Chga (chromogranin A) - Rat Genome Database

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Gene: Chga (chromogranin A) Rattus norvegicus
Analyze
Symbol: Chga
Name: chromogranin A
RGD ID: 2338
Description: Involved in several processes, including adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation; positive regulation of signal transduction; and regulation of blood circulation. Located in chromaffin granule; extracellular space; and neuronal dense core vesicle. Biomarker of hypertension. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal disease; hypertension; and prostate cancer. Orthologous to human CHGA (chromogranin A); PARTICIPATES IN G protein mediated signaling pathway; INTERACTS WITH (S)-nicotine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cgA; chromogranin A (parathyroid secretory protein 1); Chromogranin A parathyroid secretory protein 1; chromogranin A precursor; Chromogranin A, parathyroid secretory protein 1; chromogranin A-like; chromogranin-A; MGC105435
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86127,460,895 - 127,472,238 (+)NCBIGRCr8
mRatBN7.26121,696,051 - 121,707,399 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6121,696,051 - 121,707,398 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6121,834,591 - 121,845,883 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06122,129,839 - 122,141,131 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06121,466,197 - 121,477,529 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06126,434,226 - 126,445,569 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6126,434,226 - 126,445,568 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06135,645,155 - 135,656,373 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.16126,825,283 - 126,836,311 (+)NCBI
Celera6119,184,838 - 119,196,152 (+)NCBICelera
RH 3.4 Map6845.4RGD
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
atrazine  (ISO)
B 823-08  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cetrorelix  (ISO)
CGP 52608  (ISO)
chlorisondamine  (ISO)
chlorpyrifos  (EXP)
clozapine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (ISO)
DDE  (EXP)
diazinon  (EXP)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
folic acid  (ISO)
furan  (EXP)
furosemide  (EXP)
hexanal  (EXP)
lead(0)  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
lycopene  (ISO)
maneb  (ISO)
methoxychlor  (EXP)
methylphenidate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (EXP)
nicotine  (EXP,ISO)
Oxotremorine  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phenylmercury acetate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (ISO)
reserpine  (EXP,ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
Securinine  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
testosterone enanthate  (ISO)
thapsigargin  (EXP,ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
protein binding  (IPI,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Capture of Dense Core Vesicles at Synapses by JNK-Dependent Phosphorylation of Synaptotagmin-4. Bharat V, etal., Cell Rep. 2017 Nov 21;21(8):2118-2133. doi: 10.1016/j.celrep.2017.10.084.
2. Cathepsin L colocalizes with chromogranin a in chromaffin vesicles to generate active peptides. Biswas N, etal., Endocrinology. 2009 Aug;150(8):3547-57. Epub 2009 Apr 16.
3. Naturally occurring genetic variants in human chromogranin A (CHGA) associated with hypertension as well as hypertensive renal disease. Chen Y, etal., Cell Mol Neurobiol. 2010 Nov;30(8):1395-400.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Role of reactive oxygen species in hyperadrenergic hypertension: biochemical, physiological, and pharmacological evidence from targeted ablation of the chromogranin a (Chga) gene. Gayen JR, etal., Circ Cardiovasc Genet. 2010 Oct;3(5):414-25. Epub 2010 Aug 20.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Pancreastatin, a chromogranin A-derived peptide, activates protein synthesis signaling cascade in rat adipocytes. Gonzalez-Yanes C and Sanchez-Margalet V, Biochem Biophys Res Commun 2002 Dec 13;299(4):525-31.
8. Pancreastatin, a chromogranin A-derived peptide, activates Galpha(16) and phospholipase C-beta(2) by interacting with specific receptors in rat heart membranes. Gonzalez-Yanes C, etal., Cell Signal. 2001 Jan;13(1):43-9.
9. Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells. Hosaka M, etal., Mol Biol Cell. 2002 Oct;13(10):3388-99.
10. Chromogranin A in familial pheochromocytoma: diagnostic screening value, prediction of tumor mass, and post-resection kinetics indicating two-compartment distribution. Hsiao RJ, etal., Am J Med. 1990 Jun;88(6):607-13.
11. Primary structure of rat chromogranin A and distribution of its mRNA. Iacangelo A, etal., FEBS Lett 1988 Jan 25;227(2):115-21.
12. Large dense-core secretory granule biogenesis is under the control of chromogranin A in neuroendocrine cells. Kim T, etal., Ann N Y Acad Sci 2002 Oct;971:323-31.
13. Role of pGlu-serpinin, a novel chromogranin A-derived peptide in inhibition of cell death. Koshimizu H, etal., J Mol Neurosci. 2011 Oct;45(2):294-303. Epub 2011 May 3.
14. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
15. Clinical significance of polymorphism and expression of chromogranin a and endothelin-1 in prostate cancer. Ma Z, etal., J Urol. 2010 Sep;184(3):1182-8. Epub 2010 Jul 21.
16. Chromogranin A-derived peptides: interaction with the rat posterior cerebral artery. Mandala M, etal., Regul Pept. 2005 Jan 15;124(1-3):73-80.
17. Chromogranin A proteolysis to generate beta-granin and WE-14 in the adenohypophysis during the rat oestrous cycle. McVicar CM, etal., Regul Pept. 2003 Aug 15;115(1):1-10.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Evaluation of chromogranin A determined by three different procedures in patients with benign diseases, neuroendocrine tumors and other malignancies. Molina R, etal., Tumour Biol. 2011 Feb;32(1):13-22. Epub 2010 Aug 21.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Catecholamine storage vesicle protein expression in genetic hypertension. O'Connor DT, etal., Blood Press. 1999;8(5-6):285-95.
22. Molecular cloning of chromogranin A from rat pheochromocytoma cells. Parmer RJ, etal., Hypertension 1989 Oct;14(4):435-44.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Comprehensive gene review and curation RGD comprehensive gene curation
27. Chromogranin A polymorphisms are associated with hypertensive renal disease. Salem RM, etal., J Am Soc Nephrol. 2008 Mar;19(3):600-14. Epub 2008 Jan 30.
28. The novel chromogranin A-derived serpinin and pyroglutaminated serpinin peptides are positive cardiac beta-adrenergic-like inotropes. Tota B, etal., FASEB J. 2012 Jul;26(7):2888-98. Epub 2012 Mar 29.
29. Expression of chromogranin/secretogranin mRNA in spontaneous mammary tumors in aging Fischer-344 rats. Umemura S, etal., Pathol Int 2001 Sep;51(9):667-70.
30. Common genetic variants in the chromogranin a promoter are associated with renal injury in IgA nephropathy patients with malignant hypertension. Yu L, etal., Ren Fail. 2010 Jan;32(1):41-6.
Additional References at PubMed
PMID:3044825   PMID:3896848   PMID:12242039   PMID:12397377   PMID:12477932   PMID:12646581   PMID:12902350   PMID:15326220   PMID:15723172   PMID:16219686   PMID:17540723   PMID:18483175  
PMID:18697842   PMID:18802106   PMID:19800883   PMID:20862257   PMID:21214543   PMID:21436258   PMID:23674521   PMID:23751870  


Genomics

Comparative Map Data
Chga
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86127,460,895 - 127,472,238 (+)NCBIGRCr8
mRatBN7.26121,696,051 - 121,707,399 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6121,696,051 - 121,707,398 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6121,834,591 - 121,845,883 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06122,129,839 - 122,141,131 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06121,466,197 - 121,477,529 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06126,434,226 - 126,445,569 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6126,434,226 - 126,445,568 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06135,645,155 - 135,656,373 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.16126,825,283 - 126,836,311 (+)NCBI
Celera6119,184,838 - 119,196,152 (+)NCBICelera
RH 3.4 Map6845.4RGD
Cytogenetic Map6q32NCBI
CHGA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381492,922,664 - 92,935,285 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1492,923,150 - 92,935,285 (+)EnsemblGRCh38hg38GRCh38
GRCh371493,389,495 - 93,401,630 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361492,459,198 - 92,471,391 (+)NCBINCBI36Build 36hg18NCBI36
Build 341492,459,244 - 92,471,389NCBI
Celera1473,443,584 - 73,455,777 (+)NCBICelera
Cytogenetic Map14q32.12NCBI
HuRef1473,571,127 - 73,583,341 (+)NCBIHuRef
CHM1_11493,327,694 - 93,339,887 (+)NCBICHM1_1
T2T-CHM13v2.01487,154,582 - 87,167,278 (+)NCBIT2T-CHM13v2.0
Chga
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912102,521,200 - 102,531,286 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12102,521,228 - 102,531,287 (+)EnsemblGRCm39 Ensembl
GRCm3812102,554,941 - 102,565,027 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12102,554,969 - 102,565,028 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712103,793,179 - 103,803,237 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612102,956,019 - 102,966,077 (+)NCBIMGSCv36mm8
Celera12103,769,159 - 103,779,238 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1251.66NCBI
Chga
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543815,092,394 - 15,104,381 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543815,092,267 - 15,104,321 (+)NCBIChiLan1.0ChiLan1.0
CHGA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21594,080,914 - 94,093,582 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11493,297,419 - 93,310,088 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01473,555,834 - 73,568,547 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11492,895,450 - 92,908,159 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1492,895,450 - 92,908,159 (+)Ensemblpanpan1.1panPan2
CHGA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.181,970,966 - 1,973,511 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha81,985,680 - 1,997,123 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.082,017,991 - 2,029,452 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.181,954,080 - 1,965,378 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.081,904,121 - 1,915,537 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.082,031,347 - 2,042,802 (+)NCBIUU_Cfam_GSD_1.0
Chga
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864012,539,821 - 12,551,315 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936733915,830 - 927,409 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936733915,700 - 927,220 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHGA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7114,345,305 - 114,358,075 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17114,345,542 - 114,357,799 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27120,954,018 - 120,966,278 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CHGA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12470,663,040 - 70,675,827 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2470,663,298 - 70,677,116 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605357,912,590 - 57,924,715 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chga
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247349,404,916 - 9,416,902 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247349,405,121 - 9,416,774 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Chga
74 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:71
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000010592
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat

Markers in Region
RH94856  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26121,707,160 - 121,707,308 (+)MAPPERmRatBN7.2
Rnor_6.06126,445,331 - 126,445,478NCBIRnor6.0
Rnor_5.06135,656,135 - 135,656,282UniSTSRnor5.0
RGSC_v3.46126,832,327 - 126,832,474UniSTSRGSC3.4
Celera6119,195,914 - 119,196,061UniSTS
RH 3.4 Map6845.4UniSTS
Cytogenetic Map6q32UniSTS
RH94857  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26121,707,208 - 121,707,342 (+)MAPPERmRatBN7.2
Rnor_6.06126,445,379 - 126,445,512NCBIRnor6.0
Rnor_5.06135,656,183 - 135,656,316UniSTSRnor5.0
RGSC_v3.46126,832,375 - 126,832,508UniSTSRGSC3.4
Celera6119,195,962 - 119,196,095UniSTS
Cytogenetic Map6q32UniSTS
RH135429  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26121,707,104 - 121,707,289 (+)MAPPERmRatBN7.2
Rnor_6.06126,445,275 - 126,445,459NCBIRnor6.0
Rnor_5.06135,656,079 - 135,656,263UniSTSRnor5.0
RGSC_v3.46126,832,271 - 126,832,455UniSTSRGSC3.4
Celera6119,195,858 - 119,196,042UniSTS
RH 3.4 Map6844.19UniSTS
Cytogenetic Map6q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 8 72 6
Low 1 15 7 13 7 4 4 2 6 29 5 4
Below cutoff 19 12 12 4 12 4 4 15 6 6 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000090857   ⟹   ENSRNOP00000070296
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6121,696,051 - 121,707,398 (+)Ensembl
Rnor_6.0 Ensembl6126,434,226 - 126,445,568 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100782   ⟹   ENSRNOP00000081505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6121,698,889 - 121,707,398 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114564   ⟹   ENSRNOP00000081394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6121,698,889 - 121,707,398 (+)Ensembl
RefSeq Acc Id: NM_021655   ⟹   NP_067687
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86127,460,895 - 127,472,238 (+)NCBI
mRatBN7.26121,696,051 - 121,707,399 (+)NCBI
Rnor_6.06126,434,226 - 126,445,569 (+)NCBI
Rnor_5.06135,645,155 - 135,656,373 (+)NCBI
Celera6119,184,838 - 119,196,152 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_067687   ⟸   NM_021655
- Peptide Label: precursor
- UniProtKB: P10354 (UniProtKB/Swiss-Prot),   Q5PPG5 (UniProtKB/TrEMBL),   A6JEK5 (UniProtKB/TrEMBL),   F8QYX0 (UniProtKB/TrEMBL),   A0A0G2JXJ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070296   ⟸   ENSRNOT00000090857
RefSeq Acc Id: ENSRNOP00000081505   ⟸   ENSRNOT00000100782
RefSeq Acc Id: ENSRNOP00000081394   ⟸   ENSRNOT00000114564

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10354-F1-model_v2 AlphaFold P10354 1-466 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694784
Promoter ID:EPDNEW_R5308
Type:single initiation site
Name:Chga_1
Description:chromogranin A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06126,434,227 - 126,434,287EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2338 AgrOrtholog
BioCyc Gene G2FUF-36446 BioCyc
Ensembl Genes ENSRNOG00000052549 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00065014166 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000090857 ENTREZGENE
  ENSRNOT00000090857.2 UniProtKB/TrEMBL
  ENSRNOT00000100782.1 UniProtKB/TrEMBL
  ENSRNOT00000114564.1 UniProtKB/TrEMBL
  ENSRNOT00065023396 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7313842 IMAGE-MGC_LOAD
InterPro Chromogranin_AB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chromogranin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Granin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24258 UniProtKB/TrEMBL
MGC_CLONE MGC:105435 IMAGE-MGC_LOAD
NCBI Gene 24258 ENTREZGENE
PANTHER CHROMOGRANIN-A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10583 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Granin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Chga PhenoGen
PRINTS CHROMOGRANIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GRANINS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GRANINS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000052549 RatGTEx
  ENSRNOG00065014166 RatGTEx
UniProt A0A0G2JXJ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G7X3_RAT UniProtKB/TrEMBL
  A0A8I6G819_RAT UniProtKB/TrEMBL
  A6JEK5 ENTREZGENE, UniProtKB/TrEMBL
  A6JEK6_RAT UniProtKB/TrEMBL
  A6JEK7_RAT UniProtKB/TrEMBL
  A6JEK8_RAT UniProtKB/TrEMBL
  A6JEK9_RAT UniProtKB/TrEMBL
  CMGA_RAT UniProtKB/Swiss-Prot
  F8QYX0 ENTREZGENE, UniProtKB/TrEMBL
  F8QYX1_RAT UniProtKB/TrEMBL
  P10354 ENTREZGENE
  Q5PPG5 ENTREZGENE
  Q9R1B7_RAT UniProtKB/TrEMBL
UniProt Secondary Q5PPG5 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-26 Chga  chromogranin A  Chga  chromogranin A (parathyroid secretory protein 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-17 Chga  chromogranin A (parathyroid secretory protein 1)  Chga  chromogranin A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-09 Chga  chromogranin A (parathyroid secretory protein 1)  Chga  chromogranin A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Chga  chromogranin A    Chromogranin A, parathyroid secretory protein 1  Name updated 625702 APPROVED
2002-06-10 Chga  Chromogranin A, parathyroid secretory protein 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the secretory granule 724711
gene_pathway may stimulate protein synthesis machinery by stimulating Pkc and downstream elements like S6k,4E-BP1 and eIF4E 628522
gene_process counter regulates insulin action by activating a receptor-effector system(G alphaQ/11protin-PLC-beta-PKCclassical); stimulates basal and insulin-mediated protein synthesis; promotes phosphorylation of eIF2E and 4E-BP1 by stimulating S6 kinase activity 628522
gene_process chromogranin A-derived peptide involved in metabolic activation, regulation of insulin signaling and stimulation of protein synthesis in adipocytes 628522
gene_process modulates glucose, lipid and protein metabolism in adipocytes 628522