Predicted to enable several functions, including cyclin binding activity; phosphothreonine residue binding activity; and ubiquitin ligase-substrate adaptor activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of intracellular signal transduction; and positive regulation of protein metabolic process. Predicted to act upstream of or within several processes, including Notch signaling pathway; protein destabilization; and vasculogenesis. Predicted to be located in several cellular components, including Golgi apparatus; nuclear lumen; and perinuclear region of cytoplasm. Predicted to be part of Parkin-FBXW7-Cul1 ubiquitin ligase complex and SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in developmental delay, hypotonia, and impaired language. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7); PARTICIPATES IN Notch signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bisphenol A.
[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FBXW7 mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to FBXW7 promoter]
Arsenic Trioxide promotes the reaction [Tretinoin results in decreased expression of FBXW7 protein] and Tretinoin promotes the reaction [Arsenic Trioxide results in decreased expression of FBXW7 protein]
[FBXW7 gene mutant form results in increased susceptibility to arsenite] which results in increased expression of MYC protein and FBXW7 gene mutant form promotes the reaction [arsenite results in increased cleavage of CASP3 protein]
FBXW7 protein promotes the reaction [NFKB1 gene mutant form inhibits the reaction [arsenite inhibits the reaction [Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of and results in increased expression of MYC protein]]]]
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of FBXW7-AS1 mRNA] which results in increased expression of FBXW7 mRNA and [[Ozone results in increased oxidation of dimethylselenide] which results in increased expression of FBXW7-AS1 mRNA] which results in increased expression of FBXW7 mRNA
FBXW7 mRNA affects the reaction [Oxygen deficiency results in increased degradation of MYC protein] and FBXW7 protein affects the reaction [Oxygen deficiency results in increased degradation of MYC protein]
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of FBXW7-AS1 mRNA] which results in increased expression of FBXW7 mRNA
FBXW7 protein promotes the reaction [NFKB1 gene mutant form inhibits the reaction [arsenite inhibits the reaction [Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of and results in increased expression of MYC protein]]]]
FBXW7 mRNA affects the reaction [nickel sulfate results in increased degradation of MYC protein] and FBXW7 protein affects the reaction [nickel sulfate results in increased degradation of MYC protein]
[[Ozone results in increased oxidation of dimethylselenide] which results in increased expression of FBXW7-AS1 mRNA] which results in increased expression of FBXW7 mRNA and [Air Pollutants results in increased abundance of Ozone] which affects the expression of FBXW7 mRNA