Predicted to enable several functions, including ATP binding activity; disordered domain specific binding activity; and identical protein binding activity. Involved in several processes, including male gonad development; pyrimidine nucleobase metabolic process; and response to ionizing radiation. Located in cell projection; neuronal cell body; and nuclear envelope. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in chronic progressive external ophthalmoplegia. Orthologous to human RRM1 (ribonucleotide reductase catalytic subunit M1); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Note: NCBI's current annotation of the functional gene (chromosome 1) and a pseudogene (chromosome 14) are not consistent on all assemblies. The functional gene on the Celera assembly is currently annotated with the GeneID of the pseudogene on chromosome 14. [17 Jun 2014]
[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RRM1 mRNA and AHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of RRM1 mRNA]
[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RRM1 mRNA
[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RRM1 mRNA
[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RRM1 mRNA
[Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of RRM1 mRNA and [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of RRM1 protein
[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of RRM1 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in increased expression of RRM1 mRNA
[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RRM1 mRNA
[Coumestrol co-treated with Resveratrol] results in increased expression of RRM1 mRNA and [Plant Extracts co-treated with Resveratrol] results in increased expression of RRM1 mRNA
[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RRM1 mRNA
Tumor BRCA1, RRM1 and RRM2 mRNA expression levels and clinical response to first-line gemcitabine plus docetaxel in non-small-cell lung cancer patients.
Gene expression profiling of alpha-radiation-induced rat osteosarcomas: identification of dysregulated genes involved in radiation-induced tumorigenesis of bone.
Changes in the distribution of insulin-like growth factor I, thioredoxin, thioredoxin reductase and ribonucleotide reductase during the development of the retina.
Changes in the cytoplasmic and nuclear activities of the ribonucleotide reductase holoenzyme and its subunits in regenerating liver cells in normal and thyroparathyroidectomized rats.
Characterization of cell proliferation in the adult dentate under normal conditions and after kainate induced seizures using ribonucleotide reductase and BrdU.