Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Myocardial Ischemia | | ISO | TLE5 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:16214533 | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Myocardial Ischemia | | ISO | TLE5 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:16214533 | |
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# | Reference Title | Reference Citation |
1. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
2. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
3. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
4. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
5. | GOA pipeline | RGD automated data pipeline |
6. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
7. | A rat homolog of the Drosophila enhancer of split (groucho) locus lacking WD-40 repeats. | Schmidt CJ and Sladek TE, J Biol Chem 1993 Dec 5;268(34):25681-6. |
8. | Tentative Sequence Identification Numbers | Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
PMID:10322635 | PMID:10660609 | PMID:11984876 | PMID:12050133 | PMID:12477932 | PMID:15006356 | PMID:15489227 | PMID:16002402 | PMID:19460168 | PMID:19796622 | PMID:22871113 | PMID:22952044 |
PMID:27107012 |
Tle5 (Rattus norvegicus - Norway rat) |
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TLE5 (Homo sapiens - human) |
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Tle5 (Mus musculus - house mouse) |
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Tle5 (Chinchilla lanigera - long-tailed chinchilla) |
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TLE5 (Pan paniscus - bonobo/pygmy chimpanzee) |
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TLE5 (Canis lupus familiaris - dog) |
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Tle5 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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TLE5 (Sus scrofa - pig) |
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TLE5 (Chlorocebus sabaeus - green monkey) |
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Tle5 (Heterocephalus glaber - naked mole-rat) |
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Variants in Tle5
27 total Variants |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
RH127590 |
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RH135261 |
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RH125487 |
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UniSTS:532261 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | 2 | 1 | 2 | ||||||||||
Medium | 3 | 41 | 57 | 41 | 19 | 41 | 8 | 10 | 72 | 35 | 41 | 11 | 8 |
Low | |||||||||||||
Below cutoff |
RefSeq Transcripts | NM_019220 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_039078583 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039078584 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039078585 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039078586 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039078587 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AC127191 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
BC101855 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH474029 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000007 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
L14462 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000092061 ⟹ ENSRNOP00000071178 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000098364 ⟹ ENSRNOP00000079330 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000100632 ⟹ ENSRNOP00000097044 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000113477 ⟹ ENSRNOP00000092723 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_019220 ⟹ NP_062093 | ||||||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039078583 ⟹ XP_038934511 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039078584 ⟹ XP_038934512 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039078585 ⟹ XP_038934513 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039078586 ⟹ XP_038934514 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039078587 ⟹ XP_038934515 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Protein RefSeqs | NP_062093 | (Get FASTA) | NCBI Sequence Viewer |
XP_038934511 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038934512 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038934513 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038934514 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038934515 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAC37639 | (Get FASTA) | NCBI Sequence Viewer |
AAI01856 | (Get FASTA) | NCBI Sequence Viewer | |
EDL89139 | (Get FASTA) | NCBI Sequence Viewer | |
EDL89140 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000071178.2 | ||
ENSRNOP00000079330.1 | |||
ENSRNOP00000092723 | |||
ENSRNOP00000092723.1 | |||
ENSRNOP00000097044 | |||
ENSRNOP00000097044.1 | |||
ENSRNOP00055047234 | |||
ENSRNOP00060043294 | |||
ENSRNOP00065029428 | |||
GenBank Protein | P63003 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_062093 ⟸ NM_019220 |
- UniProtKB: | Q3MIF3 (UniProtKB/Swiss-Prot), P63003 (UniProtKB/Swiss-Prot), A0A0G2JZT6 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000071178 ⟸ ENSRNOT00000092061 |
RefSeq Acc Id: | XP_038934512 ⟸ XM_039078584 |
- Peptide Label: | isoform X2 |
- UniProtKB: | A0A8I6ARX3 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_038934513 ⟸ XM_039078585 |
- Peptide Label: | isoform X3 |
- UniProtKB: | A0A0G2JZT6 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_038934511 ⟸ XM_039078583 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A0A8I6ARX3 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_038934514 ⟸ XM_039078586 |
- Peptide Label: | isoform X4 |
RefSeq Acc Id: | XP_038934515 ⟸ XM_039078587 |
- Peptide Label: | isoform X5 |
RefSeq Acc Id: | ENSRNOP00000097044 ⟸ ENSRNOT00000100632 |
RefSeq Acc Id: | ENSRNOP00000079330 ⟸ ENSRNOT00000098364 |
RefSeq Acc Id: | ENSRNOP00000092723 ⟸ ENSRNOT00000113477 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-P63003-F1-model_v2 | AlphaFold | P63003 | 1-197 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13694967 | ||||||||
Promoter ID: | EPDNEW_R5492 | ||||||||
Type: | single initiation site | ||||||||
Name: | Aes_1 | ||||||||
Description: | amino-terminal enhancer of split | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:2731 | AgrOrtholog |
BioCyc Gene | G2FUF-35040 | BioCyc |
Ensembl Genes | ENSRNOG00000052025 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
ENSRNOG00055033151 | UniProtKB/Swiss-Prot | |
ENSRNOG00060029904 | UniProtKB/Swiss-Prot | |
ENSRNOG00065021444 | UniProtKB/Swiss-Prot | |
Ensembl Transcript | ENSRNOT00000092061.2 | UniProtKB/TrEMBL |
ENSRNOT00000098364.1 | UniProtKB/TrEMBL | |
ENSRNOT00000100632.1 | UniProtKB/TrEMBL | |
ENSRNOT00000113477 | ENTREZGENE | |
ENSRNOT00000113477.1 | UniProtKB/Swiss-Prot | |
ENSRNOT00055057299 | UniProtKB/Swiss-Prot | |
ENSRNOT00060052056 | UniProtKB/Swiss-Prot | |
ENSRNOT00065036520 | UniProtKB/Swiss-Prot | |
IMAGE_CLONE | IMAGE:7933368 | IMAGE-MGC_LOAD |
InterPro | Groucho/TLE_N | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Groucho_enhance | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:29466 | UniProtKB/Swiss-Prot |
MGC_CLONE | MGC:124620 | IMAGE-MGC_LOAD |
NCBI Gene | Tle5 | ENTREZGENE |
PANTHER | PTHR10814 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
TRANSDUCIN-LIKE ENHANCER PROTEIN 4 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | TLE_N | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PhenoGen | Tle5 | PhenoGen |
RatGTEx | ENSRNOG00000052025 | RatGTEx |
ENSRNOG00055033151 | RatGTEx | |
ENSRNOG00060029904 | RatGTEx | |
ENSRNOG00065021444 | RatGTEx | |
TIGR | TC216876 | |
UniProt | A0A0G2JZT6 | ENTREZGENE, UniProtKB/TrEMBL |
A0A8I6ARX3 | ENTREZGENE, UniProtKB/TrEMBL | |
A0A8I6G347_RAT | UniProtKB/TrEMBL | |
P63003 | ENTREZGENE | |
Q3MIF3 | ENTREZGENE | |
TLE5_RAT | UniProtKB/Swiss-Prot | |
UniProt Secondary | Q06195 | UniProtKB/Swiss-Prot |
Q3MIF3 | UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2019-03-25 | Tle5 | TLE family member 5, transcriptional modulator | Aes | amino-terminal enhancer of split | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2002-06-10 | Aes | amino-terminal enhancer of split | Name updated | 70584 | APPROVED | ||
2001-10-24 | Aes | amino-terminal enhancer of split | Symbol and Name updated to reflect Human and Mouse nomenclature | 68913 | APPROVED |
Note Type | Note | Reference |
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gene_expression | acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state | 724707 |