Zfp300 (zinc finger protein 300) - Rat Genome Database

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Gene: Zfp300 (zinc finger protein 300) Rattus norvegicus
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Symbol: Zfp300
Name: zinc finger protein 300
RGD ID: 2321626
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF567 (zinc finger protein 567); INTERACTS WITH (-)-epigallocatechin 3-gallate (ortholog); 17beta-estradiol (ortholog); 4-(ethoxymethylene)-2-phenyloxazol-5-one (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC100364132; rCG42947-like; zinc finger protein 84
RGD Orthologs
Human
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X3,452,993 - 3,472,102 (+)NCBIGRCr8
mRatBN7.2X899,469 - 921,285 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX913,805 - 918,292 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X893,915 - 912,840 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX908,044 - 911,067 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X888,763 - 907,533 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX1,469,009 - 1,488,532 (+)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Zfp300
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X3,452,993 - 3,472,102 (+)NCBIGRCr8
mRatBN7.2X899,469 - 921,285 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX913,805 - 918,292 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X893,915 - 912,840 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX908,044 - 911,067 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X888,763 - 907,533 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX1,469,009 - 1,488,532 (+)NCBICelera
Cytogenetic MapXq11NCBI
ZNF567
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381936,666,934 - 36,727,506 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1936,687,612 - 36,727,701 (+)EnsemblGRCh38hg38GRCh38
GRCh371937,157,836 - 37,214,257 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361941,872,142 - 41,904,066 (+)NCBINCBI36Build 36hg18NCBI36
Build 341941,872,141 - 41,904,063NCBI
Celera1933,964,887 - 33,996,810 (+)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1933,648,230 - 33,680,132 (+)NCBIHuRef
CHM1_11937,180,850 - 37,212,782 (+)NCBICHM1_1
T2T-CHM13v2.01939,342,219 - 39,398,624 (+)NCBIT2T-CHM13v2.0
Znf567
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554682,283,693 - 2,360,053 (+)NCBIChiLan1.0ChiLan1.0
ZNF567
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22042,808,632 - 42,862,926 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11944,693,397 - 44,747,702 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01933,627,634 - 33,681,992 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11943,085,419 - 43,139,154 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1943,086,087 - 43,094,782 (-)Ensemblpanpan1.1panPan2
ZNF567
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11116,337,603 - 116,382,287 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1116,355,473 - 116,382,415 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1115,761,607 - 115,789,601 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01116,958,233 - 116,986,171 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11116,528,131 - 116,555,855 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,146,642 - 116,174,390 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01117,198,525 - 117,226,296 (+)NCBIUU_Cfam_GSD_1.0
Znf567
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934911,492,266 - 11,511,142 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936922262,393 - 267,738 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936922261,959 - 281,243 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNF567
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl645,707,074 - 45,737,962 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1645,709,663 - 45,738,030 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2641,156,394 - 41,184,613 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZNF567
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1631,528,446 - 31,585,848 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660739,331,884 - 9,393,885 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf567
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479410,511,410 - 10,536,924 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479410,512,212 - 10,539,350 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zfp300
23 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:40
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000072087
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 1 6 6
Low 2 40 44 36 19 36 8 8 73 34 30 5 8
Below cutoff 1 2 5 5 5 3 1 5

Sequence


RefSeq Acc Id: ENSRNOT00000072087   ⟹   ENSRNOP00000067586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX913,805 - 918,292 (+)Ensembl
Rnor_6.0 EnsemblX908,044 - 911,067 (+)Ensembl
RefSeq Acc Id: XM_006256621   ⟹   XP_006256683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X3,453,025 - 3,472,102 (+)NCBI
mRatBN7.2X899,469 - 921,285 (+)NCBI
Rnor_6.0X893,916 - 912,839 (+)NCBI
Rnor_5.0X888,763 - 907,533 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256622   ⟹   XP_006256684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X3,452,993 - 3,472,102 (+)NCBI
mRatBN7.2X899,469 - 921,285 (+)NCBI
Rnor_6.0X893,915 - 912,840 (+)NCBI
Rnor_5.0X888,763 - 907,533 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_006256683 (Get FASTA)   NCBI Sequence Viewer  
  XP_006256684 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97737 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067586
  ENSRNOP00000067586.3
RefSeq Acc Id: XP_006256683   ⟸   XM_006256621
- Peptide Label: isoform X1
- UniProtKB: A6JZP8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256684   ⟸   XM_006256622
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000067586   ⟸   ENSRNOT00000072087
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RD89-F1-model_v2 AlphaFold M0RD89 1-611 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2321626 AgrOrtholog
BioCyc Gene G2FUF-3208 BioCyc
Ensembl Genes ENSRNOG00000046469 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072087.3 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:100364132 UniProtKB/TrEMBL
NCBI Gene 100364132 ENTREZGENE
PANTHER ZINC FINGER PROTEIN 200 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 436 UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp300 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046469 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A6JZP8 ENTREZGENE, UniProtKB/TrEMBL
  M0RD89_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-09-16 Zfp300  zinc finger protein 300  LOC100364132  rCG42947-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100364132  rCG42947-like      Symbol and Name status set to provisional 70820 PROVISIONAL