Ear1 (eosinophil-associated, ribonuclease A family, member 1) - Rat Genome Database

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Gene: Ear1 (eosinophil-associated, ribonuclease A family, member 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ear1
Name: eosinophil-associated, ribonuclease A family, member 1
RGD ID: 2324564
Description: Predicted to enable RNA nuclease activity. Predicted to be involved in chemotaxis; defense response to Gram-positive bacterium; and innate immune response in mucosa. Predicted to be active in extracellular space. Orthologous to human RNASE2 (ribonuclease A family member 2) and RNASE3 (ribonuclease A family member 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ear3; eosinophil-associated ribonuclease 3; eosinophil-associated ribonuclease 3-like; LOC100361909; Raf4; ribonuclease A f4
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81527,028,785 - 27,029,694 (+)NCBIGRCr8
mRatBN7.21524,555,280 - 24,556,189 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,555,298 - 24,556,199 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01528,260,133 - 28,261,049 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,260,411 - 28,260,866 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01532,073,048 - 32,073,900 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,292,006 - 27,292,461 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1524,864,195 - 24,865,007 (+)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:24337645  


Genomics

Variants

.
Variants in Ear1
25 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:46
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000021645
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat

Markers in Region
RH133047  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1524,766,542 - 24,766,758UniSTS
Celera1524,864,784 - 24,865,001UniSTS
Cytogenetic Map15p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system reproductive system respiratory system
High
Medium 2
Low 19 16 8 16 5
Below cutoff 9 6 4 6 1 6 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021645   ⟹   ENSRNOP00000021645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,555,298 - 24,556,199 (+)Ensembl
Rnor_6.0 Ensembl1528,260,411 - 28,260,866 (+)Ensembl
RefSeq Acc Id: NM_001408671   ⟹   NP_001395600
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,028,785 - 27,029,694 (+)NCBI
mRatBN7.21524,555,280 - 24,556,189 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001395600 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL60159 (Get FASTA)   NCBI Sequence Viewer  
  CDG32039 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021645
  ENSRNOP00000021645.2
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000021645   ⟸   ENSRNOT00000021645
RefSeq Acc Id: NP_001395600   ⟸   NM_001408671
- Peptide Label: precursor
- UniProtKB: E9PU07 (UniProtKB/TrEMBL)
Protein Domains
Ribonuclease A-domain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PU07-F1-model_v2 AlphaFold E9PU07 1-151 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2324564 AgrOrtholog
BioCyc Gene G2FUF-14005 BioCyc
Ensembl Genes ENSRNOG00000025515 Ensembl
  ENSRNOG00000062969 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021645 ENTREZGENE
  ENSRNOT00000021645.3 UniProtKB/TrEMBL
Gene3D-CATH 3.10.130.10 UniProtKB/TrEMBL
InterPro RNaseA UniProtKB/TrEMBL
  RNaseA-like_dom_sf UniProtKB/TrEMBL
  RNaseA_AS UniProtKB/TrEMBL
  RNaseA_domain UniProtKB/TrEMBL
KEGG Report rno:100361909 UniProtKB/TrEMBL
NCBI Gene 100361909 ENTREZGENE
PANTHER EOSINOPHIL CATIONIC PROTEIN UniProtKB/TrEMBL
  RNaseA UniProtKB/TrEMBL
Pfam RnaseA UniProtKB/TrEMBL
PhenoGen Ear1 PhenoGen
PRINTS RIBONUCLEASE UniProtKB/TrEMBL
PROSITE RNASE_PANCREATIC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025515 RatGTEx
  ENSRNOG00000062969 RatGTEx
SMART RNAse_Pc UniProtKB/TrEMBL
Superfamily-SCOP RNaseA UniProtKB/TrEMBL
UniProt E9PU07 ENTREZGENE, UniProtKB/TrEMBL
  Q8VHR9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Ear1  eosinophil-associated, ribonuclease A family, member 1  Ear1  eosinophil-associated, ribonuclease A family, member 1  Data merged from RGD:149736245 737654 PROVISIONAL
2021-08-09 Ear1  eosinophil-associated, ribonuclease A family, member 1      Symbol and Name status set to provisional 45752 PROVISIONAL
2013-08-07 Ear1  eosinophil-associated, ribonuclease A family, member 1  LOC100361909  eosinophil-associated ribonuclease 3-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100361909  eosinophil-associated ribonuclease 3-like      Symbol and Name status set to provisional 70820 PROVISIONAL