Flvcr1 (FLVCR choline and heme transporter 1) - Rat Genome Database

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Gene: Flvcr1 (FLVCR choline and heme transporter 1) Rattus norvegicus
Analyze
Symbol: Flvcr1
Name: FLVCR choline and heme transporter 1 (Ensembl:FLVCR heme transporter 1)
RGD ID: 1596541
Description: Predicted to enable heme B transmembrane transporter activity. Predicted to be involved in heme B biosynthetic process and heme export. Predicted to act upstream of or within several processes, including chordate embryonic development; embryonic digit morphogenesis; and spleen development. Predicted to be located in mitochondrion and plasma membrane. Predicted to be active in mitochondrial membrane. Orthologous to human FLVCR1 (FLVCR choline and heme transporter 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: feline leukemia virus subgroup C cellular receptor 1; feline leukemia virus subgroup C receptor-related protein 1; feline leukemia virus subgroup C receptor-related protein 1-like; FLVCR heme transporter 1; heme transporter FLVCR1; LOC100909719; LOC108348225; LOC683955; similar to Feline leukemia virus subgroup C receptor-related protein 1 (Feline leukemia virus subgroup C receptor) (hFLVCR)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813105,117,402 - 105,139,780 (-)NCBIGRCr8
mRatBN7.213102,586,263 - 102,608,647 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13102,586,257 - 102,608,661 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.013109,578,294 - 109,624,235 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13109,578,074 - 109,629,482 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013114,211,863 - 114,224,490 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.013114,180,812 - 114,183,817 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera13102,055,793 - 102,074,779 (-)NCBICelera
Cytogenetic Map13q27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IBA)
mitochondrion  (IBA,ISO)
plasma membrane  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15369674   PMID:18258918   PMID:20610401   PMID:23187127  


Genomics

Comparative Map Data
Flvcr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813105,117,402 - 105,139,780 (-)NCBIGRCr8
mRatBN7.213102,586,263 - 102,608,647 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13102,586,257 - 102,608,661 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.013109,578,294 - 109,624,235 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13109,578,074 - 109,629,482 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013114,211,863 - 114,224,490 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.013114,180,812 - 114,183,817 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera13102,055,793 - 102,074,779 (-)NCBICelera
Cytogenetic Map13q27NCBI
FLVCR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381212,858,275 - 212,899,363 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1212,858,275 - 212,899,363 (+)EnsemblGRCh38hg38GRCh38
GRCh371213,031,617 - 213,072,705 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361211,098,220 - 211,135,379 (+)NCBINCBI36Build 36hg18NCBI36
Celera1186,257,592 - 186,295,983 (+)NCBICelera
Cytogenetic Map1q32.3NCBI
HuRef1183,708,670 - 183,749,562 (+)NCBIHuRef
CHM1_11214,303,965 - 214,345,035 (+)NCBICHM1_1
T2T-CHM13v2.01212,103,255 - 212,144,367 (+)NCBIT2T-CHM13v2.0
Flvcr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391190,738,029 - 190,758,387 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1190,738,044 - 190,758,355 (-)EnsemblGRCm39 Ensembl
GRCm381191,005,832 - 191,026,190 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1191,005,847 - 191,026,158 (-)EnsemblGRCm38mm10GRCm38
MGSCv371192,829,711 - 192,850,069 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361192,706,447 - 192,726,805 (-)NCBIMGSCv36mm8
Celera1197,930,699 - 197,951,041 (-)NCBICelera
Cytogenetic Map1H6NCBI
cM Map196.28NCBI
Flvcr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554064,674,140 - 4,702,763 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554064,673,797 - 4,702,858 (-)NCBIChiLan1.0ChiLan1.0
FLVCR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2136,504,306 - 36,545,327 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1136,468,659 - 36,509,726 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01188,425,697 - 188,466,721 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11193,284,158 - 193,321,962 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1193,284,158 - 193,320,554 (+)Ensemblpanpan1.1panPan2
FLVCR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1711,001,155 - 11,038,910 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl711,001,101 - 11,035,980 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha710,576,761 - 10,614,312 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0710,707,668 - 10,745,429 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl710,707,433 - 10,745,177 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1710,630,123 - 10,667,529 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0710,731,550 - 10,769,463 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0710,856,188 - 10,893,897 (+)NCBIUU_Cfam_GSD_1.0
Flvcr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934463,453,117 - 63,486,909 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936557692,489 - 726,965 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936557693,445 - 727,166 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLVCR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9130,541,660 - 130,570,702 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19130,543,911 - 130,570,486 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29143,470,869 - 143,497,447 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FLVCR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12516,656,219 - 16,688,397 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2516,652,246 - 16,688,376 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605517,151,582 - 17,183,388 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Flvcr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477118,239,437 - 18,270,408 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Flvcr1
150 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:26
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000072452
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12 4 11 4 31 2 8
Low 3 43 45 37 8 37 8 11 43 33 31 11 8
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000072452   ⟹   ENSRNOP00000066732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl13102,586,257 - 102,608,661 (-)Ensembl
Rnor_6.0 Ensembl13109,578,074 - 109,629,482 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000088326   ⟹   ENSRNOP00000075109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl13109,578,287 - 109,580,271 (-)Ensembl
RefSeq Acc Id: NM_001427625   ⟹   NP_001414554
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,117,402 - 105,139,759 (-)NCBI
RefSeq Acc Id: XR_005492749
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,120,697 - 105,139,777 (-)NCBI
mRatBN7.213102,588,661 - 102,608,647 (-)NCBI
RefSeq Acc Id: XR_005492750
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,128,352 - 105,139,780 (-)NCBI
mRatBN7.213102,597,225 - 102,608,647 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414554 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066732.3
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000066732   ⟸   ENSRNOT00000072452
RefSeq Acc Id: ENSRNOP00000075109   ⟸   ENSRNOT00000088326
RefSeq Acc Id: NP_001414554   ⟸   NM_001427625
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RB11-F1-model_v2 AlphaFold M0RB11 1-558 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699119
Promoter ID:EPDNEW_R9635
Type:single initiation site
Name:Flvcr1_1
Description:Feline leukemia virus subgroup C receptor-related protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013109,629,577 - 109,629,637EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596541 AgrOrtholog
Ensembl Genes ENSRNOG00000049633 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072452.3 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
InterPro MFS UniProtKB/TrEMBL
  MFS_dom UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
  SLC49-like UniProtKB/TrEMBL
NCBI Gene Flvcr1 ENTREZGENE
PANTHER FELINE LEUKEMIA VIRUS SUBGROUP C RECEPTOR-RELATED PROTEIN 1 UniProtKB/TrEMBL
  MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/TrEMBL
PhenoGen Flvcr1 PhenoGen
PROSITE MFS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049633 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/TrEMBL
UniProt M0RB11_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-08-03 Flvcr1  FLVCR choline and heme transporter 1  Flvcr1  FLVCR heme transporter 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-03-09 Flvcr1  FLVCR heme transporter 1  LOC108348225  feline leukemia virus subgroup C receptor-related protein 1  Data merged from RGD:11421226 737654 PROVISIONAL
2019-11-11 Flvcr1  FLVCR heme transporter 1  Flvcr1  feline leukemia virus subgroup C cellular receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-08-02 LOC108348225  feline leukemia virus subgroup C receptor-related protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2015-07-29 Flvcr1  feline leukemia virus subgroup C cellular receptor 1  LOC100909719  feline leukemia virus subgroup C receptor-related protein 1-like  Data merged from RGD:6501904 737654 PROVISIONAL
2014-10-03 Flvcr1  feline leukemia virus subgroup C cellular receptor 1  LOC683955  similar to Feline leukemia virus subgroup C receptor-related protein 1 (Feline leukemia virus subgroup C receptor) (hFLVCR)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100909719  feline leukemia virus subgroup C receptor-related protein 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC683955  similar to Feline leukemia virus subgroup C receptor-related protein 1 (Feline leukemia virus subgroup C receptor) (hFLVCR)      Symbol and Name status set to provisional 70820 PROVISIONAL