Gene: App (amyloid beta (A4) precursor protein) Rattus norvegicus
Symbol: App
Name: amyloid beta (A4) precursor protein
Description: ENCODES a protein that exhibits growth factor receptor binding; peptidase activator activity; acetylcholine receptor binding (ortholog); INVOLVED IN positive regulation of peptidase activity; adult locomotory behavior (ortholog); axon cargo transport (ortholog); PARTICIPATES IN glypican signaling pathway; Alzheimer disease pathway; ASSOCIATED WITH Alzheimer Disease (ortholog); Alzheimer disease type 1 (ortholog); Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy (ortholog); FOUND IN axon; cell surface; Golgi apparatus; INTERACTS WITH (+)-catechin; (S)-naringenin; (S)-nicotine
Type: protein-coding
Also known as: Abeta; ABPP; AG; alzheimer disease amyloid A4 protein homolog; amyloid A4; amyloid beta A4 protein; amyloidogenic glycoprotein
Latest Assembly: RGSC Genome Assembly v5.0
RGSC Genome Assembly v6.01124,425,013 - 24,641,837-NCBI
Rat Cytogenetic Map11q11 NCBI
RGSC Genome Assembly v5.01128,048,897 - 28,265,250-NCBI
RGSC Genome Assembly v3.41124,457,855 - 24,693,851-NCBI
Rat Celera Assembly1123,853,696 - 24,069,048-NCBI
Genome Assembly 3.11124,457,854 - 24,693,851-NCBI
RH 3.41194.7 RGD

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Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (RGSC Genome Assembly v5.0)


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on App
Entrez Gene
Ensembl Gene
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NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 2139
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2015-05-12
Status: ACTIVE