Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-nicotine | increases expression | ISO | H3C1 (Homo sapiens) | 6480464 | Nicotine results in increased expression of H3C1 protein | CTD | PMID:35929799 | 1,2-dimethylhydrazine | multiple interactions | ISO | H3c1 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of H3C4 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | increases expression | ISO | H3c1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of H3C1 mRNA | CTD | PMID:22206623 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | H3c1 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | H3c1 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | H3C1 (Homo sapiens) | 6480464 | [Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of H3C1 mRNA | CTD | PMID:26159488 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of H3C1 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | H3c1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to H3C4 promoter] | CTD | PMID:19654925 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | H3c1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of H3C1 mRNA more ... | CTD | PMID:21570461 and PMID:24680724 | 2-hydroxypropanoic acid | affects expression | ISO | H3C1 (Homo sapiens) | 6480464 | Lactic Acid affects the expression of H3C1 mRNA | CTD | PMID:30851411 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of H3C1 mRNA | CTD | PMID:30047161 | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of H3C1 mRNA | CTD | PMID:28959563 | all-trans-retinoic acid | increases acetylation | ISO | H3C1 (Homo sapiens) | 6480464 | Tretinoin results in increased acetylation of H3C1 protein | CTD | PMID:28053092 | amitrole | increases expression | EXP | | 6480464 | Amitrole results in increased expression of H3C1 mRNA | CTD | PMID:30047161 | benzene | decreases expression | ISO | H3C1 (Homo sapiens) | 6480464 | Benzene results in decreased expression of H3C1 mRNA | CTD | PMID:19162166 | benzo[a]pyrene | increases expression | ISO | H3c1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of H3C1 mRNA | CTD | PMID:19770486 | benzo[a]pyrene | decreases expression | ISO | H3c1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of H3C4 mRNA | CTD | PMID:20127859 | benzo[a]pyrene | decreases methylation | ISO | H3C1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of H3C1 5' UTR and Benzo(a)pyrene results in decreased methylation of H3C1 exon | CTD | PMID:27901495 | benzo[a]pyrene | multiple interactions | ISO | H3c1 (Mus musculus) | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to H3C10 promoter] | CTD | PMID:19654925 | benzo[a]pyrene | decreases expression | ISO | H3C1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of H3C1 mRNA and Benzo(a)pyrene results in decreased expression of H3C1 protein | CTD | PMID:32234424 and PMID:33044785 | berberine | decreases expression | ISO | H3C1 (Homo sapiens) | 6480464 | Berberine results in decreased expression of H3C1 mRNA | CTD | PMID:27311644 | bisphenol A | decreases expression | ISO | H3C1 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of H3C1 mRNA | CTD | PMID:29275510 | bisphenol A | decreases expression | ISO | H3c1 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of H3C4 mRNA | CTD | PMID:36347119 | bisphenol A | increases expression | ISO | H3c1 (Mus musculus) | 6480464 | bisphenol A results in increased expression of H3C10 mRNA | CTD | PMID:36347119 | cadmium atom | multiple interactions | ISO | H3C1 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of H3C1 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | H3C1 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of H3C1 mRNA | CTD | PMID:35301059 | calcitriol | decreases expression | ISO | H3C1 (Homo sapiens) | 6480464 | Calcitriol results in decreased expression of H3C1 mRNA | CTD | PMID:21592394 | calcitriol | multiple interactions | ISO | H3C1 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of H3C1 mRNA | CTD | PMID:21592394 | cannabidiol | increases expression | ISO | H3c1 (Mus musculus) | 6480464 | Cannabidiol results in increased expression of H3C4 mRNA | CTD | PMID:21542829 | cannabidiol | decreases expression | ISO | H3C1 (Homo sapiens) | 6480464 | Cannabidiol results in decreased expression of H3C1 mRNA | CTD | PMID:33244087 | captan | decreases expression | ISO | H3c1 (Mus musculus) | 6480464 | Captan results in decreased expression of H3C1 mRNA | CTD | PMID:31558096 | carbon nanotube | increases expression | ISO | H3c1 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | H3C1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to H3C1 gene] | CTD | PMID:28238834 | chlordecone | increases expression | ISO | H3c1 (Mus musculus) | 6480464 | Chlordecone results in increased expression of H3C4 mRNA | CTD | PMID:33711761 | ciguatoxin CTX1B | affects expression | ISO | H3c1 (Mus musculus) | 6480464 | Ciguatoxins affects the expression of H3C4 mRNA | CTD | PMID:18353800 | Cuprizon | affects expression | EXP | | 6480464 | Cuprizone affects the expression of H3C1 mRNA | CTD | PMID:27523638 | diazinon | increases methylation | ISO | H3C1 (Homo sapiens) | 6480464 | Diazinon results in increased methylation of H3C1 gene | CTD | PMID:22964155 | dichloroacetic acid | increases expression | ISO | H3c1 (Mus musculus) | 6480464 | Dichloroacetic Acid results in increased expression of H3C1 mRNA and Dichloroacetic Acid results in increased expression of H3C10 mRNA | CTD | PMID:28962523 | dimethylarsinous acid | increases expression | ISO | H3C1 (Homo sapiens) | 6480464 | dimethylarsinous acid results in increased expression of H3C1 mRNA | CTD | PMID:23876855 | dioxygen | decreases expression | ISO | H3C1 (Homo sapiens) | 6480464 | Oxygen deficiency results in decreased expression of H3C1 mRNA | CTD | PMID:26516004 | doxorubicin | decreases expression | ISO | H3C1 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of H3C1 mRNA | CTD | PMID:29803840 | endosulfan | multiple interactions | ISO | H3C1 (Homo sapiens) | 6480464 | [Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of H3C1 mRNA | CTD | PMID:26159488 | ferric oxide | decreases expression | ISO | H3c1 (Mus musculus) | 6480464 | ferric oxide analog results in decreased expression of H3C1 mRNA | CTD | PMID:25086211 | folic acid | multiple interactions | ISO | H3C1 (Homo sapiens) | 6480464 | [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of H3C1 mRNA | CTD | PMID:24657277 | folic acid | increases expression | ISO | H3c1 (Mus musculus) | 6480464 | Folic Acid results in increased expression of H3C1 mRNA | CTD | PMID:25629700 | folic acid | multiple interactions | ISO | H3c1 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of H3C4 mRNA | CTD | PMID:22206623 | folpet | decreases expression | ISO | H3c1 (Mus musculus) | 6480464 | folpet results in decreased expression of H3C1 mRNA | CTD | PMID:31558096 | formaldehyde | increases expression | ISO | H3C1 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of H3C1 mRNA | CTD | PMID:20655997 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of H3C1 mRNA | CTD | PMID:33387578 | hydrogen sulfide | decreases expression | ISO | H3c1 (Mus musculus) | 6480464 | Hydrogen Sulfide results in decreased expression of H3C1 protein | CTD | PMID:29932956 | iron dichloride | increases expression | ISO | H3C1 (Homo sapiens) | 6480464 | ferrous chloride results in increased expression of H3C1 mRNA | CTD | PMID:35984750 | leflunomide | decreases expression | ISO | H3C1 (Homo sapiens) | 6480464 | Leflunomide results in decreased expression of H3C1 mRNA | CTD | PMID:28988120 | Licochalcone B | increases expression | ISO | H3C1 (Homo sapiens) | 6480464 | licochalcone B results in increased expression of H3C1 mRNA | CTD | PMID:33647349 | manganese(II) chloride | decreases expression | EXP | | 6480464 | manganese chloride results in decreased expression of H3C1 mRNA | CTD | PMID:28801915 | methidathion | increases expression | ISO | H3c1 (Mus musculus) | 6480464 | methidathion results in increased expression of H3C1 mRNA | CTD | PMID:34813904 | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of H3C1 mRNA | CTD | PMID:30047161 | methotrexate | multiple interactions | ISO | H3C1 (Homo sapiens) | 6480464 | [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of H3C1 mRNA | CTD | PMID:24657277 | methylisothiazolinone | increases expression | ISO | H3C1 (Homo sapiens) | 6480464 | 2-methyl-4-isothiazolin-3-one results in increased expression of H3C1 mRNA | CTD | PMID:31629900 | N-methyl-4-phenylpyridinium | decreases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of H3C1 mRNA | CTD | PMID:28801915 | N-Nitrosopyrrolidine | decreases expression | ISO | H3C1 (Homo sapiens) | 6480464 | N-Nitrosopyrrolidine results in decreased expression of H3C1 mRNA | CTD | PMID:32234424 | nicotine | increases expression | ISO | H3C1 (Homo sapiens) | 6480464 | Nicotine results in increased expression of H3C1 protein | CTD | PMID:35929799 | O-methyleugenol | decreases expression | ISO | H3C1 (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of H3C1 mRNA | CTD | PMID:32234424 | ozone | multiple interactions | ISO | H3c1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in increased expression of H3C1 mRNA | CTD | PMID:27106289 | paracetamol | affects expression | ISO | H3c1 (Mus musculus) | 6480464 | Acetaminophen affects the expression of H3C1 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of H3C1 mRNA | CTD | PMID:33387578 | PCB138 | multiple interactions | ISO | H3c1 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | perfluorooctanoic acid | increases expression | ISO | H3c1 (Mus musculus) | 6480464 | perfluorooctanoic acid results in increased expression of H3C1 protein | CTD | PMID:36214631 | phenethyl isothiocyanate | decreases expression | ISO | H3C1 (Homo sapiens) | 6480464 | phenethyl isothiocyanate results in decreased expression of H3C1 mRNA | CTD | PMID:26678675 | pirinixic acid | decreases expression | ISO | H3c1 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of H3C4 mRNA | CTD | PMID:25270620 | pregnenolone 16alpha-carbonitrile | increases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of H3C1 mRNA | CTD | PMID:30047161 | pyridaben | decreases expression | ISO | H3c1 (Mus musculus) | 6480464 | pyridaben results in decreased expression of H3C1 mRNA | CTD | PMID:22563483 | rac-lactic acid | affects expression | ISO | H3C1 (Homo sapiens) | 6480464 | Lactic Acid affects the expression of H3C1 mRNA | CTD | PMID:30851411 | silicon dioxide | increases expression | ISO | H3c1 (Mus musculus) | 6480464 | Silicon Dioxide results in increased expression of H3C1 mRNA and Silicon Dioxide results in increased expression of H3C4 mRNA | CTD | PMID:19073995 and PMID:33720480 | sodium arsenite | decreases expression | ISO | H3C1 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of H3C1 mRNA | CTD | PMID:23876855 | sodium arsenite | decreases expression | ISO | H3c1 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of H3C4 mRNA | CTD | PMID:37682722 | sodium arsenite | increases expression | ISO | H3C1 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of H3C1 mRNA | CTD | PMID:34032870 | sodium dichromate | decreases expression | ISO | H3c1 (Mus musculus) | 6480464 | sodium bichromate results in decreased expression of H3C1 mRNA | CTD | PMID:31558096 | sulfadimethoxine | increases expression | EXP | | 6480464 | Sulfadimethoxine results in increased expression of H3C1 mRNA | CTD | PMID:30047161 | testosterone | multiple interactions | ISO | H3C1 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of H3C1 mRNA | CTD | PMID:21592394 | testosterone | decreases expression | ISO | H3C1 (Homo sapiens) | 6480464 | Testosterone results in decreased expression of H3C1 mRNA | CTD | PMID:21592394 | Testosterone propionate | decreases expression | ISO | H3c1 (Mus musculus) | 6480464 | Testosterone Propionate results in decreased expression of H3C1 mRNA | CTD | PMID:15601916 | thalidomide | decreases expression | ISO | H3c1 (Mus musculus) | 6480464 | Thalidomide results in decreased expression of H3C1 mRNA | CTD | PMID:26217789 | tributylstannane | increases expression | ISO | H3c1 (Mus musculus) | 6480464 | tributyltin results in increased expression of H3C1 mRNA | CTD | PMID:31939706 | trichloroethene | affects expression | EXP | | 6480464 | Trichloroethylene affects the expression of H3C1 mRNA | CTD | PMID:33387578 | trimellitic anhydride | increases expression | ISO | H3c1 (Mus musculus) | 6480464 | trimellitic anhydride results in increased expression of H3C1 mRNA | CTD | PMID:19042947 | Triptolide | increases expression | ISO | H3c1 (Mus musculus) | 6480464 | triptolide results in increased expression of H3C4 mRNA | CTD | PMID:32835833 | triptonide | decreases expression | ISO | H3c1 (Mus musculus) | 6480464 | triptonide results in decreased expression of H3C10 mRNA | CTD | PMID:33045310 | trovafloxacin | decreases expression | ISO | H3c1 (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of H3C10 mRNA and trovafloxacin results in decreased expression of H3C4 mRNA | CTD | PMID:35537566 | versicolorin A | decreases expression | ISO | H3C1 (Homo sapiens) | 6480464 | versicolorin A results in decreased expression of H3C1 mRNA | CTD | PMID:32106047 | |