Ak2 (adenylate kinase 2) - Rat Genome Database

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Gene: Ak2 (adenylate kinase 2) Rattus norvegicus
Analyze
Symbol: Ak2
Name: adenylate kinase 2
RGD ID: 2077
Description: Enables adenylate kinase activity. Contributes to nucleobase-containing compound kinase activity. Involved in several processes, including oxidative phosphorylation; purine nucleotide metabolic process; and response to thyroid hormone. Predicted to be located in sperm mitochondrial sheath. Predicted to be active in mitochondrion. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in reticular dysgenesis. Orthologous to human AK2 (adenylate kinase 2); PARTICIPATES IN adefovir pharmacokinetics pathway; tenofovir pharmacokinetics pathway; de novo purine biosynthetic pathway; INTERACTS WITH (R)-adrenaline; 17beta-estradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adenylate kinase 2, mitochondrial; adenylate monophosphate kinase; AK 2; ATP-AMP transphosphorylase 2; ATP:AMP phosphotransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Ak2-ps3  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85146,609,469 - 146,649,008 (+)NCBIGRCr8
mRatBN7.25141,308,650 - 141,364,633 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5141,346,063 - 141,364,632 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5144,044,192 - 144,062,698 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05145,814,021 - 145,832,527 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05145,813,302 - 145,831,915 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05147,185,474 - 147,204,050 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,185,474 - 147,204,050 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05150,910,910 - 150,929,525 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45148,156,751 - 148,176,195 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15148,166,789 - 148,183,198 (+)NCBI
Celera5139,827,913 - 139,846,149 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
dibutyl phthalate  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (EXP,ISO)
irinotecan  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
piroxicam  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
tolcapone  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Distinct organization of energy metabolism in HL-1 cardiac cell line and cardiomyocytes. Eimre M, etal., Biochim Biophys Acta. 2008 Jun;1777(6):514-24. Epub 2008 Mar 29.
2. Development of adenylate kinase isoenzymes in rat liver. Filler R and Criss WE, Biochem J. 1971 May;122(4):553-5.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Distribution and developmental changes of adenylate kinase isozymes in the rat brain: localization of adenylate kinase 1 in the olfactory bulb. Inouye S, etal., Biochem Biophys Res Commun 1999 Jan 27;254(3):618-22.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Lagresle-Peyrou C, etal., Nat Genet. 2009 Jan;41(1):106-11. doi: 10.1038/ng.278. Epub 2008 Nov 30.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Mechanism of mitochondrial import of adenylate kinase isozymes. Nobumoto M, etal., J Biochem. 1998 Jan;123(1):128-35.
10. Dynamics of nucleotide metabolism as a supporter of life phenomena. Noma T J Med Invest. 2005 Aug;52(3-4):127-36.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Dynamic expression of adenylate kinase 2 in the hippocampus of pilocarpine model rats. Peng X, etal., J Mol Neurosci. 2012 May;47(1):150-7. doi: 10.1007/s12031-011-9703-3. Epub 2012 Jan 14.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Purification of rat liver adenylate kinase isozyme II and comparison with isozyme 3. Sapico V, etal., Biochim Biophys Acta. 1972 Feb 28;258(2):436-45.
19. Proteomic characterization of early changes induced by triiodothyronine in rat liver. Severino V, etal., J Proteome Res. 2011 Jul 1;10(7):3212-24. Epub 2011 Jun 1.
20. Tissue-specific and developmentally regulated expression of the genes encoding adenylate kinase isozymes. Tanabe T, etal., J Biochem. 1993 Feb;113(2):200-7.
21. Evidence of a new phosphoryl transfer system in nucleotide metabolism. Vannoni D, etal., FEBS J. 2009 Jan;276(1):271-85. Epub 2008 Nov 27.
22. Distinct behaviors of adenylate kinase and cytochrome c observed following induction of mitochondrial permeability transition by Ca(2+) in the absence of respiratory substrate. Yamamoto T, etal., J Bioenerg Biomembr. 2008 Dec;40(6):619-23. Epub 2009 Jan 13.
Additional References at PubMed
PMID:6182143   PMID:8889548   PMID:12477932   PMID:12865426   PMID:14651853   PMID:15632090   PMID:16790685   PMID:18614015   PMID:20458337  


Genomics

Comparative Map Data
Ak2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85146,609,469 - 146,649,008 (+)NCBIGRCr8
mRatBN7.25141,308,650 - 141,364,633 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5141,346,063 - 141,364,632 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5144,044,192 - 144,062,698 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05145,814,021 - 145,832,527 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05145,813,302 - 145,831,915 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05147,185,474 - 147,204,050 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,185,474 - 147,204,050 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05150,910,910 - 150,929,525 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45148,156,751 - 148,176,195 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15148,166,789 - 148,183,198 (+)NCBI
Celera5139,827,913 - 139,846,149 (+)NCBICelera
Cytogenetic Map5q36NCBI
AK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38133,007,940 - 33,036,883 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl133,007,986 - 33,080,996 (-)EnsemblGRCh38hg38GRCh38
GRCh37133,473,541 - 33,502,484 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36133,246,173 - 33,275,079 (-)NCBINCBI36Build 36hg18NCBI36
Build 34133,147,675 - 33,171,564NCBI
Celera131,743,797 - 31,772,701 (-)NCBICelera
Cytogenetic Map1p35.1NCBI
HuRef131,590,115 - 31,619,093 (-)NCBIHuRef
CHM1_1133,589,052 - 33,618,018 (-)NCBICHM1_1
T2T-CHM13v2.0132,867,728 - 32,896,675 (-)NCBIT2T-CHM13v2.0
Ak2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394128,887,017 - 128,905,322 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4128,885,751 - 128,905,322 (+)EnsemblGRCm39 Ensembl
GRCm384128,993,224 - 129,011,529 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4128,991,958 - 129,011,529 (+)EnsemblGRCm38mm10GRCm38
MGSCv374128,670,509 - 128,688,773 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364128,495,569 - 128,513,833 (+)NCBIMGSCv36mm8
Celera4127,337,482 - 127,350,601 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map462.62NCBI
Ak2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545211,254,853 - 11,275,587 (-)NCBIChiLan1.0ChiLan1.0
AK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21193,789,141 - 193,817,156 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11192,911,293 - 192,939,311 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0132,295,668 - 32,323,681 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1133,480,074 - 33,508,697 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl133,480,947 - 33,508,621 (-)Ensemblpanpan1.1panPan2
AK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1268,342,769 - 68,371,769 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,350,057 - 68,371,090 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha264,922,664 - 64,951,721 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0268,906,961 - 68,936,418 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl268,914,650 - 68,936,416 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1265,719,275 - 65,748,337 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0266,741,685 - 66,770,757 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0267,733,734 - 67,762,814 (+)NCBIUU_Cfam_GSD_1.0
Ak2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505850,062,232 - 50,083,751 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493647415,887,014 - 15,908,522 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1689,295,164 - 89,318,169 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
AK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12099,834,286 - 99,863,071 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2099,834,334 - 99,858,781 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603316,834,347 - 16,863,178 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ak2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476416,089,357 - 16,113,275 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ak2
507 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat

Markers in Region
Ak2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25141,361,345 - 141,361,511 (+)MAPPERmRatBN7.2
Rnor_6.05147,200,763 - 147,200,928NCBIRnor6.0
Rnor_5.05150,926,238 - 150,926,403UniSTSRnor5.0
RGSC_v3.45148,172,908 - 148,173,073UniSTSRGSC3.4
Celera5139,842,862 - 139,843,027UniSTS
Cytogenetic Map5q36UniSTS
RH134035  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2444,967,927 - 44,968,117 (+)MAPPERmRatBN7.2
mRatBN7.25141,364,313 - 141,364,510 (+)MAPPERmRatBN7.2
Rnor_6.05147,203,731 - 147,203,927NCBIRnor6.0
Rnor_6.0443,916,634 - 43,916,823NCBIRnor6.0
Rnor_5.05150,929,206 - 150,929,402UniSTSRnor5.0
Rnor_5.0444,523,232 - 44,523,421UniSTSRnor5.0
RGSC_v3.4442,278,501 - 42,278,690UniSTSRGSC3.4
RGSC_v3.45148,175,876 - 148,176,072UniSTSRGSC3.4
Celera5139,845,830 - 139,846,026UniSTS
Celera440,259,514 - 40,259,703UniSTS
Cytogenetic Map5q36UniSTS
RH134503  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25141,361,306 - 141,361,512 (+)MAPPERmRatBN7.2
Rnor_6.05147,200,724 - 147,200,929NCBIRnor6.0
Rnor_5.05150,926,199 - 150,926,404UniSTSRnor5.0
RGSC_v3.45148,172,869 - 148,173,074UniSTSRGSC3.4
Celera5139,842,823 - 139,843,028UniSTS
RH 3.4 Map5957.2UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000134   ⟹   ENSRNOP00000000134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5141,346,063 - 141,364,632 (+)Ensembl
Rnor_6.0 Ensembl5147,185,474 - 147,204,050 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093801   ⟹   ENSRNOP00000095127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5141,346,063 - 141,357,320 (+)Ensembl
RefSeq Acc Id: NM_001033967   ⟹   NP_001029139
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85146,630,494 - 146,649,008 (+)NCBI
mRatBN7.25141,346,119 - 141,364,633 (+)NCBI
Rnor_6.05147,185,474 - 147,204,050 (+)NCBI
Rnor_5.05150,910,910 - 150,929,525 (+)NCBI
RGSC_v3.45148,156,751 - 148,176,195 (+)RGD
Celera5139,827,913 - 139,846,149 (+)NCBI
Sequence:
RefSeq Acc Id: NM_030986   ⟹   NP_112248
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85146,630,494 - 146,645,972 (+)NCBI
mRatBN7.25141,346,119 - 141,361,597 (+)NCBI
Rnor_6.05147,185,474 - 147,201,014 (+)NCBI
Rnor_5.05150,910,910 - 150,929,525 (+)NCBI
RGSC_v3.45148,156,751 - 148,176,195 (+)RGD
Celera5139,827,913 - 139,843,113 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109253   ⟹   XP_038965181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85146,609,469 - 146,645,973 (+)NCBI
mRatBN7.25141,325,153 - 141,361,603 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_112248   ⟸   NM_030986
- Peptide Label: isoform a
- UniProtKB: Q6P7C6 (UniProtKB/Swiss-Prot),   P29410 (UniProtKB/Swiss-Prot),   A6ISG8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001029139   ⟸   NM_001033967
- Peptide Label: isoform b
- UniProtKB: Q6P7C6 (UniProtKB/Swiss-Prot),   P29410 (UniProtKB/Swiss-Prot),   A0A0G2JSG6 (UniProtKB/TrEMBL),   A6ISG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000134   ⟸   ENSRNOT00000000134
RefSeq Acc Id: XP_038965181   ⟸   XM_039109253
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000095127   ⟸   ENSRNOT00000093801
Protein Domains
Adenylate kinase active site lid

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29410-F1-model_v2 AlphaFold P29410 1-239 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694053
Promoter ID:EPDNEW_R4578
Type:initiation region
Name:Ak2_1
Description:adenylate kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05147,185,497 - 147,185,557EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2077 AgrOrtholog
BioCyc Gene G2FUF-39829 BioCyc
BioCyc Pathway PWY-7219 [adenosine ribonucleotides de novo biosynthesis] BioCyc
BioCyc Pathway Image PWY-7219 BioCyc
Ensembl Genes ENSRNOG00000000122 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000134 ENTREZGENE
  ENSRNOT00000000134.5 UniProtKB/TrEMBL
  ENSRNOT00000093801.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598607 IMAGE-MGC_LOAD
InterPro Adenyl_kin_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adenylat/UMP-CMP_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adenylat_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adenylate_kinase_lid-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AK2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72419 IMAGE-MGC_LOAD
NCBI Gene 24184 ENTREZGENE
PANTHER ADENYLATE KINASE 2, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23359 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADK_lid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ak2 PhenoGen
PRINTS ADENYLTKNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADENYLATE_KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000122 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSG6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASX2_RAT UniProtKB/TrEMBL
  A6ISG7 ENTREZGENE, UniProtKB/TrEMBL
  A6ISG8 ENTREZGENE, UniProtKB/TrEMBL
  KAD2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6P7C6 ENTREZGENE
UniProt Secondary Q6P7C6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ak2  Adenylate kinase 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expression in liver is maintained at high levels throughout development; activity in liver increases after birth and was further elevated during growth 631735
gene_process functions in adenine nucleotide metabolism homeostasis 631735