Cdkn2c (cyclin-dependent kinase inhibitor 2C) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Cdkn2c (cyclin-dependent kinase inhibitor 2C) Rattus norvegicus
Analyze
Symbol: Cdkn2c
Name: cyclin-dependent kinase inhibitor 2C
RGD ID: 2325
Description: Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding activity. Involved in oligodendrocyte differentiation. Predicted to be located in cytoplasm and nucleus. Orthologous to human CDKN2C (cyclin dependent kinase inhibitor 2C); PARTICIPATES IN G1/S transition pathway; cell cycle pathway, mitotic; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cyclin dependent kinase inhibitor 2C; Cyclin dependent kinase inhibitor 2C(p18 inhibits CDK4) see also D5Lev19; Cyclin dependent kinase inhibitor 2C(p18, inhibits CDK4), see also D5Lev19; cyclin-dependent kinase 4 inhibitor C; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); p18
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Emca12
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85129,639,736 - 129,645,564 (-)NCBIGRCr8
mRatBN7.25124,411,123 - 124,416,278 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5124,411,124 - 124,416,278 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5127,025,144 - 127,030,301 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05128,748,224 - 128,753,381 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05128,799,502 - 128,804,659 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05129,347,731 - 129,352,886 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5129,347,732 - 129,352,886 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05133,181,576 - 133,187,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45131,012,524 - 131,017,679 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15131,017,750 - 131,022,905 (-)NCBI
Celera5123,151,768 - 123,156,925 (-)NCBICelera
Cytogenetic Map5q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
apigenin  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
auraptene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
clomipramine  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
ethanol  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
genistein  (ISO)
geraniol  (ISO)
GW 4064  (ISO)
imipramine  (EXP)
isoflavones  (ISO)
kaempferol  (ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
lamivudine  (ISO)
lead diacetate  (EXP)
leflunomide  (EXP,ISO)
lidocaine  (EXP)
linalool  (ISO)
luteolin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monoethyl phthalate  (ISO)
myricetin  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nimesulide  (ISO)
oxaliplatin  (EXP)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sterigmatocystin  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
nucleus  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. The Pezcoller lecture: cancer cell cycles revisited. Sherr CJ Cancer Res. 2000 Jul 15;60(14):3689-95.
7. Posttranscriptional regulation of p18 and p27 Cdk inhibitor proteins and the timing of oligodendrocyte differentiation. Tokumoto YM, etal., Dev Biol 2002 May 1;245(1):224-34.
Additional References at PubMed
PMID:7739547   PMID:8001816   PMID:10208428   PMID:11800646   PMID:12477932   PMID:17409423  


Genomics

Comparative Map Data
Cdkn2c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85129,639,736 - 129,645,564 (-)NCBIGRCr8
mRatBN7.25124,411,123 - 124,416,278 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5124,411,124 - 124,416,278 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5127,025,144 - 127,030,301 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05128,748,224 - 128,753,381 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05128,799,502 - 128,804,659 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05129,347,731 - 129,352,886 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5129,347,732 - 129,352,886 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05133,181,576 - 133,187,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45131,012,524 - 131,017,679 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15131,017,750 - 131,022,905 (-)NCBI
Celera5123,151,768 - 123,156,925 (-)NCBICelera
Cytogenetic Map5q35NCBI
CDKN2C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38150,968,706 - 50,974,634 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl150,960,745 - 50,974,634 (+)EnsemblGRCh38hg38GRCh38
GRCh37151,434,378 - 51,440,306 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36151,206,955 - 51,212,897 (+)NCBINCBI36Build 36hg18NCBI36
Celera149,720,878 - 49,726,820 (+)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef149,551,948 - 49,557,890 (+)NCBIHuRef
CHM1_1151,551,919 - 51,557,861 (+)NCBICHM1_1
T2T-CHM13v2.0150,848,587 - 50,854,515 (+)NCBIT2T-CHM13v2.0
Cdkn2c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394109,518,073 - 109,523,953 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4109,518,073 - 109,524,386 (-)EnsemblGRCm39 Ensembl
GRCm384109,660,876 - 109,666,756 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4109,660,876 - 109,667,189 (-)EnsemblGRCm38mm10GRCm38
MGSCv374109,333,481 - 109,337,977 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364109,158,808 - 109,163,304 (-)NCBIMGSCv36mm8
Celera4108,000,724 - 108,005,200 (-)NCBICelera
Cytogenetic Map4C7NCBI
cM Map451.32NCBI
Cdkn2c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554648,021,887 - 8,028,241 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554648,022,596 - 8,028,241 (-)NCBIChiLan1.0ChiLan1.0
CDKN2C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21175,890,034 - 175,898,033 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11175,003,649 - 175,036,456 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0150,214,767 - 50,221,465 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1151,704,528 - 51,718,374 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl151,704,528 - 51,718,374 (+)Ensemblpanpan1.1panPan2
CDKN2C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11510,219,974 - 10,224,944 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1510,220,185 - 10,224,390 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1510,371,011 - 10,375,935 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01510,351,609 - 10,356,542 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1510,351,820 - 10,356,034 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11510,156,940 - 10,161,864 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01510,245,354 - 10,250,296 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01510,262,239 - 10,267,163 (-)NCBIUU_Cfam_GSD_1.0
Cdkn2c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505865,640,933 - 65,646,533 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365229,769,756 - 9,775,077 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365229,769,761 - 9,775,374 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDKN2C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6161,160,297 - 161,166,529 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16161,160,290 - 161,166,681 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26148,743,931 - 148,749,851 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDKN2C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12081,964,164 - 81,970,891 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2081,963,562 - 81,968,450 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603335,266,761 - 35,273,493 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdkn2c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248592,091,734 - 2,097,659 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248592,092,622 - 2,097,628 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdkn2c
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:242
Count of miRNA genes:136
Interacting mature miRNAs:145
Transcripts:ENSRNOT00000012088
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
7794739Bp372Blood pressure QTL 3720.0058arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5117913688125222967Rat
1582230Bw78Body weight QTL 783.20.0016epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)5119085612128034027Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5124160767133749643Rat

Markers in Region
D5Lev19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25124,411,616 - 124,411,799 (+)MAPPERmRatBN7.2
Rnor_6.05129,348,225 - 129,348,407NCBIRnor6.0
Rnor_5.05133,182,070 - 133,182,252UniSTSRnor5.0
RGSC_v3.45131,013,018 - 131,013,200UniSTSRGSC3.4
RGSC_v3.45131,013,017 - 131,013,199RGDRGSC3.4
Celera5123,152,262 - 123,152,444UniSTS
Cytogenetic Map5q35UniSTS
AI169557  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25124,411,200 - 124,411,292 (+)MAPPERmRatBN7.2
Rnor_6.05129,347,809 - 129,347,900NCBIRnor6.0
Rnor_5.05133,181,654 - 133,181,745UniSTSRnor5.0
RGSC_v3.45131,012,602 - 131,012,693UniSTSRGSC3.4
Celera5123,151,846 - 123,151,937UniSTS
RH 3.4 Map5810.8UniSTS
Cytogenetic Map5q35UniSTS
PMC141153P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25124,415,101 - 124,415,371 (+)MAPPERmRatBN7.2
Rnor_6.05129,360,167 - 129,360,436NCBIRnor6.0
Rnor_6.05129,351,710 - 129,351,979NCBIRnor6.0
Rnor_5.05133,185,555 - 133,185,824UniSTSRnor5.0
Rnor_5.05133,192,585 - 133,192,854UniSTSRnor5.0
RGSC_v3.45131,016,503 - 131,016,772UniSTSRGSC3.4
Celera5123,155,748 - 123,156,017UniSTS
Cytogenetic Map5q35UniSTS
PMC141153P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25124,411,869 - 124,412,205 (+)MAPPERmRatBN7.2
Rnor_6.05129,348,478 - 129,348,813NCBIRnor6.0
Rnor_5.05133,182,323 - 133,182,658UniSTSRnor5.0
RGSC_v3.45131,013,271 - 131,013,606UniSTSRGSC3.4
Celera5123,152,515 - 123,152,850UniSTS
Cytogenetic Map5q35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 22 32 16 18 16 28 18 30 11
Low 1 21 25 25 1 25 8 11 46 17 11 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012088   ⟹   ENSRNOP00000012088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5124,411,124 - 124,416,278 (-)Ensembl
Rnor_6.0 Ensembl5129,347,732 - 129,352,886 (-)Ensembl
RefSeq Acc Id: NM_131902   ⟹   NP_571977
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85129,639,736 - 129,644,891 (-)NCBI
mRatBN7.25124,411,123 - 124,416,278 (-)NCBI
Rnor_6.05129,347,731 - 129,352,886 (-)NCBI
Rnor_5.05133,181,576 - 133,187,391 (-)NCBI
RGSC_v3.45131,012,524 - 131,017,679 (-)RGD
Celera5123,151,768 - 123,156,925 (-)RGD
Sequence:
RefSeq Acc Id: XM_063288321   ⟹   XP_063144391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85129,639,736 - 129,645,564 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_571977   ⟸   NM_131902
- UniProtKB: Q8R5G4 (UniProtKB/TrEMBL),   Q8R5G3 (UniProtKB/TrEMBL),   A6JYZ7 (UniProtKB/TrEMBL),   A6JYZ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012088   ⟸   ENSRNOT00000012088
RefSeq Acc Id: XP_063144391   ⟸   XM_063288321
- Peptide Label: isoform X1
- UniProtKB: A6JYZ6 (UniProtKB/TrEMBL),   A6JYZ7 (UniProtKB/TrEMBL),   Q8R5G3 (UniProtKB/TrEMBL),   Q8R5G4 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R5G4-F1-model_v2 AlphaFold Q8R5G4 1-168 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325 AgrOrtholog
BioCyc Gene G2FUF-40345 BioCyc
Ensembl Genes ENSRNOG00000008956 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012088 ENTREZGENE
  ENSRNOT00000012088.8 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7319164 IMAGE-MGC_LOAD
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
KEGG Report rno:54238 UniProtKB/TrEMBL
MGC_CLONE MGC:105252 IMAGE-MGC_LOAD
NCBI Gene 54238 ENTREZGENE
PANTHER ANK_REP_REGION DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  CYCLIN-DEPENDENT KINASE 4 INHIBITOR C UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
PhenoGen Cdkn2c PhenoGen
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008956 RatGTEx
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
UniProt A6JYZ6 ENTREZGENE, UniProtKB/TrEMBL
  A6JYZ7 ENTREZGENE
  Q8R5G3 ENTREZGENE
  Q8R5G4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6JYZ7 UniProtKB/TrEMBL
  Q8R5G3 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Cdkn2c  cyclin-dependent kinase inhibitor 2C  Cdkn2c  cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cdkn2c  cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)    cyclin dependent kinase inhibitor 2C   Name updated 1299863 APPROVED
2002-11-06 Cdkn2c  cyclin dependent kinase inhibitor 2C     Cyclin dependent kinase inhibitor 2C(p18, inhibits CDK4), see also D5Lev19  Name updated 625702 APPROVED
2002-06-10 Cdkn2c  Cyclin dependent kinase inhibitor 2C(p18, inhibits CDK4), see also D5Lev19      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process functions as a cyclin-dependent kinase inhibitor (CKI) 1298749
gene_process may be part of a cell cycle "timer" mechanism in the terminal differentiation of oligodendrocyte precursor cells 1298749