Mir218-2 (microRNA 218-2) - Rat Genome Database

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Pathways
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Gene: Mir218-2 (microRNA 218-2) Rattus norvegicus
Analyze
Symbol: Mir218-2
Name: microRNA 218-2
RGD ID: 2325546
Description: Predicted to enable mRNA base-pairing translational repressor activity. Predicted to be involved in negative regulation of biosynthetic process; negative regulation of cell population proliferation; and negative regulation of vascular associated smooth muscle cell migration. Predicted to act upstream of or within several processes, including Roundabout signaling pathway; long-term synaptic potentiation; and retina vasculature development in camera-type eye. Orthologous to human MIR218-2 (microRNA 218-2); INTERACTS WITH perfluorooctane-1-sulfonic acid; sodium arsenite; chloroform (ortholog).
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: Mir218a-2; rno-mir-218-2; rno-mir-218a-2
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81020,572,523 - 20,572,632 (+)NCBIGRCr8
mRatBN7.21020,068,451 - 20,068,560 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1020,068,451 - 20,068,560 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1024,825,189 - 24,825,298 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01024,313,709 - 24,313,818 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01019,792,130 - 19,792,239 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01020,428,661 - 20,428,770 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1020,428,661 - 20,428,770 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01020,303,158 - 20,303,267 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1019,694,948 - 19,695,057 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14691248   PMID:16381832   PMID:16766679   PMID:17604727   PMID:20403161   PMID:20947829   PMID:25858512   PMID:28074855   PMID:30556885   PMID:32048632   PMID:33144090  


Genomics

Comparative Map Data
Mir218-2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81020,572,523 - 20,572,632 (+)NCBIGRCr8
mRatBN7.21020,068,451 - 20,068,560 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1020,068,451 - 20,068,560 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1024,825,189 - 24,825,298 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01024,313,709 - 24,313,818 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01019,792,130 - 19,792,239 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01020,428,661 - 20,428,770 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1020,428,661 - 20,428,770 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01020,303,158 - 20,303,267 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1019,694,948 - 19,695,057 (+)NCBICelera
Cytogenetic Map10q12NCBI
MIR218-2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385168,768,146 - 168,768,255 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5168,768,146 - 168,768,255 (-)EnsemblGRCh38hg38GRCh38
GRCh375168,195,151 - 168,195,260 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365168,127,728 - 168,127,837 (-)NCBINCBI36Build 36hg18NCBI36
Celera5164,229,947 - 164,230,056 (-)NCBICelera
Cytogenetic Map5q34NCBI
HuRef5163,292,798 - 163,292,907 (-)NCBIHuRef
CHM1_15167,627,964 - 167,628,073 (-)NCBICHM1_1
T2T-CHM13v2.05169,303,781 - 169,303,890 (-)NCBIT2T-CHM13v2.0
Mir218-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,507,643 - 35,507,752 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,507,643 - 35,507,752 (+)EnsemblGRCm39 Ensembl
GRCm381135,616,816 - 35,616,925 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,616,816 - 35,616,925 (+)EnsemblGRCm38mm10GRCm38
MGSCv371135,430,318 - 35,430,427 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1139,398,530 - 39,398,639 (+)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1121.71NCBI
MIR218-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1443,010,775 - 43,010,838 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl443,010,751 - 43,010,860 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha442,968,748 - 42,968,811 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0443,432,368 - 43,432,431 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl443,432,344 - 43,432,453 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1443,203,872 - 43,203,935 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0443,396,723 - 43,396,786 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0443,902,474 - 43,902,537 (+)NCBIUU_Cfam_GSD_1.0
MIR218B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1655,115,926 - 55,116,009 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11655,115,926 - 55,116,009 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21659,686,628 - 59,686,711 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Mir218-2
2 total Variants
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:6200
Count of gene targets:4492
Count of transcripts:4796
Interacting mature miRNAs:rno-miR-218a-2-3p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 6 2 2 14 2 10 8
Below cutoff 3 1 1 3 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000053604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1020,068,451 - 20,068,560 (+)Ensembl
Rnor_6.0 Ensembl1020,428,661 - 20,428,770 (+)Ensembl
RefSeq Acc Id: NR_031930
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81020,572,523 - 20,572,632 (+)NCBI
mRatBN7.21020,068,451 - 20,068,560 (+)NCBI
Rnor_6.01020,428,661 - 20,428,770 (+)NCBI
Rnor_5.01020,303,158 - 20,303,267 (+)NCBI
Celera1019,694,948 - 19,695,057 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325546 AgrOrtholog
BioCyc Gene G2FUF-25551 BioCyc
Ensembl Genes ENSRNOG00000035481 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053604 ENTREZGENE
miRBase MI0000957 ENTREZGENE
NCBI Gene 100314057 ENTREZGENE
PhenoGen Mir218-2 PhenoGen
RatGTEx ENSRNOG00000035481 RatGTEx
RNAcentral URS00001F9A0F RNACentral
  URS000020D84A RNACentral
  URS000075ED64 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-09 Mir218-2  microRNA 218-2  Mir218-2  microRNA mir-218-2  Name updated 61478 APPROVED
2010-06-02 Mir218-2  microRNA mir-218-2      Symbol and Name status set to provisional 70820 PROVISIONAL