 - 100,506,427 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10105,548,769 - 105,566,341 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010105,011,829 - 105,029,401 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010100,409,542 - 100,427,149 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010103,798,290 - 103,816,923 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10103,798,291 - 103,816,287 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010104,479,941 - 104,497,938 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410105,323,371 - 105,340,976 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110105,337,754 - 105,355,751 (-)NCBI
Celera1099,064,978 - 99,082,583 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
aflatoxin B1  (EXP,ISO)
ammonium chloride  (EXP,ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
Butylparaben  (EXP)
carbon nanotube  (ISO)
celecoxib  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clozapine  (EXP)
cocaine  (EXP)
cordycepin  (ISO)
Cuprizon  (EXP)
diazinon  (EXP)
dieldrin  (EXP)
dizocilpine maleate  (EXP)
endosulfan  (EXP)
enzacamene  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
excitatory amino acid agonist  (ISO)
felbamate  (EXP)
folic acid  (ISO)
fonofos  (ISO)
gentamycin  (EXP)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
kainic acid  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lead nitrate  (EXP)
melphalan  (ISO)
menadione  (ISO)
methotrexate  (ISO)
methylmercury chloride  (EXP)
minocycline  (EXP)
monosodium L-glutamate  (EXP)
morphine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (EXP)
O-methyleugenol  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
parathion  (ISO)
PCB138  (EXP,ISO)
pentobarbital  (EXP)
phenobarbital  (EXP)
piperonyl butoxide  (EXP)
poly(cytidylic acid)  (EXP)
propanal  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thalidomide  (ISO)
titanium dioxide  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit. Abe M, etal., J Neurosci. 2004 Aug 18;24(33):7292-304. doi: 10.1523/JNEUROSCI.1261-04.2004.
2. Colocalization and hormone regulation of estrogen receptor alpha and N-methyl-D-aspartate receptor in the hypothalamus of female rats. Chakraborty TR, etal., Endocrinology 2003 Jan;144(1):299-305.
3. Regulation of NR1/NR2C N-methyl-D-aspartate (NMDA) receptors by phosphorylation. Chen BS, etal., J Biol Chem. 2006 Jun 16;281(24):16583-90. Epub 2006 Apr 10.
4. Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain. Cui Z, etal., Neuron. 2004 Mar 4;41(5):781-93. doi: 10.1016/s0896-6273(04)00072-8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Depolarization induces insulin-like growth factor binding protein-2 expression in vivo via NMDA receptor stimulation. Holmin S, etal., Growth Horm IGF Res 2001 Dec;11(6):399-406.
8. Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. Ishii T, etal., J Biol Chem 1993 Feb 5;268(4):2836-43.
9. CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. Kurschner C, etal., Mol Cell Neurosci. 1998 Jun;11(3):161-72.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Monyer H, etal., Science 1992 May 22;256(5060):1217-21.
12. Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones. Nagy J, etal., Neurochem Int 2003 Jan;42(1):35-43.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1. Yaka R, etal., J Biol Chem 2003 Mar 14;278(11):9630-8.
19. NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1. Yaka R, etal., Proc Natl Acad Sci U S A 2002 Apr 16;99(8):5710-5. Epub 2002 Apr 9.
20. Control of NMDA receptor function by the NR2 subunit amino-terminal domain. Yuan H, etal., J Neurosci. 2009 Sep 30;29(39):12045-58. doi: 10.1523/JNEUROSCI.1365-09.2009.
Additional References at PubMed
PMID:1377365   PMID:7569905   PMID:7929101   PMID:8756432   PMID:8987814   PMID:9427357   PMID:9458051   PMID:9512392   PMID:9651389   PMID:9718984   PMID:10197777   PMID:10479680  
PMID:11483648   PMID:11606043   PMID:11792837   PMID:11799243   PMID:11906698   PMID:11936777   PMID:11992467   PMID:12140784   PMID:12408866   PMID:12411521   PMID:12414113   PMID:12428135  
PMID:12775422   PMID:14644469   PMID:14667572   PMID:14983054   PMID:15469880   PMID:15519237   PMID:17961930   PMID:19193935   PMID:19477150   PMID:20887777   PMID:23627311   PMID:24008353  
PMID:26229101   PMID:26875626   PMID:26919761   PMID:27845401   PMID:31969570  


Genomics

Comparative Map Data
Grin2c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810100,987,410 - 101,006,064 (-)NCBIGRCr8
mRatBN7.210100,488,430 - 100,507,083 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10100,488,431 - 100,506,427 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10105,548,769 - 105,566,341 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010105,011,829 - 105,029,401 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010100,409,542 - 100,427,149 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010103,798,290 - 103,816,923 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10103,798,291 - 103,816,287 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010104,479,941 - 104,497,938 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410105,323,371 - 105,340,976 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110105,337,754 - 105,355,751 (-)NCBI
Celera1099,064,978 - 99,082,583 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
GRIN2C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381774,842,023 - 74,861,532 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1774,842,023 - 74,861,504 (-)EnsemblGRCh38hg38GRCh38
GRCh371772,838,162 - 72,856,966 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361770,349,759 - 70,367,602 (-)NCBINCBI36Build 36hg18NCBI36
Build 341770,349,762 - 70,367,602NCBI
Celera1769,431,345 - 69,449,257 (-)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1768,248,662 - 68,267,666 (-)NCBIHuRef
CHM1_11772,902,989 - 72,921,796 (-)NCBICHM1_1
T2T-CHM13v2.01775,733,798 - 75,753,286 (-)NCBIT2T-CHM13v2.0
Grin2c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911115,139,995 - 115,158,123 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11115,139,995 - 115,158,069 (-)EnsemblGRCm39 Ensembl
GRCm3811115,249,169 - 115,267,297 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11115,249,169 - 115,267,243 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711115,110,483 - 115,128,557 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611115,065,259 - 115,083,333 (-)NCBIMGSCv36mm8
Celera11127,014,742 - 127,032,873 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1180.8NCBI
Grin2c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555531,729,860 - 1,737,751 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555531,729,431 - 1,746,754 (-)NCBIChiLan1.0ChiLan1.0
GRIN2C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21990,879,305 - 90,898,860 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11795,702,220 - 95,721,764 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01768,787,670 - 68,807,192 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11774,344,940 - 74,363,540 (-)NCBIpanpan1.1PanPan1.1panPan2
GRIN2C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.195,582,404 - 5,595,540 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl95,576,681 - 5,595,146 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha96,261,897 - 6,274,915 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.096,254,398 - 6,267,415 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl96,255,404 - 6,267,017 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.196,291,347 - 6,304,344 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.096,401,937 - 6,414,998 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.096,462,275 - 6,475,342 (+)NCBIUU_Cfam_GSD_1.0
Grin2c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056026,200,706 - 6,214,622 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936594197,737 - 208,376 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936594197,337 - 208,468 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIN2C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl126,383,609 - 6,399,550 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1126,385,407 - 6,401,454 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2126,378,936 - 6,390,260 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRIN2C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11646,797,136 - 46,816,703 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1646,803,535 - 46,816,292 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607717,587,830 - 17,602,104 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grin2c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248014,697,512 - 4,712,276 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248014,697,891 - 4,713,771 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grin2c
56 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:233
Count of miRNA genes:145
Interacting mature miRNAs:161
Transcripts:ENSRNOT00000004477
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1558652Bw57Body weight QTL 574.20.0008body mass (VT:0001259)body weight (CMO:0000012)1090910316107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1092238497101012337Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
631539Oia6Oil induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1097010147104670812Rat

Markers in Region
RH132419  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210100,488,625 - 100,488,825 (+)MAPPERmRatBN7.2
Rnor_6.010103,798,486 - 103,798,685NCBIRnor6.0
Rnor_5.010104,497,543 - 104,497,742UniSTSRnor5.0
RGSC_v3.410105,323,446 - 105,323,645UniSTSRGSC3.4
Celera1099,065,053 - 99,065,252UniSTS
Cytogenetic Map10q32.2UniSTS
RH94563  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210100,488,555 - 100,488,747 (+)MAPPERmRatBN7.2
Rnor_6.010103,798,416 - 103,798,607NCBIRnor6.0
Rnor_5.010104,497,621 - 104,497,812UniSTSRnor5.0
RGSC_v3.410105,323,376 - 105,323,567UniSTSRGSC3.4
Celera1099,064,983 - 99,065,174UniSTS
Cytogenetic Map10q32.2UniSTS
Grin2c  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210100,488,917 - 100,489,096 (+)MAPPERmRatBN7.2
Rnor_6.010103,798,778 - 103,798,956NCBIRnor6.0
Rnor_5.010104,497,272 - 104,497,450UniSTSRnor5.0
RGSC_v3.410105,323,738 - 105,323,916UniSTSRGSC3.4
Celera1099,065,345 - 99,065,523UniSTS
Cytogenetic Map10q32.2UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 25
Low 6 12 4 4 31 12 23 11
Below cutoff 2 11 21 13 19 13 6 6 18 11 16 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC094435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D13212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M91563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U08259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000004477   ⟹   ENSRNOP00000004477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10100,488,431 - 100,506,427 (-)Ensembl
Rnor_6.0 Ensembl10103,798,291 - 103,816,287 (-)Ensembl
RefSeq Acc Id: NM_012575   ⟹   NP_036707
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810100,987,531 - 101,005,138 (-)NCBI
mRatBN7.210100,488,551 - 100,506,156 (-)NCBI
Rnor_6.010103,798,411 - 103,816,016 (-)NCBI
Rnor_5.010104,479,941 - 104,497,938 (+)NCBI
RGSC_v3.410105,323,371 - 105,340,976 (-)RGD
Celera1099,064,978 - 99,082,583 (-)RGD
Sequence:
RefSeq Acc Id: XM_006247709   ⟹   XP_006247771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810100,987,410 - 101,006,062 (-)NCBI
mRatBN7.210100,488,668 - 100,507,082 (-)NCBI
Rnor_6.010103,798,290 - 103,816,923 (-)NCBI
Rnor_5.010104,479,941 - 104,497,938 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596988   ⟹   XP_017452477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810100,987,410 - 101,006,062 (-)NCBI
mRatBN7.210100,488,668 - 100,507,082 (-)NCBI
Rnor_6.010103,798,290 - 103,816,923 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596989   ⟹   XP_017452478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810100,987,410 - 101,006,062 (-)NCBI
mRatBN7.210100,488,668 - 100,507,082 (-)NCBI
Rnor_6.010103,798,290 - 103,816,923 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596990   ⟹   XP_017452479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810100,987,410 - 101,006,062 (-)NCBI
mRatBN7.210100,488,668 - 100,507,082 (-)NCBI
Rnor_6.010103,798,290 - 103,816,923 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596992   ⟹   XP_017452481
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810100,987,410 - 101,006,062 (-)NCBI
mRatBN7.210100,488,668 - 100,507,082 (-)NCBI
Rnor_6.010103,798,290 - 103,816,923 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085181   ⟹   XP_038941109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810100,987,410 - 101,006,062 (-)NCBI
mRatBN7.210100,488,668 - 100,507,082 (-)NCBI
RefSeq Acc Id: XM_039085182   ⟹   XP_038941110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810100,987,410 - 101,006,062 (-)NCBI
mRatBN7.210100,488,668 - 100,507,082 (-)NCBI
RefSeq Acc Id: XM_039085184   ⟹   XP_038941112
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810100,987,410 - 101,006,062 (-)NCBI
mRatBN7.210100,488,668 - 100,507,082 (-)NCBI
RefSeq Acc Id: XM_063268390   ⟹   XP_063124460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810100,987,410 - 101,006,062 (-)NCBI
RefSeq Acc Id: XM_063268391   ⟹   XP_063124461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810100,987,410 - 101,006,062 (-)NCBI
RefSeq Acc Id: XM_063268392   ⟹   XP_063124462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810100,987,410 - 101,006,062 (-)NCBI
RefSeq Acc Id: XM_063268393   ⟹   XP_063124463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810100,987,410 - 101,006,062 (-)NCBI
RefSeq Acc Id: XM_063268394   ⟹   XP_063124464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810100,987,410 - 101,006,062 (-)NCBI
RefSeq Acc Id: XM_063268395   ⟹   XP_063124465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810100,987,410 - 101,006,062 (-)NCBI
RefSeq Acc Id: XM_063268396   ⟹   XP_063124466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810100,987,410 - 101,003,622 (-)NCBI
RefSeq Acc Id: XM_063268397   ⟹   XP_063124467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810100,987,410 - 100,995,244 (-)NCBI
RefSeq Acc Id: XR_010055128
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810100,991,194 - 101,006,064 (-)NCBI
RefSeq Acc Id: NP_036707   ⟸   NM_012575
- UniProtKB: A0A0G2JSH8 (UniProtKB/TrEMBL),   A6HKL2 (UniProtKB/TrEMBL),   Q62644 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247771   ⟸   XM_006247709
- Peptide Label: isoform X2
- UniProtKB: Q00961 (UniProtKB/Swiss-Prot),   Q62644 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452479   ⟸   XM_017596990
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JSH8 (UniProtKB/TrEMBL),   A6HKL2 (UniProtKB/TrEMBL),   Q62644 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452478   ⟸   XM_017596989
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JSH8 (UniProtKB/TrEMBL),   A6HKL2 (UniProtKB/TrEMBL),   Q62644 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452481   ⟸   XM_017596992
- Peptide Label: isoform X2
- UniProtKB: Q00961 (UniProtKB/Swiss-Prot),   Q62644 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452477   ⟸   XM_017596988
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JSH8 (UniProtKB/TrEMBL),   A6HKL2 (UniProtKB/TrEMBL),   Q62644 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004477   ⟸   ENSRNOT00000004477
RefSeq Acc Id: XP_038941110   ⟸   XM_039085182
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JSH8 (UniProtKB/TrEMBL),   A6HKL2 (UniProtKB/TrEMBL),   Q62644 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941112   ⟸   XM_039085184
- Peptide Label: isoform X2
- UniProtKB: Q00961 (UniProtKB/Swiss-Prot),   Q62644 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941109   ⟸   XM_039085181
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JSH8 (UniProtKB/TrEMBL),   A6HKL2 (UniProtKB/TrEMBL),   Q62644 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124462   ⟸   XM_063268392
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063124464   ⟸   XM_063268394
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063124465   ⟸   XM_063268395
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063124463   ⟸   XM_063268393
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063124460   ⟸   XM_063268390
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063124461   ⟸   XM_063268391
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063124466   ⟸   XM_063268396
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063124467   ⟸   XM_063268397
- Peptide Label: isoform X3
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q00961-F1-model_v2 AlphaFold Q00961 1-1237 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2739 AgrOrtholog
BioCyc Gene G2FUF-22694 BioCyc
Ensembl Genes ENSRNOG00000003280 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004477.6 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.2300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Periplasmic binding protein-like II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glu/Gly-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iono_rcpt_met UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ionotropic_Glu_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iontro_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NMDAR2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Solute-binding_3/MltF_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24411 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24411 ENTREZGENE
PANTHER GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IONOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NMDAR2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SBP_bac_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grin2c PhenoGen
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003280 RatGTEx
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PBPe UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSH8 ENTREZGENE, UniProtKB/TrEMBL
  A6HKL2 ENTREZGENE, UniProtKB/TrEMBL
  NMDE3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q62644 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Grin2c  glutamate ionotropic receptor NMDA type subunit 2C  Grin2c  glutamate receptor, ionotropic, N-methyl D-aspartate 2C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Grin2c  glutamate receptor, ionotropic, N-methyl D-aspartate 2C  Grin2c  glutamate receptor, ionotropic, NMDA2C   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Grin2c  glutamate receptor, ionotropic, NMDA2C     Glutamate receptor, ionotropic, N-methyl D-aspartate 2C  Name updated 625702 APPROVED
2002-06-10 Grin2c  Glutamate receptor, ionotropic, N-methyl D-aspartate 2C      Symbol and Name status set to approved 70586 APPROVED