Alox5ap (arachidonate 5-lipoxygenase activating protein) - Rat Genome Database

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Gene: Alox5ap (arachidonate 5-lipoxygenase activating protein) Rattus norvegicus
Analyze
Symbol: Alox5ap
Name: arachidonate 5-lipoxygenase activating protein
RGD ID: 2097
Description: Enables enzyme binding activity and identical protein binding activity. Contributes to arachidonate 5-lipoxygenase activity. Involved in leukotriene biosynthetic process; lipoxygenase pathway; and positive regulation of acute inflammatory response. Located in nuclear envelope. Used to study pulmonary hypertension. Biomarker of glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including asthma; brain infarction (multiple); breast cancer; cerebral palsy; and coronary artery disease (multiple). Orthologous to human ALOX5AP (arachidonate 5-lipoxygenase activating protein); PARTICIPATES IN leukotriene metabolic pathway; lipoxygenase mediated pathway of arachidonic acid metabolism; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 5-lipoxygenase-activating protein FLAP; 5-lipoxygenase-activating protein, FLAP; arachidonate 5-lipoxygenase-activating protein; FLAP; MK-886-binding protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,785,254 - 10,809,295 (-)NCBIGRCr8
mRatBN7.2125,748,941 - 5,772,986 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl125,748,944 - 5,772,986 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx126,415,168 - 6,438,995 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0127,038,642 - 7,062,468 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0126,066,300 - 6,090,127 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0126,854,930 - 6,879,112 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl126,854,920 - 6,879,154 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0128,950,727 - 8,974,708 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4126,245,808 - 6,269,796 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1126,245,808 - 6,269,796 (-)NCBI
Celera127,507,392 - 7,531,448 (-)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
choline  (ISO)
cisplatin  (ISO)
clopidogrel  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-penicillamine  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP)
herbicide  (ISO)
hexachlorobenzene  (EXP)
histamine  (ISO)
hydrogen peroxide  (ISO)
imidazopyrazole  (ISO)
indinavir  (ISO)
kainic acid  (EXP)
L-methionine  (ISO)
lamivudine  (ISO)
leukotriene B4  (ISO)
leukotriene C4  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
medroxyprogesterone acetate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrobenzenes  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (EXP)
Phenelzine  (ISO)
phenobarbital  (ISO)
picrotoxin  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propanal  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP)
saquinavir  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
streptozocin  (ISO)
sulforaphane  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (EXP)
troglitazone  (ISO)
tungsten  (ISO)
vinclozolin  (EXP)
warfarin  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. 5-Lipoxygenase-activating protein: a potential link between innate and adaptive immunity in atherosclerosis and adipose tissue inflammation. Back M, etal., Circ Res. 2007 Apr 13;100(7):946-9. Epub 2007 Mar 22.
2. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells. Brock TG, etal., J Biol Chem. 1994 Sep 2;269(35):22059-66.
4. In situ amplification of 5-lipoxygenase and 5-lipoxygenase-activating protein in allergic airway inflammation and inhibition by leukotriene blockade. Chu SJ, etal., J Immunol. 2000 Oct 15;165(8):4640-8.
5. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Dixon RA, etal., Nature 1990 Jan 18;343(6255):282-4.
6. Increased expression of cytosolic phospholipase A2, 5-lipoxygenase and 5-lipoxygenase-activating protein in rat peritoneal macrophages during ovalbumin-induced sensitization. Escoubet-Lozach L, etal., Clin Exp Allergy 2001 Jul;31(7):1094-104.
7. Decreased paraoxonase-2 expression in human carotids during the progression of atherosclerosis. Fortunato G, etal., Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):594-600. Epub 2008 Feb 7.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Candidate genes and cerebral palsy: a population-based study. Gibson CS, etal., Pediatrics. 2008 Nov;122(5):1079-85.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Helgadottir A, etal., Nat Genet. 2004 Mar;36(3):233-9. Epub 2004 Feb 8.
12. The importance of leukotrienes in airway inflammation in a mouse model of asthma. Henderson WR Jr, etal., J Exp Med. 1996 Oct 1;184(4):1483-94.
13. The role of LTA4H and ALOX5AP polymorphism in asthma and allergy susceptibility. Holloway JW, etal., Allergy. 2008 Aug;63(8):1046-53. Epub 2008 Jun 10.
14. Hyperoxia increases protein mass of 5-lipoxygenase and its activating protein, flap, and leukotriene B(4) output in newborn rat lungs. Hosford GE, etal., Exp Lung Res. 2002 Dec;28(8):671-84.
15. Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4. Jame AJ, etal., Clin Exp Allergy. 2007 Jun;37(6):880-92.
16. Polymorphisms in the 5-lipoxygenase activating protein (ALOX5AP) gene are not associated with asthma in an Australian population. Kedda MA, etal., Clin Exp Allergy. 2005 Mar;35(3):332-8.
17. Expression of 5-lipoxygenase and 5-lipoxygenase-activating protein mRNAs in the peripheral blood leukocytes of asthmatics. Koshino T, etal., Biochem Biophys Res Commun. 1998 Jun 18;247(2):510-3.
18. Novel polymorphism of the 5-lipoxygenase activating protein (FLAP) promoter gene associated with asthma. Koshino T, etal., Mol Cell Biol Res Commun. 1999 Jul;2(1):32-5.
19. Differential gene signatures in rat mammary tumors induced by DMBA and those induced by fractionated gamma radiation. Lee HJ, etal., Radiat Res. 2008 Nov;170(5):579-90.
20. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. Lemaitre RN, etal., Atherosclerosis. 2009 Jun;204(2):e58-63. Epub 2008 Nov 1.
21. Association of three-gene interaction among MTHFR, ALOX5AP and NOTCH3 with thrombotic stroke: a multicenter case-control study. Liu J, etal., Hum Genet. 2009 Jun;125(5-6):649-56. Epub 2009 Apr 17.
22. Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation. Lorrain DS, etal., Eur J Pharmacol. 2010 Aug 25;640(1-3):211-8. Epub 2010 May 21.
23. Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2 -ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute and chronic inflammation. Lorrain DS, etal., J Pharmacol Exp Ther. 2009 Dec;331(3):1042-50. Epub 2009 Sep 11.
24. The membrane organization of leukotriene synthesis. Mandal AK, etal., Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6587-92. Epub 2004 Apr 14.
25. The nuclear membrane organization of leukotriene synthesis. Mandal AK, etal., Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20434-9. Epub 2008 Dec 15.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. Increased 5-lipoxygenase activating protein in immune-mediated experimental nephritis. Montero A, etal., J Nephrol. 2003 Sep-Oct;16(5):682-90.
28. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
30. Placenta growth factor induces 5-lipoxygenase-activating protein to increase leukotriene formation in sickle cell disease. Patel N, etal., Blood. 2009 Jan 29;113(5):1129-38. Epub 2008 Oct 22.
31. GOA pipeline RGD automated data pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population. Sayers I, etal., Clin Exp Allergy. 2003 Aug;33(8):1103-10.
35. Rhinovirus infection increases 5-lipoxygenase and cyclooxygenase-2 in bronchial biopsy specimens from nonatopic subjects. Seymour ML, etal., J Infect Dis. 2002 Feb 15;185(4):540-4. Epub 2002 Jan 31.
36. Increased urinary leukotriene E4 excretion in obstructive sleep apnea: effects of obesity and hypoxia. Stanke-Labesque F, etal., J Allergy Clin Immunol. 2009 Aug;124(2):364-70, 370.e1-2. Epub 2009 Jul 12.
37. Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy. Sveinbjornsson B, etal., FASEB J. 2008 Oct;22(10):3525-36. Epub 2008 Jun 30.
38. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
39. 5-Lipoxygenase pathway gene polymorphisms: lack of association with asthma in a Spanish population. Torres-Galvan SM, etal., J Investig Allergol Clin Immunol. 2009;19(6):453-8.
40. Associations of genetic polymorphisms of arachidonate 5-lipoxygenase-activating protein with risk of coronary artery disease in a European-American population. Tsai AK, etal., Atherosclerosis. 2009 Jun 18.
41. The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos. Via M, etal., Clin Exp Allergy. 2010 Apr;40(4):582-9. Epub 2010 Jan 11.
42. Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats. Voelkel NF, etal., J Clin Invest 1996 Jun 1;97(11):2491-8.
43. 5-lipoxygenase and 5-lipoxygenase-activating protein gene polymorphisms, dietary linoleic acid, and risk for breast cancer. Wang J, etal., Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2748-54.
44. Nasal mucosal expression of the leukotriene and prostanoid pathways in seasonal and perennial allergic rhinitis. Westergren VS, etal., Clin Exp Allergy. 2009 Jun;39(6):820-8. Epub 2009 Apr 2.
45. 5-Lipoxygenase and 5-lipoxygenase activating protein (FLAP) immunoreactivity in lungs from patients with primary pulmonary hypertension. Wright L, etal., Am J Respir Crit Care Med. 1998 Jan;157(1):219-29.
46. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics Xu XW, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Oct;24(5):491-4.
47. Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome. Yamada Y, etal., Int J Mol Med. 2008 Jun;21(6):801-8.
48. Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus. Yoshida T, etal., Int J Mol Med. 2009 Apr;23(4):529-37.
Additional References at PubMed
PMID:2300172   PMID:8245774   PMID:8440384   PMID:9091580   PMID:10779800   PMID:12477932   PMID:17600184   PMID:19233132   PMID:19946888   PMID:24641614   PMID:29936999   PMID:30735559  
PMID:31010302  


Genomics

Comparative Map Data
Alox5ap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,785,254 - 10,809,295 (-)NCBIGRCr8
mRatBN7.2125,748,941 - 5,772,986 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl125,748,944 - 5,772,986 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx126,415,168 - 6,438,995 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0127,038,642 - 7,062,468 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0126,066,300 - 6,090,127 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0126,854,930 - 6,879,112 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl126,854,920 - 6,879,154 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0128,950,727 - 8,974,708 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4126,245,808 - 6,269,796 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1126,245,808 - 6,269,796 (-)NCBI
Celera127,507,392 - 7,531,448 (-)NCBICelera
Cytogenetic Map12p11NCBI
ALOX5AP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381330,713,485 - 30,764,426 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1330,713,478 - 30,764,426 (+)EnsemblGRCh38hg38GRCh38
GRCh371331,287,622 - 31,338,563 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361330,207,669 - 30,236,556 (+)NCBINCBI36Build 36hg18NCBI36
Build 341330,207,668 - 30,236,556NCBI
Celera1312,378,644 - 12,407,516 (+)NCBICelera
Cytogenetic Map13q12.3NCBI
HuRef1312,105,618 - 12,156,585 (+)NCBIHuRef
CHM1_11331,255,200 - 31,306,135 (+)NCBICHM1_1
T2T-CHM13v2.01329,935,580 - 29,986,538 (+)NCBIT2T-CHM13v2.0
Alox5ap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395149,201,814 - 149,224,963 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5149,201,577 - 149,224,963 (+)EnsemblGRCm39 Ensembl
GRCm385149,265,004 - 149,288,153 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5149,264,767 - 149,288,153 (+)EnsemblGRCm38mm10GRCm38
MGSCv375150,076,634 - 150,099,623 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365149,575,407 - 149,596,895 (+)NCBIMGSCv36mm8
Celera5147,280,239 - 147,303,063 (+)NCBICelera
Cytogenetic Map5G3NCBI
cM Map589.18NCBI
Alox5ap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543115,069,089 - 15,097,580 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543115,071,535 - 15,097,496 (-)NCBIChiLan1.0ChiLan1.0
ALOX5AP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21430,318,849 - 30,348,046 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11321,425,689 - 21,454,792 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01312,012,399 - 12,041,557 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11330,425,510 - 30,476,607 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1330,425,510 - 30,476,607 (+)Ensemblpanpan1.1panPan2
ALOX5AP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,320,868 - 9,351,056 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,320,864 - 9,351,836 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha259,363,720 - 9,390,082 (-)NCBIDog10K_Boxer_Tasha
Alox5ap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945170,449,329 - 170,475,151 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647225,477,010 - 25,502,840 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647225,477,094 - 25,502,823 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALOX5AP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl117,411,644 - 7,438,108 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1117,371,328 - 7,438,111 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2117,222,771 - 7,287,566 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALOX5AP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.139,618,030 - 9,642,990 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl39,617,949 - 9,643,184 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605734,722,809 - 34,747,583 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alox5ap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247767,475,200 - 7,506,283 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247767,475,269 - 7,646,805 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Alox5ap
158 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:51
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000001207
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)1219318387Rat
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)127977298525593Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12390696910373166Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 1 8 8 11 8 10 11
Low 2 42 49 33 8 33 8 11 74 35 31 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001207   ⟹   ENSRNOP00000001207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl125,748,944 - 5,772,986 (-)Ensembl
Rnor_6.0 Ensembl126,854,920 - 6,879,154 (-)Ensembl
RefSeq Acc Id: NM_017260   ⟹   NP_058956
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81210,785,254 - 10,809,295 (-)NCBI
mRatBN7.2125,748,941 - 5,772,986 (-)NCBI
Rnor_6.0126,854,930 - 6,879,112 (-)NCBI
Rnor_5.0128,950,727 - 8,974,708 (-)NCBI
RGSC_v3.4126,245,808 - 6,269,796 (-)RGD
Celera127,507,392 - 7,531,448 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058956 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH86593 (Get FASTA)   NCBI Sequence Viewer  
  CAA36442 (Get FASTA)   NCBI Sequence Viewer  
  EDL89525 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001207
  ENSRNOP00000001207.3
  ENSRNOP00055003946
  ENSRNOP00060002634
  ENSRNOP00065007016
GenBank Protein P20291 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_058956   ⟸   NM_017260
- UniProtKB: Q5RJL3 (UniProtKB/Swiss-Prot),   P20291 (UniProtKB/Swiss-Prot),   A6K167 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001207   ⟸   ENSRNOT00000001207

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20291-F1-model_v2 AlphaFold P20291 1-161 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698391
Promoter ID:EPDNEW_R8915
Type:multiple initiation site
Name:Alox5ap_1
Description:arachidonate 5-lipoxygenase activating protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0126,879,131 - 6,879,191EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2097 AgrOrtholog
BioCyc Gene G2FUF-20189 BioCyc
Ensembl Genes ENSRNOG00000000907 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055003427 UniProtKB/Swiss-Prot
  ENSRNOG00060002388 UniProtKB/Swiss-Prot
  ENSRNOG00065006327 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001207 ENTREZGENE
  ENSRNOT00000001207.7 UniProtKB/Swiss-Prot
  ENSRNOT00055005320 UniProtKB/Swiss-Prot
  ENSRNOT00060003776 UniProtKB/Swiss-Prot
  ENSRNOT00065009709 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7310271 IMAGE-MGC_LOAD
InterPro 5_LipOase_AP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FLAP/GST2/LTC4S_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAPEG-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Membr-assoc_MAPEG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29624 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105473 IMAGE-MGC_LOAD
NCBI Gene 29624 ENTREZGENE
PANTHER ARACHIDONATE 5-LIPOXYGENASE-ACTIVATING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MICROSOMAL GLUTATHIONE S-TRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MAPEG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Alox5ap PhenoGen
PRINTS 5LPOXGNASEAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FLAP_GST2_LTC4S UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000907 RatGTEx
  ENSRNOG00055003427 RatGTEx
  ENSRNOG00060002388 RatGTEx
  ENSRNOG00065006327 RatGTEx
Superfamily-SCOP MAPEG domain-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC220528
UniProt A6K167 ENTREZGENE, UniProtKB/TrEMBL
  AL5AP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5RJL3 ENTREZGENE
UniProt Secondary Q5RJL3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Alox5ap  arachidonate 5-lipoxygenase activating protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in macrophages 632195
gene_function binds MK-886, a protein that blocks leukotriene synthesis 69749
gene_process required for leukotriene synthesis 69749
gene_process plays a role in macrophage immediate hypersensitivity response 632195
gene_regulation expression is induced by ovalbumin challenge 632195