Atp4b (ATPase H+/K+ transporting subunit beta) - Rat Genome Database

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Gene: Atp4b (ATPase H+/K+ transporting subunit beta) Rattus norvegicus
Analyze
Symbol: Atp4b
Name: ATPase H+/K+ transporting subunit beta
RGD ID: 2178
Description: Contributes to heterocyclic compound binding activity. Involved in pH reduction; response to lipopolysaccharide; and response to organonitrogen compound. Predicted to be located in apical plasma membrane. Predicted to be part of potassium:proton exchanging ATPase complex and sodium:potassium-exchanging ATPase complex. Used to study obesity. Human ortholog(s) of this gene implicated in atrophic gastritis; autoimmune gastritis; and stomach cancer. Orthologous to human ATP4B (ATPase H+/K+ transporting subunit beta); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; esomeprazole pharmacokinetics pathway; INTERACTS WITH ammonium chloride; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATPase H+/K+ transporting beta subunit; ATPase H+K+-transporting beta / (gastric HK-ATPase beta subunit) defined by SSR; ATPase, H+,K+-transporting, beta / (gastric H,K-ATPase beta subunit), defined by SSR; ATPase, H+,K+-transporting, beta / (gastric H,K-ATPase beta subunit), defined by SSR,; ATPase, H+/K+ exchanging, beta polypeptide; ATPase, H+/K+ transporting, beta polypeptide; gastric H(+)/K(+) ATPase subunit beta; potassium-transporting ATPase subunit beta; proton pump beta chain; S76401S1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81682,846,329 - 82,855,242 (+)NCBIGRCr8
mRatBN7.21676,144,150 - 76,153,063 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1676,144,150 - 76,153,063 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1681,424,745 - 81,433,658 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01684,877,703 - 84,886,616 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01680,126,502 - 80,135,394 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01681,136,218 - 81,145,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1681,136,218 - 81,145,131 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01680,624,778 - 80,633,691 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41681,000,154 - 81,009,067 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11681,000,418 - 81,009,332 (+)NCBI
Celera1673,951,353 - 73,960,266 (+)NCBICelera
RH 3.4 Map16743.6RGD
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Effects of the Histamine 1 Receptor Antagonist Cetirizine on the Osteoporotic Phenotype in H(+) /K(+) ATPase Beta Subunit KO Mice. Aasarød KM, etal., J Cell Biochem. 2016 Sep;117(9):2089-96. doi: 10.1002/jcb.25514. Epub 2016 Mar 4.
2. An autoimmune disease with multiple molecular targets abrogated by the transgenic expression of a single autoantigen in the thymus. Alderuccio F, etal., J Exp Med. 1993 Aug 1;178(2):419-26. doi: 10.1084/jem.178.2.419.
3. Remodeling of the residual gastric mucosa after roux-en-y gastric bypass or vertical sleeve gastrectomy in diet-induced obese rats. Arapis K, etal., PLoS One. 2015 Mar 30;10(3):e0121414. doi: 10.1371/journal.pone.0121414. eCollection 2015.
4. Long-term gastric changes in achlorhydric H(+)/K(+)-ATPase beta subunit deficient mice. Bakkelund KE, etal., Scand J Gastroenterol. 2010 Sep;45(9):1042-7. doi: 10.3109/00365521.2010.490952.
5. Effects of streptozotocin-induced long-term diabetes on parietal cell function and morphology in rats. Bastaki SM, etal., Mol Cell Biochem. 2010 Aug;341(1-2):43-50. doi: 10.1007/s11010-010-0435-4. Epub 2010 Mar 17.
6. Alpha and beta subunits of the gastric H+/K(+)-ATPase are concordantly targeted by parietal cell autoantibodies associated with autoimmune gastritis. Callaghan JM, etal., Autoimmunity. 1993;16(4):289-95.
7. Cloning of the H,K-ATPase beta subunit. Tissue-specific expression, chromosomal assignment, and relationship to Na,K-ATPase beta subunits. Canfield VA, etal., J Biol Chem 1990 Nov 15;265(32):19878-84.
8. Functional significance of E2 state stabilization by specific alpha/beta-subunit interactions of Na,K- and H,K-ATPase. Dürr KL, etal., J Biol Chem. 2009 Feb 6;284(6):3842-54. doi: 10.1074/jbc.M808101200. Epub 2008 Dec 8.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Lipopolysaccharide-induced changes in rat gastric H/K-ATPase expression. Helmer KS, etal., Ann Surg. 2004 Apr;239(4):501-9.
12. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
13. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
14. Measurement of Autoantibodies to Gastric H+,K+-ATPase (ATP4A/B) Using a Luciferase Immunoprecipitation System (LIPS). Lahner E, etal., Methods Mol Biol. 2019;1901:113-131. doi: 10.1007/978-1-4939-8949-2_10.
15. The rat H+/K(+)-ATPase beta subunit gene and recognition of its control region by gastric DNA binding protein. Maeda M, etal., J Biol Chem 1991 Nov 15;266(32):21584-8.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. Intragenic DNA methylation concomitant with repression of ATP4B and ATP4A gene expression in gastric cancer is a potential serum biomarker. Raja UM, etal., Asian Pac J Cancer Prev. 2012;13(11):5563-8. doi: 10.7314/apjcp.2012.13.11.5563.
21. GOA pipeline RGD automated data pipeline
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Comprehensive gene review and curation RGD comprehensive gene curation
24. cDNA cloning of the beta-subunit of the rat gastric H,K-ATPase. Shull GE J Biol Chem 1990 Jul 25;265(21):12123-6.
25. Na+-K+-ATPase alpha-subunit containing Q905-V930 of gastric H+-K+-ATPase alpha preferentially assembles with H+-K+-ATPase beta. Wang SG, etal., Am J Physiol. 1997 Mar;272(3 Pt 1):C923-30. doi: 10.1152/ajpcell.1997.272.3.C923.
Additional References at PubMed
PMID:1663070   PMID:16046397   PMID:16531406   PMID:19491099  


Genomics

Comparative Map Data
Atp4b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81682,846,329 - 82,855,242 (+)NCBIGRCr8
mRatBN7.21676,144,150 - 76,153,063 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1676,144,150 - 76,153,063 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1681,424,745 - 81,433,658 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01684,877,703 - 84,886,616 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01680,126,502 - 80,135,394 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01681,136,218 - 81,145,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1681,136,218 - 81,145,131 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01680,624,778 - 80,633,691 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41681,000,154 - 81,009,067 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11681,000,418 - 81,009,332 (+)NCBI
Celera1673,951,353 - 73,960,266 (+)NCBICelera
RH 3.4 Map16743.6RGD
Cytogenetic Map16q12.5NCBI
ATP4B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813113,648,804 - 113,658,198 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13113,648,804 - 113,658,198 (-)EnsemblGRCh38hg38GRCh38
GRCh3713114,303,119 - 114,312,513 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613113,351,120 - 113,360,502 (-)NCBINCBI36Build 36hg18NCBI36
Build 3413113,351,122 - 113,360,502NCBI
Celera1395,130,374 - 95,139,808 (-)NCBICelera
Cytogenetic Map13q34NCBI
HuRef1394,742,367 - 94,751,761 (-)NCBIHuRef
CHM1_113114,272,447 - 114,281,841 (-)NCBICHM1_1
T2T-CHM13v2.013112,907,872 - 112,917,266 (-)NCBIT2T-CHM13v2.0
Atp4b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39813,436,209 - 13,446,778 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl813,436,205 - 13,446,825 (-)EnsemblGRCm39 Ensembl
GRCm38813,386,209 - 13,396,778 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl813,386,205 - 13,396,825 (-)EnsemblGRCm38mm10GRCm38
MGSCv37813,386,209 - 13,396,778 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36813,386,186 - 13,396,755 (-)NCBIMGSCv36mm8
Celera813,554,643 - 13,565,216 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map85.89NCBI
Atp4b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955404362,368 - 372,077 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955404362,410 - 372,077 (+)NCBIChiLan1.0ChiLan1.0
ATP4B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214115,160,113 - 115,170,521 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113113,851,442 - 113,861,871 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01394,796,689 - 94,807,210 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113113,848,121 - 113,859,054 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13113,848,126 - 113,859,054 (-)Ensemblpanpan1.1panPan2
ATP4B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12260,898,801 - 60,904,223 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2260,898,833 - 60,904,223 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2260,609,212 - 60,615,183 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02261,582,729 - 61,588,695 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2261,583,223 - 61,588,608 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12261,021,472 - 61,027,443 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02261,023,514 - 61,029,484 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02261,054,593 - 61,060,564 (-)NCBIUU_Cfam_GSD_1.0
Atp4b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945195,778,134 - 195,783,608 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936472168,750 - 173,968 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936472168,745 - 173,996 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP4B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1178,780,013 - 78,785,116 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11178,780,013 - 78,785,143 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21186,513,302 - 86,518,449 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATP4B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1391,618,147 - 91,629,177 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl391,618,957 - 91,627,679 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604648,705,491 - 48,714,926 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp4b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624793472,241 - 479,753 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624793472,241 - 479,753 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atp4b
59 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:243
Count of miRNA genes:169
Interacting mature miRNAs:196
Transcripts:ENSRNOT00000025958
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat

Markers in Region
D16Mco8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21676,142,842 - 76,143,097 (-)MAPPERmRatBN7.2
Rnor_6.01681,146,184 - 81,146,436NCBIRnor6.0
Rnor_5.01680,634,744 - 80,634,996UniSTSRnor5.0
RGSC_v3.41680,998,848 - 80,999,101RGDRGSC3.4
RGSC_v3.41680,998,849 - 80,999,101UniSTSRGSC3.4
RGSC_v3.11680,999,113 - 80,999,366RGD
Celera1673,950,049 - 73,950,300UniSTS
Cytogenetic Map16q12.5UniSTS
D16Arb12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21676,142,864 - 76,143,092 (-)MAPPERmRatBN7.2
Rnor_6.01681,146,189 - 81,146,414NCBIRnor6.0
Rnor_5.01680,634,749 - 80,634,974UniSTSRnor5.0
RGSC_v3.41680,998,870 - 80,999,096RGDRGSC3.4
RGSC_v3.41680,998,871 - 80,999,096UniSTSRGSC3.4
RGSC_v3.11680,999,135 - 80,999,361RGD
Celera1673,950,071 - 73,950,295UniSTS
Cytogenetic Map16q12.5UniSTS
D16Wox17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21676,142,845 - 76,143,096 (-)MAPPERmRatBN7.2
Rnor_6.01681,146,185 - 81,146,433NCBIRnor6.0
Rnor_5.01680,634,745 - 80,634,993UniSTSRnor5.0
RGSC_v3.41680,998,852 - 80,999,100UniSTSRGSC3.4
Celera1673,950,052 - 73,950,299UniSTS
Cytogenetic Map16q12.5UniSTS
RH94695  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21676,152,803 - 76,152,956 (-)MAPPERmRatBN7.2
Rnor_6.01681,136,325 - 81,136,477NCBIRnor6.0
Rnor_5.01680,624,885 - 80,625,037UniSTSRnor5.0
RGSC_v3.41681,008,808 - 81,008,960UniSTSRGSC3.4
Celera1673,960,007 - 73,960,159UniSTS
RH 3.4 Map16743.6UniSTS
Cytogenetic Map16q12.5UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system nervous system renal system reproductive system respiratory system
High
Medium
Low 9
Below cutoff 1 5 4 1 14 12 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025958   ⟹   ENSRNOP00000025957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,144,150 - 76,153,063 (+)Ensembl
Rnor_6.0 Ensembl1681,136,218 - 81,145,131 (-)Ensembl
RefSeq Acc Id: NM_012510   ⟹   NP_036642
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81682,846,329 - 82,855,242 (+)NCBI
mRatBN7.21676,144,150 - 76,153,063 (+)NCBI
Rnor_6.01681,136,218 - 81,145,131 (-)NCBI
Rnor_5.01680,624,778 - 80,633,691 (-)NCBI
RGSC_v3.41681,000,154 - 81,009,067 (+)RGD
Celera1673,951,353 - 73,960,266 (+)RGD
Sequence:
RefSeq Acc Id: XM_039094190   ⟹   XP_038950118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81682,846,504 - 82,854,932 (+)NCBI
mRatBN7.21676,144,325 - 76,152,753 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_036642   ⟸   NM_012510
- UniProtKB: P18598 (UniProtKB/Swiss-Prot),   A6IWH6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025957   ⟸   ENSRNOT00000025958
RefSeq Acc Id: XP_038950118   ⟸   XM_039094190
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18598-F1-model_v2 AlphaFold P18598 1-294 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700223
Promoter ID:EPDNEW_R10747
Type:multiple initiation site
Name:Atp4b_1
Description:ATPase H+/K+ transporting beta subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01681,144,979 - 81,145,039EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2178 AgrOrtholog
BioCyc Gene G2FUF-10721 BioCyc
Ensembl Genes ENSRNOG00000018543 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055014550 UniProtKB/Swiss-Prot
  ENSRNOG00060018512 UniProtKB/Swiss-Prot
  ENSRNOG00065009156 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025958 ENTREZGENE
  ENSRNOT00000025958.3 UniProtKB/Swiss-Prot
  ENSRNOT00055024961 UniProtKB/Swiss-Prot
  ENSRNOT00060031847 UniProtKB/Swiss-Prot
  ENSRNOT00065014620 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1660 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Na/K_ATPase_sub_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na/K_ATPase_sub_beta_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24217 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24217 ENTREZGENE
PANTHER POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11523 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Na_K-ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ATP4B RGD
PhenoGen Atp4b PhenoGen
PROSITE ATPASE_NA_K_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPASE_NA_K_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018543 RatGTEx
  ENSRNOG00055014550 RatGTEx
  ENSRNOG00060018512 RatGTEx
  ENSRNOG00065009156 RatGTEx
UniProt A6IWH6 ENTREZGENE, UniProtKB/TrEMBL
  ATP4B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-03 Atp4b  ATPase H+/K+ transporting subunit beta  Atp4b  ATPase H+/K+ transporting beta subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-17 Atp4b  ATPase H+/K+ transporting beta subunit  Atp4b  ATPase, H+/K+ exchanging, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Atp4b  ATPase, H+/K+ exchanging, beta polypeptide    ATPase, H+/K+ transporting, beta polypeptide  Name updated 1299863 APPROVED
2002-11-06 Atp4b  ATPase, H+/K+ transporting, beta polypeptide    ATPase, H+,K+-transporting, beta / (gastric H,K-ATPase beta subunit), defined by SSR,  Name updated 625702 APPROVED
2002-06-10 Atp4b  ATPase, H+,K+-transporting, beta / (gastric H,K-ATPase beta subunit), defined by SSR,      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in gastric parietal cells 631782
gene_expression expressed at high level and exclusively in stomach 631783
gene_function subunit of ATP dependent pump that catalyzes the exchange of H+ and K+ 631715
gene_process involved in secretion of acid into the stomach 631715
gene_protein 33.689 kDa, 294 amino acids 631783
gene_regulation only nuclear proteins from gastric tissue showed binding to upstream transcription regulatory sites 631782
gene_transcript coding region has 6 introns 631782