Mln (motilin) - Rat Genome Database

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Gene: Mln (motilin) Rattus norvegicus
Analyze
Symbol: Mln
Name: motilin
RGD ID: 1642907
Description: Predicted to enable motilin receptor binding activity. Predicted to be located in membrane. Orthologous to human MLN (motilin); INTERACTS WITH bisphenol A; cadmium dichloride; copper atom.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: promotilin
RGD Orthologs
Human
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   DA.KHW-(RT1-DMa-Mln)  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8205,306,126 - 5,310,825 (-)NCBIGRCr8
mRatBN7.2205,304,249 - 5,308,948 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl205,304,249 - 5,308,948 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx206,015,902 - 6,020,620 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,377,647 - 5,382,365 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,858,136 - 5,862,846 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0206,567,092 - 6,571,791 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl206,567,092 - 6,571,791 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,809,892 - 8,814,591 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,447,053 - 5,451,752 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera206,868,101 - 6,872,810 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10381885   PMID:17592529   PMID:21756270   PMID:24727237  


Genomics

Comparative Map Data
Mln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8205,306,126 - 5,310,825 (-)NCBIGRCr8
mRatBN7.2205,304,249 - 5,308,948 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl205,304,249 - 5,308,948 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx206,015,902 - 6,020,620 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,377,647 - 5,382,365 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,858,136 - 5,862,846 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0206,567,092 - 6,571,791 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl206,567,092 - 6,571,791 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,809,892 - 8,814,591 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,447,053 - 5,451,752 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera206,868,101 - 6,872,810 (-)NCBICelera
Cytogenetic Map20p12NCBI
MLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38633,794,673 - 33,804,003 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl633,794,673 - 33,804,003 (-)EnsemblGRCh38hg38GRCh38
GRCh37633,762,450 - 33,771,780 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,870,427 - 33,879,771 (-)NCBINCBI36Build 36hg18NCBI36
Build 34633,870,426 - 33,879,771NCBI
Celera635,316,856 - 35,326,200 (-)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef633,504,396 - 33,513,741 (-)NCBIHuRef
CHM1_1633,764,700 - 33,774,044 (-)NCBICHM1_1
T2T-CHM13v2.0633,615,853 - 33,625,183 (-)NCBIT2T-CHM13v2.0
Mln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554372,188,719 - 2,193,102 (-)NCBIChiLan1.0ChiLan1.0
MLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2548,274,131 - 48,279,842 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1644,140,943 - 44,147,274 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0633,368,091 - 33,377,405 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1634,476,050 - 34,485,166 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl634,476,050 - 34,485,166 (-)Ensemblpanpan1.1panPan2
MLN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1123,137,408 - 3,147,566 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl123,137,422 - 3,146,836 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha123,153,309 - 3,162,521 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0123,469,843 - 3,480,009 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,469,860 - 3,479,073 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1123,136,030 - 3,145,233 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0123,218,061 - 3,227,248 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0123,315,397 - 3,324,561 (-)NCBIUU_Cfam_GSD_1.0
Mln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,795,095 - 38,802,389 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493647625,141,317 - 25,165,161 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MLN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl730,003,526 - 30,013,064 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1730,003,501 - 30,013,064 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,663,308 - 34,672,854 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MLN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11738,275,784 - 38,286,662 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604433,686,702 - 33,693,789 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mln
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475423,148,723 - 23,153,427 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mln
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:85
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000067667
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2046066076691706Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat

Markers in Region
D20Rat45  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2205,304,575 - 5,304,690 (+)MAPPERmRatBN7.2
Rnor_6.0206,567,419 - 6,567,533NCBIRnor6.0
Rnor_5.0208,810,219 - 8,810,333UniSTSRnor5.0
RGSC_v3.46133,455,626 - 133,455,718RGDRGSC3.4
RGSC_v3.4205,447,380 - 5,447,494UniSTSRGSC3.4
RGSC_v3.1205,447,483 - 5,447,954RGD
Celera206,868,428 - 6,868,552UniSTS
SHRSP x BN Map200.0UniSTS
SHRSP x BN Map200.0RGD


Related Rat Strains
The following Strains have been annotated to Mln


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system nervous system renal system reproductive system respiratory system
High
Medium
Low 2 8 9 2 15
Below cutoff 4 4 14 5 4 3

Sequence


RefSeq Acc Id: ENSRNOT00000067667
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl205,304,249 - 5,308,948 (-)Ensembl
Rnor_6.0 Ensembl206,567,092 - 6,571,791 (-)Ensembl
RefSeq Acc Id: NM_001110056   ⟹   NP_001103526
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8205,306,126 - 5,310,825 (-)NCBI
mRatBN7.2205,304,249 - 5,308,948 (-)NCBI
Rnor_6.0206,567,092 - 6,571,791 (-)NCBI
Rnor_5.0208,809,892 - 8,814,591 (-)NCBI
RGSC_v3.4205,447,053 - 5,451,752 (-)RGD
Celera206,868,101 - 6,872,810 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001103526 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC99047 (Get FASTA)   NCBI Sequence Viewer  
  BAF85821 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000079795
  ENSRNOP00000079795.1
RefSeq Acc Id: NP_001103526   ⟸   NM_001110056
- UniProtKB: A8IRI0 (UniProtKB/TrEMBL),   A8IR99 (UniProtKB/TrEMBL)
- Sequence:

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1642907 AgrOrtholog
BioCyc Gene G2FUF-4485 BioCyc
Ensembl Genes ENSRNOG00000042186 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067667 ENTREZGENE
  ENSRNOT00000067667.2 UniProtKB/TrEMBL
InterPro Promotilin UniProtKB/TrEMBL
KEGG Report rno:100126231 UniProtKB/TrEMBL
NCBI Gene 100126231 ENTREZGENE
PANTHER MOTILIN UniProtKB/TrEMBL
  PROMOTILIN UniProtKB/TrEMBL
PhenoGen Mln PhenoGen
RatGTEx ENSRNOG00000042186 RatGTEx
UniProt A8IR99 ENTREZGENE, UniProtKB/TrEMBL
  A8IRI0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-10-26 Mln  motilin      Symbol and Name status set to provisional 70820 PROVISIONAL