Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Hypophosphatemic Rickets, Autosomal Recessive, 1 | | ISO | DMP1 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Hypophosphatemic Rickets, Autosomal Recessive, 1 | | ISO | DMP1 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | | |
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# | Reference Title | Reference Citation |
1. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
2. | Characterization of a novel dentin matrix acidic phosphoprotein. Implications for induction of biomineralization. | George A, etal., J Biol Chem 1993 Jun 15;268(17):12624-30. |
3. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
4. | High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. | Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 |
5. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
6. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
7. | OMIM Disease Annotation Pipeline | OMIM Disease Annotation Pipeline |
8. | Endoplasmic reticulum chaperone protein GRP-78 mediates endocytosis of dentin matrix protein 1. | Ravindran S, etal., J Biol Chem. 2008 Oct 31;283(44):29658-70. doi: 10.1074/jbc.M800786200. Epub 2008 Aug 28. |
9. | GOA pipeline | RGD automated data pipeline |
10. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
11. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
PMID:10744713 | PMID:11697797 | PMID:12005026 | PMID:12369786 | PMID:12477932 | PMID:12647294 | PMID:12813042 | PMID:14699165 | PMID:14751569 | PMID:15193538 | PMID:15533758 | PMID:16014627 |
PMID:17950631 | PMID:18215377 | PMID:18698129 | PMID:18757743 | PMID:18854597 | PMID:19001636 | PMID:19908197 | PMID:20200415 | PMID:24076023 | PMID:24085820 | PMID:25158192 | PMID:25158195 |
PMID:27039006 | PMID:27614627 | PMID:30238933 |
Dmp1 (Rattus norvegicus - Norway rat) |
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DMP1 (Homo sapiens - human) |
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Dmp1 (Mus musculus - house mouse) |
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Dmp1 (Chinchilla lanigera - long-tailed chinchilla) |
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DMP1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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DMP1 (Canis lupus familiaris - dog) |
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Dmp1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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DMP1 (Sus scrofa - pig) |
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DMP1 (Chlorocebus sabaeus - green monkey) |
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Dmp1 (Heterocephalus glaber - naked mole-rat) |
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Variants in Dmp1
201 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
RH94681 |
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circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | ||||||||||||
Medium | ||||||||||||
Low | 12 | 6 | 4 | 5 | 6 | 4 | 18 | 16 | 2 | 5 | ||
Below cutoff | 15 | 13 | 3 | 8 | 3 | 3 | 5 | 65 | 17 | 17 | 8 | 3 |
RefSeq Transcripts | NM_203493 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_006250622 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_008769994 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_008769995 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063272869 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AC129695 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AF263369 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC129082 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH474022 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000014 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
L11354 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000061224 ⟹ ENSRNOP00000057936 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000116244 ⟹ ENSRNOP00000095386 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_203493 ⟹ NP_987089 | ||||||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006250622 ⟹ XP_006250684 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_063272869 ⟹ XP_063128939 | ||||||||
Type: | CODING | ||||||||
Position: |
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Protein RefSeqs | NP_987089 | (Get FASTA) | NCBI Sequence Viewer |
XP_006250684 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063128939 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAI29083 | (Get FASTA) | NCBI Sequence Viewer |
AAS55638 | (Get FASTA) | NCBI Sequence Viewer | |
EDL99499 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000057936.2 | ||
ENSRNOP00000095386 | |||
ENSRNOP00000095386.1 | |||
GenBank Protein | P98193 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_987089 ⟸ NM_203493 |
- Peptide Label: | precursor |
- UniProtKB: | P98193 (UniProtKB/Swiss-Prot), A2VD06 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006250684 ⟸ XM_006250622 |
- Peptide Label: | isoform X1 |
- UniProtKB: | P98193 (UniProtKB/Swiss-Prot), A0A8I6GLL4 (UniProtKB/TrEMBL), A6K5S9 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000057936 ⟸ ENSRNOT00000061224 |
RefSeq Acc Id: | ENSRNOP00000095386 ⟸ ENSRNOT00000116244 |
RefSeq Acc Id: | XP_063128939 ⟸ XM_063272869 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A0A8I6GLL4 (UniProtKB/TrEMBL), A6K5S9 (UniProtKB/TrEMBL) |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-P98193-F1-model_v2 | AlphaFold | P98193 | 1-489 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13699174 | ||||||||
Promoter ID: | EPDNEW_R9699 | ||||||||
Type: | single initiation site | ||||||||
Name: | Dmp1_1 | ||||||||
Description: | dentin matrix acidic phosphoprotein 1 | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:2508 | AgrOrtholog |
BioCyc Gene | G2FUF-16503 | BioCyc |
Ensembl Genes | ENSRNOG00000002167 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000061224.4 | UniProtKB/TrEMBL |
ENSRNOT00000116244.1 | UniProtKB/TrEMBL | |
IMAGE_CLONE | IMAGE:8365946 | IMAGE-MGC_LOAD |
InterPro | DMP1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
KEGG Report | rno:25312 | UniProtKB/TrEMBL |
MGC_CLONE | MGC:156551 | IMAGE-MGC_LOAD |
NCBI Gene | 25312 | ENTREZGENE |
PANTHER | DENTIN MATRIX ACIDIC PHOSPHOPROTEIN 1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PTHR23400 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | DMP1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PhenoGen | Dmp1 | PhenoGen |
PROSITE | PROKAR_LIPOPROTEIN | UniProtKB/TrEMBL |
RatGTEx | ENSRNOG00000002167 | RatGTEx |
UniProt | A0A8I6GLL4 | ENTREZGENE, UniProtKB/TrEMBL |
A2VD06 | ENTREZGENE, UniProtKB/TrEMBL | |
A6K5S9 | ENTREZGENE, UniProtKB/TrEMBL | |
DMP1_RAT | UniProtKB/Swiss-Prot, ENTREZGENE |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2008-10-17 | Dmp1 | dentin matrix acidic phosphoprotein 1 | Dmp1 | dentin matrix protein 1 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2002-11-06 | Dmp1 | dentin matrix protein 1 | Dentin matrix acidic phosphoprotein 1 | Symbol and Name updated | 625702 | APPROVED | |
2002-06-10 | Dmp1 | Dentin matrix acidic phosphoprotein 1 | Symbol and Name status set to approved | 70586 | APPROVED |
Note Type | Note | Reference |
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gene_domains | protein contains acidic consensus sites for phosphorylation by casein kinases I and II, and single RGD integrin binding and N-glycosylation sequences | 728616 |
gene_expression | protein is found in phosphorylated form in the dentin matrix | 728616 |
gene_protein | predicted protein contains 473 aa residues | 728616 |