Tmx3 (thioredoxin-related transmembrane protein 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Tmx3 (thioredoxin-related transmembrane protein 3) Rattus norvegicus
Analyze
Symbol: Tmx3
Name: thioredoxin-related transmembrane protein 3
RGD ID: 1592777
Description: Predicted to enable protein-disulfide reductase activity. Predicted to be located in cell surface and endoplasmic reticulum membrane. Orthologous to human TMX3 (thioredoxin related transmembrane protein 3); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC682967; similar to Protein disulfide-isomerase TXNDC10 precursor (Thioredoxin domain-containing protein 10)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81886,021,137 - 86,054,025 (+)NCBIGRCr8
mRatBN7.21883,731,777 - 83,764,719 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1883,731,868 - 83,762,263 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1885,816,215 - 85,849,084 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01886,489,442 - 86,522,311 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01884,330,820 - 84,363,671 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01887,580,227 - 87,613,481 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1887,580,424 - 87,610,390 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01886,612,826 - 86,645,703 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1882,248,676 - 82,280,969 (+)NCBICelera
Cytogenetic Map18q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15623505   PMID:19995400  


Genomics

Comparative Map Data
Tmx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81886,021,137 - 86,054,025 (+)NCBIGRCr8
mRatBN7.21883,731,777 - 83,764,719 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1883,731,868 - 83,762,263 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1885,816,215 - 85,849,084 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01886,489,442 - 86,522,311 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01884,330,820 - 84,363,671 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01887,580,227 - 87,613,481 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1887,580,424 - 87,610,390 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01886,612,826 - 86,645,703 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1882,248,676 - 82,280,969 (+)NCBICelera
Cytogenetic Map18q13NCBI
TMX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381868,673,688 - 68,715,108 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1868,673,688 - 68,715,108 (-)EnsemblGRCh38hg38GRCh38
GRCh371866,340,925 - 66,382,345 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361864,491,905 - 64,533,333 (-)NCBINCBI36Build 36hg18NCBI36
Build 341864,491,906 - 64,533,333NCBI
Celera1863,187,511 - 63,228,954 (-)NCBICelera
Cytogenetic Map18q22.1NCBI
HuRef1863,058,873 - 63,100,314 (-)NCBIHuRef
CHM1_11866,335,765 - 66,377,203 (-)NCBICHM1_1
T2T-CHM13v2.01868,889,797 - 68,931,229 (-)NCBIT2T-CHM13v2.0
Tmx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391890,528,336 - 90,561,391 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1890,528,278 - 90,561,391 (+)EnsemblGRCm39 Ensembl
GRCm381890,510,154 - 90,543,267 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1890,510,154 - 90,543,267 (+)EnsemblGRCm38mm10GRCm38
MGSCv371890,679,546 - 90,712,659 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361890,655,196 - 90,674,816 (+)NCBIMGSCv36mm8
Celera1892,226,617 - 92,259,730 (+)NCBICelera
Cytogenetic Map18E4NCBI
cM Map1859.37NCBI
Tmx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540252,274,800 - 52,315,634 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540252,271,705 - 52,315,795 (-)NCBIChiLan1.0ChiLan1.0
TMX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21786,223,046 - 86,264,030 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11871,915,665 - 71,956,596 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01862,072,290 - 62,113,574 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11865,368,718 - 65,409,664 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1865,368,718 - 65,409,664 (-)Ensemblpanpan1.1panPan2
TMX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.119,395,336 - 9,439,939 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl19,395,296 - 9,436,922 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha110,416,531 - 10,461,325 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.019,237,215 - 9,281,713 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl19,237,220 - 9,370,217 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.119,251,398 - 9,295,549 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.019,212,895 - 9,257,155 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.019,423,400 - 9,467,868 (+)NCBIUU_Cfam_GSD_1.0
Tmx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494423,054,397 - 23,092,433 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936781909,379 - 948,541 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936781909,402 - 947,406 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1153,988,050 - 154,031,120 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11153,988,020 - 154,031,124 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21170,746,593 - 170,789,616 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11811,019,907 - 11,059,284 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1811,020,037 - 11,059,414 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606014,744,423 - 14,784,519 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248401,314,514 - 1,361,073 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmx3
92 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:8
Count of miRNA genes:8
Interacting mature miRNAs:8
Transcripts:ENSRNOT00000070984
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat

Markers in Region
RH129527  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21883,762,825 - 83,763,026 (+)MAPPERmRatBN7.2
Rnor_6.01887,611,936 - 87,612,136NCBIRnor6.0
Rnor_5.01886,644,158 - 86,644,358UniSTSRnor5.0
Celera1882,279,424 - 82,279,624UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 40 44 28 19 28 8 10 74 35 36 11 8
Low 1 3 13 13 13 1 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000070984   ⟹   ENSRNOP00000064077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1883,731,885 - 83,762,263 (+)Ensembl
Rnor_6.0 Ensembl1887,580,424 - 87,610,390 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096077   ⟹   ENSRNOP00000096127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1883,731,868 - 83,762,263 (+)Ensembl
RefSeq Acc Id: NM_001400798   ⟹   NP_001387727
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81886,021,137 - 86,054,025 (+)NCBI
mRatBN7.21883,731,831 - 83,764,719 (+)NCBI
RefSeq Acc Id: XM_039097376   ⟹   XP_038953304
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81886,021,163 - 86,052,584 (+)NCBI
mRatBN7.21883,731,777 - 83,764,374 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001387727 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953304 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL75154 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064077
  ENSRNOP00000064077.3
  ENSRNOP00000096127.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000064077   ⟸   ENSRNOT00000070984
RefSeq Acc Id: XP_038953304   ⟸   XM_039097376
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ARW7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000096127   ⟸   ENSRNOT00000096077
RefSeq Acc Id: NP_001387727   ⟸   NM_001400798
- Peptide Label: precursor
- UniProtKB: M0R402 (UniProtKB/TrEMBL),   A6K5P3 (UniProtKB/TrEMBL)
Protein Domains
Thioredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R402-F1-model_v2 AlphaFold M0R402 1-459 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700918
Promoter ID:EPDNEW_R11424
Type:initiation region
Name:Tmx3_1
Description:thioredoxin-related transmembrane protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01887,580,339 - 87,580,399EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592777 AgrOrtholog
BioCyc Gene G2FUF-6685 BioCyc
Ensembl Genes ENSRNOG00000045740 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000070984 ENTREZGENE
  ENSRNOT00000070984.3 UniProtKB/TrEMBL
  ENSRNOT00000096077.1 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/TrEMBL
InterPro Thioredoxin-like_sf UniProtKB/TrEMBL
  Thioredoxin_CS UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/TrEMBL
NCBI Gene 682967 ENTREZGENE
PANTHER PROTEIN DISULFIDE-ISOMERASE TMX3 UniProtKB/TrEMBL
  PROTEIN DISULFIDE-ISOMERASE TMX3 UniProtKB/TrEMBL
Pfam Thioredoxin UniProtKB/TrEMBL
  Thioredoxin_6 UniProtKB/TrEMBL
PhenoGen Tmx3 PhenoGen
PRINTS THIOREDOXIN UniProtKB/TrEMBL
PROSITE THIOREDOXIN_1 UniProtKB/TrEMBL
  THIOREDOXIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000045740 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/TrEMBL
UniProt A0A8I6ARW7 ENTREZGENE, UniProtKB/TrEMBL
  A6K5P3 ENTREZGENE, UniProtKB/TrEMBL
  M0R402 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-13 Tmx3  thioredoxin-related transmembrane protein 3  LOC682967  similar to Protein disulfide-isomerase TXNDC10 precursor (Thioredoxin domain-containing protein 10)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC682967  similar to Protein disulfide-isomerase TXNDC10 precursor (Thioredoxin domain-containing protein 10)      Symbol and Name status set to provisional 70820 PROVISIONAL