Gene: App (amyloid beta (A4) precursor protein) Rattus norvegicus
Symbol: App
Name: amyloid beta (A4) precursor protein
Description: ENCODES a protein that exhibits growth factor receptor binding; peptidase activator activity; acetylcholine receptor binding (ortholog); INVOLVED IN cellular response to cAMP; cellular response to nerve growth factor stimulus; cellular response to norepinephrine stimulus; PARTICIPATES IN glypican signaling pathway; Alzheimer disease pathway; ASSOCIATED WITH Blast Injuries; Chronic Cerebral Hypoperfusion; Alzheimer Disease (ortholog); FOUND IN astrocyte projection; axon; cell surface; INTERACTS WITH (+)-catechin; (S)-naringenin; (S)-nicotine
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Abeta; ABPP; AG; alzheimer disease amyloid A4 protein homolog; amyloid A4; amyloid beta A4 protein; amyloidogenic glycoprotein
Orthologs:
Latest Assembly: RGSC Genome Assembly v5.0
Position:
MapChrPositionStrandSource
RGSC Genome Assembly v6.01124,425,013 - 24,641,837-NCBI
Rat Cytogenetic Map11q11 NCBI
RGSC Genome Assembly v5.01128,048,897 - 28,265,250-NCBI
RGSC Genome Assembly v3.41124,457,855 - 24,693,851-NCBI
Rat Celera Assembly1123,853,696 - 24,069,048-NCBI
Genome Assembly 3.11124,457,854 - 24,693,851-NCBI
RH 3.41194.7 RGD
Model

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Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (RGSC Genome Assembly v5.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on App
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Ensembl Gene
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RGD Object Information
RGD ID: 2139
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2015-07-07
Status: ACTIVE